Refine
Has Fulltext
- yes (199)
Is part of the Bibliography
- yes (199)
Year of publication
- 2022 (199) (remove)
Document Type
- Doctoral Thesis (199) (remove)
Language
- English (199) (remove)
Keywords
- Topologischer Isolator (8)
- HgTe (5)
- Quecksilbertellurid (5)
- topological insulator (4)
- Ökologie (4)
- Elektronentransport (3)
- GPCR (3)
- Kleinsatellit (3)
- NMR-Spektroskopie (3)
- Textverstehen (3)
- Transcription (3)
- Virtuelle Realität (3)
- 3D-Druck (2)
- Arabidopsis thaliana (2)
- Aufmerksamkeit (2)
- Bildgebendes Verfahren (2)
- Biodiversität (2)
- Blazar (2)
- Borkenkäfer (2)
- Chemische Synthese (2)
- Cloud Computing (2)
- DNA damage (2)
- Ecology (2)
- Elektronenkorrelation (2)
- Elektronenspinresonanz (2)
- Endothelzelle (2)
- Fernerkundung (2)
- Fluoreszenzmikroskopie (2)
- Furcht (2)
- G-Protein gekoppelter Rezeptor (2)
- Gasgemisch (2)
- Genmutation (2)
- Glaukom (2)
- Herbivory (2)
- Herzinfarkt (2)
- Hydrogel (2)
- Industrie 4.0 (2)
- Jugend (2)
- Kind (2)
- Klimaänderung (2)
- Low Earth Orbit (2)
- MIR-Spektroskopie (2)
- Maschinelles Lernen (2)
- Megakaryozyt (2)
- Microscopy (2)
- Modellierung (2)
- NFATc1 (2)
- Nanometerbereich (2)
- Nephroblastom (2)
- Perowskit (2)
- Photoelektronenspektroskopie (2)
- Quantenchemie (2)
- Quanteninformation (2)
- Röntgen-Photoelektronenspektroskopie (2)
- Simulation (2)
- Staphylococcus aureus (2)
- Text Comprehension (2)
- Tissue Engineering (2)
- Topologie (2)
- Validität (2)
- Verteiltes System (2)
- Zeitreihe (2)
- Zuverlässigkeit (2)
- artificial intelligence (2)
- biodiversity (2)
- deep learning (2)
- hydrogels (2)
- land use (2)
- pollination (2)
- 3C 279 (1)
- 3D cell culture (1)
- 3D structure (1)
- 3D-Struktur (1)
- 3D-Zellkultur (1)
- 7SK (1)
- ADSC (1)
- AGN (1)
- ARPES (1)
- ASM (1)
- ATRA (1)
- Ab Interno Trabekulektomie (1)
- Abscisinsäure (1)
- Absorptionsspektroskopie (1)
- Accelerated imaging (1)
- Acetaminophen (1)
- Acid Sphingomyelinase (1)
- Ackerschmalwand (1)
- Active galactic nucleus (1)
- Active self (1)
- AdMSC (1)
- AdS-CFT-Korrespondenz (1)
- AdS/CFT correspondence (1)
- Adjuvans (1)
- Adjuvant (1)
- Advanced Analytics (1)
- Adventitia (1)
- Adverse outcome pathway (AOP) (1)
- Agriculture intensification (1)
- Aharonov-Bohm (1)
- Air pollution (1)
- Aktiver galaktischer Kern (1)
- Algebraische Quantenfeldtheorie (1)
- Altproterozoikum (1)
- Ambrosia beetles (1)
- Ambrosiakäfer (1)
- Amduat (1)
- Aminobuttersäure <gamma-> (1)
- Anaphylatoxine (1)
- Anaphylatoxinrezeptoren (1)
- Angeborene Immunität (1)
- Angeregter Zustand (1)
- Angst (1)
- Angst als Eigenschaft (1)
- Angsterkrankungen (1)
- Angststörung (1)
- Anisotropic structures (1)
- Anomalieerkennung (1)
- Antarktis (1)
- Antenne (1)
- Antibiotikum (1)
- Antikörper (1)
- Aptamer (1)
- Arginine (1)
- Aromatically annulated triquinacenes (1)
- Aromatisch anellierte Triquinacene (1)
- Aromatizität (1)
- Artefakt (1)
- Arten-Energy-Theory (1)
- Artenreichtum (1)
- Artificial Intelligence (1)
- Aryl Halides (1)
- Aspergillus fumigatus (1)
- Assoziatives Lernen (1)
- Asymmetric synthesis (1)
- Asymmetrische Synthese (1)
- Atherosklerose (1)
- Augenbewegung (1)
- Aureobasidium pullulans (1)
- Autoantigen (1)
- Autofocus (1)
- Automation (1)
- Autophagy (1)
- Axion (1)
- BL Lacertae objects (1)
- Bakterielle Nanocellulose (1)
- Barth syndrome (1)
- Bee abundance (1)
- Bee assemblages (1)
- Bee species richness (1)
- Belyi map (1)
- Beschichtung (1)
- Beschleunigte Bildgebung (1)
- Beta-Adrenergic Receptor (1)
- Beta-Adrenozeptor (1)
- Betriebssystem (1)
- Bidirectional manipulation (1)
- Biodiversity conservation (1)
- Biofabrication (1)
- Biofabrication of hydrogels (1)
- Biofabrikation (1)
- Bioink (1)
- Bioinks (1)
- Biologisches Modell (1)
- Biomarker (1)
- Biomaterial (1)
- Bioprinting (1)
- Bismuthene (1)
- Bismutselenide (1)
- Bisoprolol (1)
- Blimp-1 (1)
- Blockchain (1)
- Bone regeneration (1)
- Bor (1)
- Bornitrid (1)
- Boron Nitride (1)
- Borsäureester (1)
- Borylation (1)
- Borylene (1)
- Broadcast Growth Codes (BCGC) (1)
- Burst Alert Telescope (1)
- C. difficile (1)
- CAR T cells (1)
- CAR T-Zellen (1)
- CD-Spektroskopie (1)
- CD28 (1)
- CDH13 (1)
- CDI (1)
- CRPS (1)
- CTLA-4 (1)
- CXCR4 (1)
- CXCR5 (1)
- Calcium (1)
- Calcium phosphate-based biomaterials (1)
- Calciumhydroxid (1)
- Cancer (1)
- Candida albicans (1)
- Carabid beetles (1)
- Carboxylates (1)
- Cardiac Antigens (1)
- Cardiac Efficiency (1)
- Cardiac imaging (1)
- Cardiolipin (1)
- Cardiomyocyte (1)
