Refine
Has Fulltext
- yes (14)
Is part of the Bibliography
- yes (14)
Year of publication
Document Type
- Journal article (9)
- Doctoral Thesis (5)
Keywords
- simulation (14) (remove)
Institute
- Institut für Informatik (3)
- Klinik und Poliklinik für Anästhesiologie (ab 2004) (2)
- Theodor-Boveri-Institut für Biowissenschaften (2)
- Frauenklinik und Poliklinik (1)
- Institut Mensch - Computer - Medien (1)
- Institut für Geographie und Geologie (1)
- Institut für Physikalische und Theoretische Chemie (1)
- Institut für Psychologie (1)
- Institut für Sportwissenschaft (1)
- Institut für Theoretische Physik und Astrophysik (1)
This work aims at elucidating chemical processes involving homogeneous catalysis and photo–physical relaxation of excited molecules in the solid state. Furthermore, compounds with supposedly small singlet–triplet gaps and therefore biradicaloid character are investigated with respect to their electro–chemical behavior. The work on hydroboration catalysis via a reduced 9,10–diboraanthracene (DBA) was preformed in collaboration with the Wagner group in Frankfurt, more specifically Dr. Sven Prey, who performed all laboratory experiments. The investigation of delayed luminescence properties in arylboronic esters in their solid state was conducted in collaboration with the Marder group in Würzburg. The author of this work took part in the synthesis of the investigated compounds while being supervised by Dr. Zhu Wu. The final project was a collaboration with the group of Anukul Jana from Hyderabad, India who provided the experimental data.
In this doctoral thesis we cover the performance evaluation of next generation data plane architectures, comprised of complex software as well as programmable hardware components that allow fine granular configuration. In the scope of the thesis we propose mechanisms to monitor the performance of singular components and model key performance indicators of software based packet processing solutions. We present novel approaches towards network abstraction that allow the integration of heterogeneous data plane technologies into a singular network while maintaining total transparency between control and data plane. Finally, we investigate a full, complex system consisting of multiple software-based solutions and perform a detailed performance analysis. We employ simulative approaches to investigate overload control mechanisms that allow efficient operation under adversary conditions. The contributions of this work build the foundation for future research in the areas of network softwarization and network function virtualization.
Background
Electrosurgical excisions are common procedures for treating cervical dysplasia and are often seen as minor surgeries. Yet, thorough training of this intervention is required, as there are considerable consequences of inadequate resections, e.g. preterm birth, the risk of recurrence, injuries and many more. Unfortunately, there is a lack of sufficiently validated possibilities of simulating electrosurgeries, which focus on high fidelity and patient safety.
Methods
A novel 3D printed simulator for examination and electrosurgical treatment of dysplastic areas of the cervix was compared with a conventional simulator. Sixty medical students experienced a seminar about cervical dysplasia. Group A underwent the seminar with the conventional and Group B with the novel simulator. After a theoretical introduction, the students were randomly assigned by picking a ticket from a box and went on to perform the hands-on training with their respective simulator. Each student first obtained colposcopic examination training. Then he or she performed five electrosurgical excisions (each). This was assessed with a validated score, to visualize their learning curve. Furthermore, adequate and inadequate resections and contacts between electrosurgical loop and vagina or speculum were counted. Both groups also assessed the seminar and their simulator with 18 questions (Likert-scales, 1–10, 1 = strongly agree / very good, 10 = strongly disagree / very bad). Group B additionally assessed the novel simulator with four questions (similar Likert-scales, 1–10).
Results
Nine of 18 questions showed statistically significant differences favoring Group B (p < 0.05). Group B also achieved more adequate R0-resections and less contacts between electrosurgical loop and vagina or speculum. The learning curves of the performed resections favored the novel simulator of Group B without statistically significant differences. The four questions focusing on certain aspects of the novel simulator indicate high appreciation of the students with a mean score of 1.6 points.
Conclusion
The presented novel simulator shows several advantages compared to the existing model. Thus, novice gynecologists can be supported with a higher quality of simulation to improve their training and thereby patient safety.
