Refine
Has Fulltext
- yes (5)
Is part of the Bibliography
- yes (5)
Document Type
- Journal article (5)
Language
- English (5) (remove)
Keywords
- Cutaneous leishmaniasis (1)
- activation (1)
- amber codon suppression (1)
- amber light (1)
- bio-orthogonal chemistry (1)
- biocide polyhexamethylene biguanide (1)
- click chemistry (1)
- decafluoroazobezene (1)
- dendritic cells (1)
- drug-delivery systems (1)
- experimental visceral leishmaniasis (1)
- glycocalyx (1)
- hMSC-TERT (1)
- high-throughput screening (1)
- hydrogels (1)
- metabolic glycoengineering (1)
- modified monosaccharides (1)
- online monitoring system (1)
- paromomycin (1)
- peptide stapling (1)
- perfluoroarylation (1)
- photocontrol (1)
- protein engineering (1)
- resistance (1)
- therapy (1)
- topical treatment (1)
- unnatural amino acid (1)
Institute
- Institut für Pharmazie und Lebensmittelchemie (5) (remove)
EU-Project number / Contract (GA) number
- 296679 (1)
Amber Light Control of Peptide Secondary Structure by a Perfluoroaromatic Azobenzene Photoswitch
(2023)
The incorporation of photoswitches into the molecular structure of peptides and proteins enables their dynamic photocontrol in complex biological systems. Here, a perfluorinated azobenzene derivative triggered by amber light was site‐specifically conjugated to cysteines in a helical peptide by perfluoroarylation chemistry. In response to the photoisomerization (trans→cis) of the conjugated azobenzene with amber light, the secondary structure of the peptide was modulated from a disorganized into an amphiphilic helical structure.