- Cardiomyopathy (1)
- Cartilage Tissue Engineering (1)
- Caspr1 (1)
- Cataglyphis (1)
- CdTe (1)
- CePt5 (1)
- Celaflor (1)
- Cell Sheet Engineering (1)
- Cell cycle (1)
- Cell-cell communication (1)
- Cells (1)
- Ceramid (1)
- Cerlegierung (1)
- ChR2 (1)
- Charge carrier characterization (1)
- Chemical modification of biopolymers (1)
- Chemische Synapsen (1)
- Chemokine (1)
- Chemometrie (1)
- Chemosensor (1)
- Chiralität <Chemie> (1)
- Chondrogenic Differentiation (1)
- Chondrogenic differentiation (1)
- Chromatinremodeling (1)
- Chromatinremodelling (1)
- Chronische Niereninsuffizienz (1)
- Chylomicron (1)
- Chylomicrons (1)
- Circular dichroism (1)
- Claudin (1)
- Click-Chemie (1)
- Climate change (1)
- Cloud (1)
- Cloud-native (1)
- Co-occurrence matrix (1)
- Coherent Multidimensional Spectroscopy (1)
- Compass framework (1)
- Compiler (1)
- Complex regional pain syndrome (1)
- Complexes (1)
- Complicacy (1)
- Composite-based Structural Equation Modeling (1)
- Composites (1)
- Compressed sensing (1)
- Compton-Streuung (1)
- Computational Chemistry (1)
- Conformal field theory (1)
- Contactin 1 (1)
- Core-shell (1)
- Coronary heart disease (1)
- Cortactin (1)
- Covalent inhibitors (1)
- Credibility (1)
- Crystal (1)
- Cuprate superconductor (1)
- Cyber-physisches System (1)
- DFT (1)
- DG diacyglycerol (1)
- DGCR8 (1)
- DNS-Reparatur (1)
- DNS-Schädigung (1)
- DROSHA (1)
- DSIF (1)
- Darm (1)
- Datenschutz (1)
- Debugging (1)
- Decision Support Systems (1)
- Deep Eutectics (1)
- Delay Tolerant Network (1)
- Deoxyribozymes (1)
- Dezentrale Regelung (1)
- Dialyse (1)
- Diffusion (1)
- Digital Elevation Model (1)
- Dihydrooxazole (1)
- Dimere (1)
- Dionaea (1)
- Dirac semimetal (1)
- Distributed Control (1)
- Distributed Learning (1)
- Distributed Practice (1)
- Distributed Reading (1)
- Distributed Satellite Systems (1)
- Distributed System (1)
- Distributed computing (1)
- District of Sudbury (1)
- Diversität (1)
- Dorsal Root Ganglion (1)
- Dotierung (1)
- Drahtloses Sensorsystem (1)
- Dreidimensionale Rekonstruktion (1)
- Drug Delivery System (1)
- Dual RNA-seq data analysis (1)
- Dünndarm (1)
- Earth Observation (1)
- Earth's magnetic field (1)
- Earth-Abundant Metal (1)
- Echocardiography (1)
- Echokardiographie (1)
- Echtzeitbildgebung (1)
- Ecosystem services (1)
- Einwandige Kohlenstoff-Nanoröhre (1)
- Einzelzellanalyse (1)
- Electron Paramagnetic Resonance (1)
- Electron microscopy (1)
- Electron spin (1)
- Electronic spectroscopy (1)
- Elektrochemie (1)
- Elektrochromie (1)
- Elektronenspin (1)
- Elektronische Spektroskopie (1)
- Elektronischer Transport (1)
- Elevated Plus-Maze (1)
- End-to-End Automation (1)
- Ende-zu-Ende Automatisierung (1)
- Endothelial cells (1)
- Energieeffizienz (1)
- Energy Efficiency (1)
- Entropie (1)
- Entscheidungsunterstützung (1)
- Entscheidungsunterstützungssystem (1)
- Epithel (1)
- Epithelial layer (1)
- Epitop (1)
- Epstein zeta-function (1)
- Epstein, Paul (1)
- Erklärbare Künstliche Intelligenz (1)
- Estrogens (1)
- Exosom <Vesikel> (1)
- Exosomes (1)
- Expansion Microscopy (1)
- Experimentelle Psychologie (1)
- Explainable AI (1)
- Explorationsverhalten (1)
- External-Cavity Quantum Cascade Laser (1)
- Externer-Kavitäts-Quanten-Kaskaden-Laser (1)
- Extracellular Vesicles (1)
- Extrazelluläre Matrix (1)
- Exziton (1)
- Exziton-Polariton (1)
- FCS (1)
- Fabry (1)
- Fabry disease (1)
- Fabry-Krankheit (1)
- Failure Prediction (1)
- Farbstoff (1)
- Faserorientierung (1)
- Feedback (1)
- Fehlervorhersage (1)
- Fermi (1)
- Fermion (1)
- Fermionensystem (1)
- Festkörper-NMR (1)
- Fiber Orientation (1)
- Fibroblasten (1)
- Fibroblastenwachstumsfaktor (1)
- Fibroblasts (1)
- Fluorescence (1)
- Fluorescence Correlation Spectroscopy (1)
- Fluorescence Microscopy (1)
- Fluoreszenzaktivierung (1)
- Fluoreszenzkorrelationsspektroskopie (1)
- Flüssigkristall (1)
- Food security (1)
- Forecasting (1)
- Fourier-Spektroskopie (1)
- Fraud detection (1)
- Free Fermion (1)
- Freezing (1)
- Freies Fermion (1)
- Freiwilliges Arbeitsverhalten (1)
- Funktionsgel (1)
- Furchtkonditionierung (1)
- G Protein-Coupled Receptor (1)
- G-Protein gekoppelte Rezeptoren (1)
- G-protein-coupled receptors (1)
- GABA receptor (1)
- GABA-Rezeptor (1)
- Galois-Theorie (1)
- Gammastrahlung (1)
- Gas mixtures (1)
- Gaseous Hydrocarbons (1)
- Gasförmige Kohlenwasserstoffe (1)
- Gastrointestinal tract (1)
- Gastrointestinaltrakt (1)
- Gefrierstrukturierung (1)
- Gelenkknorpel (1)
- Gentamicin (1)
- Geoarchäologie (1)