Besides the integration of renewable energies, electric vehicles pose an additional challenge to modern power grids. However, electric vehicles can also be a flexibility source and contribute to the power system stability. Today, the power system still heavily relies on conventional technologies to stay stable. In order to operate a future power system based on renewable energies only, we need to understand the flexibility potential of assets such as electric vehicles and become able to use their flexibility. In this paper, we analyzed how vast amounts of coordinated charging processes can be used to provide frequency containment reserve power, one of the most important ancillary services for system stability. Therefore, we used an extensive simulation model of a virtual power plant of millions of electric vehicles. The model considers not only technical components but also the stochastic behavior of electric vehicle drivers based on real data. Our results show that, in 2030, electric vehicles have the potential to serve the whole frequency containment reserve power market in Germany. We differentiate between using unidirectional and bidirectional chargers. Bidirectional chargers have a larger potential but also result in unwanted battery degradation. Unidirectional chargers are more constrained in terms of flexibility, but do not lead to additional battery degradation. We conclude that using a mix of both can combine the advantages of both worlds. Thereby, average private cars can provide the service without any notable additional battery degradation and achieve yearly earnings between EUR 200 and EUR 500, depending on the volatile market prices. Commercial vehicles have an even higher potential, as the results increase with vehicle utilization and consumption.
Virtual online training has emerged as one of the top 20 worldwide fitness trends for 2021 and continues to develop rapidly. Although this allows the cycling community to engage in virtual training and competition, critical evaluation of virtual training platforms is limited. Here, we discuss the strengths, weaknesses, opportunities and threats associated with virtual training technology and cycling in an attempt to enhance awareness of such aspects. Strengths include immersive worlds, innovative drafting mechanics, and versatility. Weaknesses include questionable data accuracy, inadequate strength and reliability of power-speed algorithms. Opportunities exist for expanding strategic partnerships with major cycling races, brands, and sponsors and improving user experience with the addition of video capture and “e-coaching.” Threats are present in the form of cheating during competition, and a lack of uptake and acceptance by a broader community.
After a large outbreak in Brazil, novel drugs against Zika virus became extremely necessary. Evaluation of virus-based pharmacological strategies concerning essential host factors brought us to the idea that targeting the Axl receptor by blocking its dimerization function could be critical for virus entry. Starting from experimentally validated compounds, such as RU-301, RU-302, warfarin, and R428, we identified a novel compound 2′ (R428 derivative) to be the most potent for this task amongst a number of alternative compounds and leads. The improved affinity of compound 2′ was confirmed by molecular docking as well as molecular dynamics simulation techniques using implicit solvation models. The current study summarizes a new possibility for inhibition of the Axl function as a potential target for future antiviral therapies.
Most animals live in seasonal environments and experience very different conditions throughout the year. Behavioral strategies like migration, hibernation, and a life cycle adapted to the local seasonality help to cope with fluctuations in environmental conditions. Thus, how an individual utilizes the environment depends both on the current availability of habitat and the behavioral prerequisites of the individual at that time. While the increasing availability and richness of animal movement data has facilitated the development of algorithms that classify behavior by movement geometry, changes in the environmental correlates of animal movement have so far not been exploited for a behavioral annotation. Here, we suggest a method that uses these changes in individual–environment associations to divide animal location data into segments of higher ecological coherence, which we term niche segmentation. We use time series of random forest models to evaluate the transferability of habitat use over time to cluster observational data accordingly. We show that our method is able to identify relevant changes in habitat use corresponding to both changes in the availability of habitat and how it was used using simulated data, and apply our method to a tracking data set of common teal (Anas crecca). The niche segmentation proved to be robust, and segmented habitat suitability outperformed models neglecting the temporal dynamics of habitat use. Overall, we show that it is possible to classify animal trajectories based on changes of habitat use similar to geometric segmentation algorithms. We conclude that such an environmentally informed classification of animal trajectories can provide new insights into an individuals' behavior and enables us to make sensible predictions of how suitable areas might be connected by movement in space and time.
