Refine
Has Fulltext
- yes (34)
Is part of the Bibliography
- yes (34)
Year of publication
Document Type
- Journal article (34) (remove)
Language
- English (34) (remove)
Keywords
- protein binding (3)
- S-ADAPT (2)
- allometric scaling (2)
- body composition (2)
- body size (2)
- capillary electrophoresis (2)
- chemistry (2)
- cystic fibrosis patients (2)
- healthy volunteers (2)
- population pharmacokinetics (2)
- solubility (2)
- strategy (2)
- ultrafiltration (2)
- 2,5-diketopiperazines (1)
- 77-LH-28-1 (1)
- AChE inhibitor (1)
- AGP (1)
- Alzheimer’s disease (1)
- Analytical Quality by Design (1)
- Burkholderia pseudomallei Mip (1)
- CAD detection (1)
- Candida albicans (1)
- Candida auris (1)
- Cecropia telenitida (1)
- Charged aerosol detector (CAD) (1)
- Enterobacteriaceae (1)
- Escherichia coli (1)
- Fatty acids (1)
- GABA\(_{B}\) (1)
- Gradient boosted trees (GBT) (1)
- HNSCC (1)
- HPLC–MS (1)
- High-performance liquid chromatography (HPLC) (1)
- IR (1)
- Ibuprofen (1)
- Klebsiella pneumoniae (1)
- LC-MS/MS (1)
- Mip inhibitor (1)
- Osmunda regalis (1)
- PPIase (1)
- Paeonia (1)
- Quantitative structure-property relationship modeling (QSPR) (1)
- Red Sea (1)
- Schistosomiasis (1)
- T cell (1)
- Tanzania (1)
- V. wallichii (1)
- Valeriana wallichii (1)
- Xanomeline (1)
- \(^{1}\)HNMR (1)
- absolute bioavailability (1)
- acetic acid (1)
- acetones (1)
- acetonitrile (1)
- acid value (1)
- acids (1)
- albumin (1)
- anisotropy (1)
- anti-inflammatory activity (1)
- anti-proliferative effects (1)
- anti-schistosomal activity (1)
- antibacterials (1)
- antifungal drug (1)
- antileishmanial (1)
- antimicrobial resistance (1)
- autophagy (1)
- azobenzenes (1)
- baclofen (1)
- beta-lactam antibiotics (1)
- bioactivity (1)
- biodiversity (1)
- bitopic hybrid ligands (1)
- bitopic ligand (1)
- blood brain barrier (1)
- boat conformation (1)
- bone marrow (1)
- caffeic acid bornyl ester (1)
- cecropia telenitida (1)
- cefotiam (1)
- cerebEND cells (1)
- charged aerosol detector (1)
- chenopodium quinoa (1)
- chiral separation (1)
- cholinergic system (1)
- crystal structure (1)
- cyclodextrins (1)
- cytokine modulation (1)
- cytokine production (1)
- cytotoxicity (1)
- dendritic cells (1)
- derivates (1)
- design of experiments (1)
- diketopiperazines (1)
- drug impurities (1)
- drugs (1)
- electrophoresis (1)
- emulsions oil-in-water (1)
- enantiomers (1)
- enantioselectivity (1)
- ephedrine (1)
- epitope mapping (1)
- ester value (1)
- ethanol (1)
- eugenyl cinnamate (1)
- extraction (1)
- fatty acids (1)
- field testing (1)
- fluorescence polarization (1)
- fluorescence resonance energy transfer (1)
- fluoroquinolone (1)
- forms (1)
- gallotannins (1)
- gene expression (1)
- gentamicin sulfate (1)
- gradient HPLC–UV (1)
- head and neck carcinoma (1)
- high performance liquid chromatography (1)
- high throughput screening (1)
- high-resolution tandem mass spectrometry (1)
- histamine (1)
- hybrid molecules (1)
- hydrogen bonding (1)
- hypoxia (1)
- impurity profiling (1)
- information technology (1)
- intramolecular Michael addition (1)
- invasion (1)
- iodine value (1)
- isolation (1)
- isomerization (1)
- isosteviol sodium (1)
- kappa-B activation (1)
- ketamine (1)
- leaves (1)
- leishmaniasis (1)
- linear discriminant analysis (1)
- liquid chromatography-mass spectrometry (1)
- maceration (1)
- macrophages (1)
- magnesium stearate (1)
- manufacturer (1)
- marine metagenomics (1)
- marine natural products (1)
- marine organisms (1)
- medicine authentication tools (1)
- metastasis (1)
- mobile apps (1)
- multicomponent Ugi-type reaction (1)
- muscarinic M1 receptor (1)
- muscarinic acetylcholine receptors (1)
- muscarinic receptors (1)
- natural product (1)
- neuroprotection (1)
- nicotinic receptors (1)
- nitric oxide (1)
- novel nepetolactone derivative (1)
- nuclear magnetic resonance spectroscopy (1)
- obtusifolia bertol (1)
- oleanane saponins (1)
- parasite (1)
- pefloxacin (1)
- pentacyclic triterpene (1)
- pharmaceutical analysis (1)
- phytochemicals (1)
- plant extract (1)
- plants (1)
- podophyllotoxin (1)
- polysorbate 80 (1)
- pressurized microwave‐assisted extraction (1)
- principal component analysis (1)
- proliferation (1)
- psidium guajava; (1)
- pyridobenzodiazepine (1)
- quality evaluation (1)
- quantitative 1H NMR (1)
- red fruit oil (1)
- required hydrophilic–lipophilic balance (1)
- sacha inchi oil (1)
- saponification Value (1)
- saturation transfer difference NMR (1)
- schistosoma (1)
- schistosomula (1)
- serjanic acid (1)
- sisomicin (1)
- structural elucidation (1)
- structure-activity relationship (1)
- substandard and falsified medicines (1)
- synthesis (1)
- thin-layer chromatography (1)
- thymyl cinnamate (1)
- track and trace (1)
- transport (1)
- triacylglycerides (1)
- type 2 diabetes (1)
- unsaturated fatty acids (1)
- ursolic acid (1)
- vacuoles (1)
- validation (1)
- valtrates (1)
- veterinarians (1)
- veterinary medicine (1)
Institute
- Institut für Pharmazie und Lebensmittelchemie (34) (remove)
The binding of drugs to plasma proteins is an important process in the human body and has a significant influence on pharmacokinetic parameter. Human serum albumin (HSA) has the most important function as a transporter protein. The binding of ketamine to HSA has already been described in literature, but only of the racemate. The enantiomerically pure S-ketamine is used as injection solution for induction of anesthesia and has been approved by the Food and Drug Administration for the therapy of severe depression as a nasal spray in 2019. The question arises if there is enantioselective binding to HSA. Hence, the aim of this study was to investigate whether there is enantioselective binding of S-and R-ketamine to HSA or not. Ultrafiltration (UF) followed by chiral capillary electrophoretic analysis was used to determine the extent of protein binding. Bound fraction to HSA was 71.2 % and 64.9 % for enantiomerically pure R- and S-ketamine, respectively, and 66.5 % for the racemate. Detailed binding properties were studied by Saturation Transfer Difference (STD)-, waterLOGSY- and Carr-Purcell-Meiboom-Gill (CPMG)-NMR spectroscopy. With all three methods, the aromatic ring and the N-methyl group could be identified as the structural moieties most strongly involved in binding of ketamine to HSA. pK\(_{aff}\) values determined using UF and NMR indicate that ketamine is a weak affinity ligand to HSA and no significant differences in binding behavior were found between the individual enantiomers and the racemate.