- Geographie (1)
- Geomagnetic Field (1)
- Geomorphologie (1)
- Geophysical anomaly (1)
- Gephyrin (1)
- Gittersimulator (1)
- Glaucoma (1)
- Gleichverteilung (1)
- Gletscher (1)
- Global change (1)
- Glycin (1)
- Glycinrezeptor (1)
- Goniotomie (1)
- Gradient System Transfer Function (1)
- Graphenzeichnen (1)
- Greater Sudbury (1)
- Growth (1)
- Grün fluoreszierendes Protein (1)
- Gunnarsson Schönhammer (1)
- HSV-1 (1)
- Halbleiter-Supraleiter-Kontakt (1)
- Hangstabilitätsmodellierung (1)
- Hautzelle (1)
- Heart Failure (1)
- Heavy fermion (1)
- Helix-Coil-Transition (1)
- Helix-Knäuel-Umwandlung (1)
- Herbicid (1)
- Herbivore (1)
- Herpesviren (1)
- Herpesviruses (1)
- Herzbildgebung (1)
- Herzinsuffizienz (1)
- Heteroaromaten (1)
- Heterocyclen (1)
- Heterocyclische Carbene <-N> (1)
- Higgs and Goldstone excitations (1)
- High-excited electronic states (1)
- Histone (1)
- Histones (1)
- Hochangeregte elektronische Zustände (1)
- Hochtemperatursupraleiter (1)
- Honesty-Humility (1)
- Honesty-humility (1)
- Hubbard model (1)
- Human land use (1)
- Human-Computer Interaction (1)
- Huronian Basin (1)
- Hurwitz-Raum (1)
- Hyaluronic Acid (1)
- Hyaluronsäure (1)
- Hydrogels (1)
- Hypertension (1)
- Höhengradient (1)
- ICP22 (1)
- IEEE Std 802.15.4 (1)
- IMEX (1)
- Ideomotor (1)
- Ideomotorik (1)
- Imaging spin-filter (1)
- Immunantwort (1)
- Immunisierung (1)
- Immunotherapy (1)
- Immunreaktion (1)
- Impact melts (1)
- Impaktstruktur (1)
- Impfung (1)
- Implantat (1)
- Implementierung <Informatik> (1)
- Importance of hydrophilic block in amphiphiles (1)
- Impurity Profiling (1)
- In vitro (1)
- In vitro models (1)
- In vitro testing (1)
- In-vitro-Kultur (1)
- Indole conjugation (1)
- Industry 4.0 (1)
- Informationssicherheit (1)
- Inhibition (1)
- Innate immunity (1)
- Instrumentelle Analytik (1)
- Integrity (1)
- Integrity tests (1)
- Integrität (1)
- Integritätstests (1)
- Intelligent Transportation Systems (1)
- Interaction of 7SK with the Smn complex modulates snRNP production (1)
- Inversion Symmetry Breaking (1)
- IoT (1)
- Ion Pairs (1)
- Ionenkanal (1)
- Ionic Liquids (1)
- J- and H-Aggregate (1)
- J- and H-Aggregates (1)
- Jacobsthal function (1)
- Japankärpfling (1)
- Jasmonsäure (1)
- Jugendliche (1)
- Kardinale Antigene (1)
- Kardiologie (1)
- Kardiomyozyt (1)
- Katalyse (1)
- Kathode (1)
- Keimzentrumsreaktion (1)
- Kernspintomografie (1)
- Kilimandscharo (1)
- Kinder (1)
- Kindheit und Jugend (1)
- Kinetische Gastheorie (1)
- Kognition (1)
- Kognitive Psychologie (1)
- Kohärente Anregung (1)
- Kolloidalstabilität (1)
- Kombinatorische Zahlentheorie (1)
- Kommunikationsprotokoll (1)
- Kompass (1)
- Komplement <Immunologie> (1)
- Komplement C3a (1)
- Komplement C5a (1)
- Komplexes regionales Schmerzsyndrom (1)
- Konditionierung (1)
- Kondo (1)
- Kondo-System (1)
- Koronare Herzkrankheit (1)
- Korrelation (1)
- Kristall (1)
- Kutikula (1)
- Künstliche Intelligenz (1)
- LC-MS (1)
- LCMS- based kinetic studies (1)
- LV Function (1)
- Ladungsträger-Charakterisierung (1)
- Lake Timagami (1)
- Landau type theorem (1)
- Landnutzung (1)
- Landnutzungsgradient (1)
- Landslide susceptibility modeling (1)
- Laser (1)
- Laser absorption spectroscopy (1)
- Laser pulse shaping (1)
- Laserabsorptionspektroskopie (1)
- Laserimpulsformung (1)
- Laserspektroskopie (1)
- Latenz (1)
- Lateral root development (1)
- Latrophilin (1)
- Learning & Memory (1)
- Learning Walk (1)
- Leistungsbedarf (1)
- Leistungsbewertung (1)
- Lernen (1)
- Lessons Learnt (1)
- Lewis-Addukt (1)
- Lidschlag (1)
- Ligand uncaging (1)
- Lithium-Ionen-Akkumulator (1)
- Livestock grazing (1)
- Location Factors (1)
- Logistik (1)
- Luminescence (1)
- Luttinger liquid (1)
- Lysosom (1)
- MAX (1)
- MET-T-box riboswitch (1)
- MIR spectroscopy (1)
- MRI (1)
- MRT (1)
- MYC (1)
- MYCN (1)
- Macromolecular machine (1)
- Macrophage extracellular traps (1)
- Macrophytes (1)
- Magmatismus (1)
- Magnetic Topological Insulator (1)
- Magnetism (1)
- Magnetoelastizität (1)
- Magnetoviscoelastic Fluids (1)
- Magnetoviskoelastische Flüsse (1)
- Major depression (1)
- Makrocyclische Verbindungen (1)
- Makrophyten (1)
- Markarian 501 (1)
- Mc4r (1)
- Mean-Field-Theorie (1)
- Mechanistic model (1)
- Medaka (1)
- Media Access Control (1)
- Medical Managment (1)
- Mehrkriterielle Optimierung (1)
- Melanom (1)
- Melt Electrowriting (1)
- Mensch-Maschine-Kommunikation (1)
- Mensch-Maschine-Schnittstelle (1)
- Merocyanine (1)
- Mesenchymal Stromal Cell (1)
- Mesenchymale Stromazelle (1)
