Refine
Has Fulltext
- yes (18)
Is part of the Bibliography
- yes (18)
Year of publication
Document Type
- Journal article (18)
Language
- English (18) (remove)
Keywords
- Candida albicans (12)
- protein kinase (3)
- Candida auris (2)
- antifungals (2)
- protein kinases (2)
- signaling pathway (2)
- transcription factors (2)
- AMP-activated kinases (1)
- Escherichia coli (1)
- Harnwegsinfekt (1)
- Hirnhautentzündung (1)
- Ire1 (1)
- Mig1 (1)
- NRG1 (1)
- PICD (1)
- Pan1 (1)
- SNF1 (1)
- Snf1 (1)
- UME6 (1)
- Ypk1 (1)
- antifungal drug (1)
- antimicrobial resistance (1)
- azobenzenes (1)
- biofilms (1)
- biology (1)
- candida albicans (1)
- cell wall (1)
- conditional mutants (1)
- drug resistance evolution (1)
- endocytosis (1)
- epidemiology (1)
- essential genes (1)
- expression (1)
- fluconazole resistance (1)
- functional genomics (1)
- gene (1)
- genetic recombination (1)
- growth (1)
- hyperexpression techniques (1)
- hyphae (1)
- immune response (1)
- library screening (1)
- mating (1)
- metabolic adaptation (1)
- microbiology (1)
- monocytes (1)
- morphogenesis (1)
- mutation (1)
- oligopeptides (1)
- parasexual recombination (1)
- permease (1)
- pheromones (1)
- point mutation (1)
- protein expressions (1)
- protein kinase signaling cascade (1)
- regulator (1)
- regulator genes (1)
- resistance mechanism (1)
- staib agar (1)
- suppressor mutation (1)
- transcription factor (1)
- transcriptional control (1)
- virulence (1)
- zinc cluster transcription factor (1)
Azobenzene derivatives with activity against drug‐resistant Candida albicans and Candida auris
(2023)
Increasing resistance against antimycotic drugs challenges anti‐infective therapies today and contributes to the mortality of infections by drug‐resistant Candida species and strains. Therefore, novel antifungal agents are needed. A promising approach in developing new drugs is using naturally occurring molecules as lead structures. In this work, 4,4'‐dihydroxyazobenzene, a compound structurally related to antifungal stilbene derivatives and present in Agaricus xanthodermus (yellow stainer), served as a starting point for the synthesis of five azobenzene derivatives. These compounds prevented the growth of both fluconazole‐susceptible and fluconazole‐resistant Candida albicans and Candida auris strains. Further in vivo studies are required to confirm the potential therapeutic value of these compounds.