Refine
Has Fulltext
- yes (6)
Is part of the Bibliography
- yes (6)
Document Type
- Journal article (6)
Language
- English (6) (remove)
Keywords
- neuroimmunology (2)
- 3D tissue model (1)
- NOTCH (1)
- OLFM4 (1)
- Parkinson's disease (1)
- RNS (1)
- Salmonella Typhimurium (1)
- antigen-presenting cells (1)
- bacteria (1)
- bacterial migration (1)
- bacterial virulence (1)
- biological scaffold (1)
- diseases of the nervous system (1)
- filamentous Salmonella Typhimurium (1)
- helminths (1)
- immune evasion (1)
- infection (1)
- intestinal enteroids (1)
- mechanisms of disease (1)
- mycobacteria (1)
- myelin biology and repair (1)
- olfactomedin 4 (1)
- parasitology (1)
- steady-state dendritic cells (1)
- tolerogenic dendritic cells (1)
- transcriptional profiling (1)
- transcriptomics (1)
Institute
Inflammation in the brain and gut is a critical component of several neurological diseases, such as Parkinson’s disease (PD). One trigger of the immune system in PD is aggregation of the pre-synaptic protein, α-synuclein (αSyn). Understanding the mechanism of propagation of αSyn aggregates is essential to developing disease-modifying therapeutics. Using a brain-first mouse model of PD, we demonstrate αSyn trafficking from the brain to the ileum of male mice. Immunohistochemistry revealed that the ileal αSyn aggregations are contained within CD11c+ cells. Using single-cell RNA sequencing, we demonstrate that ileal CD11c\(^+\) cells are microglia-like and the same subtype of cells is activated in the brain and ileum of PD mice. Moreover, by utilizing mice expressing the photo-convertible protein, Dendra2, we show that CD11c\(^+\) cells traffic from the brain to the ileum. Together these data provide a mechanism of αSyn trafficking between the brain and gut.