- Metallosupramolekulare Chemie (1)
- Methioninbiosynthese (1)
- Mexiko (1)
- MicF (1)
- Microarray (1)
- Microservice (1)
- Microvesicles (1)
- Mikromagnetismus (1)
- Mikroservice (1)
- Mitochondria (1)
- Moco biosynthesis (1)
- Model Predictive Control (1)
- Model based communication (1)
- Model based mission realization (1)
- Modeling (1)
- Modelling (1)
- Modellprädiktive Regelung (1)
- Mojave (1)
- Molecular Pharmacology (1)
- Molecular beam epitaxy (1)
- Molekularbiologie (1)
- Momentum- and spin-resolved hard X-ray photoelectron spectroscopy (1)
- Monodromie (1)
- Monte-Carlo-Simulation (1)
- Morphology (1)
- Motoneuron (1)
- Mrap2 (1)
- MscS (1)
- Multisensory integration (1)
- Multivariate Analyse (1)
- Multivariate Time Series (1)
- Mustererkennungsrezeptoren (1)
- Mutation (1)
- Myc (1)
- Mycardiale Heilung (1)
- Myocardial Healing (1)
- Myocardial Work (1)
- Myocardial infarction (1)
- Myokardinfarkt (1)
- Myosin (1)
- N-Heterocyclic Carbenes (1)
- NHC (1)
- NHC-Copper-catalyst (1)
- NHC-Nickel-Catalyst (1)
- NIR-Spektroskopie (1)
- NSSI (1)
- Nahrungserwerb (1)
- Nanoantenna (1)
- Nanoantenne (1)
- Nanodiamant (1)
- Nanodraht (1)
- Nanomaterialien (1)
- Nanomaterials (1)
- Nanooptik (1)
- Nanoscale (1)
- Nanowires (1)
- Naproxen (1)
- Nationalpark (1)
- Natural pest control (1)
- Naturgefahren (1)
- Navigation (1)
- Nebennierenrindenkrebs (1)
- Neisseria meningitidis (1)
- Nematic Liquid Crystals (1)
- Nematische Flüssigkristalle (1)
- Nephrotoxicity (1)
- Nervennetz (1)
- Neuroethologie (1)
- Neuroethology (1)
- Neurofascin (1)
- Neuropathic Pain (1)
- Neuropathy (1)
- Neutralisation <Chemie> (1)
- Nierenversagen (1)
- NpHR (1)
- Nucleinsäuren (1)
- Numerisches Verfahren (1)
- OCB (1)
- OLED (1)
- Oberflächenlegierung (1)
- Oberflächenzustand (1)
- Obesity (1)
- Offset Dykes (1)
- Oligomere (1)
- Open chromatin (1)
- Operations Management (1)
- Opiatrezeptor (1)
- Opsin (1)
- Optical Antenna (1)
- Optimierung (1)
- Optische Antenne (1)
- Optische Fernerkundung (1)
- Optischer Richtfunk (1)
- Optogenetics (1)
- Optogenetik (1)
- Orbital Angular Momentum (1)
- Organic Light Emitting Diode (1)
- Organic Photovoltaic (1)
- Organische Leuchtdioden (1)
- Organische Synthese (1)
- Organischer Halbleiter (1)
- Organoid (1)
- Organoids (1)
- Orientia tsutsugamushi (1)
- Oxidation (1)
- Ozone (1)
- PAC (1)
- PE Phosphoethanolamine (1)
- PGE-Cu-Ni (1)
- Paarbildung (1)
- Pain (1)
- Palaeoproterozoic (1)
- Paracetamol (1)
- Parkinson's disease (1)
- Parkinson-Krankheit (1)
- Partielle Differentialgleichung (1)
- Patch-clamp (1)
- Pattern recognition receptors (1)
- Peptidsynthese (1)
- Performance (1)
- Perovskite (1)
- Peroxisomen-Proliferator-aktivierter Rezeptor (1)
- Perylenbisdicarboximide (1)
- Pest management (1)
- Pflanzenschutzmittel (1)
- Pharmaceutische Biologie (1)
- Pharmacology (1)
- Phase cycling (1)
- Phasenmodulation (1)
- Pilze (1)
- Plant (1)
- Plant Protection (1)
- Plant cuticle (1)
- Plant-insect interactions (1)
- Plant-pollinator interactions (1)
- Plasma (1)
- Plasma membrane repair (1)
- Plasmonic Waveguide (1)
- Plasmonischer Wellenleiter (1)
- Platooning (1)
- Plausibility (1)
- Plausibilität (1)
- Pollination (1)
- Pollination services (1)
- Pollinator (1)
- Poly(2-oxazoline) (1)
- Poly(2-oxazoline)s (1)
- Poly(2-oxazoline)s and Poly(2-oxazine)s (1)
- Polyethism (1)
- Polymer Science (1)
- Polymere (1)
- Polynucleotide (1)
- Power Consumption (1)
- Predation (1)
- Predictive Analytics (1)
- Prescriptive Analytics (1)
- Primär-basierte immortalisierte Zelllinie (1)
- Production Site (1)
- Produktionsstandort (1)
- Progenitor (1)
- Prognose (1)
- Prosodie (1)
- Prospektion (1)
- Protein Corona (1)
- Protein Kinase D2 (1)
- Protein interactor (1)
- Proteinkinase D (1)
- Proteom (1)
- Protic Ionic Liquids (1)
- Protoplast (1)
- Prädation (1)
- Prävention (1)
- Pseudohalogenide (1)
- Psychische Gesundheit (1)
- Psychologie (1)
- Puberty (1)
- Pubertät (1)
- QIVIVE (1)
- QST (1)
- Quantenfeldtheorie (1)
- Quantenkaskadenlaser (1)
- Quantitative sensory testing (1)
- Quantum Chemical Calculations (1)
- Quantum Chemistry (1)
- Quantum Monte Carlo (1)
- Quantum anomalous Hall effect (1)
- Quantum information (1)
- RAFT (1)
- RLNC (1)
- RNA (1)
- RNA Abbau (1)
- RNA G-quadruplex (1)
- RNA decay (1)
- RNA modifications (1)
- RNA polymerase II (1)
- RNA structures (1)
- Radarfernerkundung (1)
- Radio (1)
- Raman-Spektroskopie (1)
- Rashba-Effekt (1)
- Rastertunnelmikroskopie (1)
