Refine
Has Fulltext
- yes (7)
Is part of the Bibliography
- yes (7)
Document Type
- Journal article (7)
Language
- English (7) (remove)
Keywords
- cognitive impairment (3)
- GFAP (2)
- glial fibrillary acidic protein (2)
- heart failure (2)
- myocardial infarction (2)
- neurofilament light chain (2)
- Alzheimer’s dementia (1)
- B cells (1)
- Brain atrophy (1)
- CIED malfunction; pacemaker (PM) (1)
- Chronic heart failure (1)
- Cognitive decline (1)
- Glial fibrillary acidic protein (1)
- MRI (1)
- Memory dysfunction (1)
- NfL (1)
- STEMI (1)
- age (1)
- antibodies (1)
- aortic valve stenosis (1)
- atrial fibrillation (1)
- battery depletion (1)
- cardiac arrest (1)
- cardiac implantable electronic devices (CIED) (1)
- cardiac magnetic resonance imaging (1)
- cardiac resynchronization therapy (CRT) (1)
- chronic heart failure (1)
- cluster analysis (1)
- coronary artery disease (1)
- dementia (1)
- eculizumab (1)
- glial damage (1)
- hypertension (1)
- implantable cardioverter defibrillator (ICD) (1)
- inebilizumab (1)
- infarction size (1)
- intensity of attention (1)
- neuroinflammation (1)
- neuromyelitis optica spectrum disorders (1)
- phosphorylated tau protein (1)
- radiotherapy (RT) (1)
- ravulizumab (1)
- renal function (1)
- satralizumab (1)
- tocilizumab (1)
- ublituximab (1)
Institute
- Medizinische Klinik und Poliklinik I (6)
- Deutsches Zentrum für Herzinsuffizienz (DZHI) (4)
- Neurologische Klinik und Poliklinik (4)
- Institut für diagnostische und interventionelle Neuroradiologie (ehem. Abteilung für Neuroradiologie) (3)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (3)
- Comprehensive Cancer Center Mainfranken (1)
- Institut für Virologie und Immunbiologie (1)
- Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik) (1)
- Klinik und Poliklinik für Strahlentherapie (1)
- Medizinische Klinik und Poliklinik II (1)
Sonstige beteiligte Institutionen
Acute and chronic cardiac disorders predispose to alterations in cognitive performance, ranging from mild cognitive impairment to overt dementia. Although this association is well-established, the factors inducing and accelerating cognitive decline beyond ageing and the intricate causal pathways and multilateral interdependencies involved remain poorly understood. Dysregulated and persistent inflammatory processes have been implicated as potentially causal mediators of the adverse consequences on brain function in patients with cardiac disease. Recent advances in positron emission tomography disclosed an enhanced level of neuroinflammation of cortical and subcortical brain regions as an important correlate of altered cognition in these patients. In preclinical and clinical investigations, the thereby involved domains and cell types of the brain are gradually better characterized. Microglia, resident myeloid cells of the central nervous system, appear to be of particular importance, as they are extremely sensitive to even subtle pathological alterations affecting their complex interplay with neighboring astrocytes, oligodendrocytes, infiltrating myeloid cells, and lymphocytes. Here, we review the current evidence linking cognitive impairment and chronic neuroinflammation in patients with various selected cardiac disorders including the aspect of chronic neuroinflammation as a potentially druggable target.