Refine
Has Fulltext
- yes (2) (remove)
Is part of the Bibliography
- yes (2)
Document Type
- Journal article (2)
Language
- English (2) (remove)
Keywords
- frontotemporal dementia (2)
- aphasia (1)
- assessment of cognitive disorders/dementia (1)
- atlas‐based volumetry (1)
- cognitive neuropsychology in dementia (1)
- disease progression (1)
- longitudinal magnetic resonance imaging (1)
- primary progressive aphasia (1)
- sample size calculation (1)
- volumetric MRI (1)
Introduction
The term primary progressive aphasia (PPA) sums up the non‐fluent (nfv), the semantic (sv), and the logopenic (lv) variant. Up to now, there is only limited data available concerning magnetic resonance imaging volumetry to monitor disease progression.
Methods
Structural brain imaging and an extensive assessment were applied at baseline and up to 4‐year(s) follow‐up in 269 participants. With automated atlas‐based volumetry 56 brain regions were assessed. Atrophy progression served to calculate sample sizes for therapeutic trials.
Results
At baseline highest atrophy appeared in parts of the left frontal lobe for nfvPPA (–17%) and of the left temporal lobe for svPPA (–34%) and lvPPA (–24%). Severest progression within 1‐year follow‐up occurred in the basal ganglia in nfvPPA (–7%), in the hippocampus/amygdala in svPPA (–9%), and in (medial) temporal regions in lvPPA (–6%).
Conclusion
PPA presents as a left‐dominant, mostly gray matter sensitive disease with considerable atrophy at baseline that proceeds variant‐specific.