- Read-through transcription (1)
- Real-time imaging (1)
- Receptor (1)
- Rechenzentrum (1)
- Rechtsventrikuläre Thrombusbildung (1)
- Regulatorische T-Lymphozyt (1)
- Remote Sensing (1)
- Rezeptor (1)
- Rho-Proteine (1)
- Ribozymes (1)
- Rifampicin (1)
- Right ventricular dysfunction (1)
- Ringöffnungspolymerisation (1)
- Risikofaktoren (1)
- Risk Assessment (1)
- River Basins (1)
- Routing (1)
- Ruthenium Komplexe (1)
- Rutheniumkomplexe (1)
- Rutschungen (1)
- Röntgendiffraktometrie (1)
- Röntgenstrahlung (1)
- SARS-CoV-2 (1)
- SCV maturation (1)
- SMN (1)
- SMN complex (1)
- STAAB Cohort Study (1)
- Salmonella (1)
- Salmonella Typhimurium (1)
- Satellite Formation Flying (1)
- Satellite Ground Station (1)
- Satellite Network (1)
- Satellite formation (1)
- Satellitenfunk (1)
- Savannah ecosystems (1)
- Scarabaeidae (1)
- Schmerz (1)
- Schwache Kompaktheit (1)
- Schwache Lösungen (1)
- Schwertkärpfling (1)
- Schädlingsbekämpfung (1)
- Self-Aware Computing (1)
- Self-assembled Monolayer (1)
- Sense of agency (1)
- Sense of ownership (1)
- Shapiro (1)
- Signaltransduktion (1)
- Silicon Carbide (1)
- Siliziumcarbid (1)
- Sinapis arvensis (1)
- Singlet Oxygen (1)
- Skalierbarkeit (1)
- Slave-boson method (1)
- Small RNA (1)
- SnRK1-bZIP complex (1)
- Softwareentwicklung (1)
- Softwaremetrie (1)
- Softwaresystem (1)
- Softwaretest (1)
- Softwarewartung (1)
- Solar bark (1)
- Solid-State NMR Spectroscopy (1)
- Source Credibility (1)
- Sourcing (1)
- Southern Province (1)
- Spacing Effect (1)
- Species richness (1)
- Spektroskopie (1)
- Spessart (1)
- Spin-Orbit Coupling (1)
- Spinell (1)
- Spirale (1)
- Spironolacton (1)
- Spliceosome (1)
- Squamous cell carcinoma (1)
- Squaraine (1)
- Standortfaktor (1)
- Standortfaktor <Wirtschaft> (1)
- Starke Kopplung (1)
- Stem Cells (1)
- Stress (1)
- Structural Equation Modeling (1)
- Structural organisation (1)
- Sudbury Igneous Complex (1)
- Supraglaziale Seen (1)
- Surface modification (1)
- Surface states (1)
- Swift (1)
- Symbiose (1)
- Synthetische Biologie (1)
- Säugetiere (1)
- T cell specificity (1)
- T-Cell Specificity (1)
- T-Lymphocytes (1)
- T-Lymphozyt (1)
- T-Lymphozyten (1)
- T-Zell Spezifität (1)
- Tabakkonsum (1)
- Tactile gating (1)
- Tactile suppression (1)
- Tanami (1)
- Tanzania (1)
- Targeting (1)
- Taxol (1)
- Technische Optik (1)
- Tensor (1)
- Tensor Tomography (1)
- Terror (1)
- Testing Effect (1)
- Theoretische Chemie (1)
- Thermoresponsive Polymere (1)
- Thiophen (1)
- Thrombus (1)
- Thymocytes (1)
- Tight Junction Proteins (1)
- Time-of-flight energy recording (1)
- Time-resolved spectroscopy (1)
- Tobacco smoking (1)
- Tomita-Takesaki-Theorie (1)
- Tomografie (1)
- Topological Kondo insulators (1)
- Topologische Laser (1)
- Trabekulopunktion (1)
- Transition metal-free (1)
- Transkription (1)
- Transkription <Genetik> (1)
- Transkriptionsfaktor (1)
- Transkriptomanalyse (1)
- Transportprozess (1)
- Transportsystem (1)
- Treg (1)
- Triarylborane (1)
- Triquinacenderivate (1)
- Trustworthiness (1)
- Tumorimmunologie (1)
- UAV (1)
- USP28 (1)
- Ubiquitin (1)
- Ubiquitin system (1)
- Ultrakurzzeitspektroskopie (1)
- Ultraviolett-Photoelektronenspektroskopie (1)
- Unconvential fermions (1)
- Unidirectional Freezing (1)
- Uniform distribution modulo one (1)
- University Teaching (1)
- Unterrichtspsychologie (1)
- Uremic cardiomyopathy (1)
- Urämie (1)
- Urämische Kardiomyopathie (1)
- Ustilago maydis (1)
- Vaccinia virus (1)
- Vaccinia virus (VACV) (1)
- Vakuole (1)
- Validation (1)
- Validity (1)
- Vapor-liquid-solid (1)
- Variants (1)
- Vaskularisation (1)
- Vehicle Routing Problem (1)
- Venusfliegenfalle (1)
- Veracruz (1)
- Vesikel (1)
- Vielteilchensystem (1)
- Volkov-Pankratov states (1)
- Volume Reconstruction (1)
- Vorderwandinfarkt (1)
- Wahrnehmung (1)
- Wasser (1)
- Wasserlösliche Polymere (1)
- Wasseroxidation (1)
- Wasserstoffperoxid (1)
- Wasted Work (1)
- Weak Solutions (1)
- Wellenleiter (1)
- Wilms Tumor (1)
- Wilms tumor (1)
- Winkel- und spin-aufgelöste Photoelektronenspektroskopie im harten Röntgenbereich (1)
- Wirkstoff-Träger-System (1)
- Wirtschaftsinformatik (1)
- Workshop Neue Aspekte zur Linksventrikulären Dysfunktion (1992 : Erbach, Rheingau) (1)
- Worterkennung (1)
- X-Ray Dark-Field (1)
- X-Ray Diffraction (1)
- X-ray (1)
- XPS (1)
- Xiphophorus (1)
- Yb1 (1)
- YnaI (1)
- Zeitaufgelöste Spektroskopie (1)
- Zeitdiskretes System (1)
- Zeitreihenvorhersage (1)
- Zellkommunikation (1)
- Zellkultur (1)
- Zellmigration (1)
- Zellzyklus (1)
