Refine
Has Fulltext
- yes (11)
Is part of the Bibliography
- yes (11)
Document Type
- Journal article (11)
Language
- English (11)
Keywords
- Bordetella pertussis (3)
- bioinformatics (2)
- cancer treatment (2)
- lung cancer (2)
- 3D lung tumor tissue models (1)
- Adenylate cyclase toxin (1)
- CXCR4 (1)
- EMT (1)
- IL-6 (1)
- KRAS biomarker signatures (1)
Institute
- Lehrstuhl für Tissue Engineering und Regenerative Medizin (6)
- Theodor-Boveri-Institut für Biowissenschaften (5)
- Klinik und Poliklinik für Thorax-, Herz- u. Thorakale Gefäßchirurgie (3)
- Klinik und Poliklinik für Hals-, Nasen- und Ohrenkrankheiten, plastische und ästhetische Operationen (2)
- Klinik und Poliklinik für Nuklearmedizin (2)
- Pathologisches Institut (2)
- Abteilung für Molekulare Innere Medizin (in der Medizinischen Klinik und Poliklinik II) (1)
- Comprehensive Cancer Center Mainfranken (1)
- Institut für Experimentelle Biomedizin (1)
- Institut für Klinische Biochemie und Pathobiochemie (1)
Sonstige beteiligte Institutionen
MicroRNAs are well-known strong RNA regulators modulating whole functional units in complex signaling networks. Regarding clinical application, they have potential as biomarkers for prognosis, diagnosis, and therapy. In this review, we focus on two microRNAs centrally involved in lung cancer progression. MicroRNA-21 promotes and microRNA-34 inhibits cancer progression. We elucidate here involved pathways and imbed these antagonistic microRNAs in a network of interactions, stressing their cancer microRNA biology, followed by experimental and bioinformatics analysis of such microRNAs and their targets. This background is then illuminated from a clinical perspective on microRNA-21 and microRNA-34 as general examples for the complex microRNA biology in lung cancer and its diagnostic value. Moreover, we discuss the immense potential that microRNAs such as microRNA-21 and microRNA-34 imply by their broad regulatory effects. These should be explored for novel therapeutic strategies in the clinic.