Refine
Has Fulltext
- yes (44)
Is part of the Bibliography
- yes (44)
Year of publication
Document Type
- Journal article (44)
Language
- English (44) (remove)
Keywords
- ADHD (8)
- bipolar disorder (5)
- depression (4)
- BDNF (3)
- Medizin (3)
- anxiety (3)
- dopamine (3)
- Bipolar disorder (2)
- FAAH (2)
- antidepressant (2)
- attention (2)
- disorder (2)
- early intervention (2)
- early recognition (2)
- electroencephalography (2)
- emotion (2)
- endocannabinoid (2)
- fear conditioning (2)
- fear-potentiated startle (2)
- genetics (2)
- hyperactivity (2)
- illness (2)
- impulsivity (2)
- mutation (2)
- near-infrared spectroscopy (2)
- polygenic risk score (2)
- psychiatry (2)
- reaction time (2)
- startle reflex (2)
- working memory (2)
- 5-HTTLPR (1)
- 5HTTLPR (1)
- 65-kda isoform (1)
- AKI (1)
- Abelson helper integration-1 (AHI1) (1)
- Adult (1)
- Aggression (1)
- Alzheimer's disease (1)
- Alzheimers disease (1)
- Antisocial behavior (1)
- Association (1)
- BDNF Val66Met (1)
- Big Five (1)
- Biomarke (1)
- C-reactive protein (1)
- CBT (1)
- CDH13 (1)
- CLN3 (1)
- COMT (1)
- COMT VAL(158)MET polymorphism (1)
- Conduct disorder (1)
- DNA methylation (1)
- DYT1 (1)
- Deficit/hyperactivity disorder (1)
- Depression (1)
- Diagnostic approach (1)
- Dystonia (1)
- EBM (1)
- GHQ-28 (1)
- GRN (1)
- GWAS (1)
- Gene (1)
- Genotype (1)
- Glutamic-acid decarboxylase anxiety (1)
- Human behaviour (1)
- Inflammatio (1)
- KDIGO (1)
- Large multicenter ADHD (1)
- Maintenance treatment (1)
- Mania (1)
- NPSR1 (1)
- Nesplora Aquarium (1)
- PARK2 (1)
- Personalized medicine (1)
- Polarity index (1)
- Predominant polarity (1)
- Prognostic markers (1)
- Psychiatric disorders (1)
- Qb-Test (1)
- Quetiapine (1)
- Rating scale (1)
- Schizophrenie (1)
- Serotonin (1)
- Susceptibility loci (1)
- Tryptophan hydroxylase-2 (Tph2) (1)
- UPPS (1)
- VBM (1)
- accidents (1)
- acoustic startle (1)
- acute mania (1)
- adult attention deficit/hyperactivity disorder (adult ADHD) (1)
- adversity (1)
- age (1)
- aggression (1)
- agreeableness (1)
- allostatic load (1)
- amygdala (1)
- analysis of variance (1)
- antibodies (1)
- anticipation (1)
- apolipoprotein-E4 (1)
- association (1)
- astrocytes (1)
- attention deficit hyperactivity disorder (1)
- attention‐deficit (1)
- at‐risk (1)
- autoantibodies (1)
- basal ganglia (1)
- behavioral activation system (1)
- bipolar disorders (1)
- brain asymmetry (1)
- brain derived neurotrophic factor (1)
- brain laterality (1)
- burden (1)
- caffeine-induced anxiety (1)
- cardiac surgery (1)
- ceramides (1)
- childhood maltreatment (1)
- chronic stress (1)
- cognitive deficits (1)
- cognitive-behavioural psychotherapy (1)
- community sample (1)
- contextual fear conditioning (1)
- continuous performance test (1)
- cross-sectional study (1)
- dementia (1)
- development (1)
- disease modelling (1)
- dopaminergics (1)
- drug-addiction (1)
- elderly (1)
- electrode recording (1)
- emotions (1)
- endocannabinoids (1)
- epigenetics (1)
- executive function training (1)
- executive functions (1)
- extinction (1)
- eyes (1)
- fNIRS (1)
- families (1)
- fear (1)
- fear generalization (1)
- fear memory (1)
- frontotemporal lobar degeneration (1)
- fumarate (1)
- gene (1)
- gene × gene interaction (1)
- gene-by-environment interaction (1)
- geneexpression (1)
- genetic phenotypes (1)
- genetic variants (1)
- genetics memory (1)
- genome-wide association (1)
- glia (1)
- group treatment (1)
- haplotypes (1)
- hiPSC (1)
- hippocampus (1)
- hospitalisation (1)
- hyperactivity disorder (1)
- impact (1)
- intervention study (1)
- large‐scale data (1)
- length of stay (1)
