Refine
Has Fulltext
- yes (3)
Is part of the Bibliography
- yes (3)
Document Type
- Journal article (3)
Language
- English (3) (remove)
Keywords
- Candida albicans (1)
- Candida auris (1)
- amber light (1)
- antifungal drug (1)
- azobenzenes (1)
- bile (1)
- decafluoroazobezene (1)
- excipient (1)
- in vitro-in vivo correlation (1)
- peptide stapling (1)
- perfluoroarylation (1)
- pharmacokinetics (1)
- photocontrol (1)
- rat study (1)
Institute
- Institut für Pharmazie und Lebensmittelchemie (3) (remove)
Sonstige beteiligte Institutionen
Amber Light Control of Peptide Secondary Structure by a Perfluoroaromatic Azobenzene Photoswitch
(2023)
The incorporation of photoswitches into the molecular structure of peptides and proteins enables their dynamic photocontrol in complex biological systems. Here, a perfluorinated azobenzene derivative triggered by amber light was site‐specifically conjugated to cysteines in a helical peptide by perfluoroarylation chemistry. In response to the photoisomerization (trans→cis) of the conjugated azobenzene with amber light, the secondary structure of the peptide was modulated from a disorganized into an amphiphilic helical structure.