Background
Precise and complete documentation of in-hospital cardiopulmonary resuscitations is important but data quality can be poor. In the present study, we investigated the effect of a tablet-based application for real-time resuscitation documentation used by the emergency team leader on documentation quality and clinical performance of the emergency team.
Methods
Senior anaesthesiologists either used the tablet-based application during the simulated resuscitation for documentation and also used the application for the final documentation or conducted the full documentation at the end of the scenario using the local hospital information system. The latter procedure represents the current local documentation method. All scenarios were video recorded. To assess the documentation, we compared the precision of intervention delivery times, documentation completeness, and final documentation time. To assess clinical performance, we compared adherence to guidelines for defibrillation and adrenaline administration, the no-flow fraction, and the time to first defibrillation.
Results
The results showed significant benefits for the tablet-based application compared to the hospital information system for precision of the intervention delivery times, the final documentation time, and the no-flow fraction. We observed no differences between the groups for documentation completeness, adherence to guidelines for defibrillation and adrenaline administration, and the time to first defibrillation.
Discussion
In the presented study, we observed that a tablet-based application can improve documentation data quality. Furthermore, we demonstrated that a well-designed application can be used in real-time by a member of the emergency team with possible beneficial effects on clinical performance.
Conclusion
The present evaluation confirms the advantage of tablet-based documentation tools and also shows that the application can be used by an active member of an emergency team without compromising clinical performance.
Classical novae are thermonuclear explosions occurring on the surface of white dwarfs.
When co-existing in a binary system with a main sequence or more evolved star, mass
accretion from the companion star to the white dwarf can take place if the companion
overflows its Roche lobe. The envelope of hydrogen-rich matter which builds on
top of the white dwarf eventually ignites under degenerate conditions, leading to
a thermonuclear runaway and an explosion in the order of 1046 erg, while leaving
the white dwarf intact. Spectral analyses from the debris indicate an abundance of
isotopes that are tracers of nuclear burning via the hot CNO cycle, which in turn
reveal some sort of mixing between the envelope and the white dwarf underneath.
The exact mechanism is still a matter of debate.
The convection and deflagration in novae develop in the low Mach number regime.
We used the Seven League Hydro code (SLH ), which employs numerical schemes
designed to correctly simulate low Mach number flows, to perform two and three-
dimensional simulations of classical novae. Based on a spherically-symmetric model
created with aid of a stellar evolution code, we developed our own nova model and
tested it on a variety of numerical grids and boundary conditions for validation. We
focused on the evolution of temperature, density and nuclear energy generation rate at
the layers between white dwarf and envelope, where most of the energy is generated,
to understand the structure of the transition region, and its effect on the nuclear
burning. We analyzed the resulting dredge-up efficiency stemming from the convective
motions in the envelope. Our models yield similar results to the literature, but seem
to depend very strongly on the numerical resolution. We followed the evolution of
the nuclear species involved in the CNO cycle and concluded that the thermonuclear
reactions primarily taking place are those of the cold and not the hot CNO cycle.
The reason behind this could be that under the conditions generally assumed for
multi-dimensional simulations, the envelope is in fact not degenerate. We performed
initial tests for 3D simulations and realized that alternative boundary conditions are
needed.
Routes to Embodiment
(2015)
Research on embodiment is rich in impressive demonstrations but somewhat poor in comprehensive explanations. Although some moderators and driving mechanisms have been identified, a comprehensive conceptual account of how bodily states or dynamics influence behavior is still missing. Here, we attempt to integrate current knowledge by describing three basic psychological mechanisms: direct state induction, which influences how humans feel or process information, unmediated by any other cognitive mechanism; modal priming, which changes the accessibility of concepts associated with a bodily state; sensorimotor simulation, which affects the ease with which congruent and incongruent actions are performed. We argue that the joint impact of these mechanisms can account for most existing embodiment effects. Additionally, we summarize empirical tests for distinguishing these mechanisms and suggest a guideline for future research about the mechanisms underlying embodiment effects.