- Zersetzer (1)
- Zetafunktion (1)
- ZnTe (1)
- Zweidimensionale konforme Feldtheorie (1)
- Zweidimensionales Material (1)
- ab interno trabeculectomy (1)
- active zone (1)
- adaptive network coding (1)
- adolescents (1)
- adrenocortical carcinoma (1)
- agroecology (1)
- anaphylatoxin receptors (1)
- antibacterial (1)
- antibakteriell (1)
- antibody (1)
- aqueous processing (1)
- aromaticity (1)
- atomic force microscopy (1)
- autoantigen (1)
- bacterial nanocellulose (1)
- bark beetles (1)
- beetles (1)
- beyond planarity (1)
- bioimage analysis (1)
- biomarker (1)
- biomaterials (1)
- bioorthogonal labeling (1)
- blazar (1)
- boron (1)
- borylation (1)
- borys (1)
- cAAC (1)
- calciumhydroxide (1)
- catalysis (1)
- cathode material (1)
- chemically programmable (1)
- chemisch programmierbar (1)
- children (1)
- chimeric antigen receptor (1)
- chronic pain (1)
- circular layouts (1)
- circular-arc drawings (1)
- climate (1)
- co-expression coefficient (1)
- coating (1)
- composite optimization (1)
- correlation (1)
- coverings (1)
- crossing minimization (1)
- curved hydrocarbons (1)
- deadwood enrichment (1)
- deep brain stimulation (1)
- delipidation (1)
- discrete-time analysis (1)
- donor-acceptor dyads (1)
- drug delivery system (1)
- earth observation (1)
- ecological validity (1)
- ecology (1)
- ecosystem service (1)
- ecosystem services (1)
- electrochromic device (1)
- electron cryomicroscopy (1)
- electron microscopy (1)
- electron transfer (1)
- electron-hole scattering (1)
- elevational gradient (1)
- endosomal trafficking (1)
- entropy minimization (1)
- epithelial to mesenchymal transition (1)
- epitope (1)
- etox database (1)
- eye tracking (1)
- fear conditioning (1)
- fear extinction (1)
- fear generalization (1)
- fibroblast growth factors (1)
- fine-mapping (1)
- follicular regulatory T cell (1)
- follikuläre regulatorische T-Zelle (1)
- forest conservation (1)
- fungi (1)
- gait analysis (1)
- gait initiation (1)
- gekrümmte Kohlenwasserstoffe (1)
- gene expression networks (1)
- geoarchaeology (1)
- geophysical prospection (1)
- germinal center (1)
- glaucoma (1)
- glaucoma surgery (1)
- glycine receptor (1)
- graph drawing (1)
- haemodialysis (1)
- helical edge states (1)
- heterocycles (1)
- high drug loading (1)
- hnRNP (1)
- hnRNP R (1)
- honeycomb lattice (1)
- host colonization (1)
- human plasma (1)
- human-environmental interactions (1)
- immune response (1)
- implant (1)
- in vitro Modelle (1)
- in vitro-Testsystem (1)
- infant (1)
- infection biology (1)
- interplay of surface states (1)
- intestinal in vitro model (1)
- invasive meningococcal diseases (1)
- invasive pulmonary aspergillosis (1)
- inverse-Compton pair cascades (1)
- ion channel (1)
- ischemia reperfusion injury (1)
- jets (1)
- kinetic model (1)
- landscape ecology (1)
- latency cybersickness (1)
- layered oxides (1)
- learning and memory (1)
- left ventricular thrombus (1)
- linksventrikulärer Thrombus (1)
- lithium-ion battery (1)
- liver (1)
- local adaptation (1)
- locomotor network (1)
- lysosome (1)
- macrocycles (1)
- measles virus (1)
- mechanosensing (1)
- mechanosensitive channels (1)
- medical device (1)
- megakaryocyte (1)
- megakaryocytes (1)
- megakaryopoiesis (1)
- melt electrowriting (1)
- metal oxides (1)
- metallopolymers (1)
- metallosupramolecular chemistry (1)
- methionine biosynthesis (1)
- miRNA (1)
- miRNS (1)
- micelles (1)
- microbiome (1)
- microprocessor complex (1)
- microscopy (1)
- mobile networks (1)
- molecular beam epitaxy (1)
- monoclonal antibodies (1)
- monoklonale Antikörper (1)
- motoneurons (1)
- movement disorders (1)
- movement interaction (1)
- mukosale Immunantwort (1)
- multi-fluid mixture (1)
- multi-source multi-sink problem (1)
- multiwavelength (1)
- mutualism (1)
- myocardial infarction (1)
- myokardiale Arbeit (1)
- national park (1)
- natural disturbance (1)
- nature conservation (1)
- network softwarization (1)
- neural biomarkers (1)
- neurodevelopmental disorders (1)
- neuronal network (1)
- neutral tint (1)
- neutralization (1)
- non-sense mutations (1)
- offshore wind energy (1)
- oligomerization (1)
- oligothiophenes (1)
- on surface self-assembly (1)
- optogenetics (1)
- p-Block Elements (1)
- pain (1)
- parkinson's disease (1)
- performance evaluation (1)
- perfused hydrogel (1)
- perylene bisimide (1)
- pest control (1)
- phenotype (1)
- photoelectron spectroscopy (1)
- platelets (1)
- poly(2-oxazoline) (1)
- polyglycidol (1)
- polymer-peptide-conjugate (1)