- life events (1)
- linkage (1)
- major depression (1)
- management (1)
- mapping susceptibility genes (1)
- massively multiplayer online role playing games (1)
- maternal (1)
- maturation (1)
- mechanismofaction (1)
- mismatch (1)
- mitochondria (1)
- monetary incentive delay task (1)
- monoamine oxidase A (1)
- monoamine transporters (1)
- mood disorders (1)
- morality (1)
- mouse model (1)
- neurodevelopment (1)
- neuronal plasticity (1)
- neurons (1)
- neuropsychology (1)
- nitricoxidesynthase (1)
- observer agreement (1)
- of-the-literature (1)
- onset (1)
- panic disorder (1)
- paternal (1)
- people (1)
- peripheral injury (1)
- postnatal depression (1)
- posttraumatic-stress-disorder (1)
- prediction (1)
- prefrontal cortex (1)
- prepulse inhibition (1)
- presynaptic inhibition (1)
- primary care (1)
- prodromal (1)
- prophylactic lithium (1)
- psychiatric-hospitalization (1)
- psychosocial stress (1)
- rare mendelian disorders (1)
- rating scale (1)
- reconsolidation (1)
- reliability (1)
- remitted/acute phase (1)
- research errors (1)
- response inhibition (1)
- resting-state fMRI (1)
- reward deficiency syndrome (1)
- risk genes (1)
- second hit (1)
- sensitivity (1)
- serious mental illness (1)
- serotonin transporter gene (1)
- skin conductance (1)
- spectrum disorder (1)
- spinal-cord-injury (1)
- stressful life events (1)
- structural MRI (1)
- substance abuse disorder (1)
- subthreshold bipolar (1)
- synaptic transmission (1)
- tandem mass spectrometry (1)
- treatment (1)
- ultra-high risk (1)
- venturesomeness (1)
- verbal fluency task (1)
- verbal n-back (1)
- video-game (1)
- world of warcraft (1)
Institute
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (35)
- Institut für Psychologie (11)
- Klinik und Poliklinik für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie (6)
- Neurologische Klinik und Poliklinik (6)
- Lehrstuhl für Molekulare Psychiatrie (3)
- Abteilung für Molekulare Innere Medizin (in der Medizinischen Klinik und Poliklinik II) (1)
- Institut für Klinische Epidemiologie und Biometrie (1)
- Institut für Pädagogik (1)
- Klinik und Poliklinik für Nuklearmedizin (1)
- Klinik und Poliklinik für Thorax-, Herz- u. Thorakale Gefäßchirurgie (1)
Neural responses to a working memory task in acute depressed and remitted phases in bipolar patients
(2023)
(1) Cognitive impairments such as working memory (WM) deficits are amongst the most common dysfunctions characterizing bipolar disorder (BD) patients, severely contributing to functional impairment. We aimed to investigate WM performance and associated brain activation during the acute phase of BD and to observe changes in the same patients during remission. (2) Frontal brain activation was recorded using functional near-infrared spectroscopy (fNIRS) during n-back task conditions (one-back, two-back and three-back) in BD patients in their acute depressive (n = 32) and remitted (n = 15) phases as well as in healthy controls (n = 30). (3) Comparison of BD patients during their acute phase with controls showed a trend (p = 0.08) towards lower dorsolateral prefrontal cortex (dlPFC) activation. In the remitted phase, BD patients showed lower dlPFC and ventrolateral prefrontal cortex (vlPFC) activation (p = 0.02) compared to controls. No difference in dlPFC and vlPFC activation between BD patients’ phases was found. (4) Our results showed decreased working memory performance in BD patients during the working memory task in the acute phase of disease. Working memory performance improved in the remitted phase of the disease but was still particularly attenuated for the more demanding conditions.