- primary school children (1)
- primary-cell-derived immortalized cell line (1)
- profiles (1)
- proplatelets (1)
- prosody (1)
- protein-DNA interactions (1)
- protein-lipid interactions (1)
- proximal Newton method (1)
- proximal gradient method (1)
- pseudohalides (1)
- quantenchemische Berechnungen (1)
- quantum interference (1)
- quantum point contact (1)
- quantum spin hall insulator (1)
- radiative processes (1)
- rats (1)
- recreation (1)
- reduced residues (1)
- remote sensing (1)
- renal toxicity (1)
- rho gtpases (1)
- riboswitch (1)
- ring opening polymerisation (1)
- ring opening polymerization (1)
- risk factors (1)
- room temperature phosphorescence (1)
- ruthenium complexes (1)
- saproxylic (1)
- scanning tunneling spectroscopy (1)
- second messenger (1)
- serotonergic system (1)
- simulation (1)
- skin model (1)
- smallholder agriculture (1)
- snRNP (1)
- social attention (1)
- species-energy-theory (1)
- sphingolipid (1)
- spiders (1)
- spin transport (1)
- spironolactone (1)
- spontaneous blinks (1)
- structure property relationship (1)
- subcutaneous implanation (1)
- super-resolution fluorescence microscopy (1)
- surface states (1)
- symbiosis (1)
- t cells (1)
- targeted therapy (1)
- thiol-ene (1)
- threat conditioning (1)
- thrombopoiesis (1)
- topological surface states (1)
- toxicity (1)
- trabectome (1)
- trabecular meshwork (1)
- trabeculopuncture (1)
- trabex+ (1)
- transcription regulator (1)
- transcriptome profiling (1)
- tree species (1)
- triquinacene derivatives (1)
- tropical ecology (1)
- tumor metabolism (1)
- two-dimensional topological insulator (1)
- unconventional T cells (1)
- vacuole (1)
- variations in genome (1)
- vascularization (1)
- velocity-dependent collision frequency (1)
- virtual reality (1)
- virtuel reality (1)
- water oxidation (1)
- wireless sensor network (1)
- woodinhabiting-fungi (1)
- word-reading accuracy (1)
- word-reading speed (1)
- x-ray micro computed tomography (1)
- Übergewicht (1)
- Überlagerung <Mathematik> (1)
- Übertragungsfunktion (1)
- ΔNp63 (1)
- α-synuclein (1)
Institute
- Graduate School of Life Sciences (76)
- Physikalisches Institut (18)
- Theodor-Boveri-Institut für Biowissenschaften (17)
- Institut für Informatik (13)
- Institut für Psychologie (10)
- Institut für Organische Chemie (9)
- Institut für Anorganische Chemie (7)
- Institut für Geographie und Geologie (7)
- Institut für Theoretische Physik und Astrophysik (7)
- Abteilung für Funktionswerkstoffe der Medizin und der Zahnheilkunde (6)
Sonstige beteiligte Institutionen
- Fraunhofer-Institut für Silicatforschung ISC (2)
- Helmholtz Institute for RNA-based Infection Research (HIRI) (2)
- Department of Cellular Therapies, University of Navarra, Pamplona, Spain (1)
- Department of X-ray Microscopy, University of Würzburg, Würzburg, Germany (1)
- EMBL Heidelberg (1)
- Institut Ruđer Bošković, Zagreb, Croatia (1)
- Institut für Tierökologie und Tropenbiologie (1)
- Interdisziplinäre Zentrum für Klinische Forschung (IZKF) (1)
- Klinik und Poliklinik für Anästhesiologie, Intensivmedizin, Notfallmedizin und Schmerztherapie des Universitätsklinikums Würzburg (1)
- Lehrstuhl für Fernerkundung der Uni Würzburg, in Kooperation mit dem Deutschen Fernerkundungsdatenzentrum (DFD) des Deutschen Zentrums für Luft- und Raumfahrt (DLR) (1)
- Politecnico di Milano (1)
- Siemens Corporate Technology Munich (1)
- University of Twente (The Netherlands) (1)
- Universität Duisburg-Essen, Institut für Molekularbiologie, AG Becker-Flegler (1)
- Universitätsklinikum Würzburg (1)
- Universitätsklinikum Würzburg (UKW) (1)
EU-Project number / Contract (GA) number
- 320377 (1)
Methionine is the first amino acid of every newly synthesised protein. In combination with its role as precursor for the vital methyl-group donor S-adenosylmethionine, methionine is essential for every living cell. The opportunistic human pathogen Staphylococcus aureus is capable of synthesising methionine de novo, when it becomes scarce in the environment. All genes required for the de novo biosynthesis are encoded by the metICFE-mdh operon, except for metX. Expression is controlled by a hierarchical network with a methionyl-tRNA-specific T-box riboswitch (MET-TBRS) as centrepiece, that is also referred to as met leader (RNA). T-box riboswitches (TBRS) are regulatory RNA elements located in the 5’-untranslated region (5’-UTR) of genes. The effector molecule of T-box riboswitches is uncharged cognate tRNA. The prevailing mechanism of action is premature termination of transcription of the nascent RNA in the absence of the effector (i.e. uncharged cognate tRNA) due to formation of a hairpin structure, the Terminator stem. In presence of the effector, a transient stabilisation of the alternative structure, the Antiterminator, enables transcription of the downstream genes (‘read-through’). Albeit, after the read-through the thermodynamically more stable Terminator eventually forms. The Terminator and the Antiterminator are two mutually exclusive structures. Previous work of the research group showed that in staphylococci the MET-TBRS ensures strictly methionine-dependent control of met operon expression. Uncharged methionyl-tRNA that activates the system is only present in sufficient amounts under methionine-deprived conditions. In contrast to other bacterial TBRS, the staphylococcal MET-TBRS has some characteristic features regarding its length and predicted secondary structure whose relevance for the function are yet unkown.
Aim of the present thesis was to experimentally determine the structure of the met leader RNA and to investigate the stability of the met operon-specific transcripts in the context of methionine biosynthesis control. Furthermore, the yet unknown function of the mdh gene within the met operon was to be determined.
In the context of this thesis, the secondary structure of the met leader was determined employing in-line probing. The structural analysis revealed the presence of almost all highly conserved T-box riboswitch structural characteristics. Furthermore, three additional stems, absent in all T-box riboswitches analysed to date, could be identified. Particularly remarkable is the above average length of the Terminator stem which renders it a potential target of the double-strand-specific endoribonuclease III (RNase III). The RNase III-dependent cleavage of the met leader could be experimentally verified by the use of suitable mutants. Moreover, the exact cleavage site within the Terminator was determined.
The unusual immediate separation of the met leader from the met operon mRNA via the RNase III cleavage within the Terminator stem induces the rapid degradation of the met leader RNA and, most likely, that of the 5’-region of the met mRNA. The met mRNA is degraded from its 5’-end by the exoribonuclease RNase J. The stability of the met mRNA was found to vary over the length of the transcript with an instable 5’-end (metI and metC) and a longer half-life towards the 3’-end (metE and mdh). The varying transcript stability is reflected by differences in the available cellular protein levels. The obtained data suggest that programmed mRNA degradation is another level of regulation in the complex network of staphylococcal de novo methionine biosynthesis control.
In addition, the MET-TBRS was studied with regard to a future use as a drug target for novel antimicrobial agents. To this end, effects of a dysregulated methionine biosynthesis on bacterial growth and survival were investigated in met leader mutants that either caused permanent transcription of the met operon (‘ON’) or prevented operon transcription (‘OFF’), irrespective of the methionine status in the cell. Methionine deprivation turned out to be a strong selection pressure, as ‘OFF’ mutants acquired adaptive mutations within the met leader to restore met operon expression that subsequently re-enabled growth.
The second part of the thesis was dedicated to the characterisation of the Mdh protein that is encoded by the last gene of the met operon and whose function is unknown yet. At first, co-transcription and -expression with the met operon could be demonstrated. Next, the Mdh protein was overexpressed and purified and the crystal structure of Mdh was solved to high resolution by the Kisker research group (Rudolf-Virchow-Zentrum Würzburg). Analysis of the structure revealed the amino acid residues crucial for catalytic activity, and zinc was identified as a co-factor of Mdh. Also, Mdh was shown to exist as a dimer. However, identification of the Mdh substrate was, in the context of this thesis, (still) unsuccessful. Nevertheless, interactions of Mdh with enzymes of the met operon could be demonstrated by employing the bacterial two-hybrid system. This fact and the high conservation of mdh/Mdh on nucleotide and amino acid level among numerous staphylococcal species suggests an important role of Mdh within the methionine metabolism that should be a worthwhile subject of future research.