Refine
Has Fulltext
- yes (54)
Year of publication
- 2021 (54) (remove)
Document Type
- Journal article (36)
- Doctoral Thesis (18)
Keywords
- Parkinson's disease (5)
- COVID-19 (4)
- Parkinson-Krankheit (4)
- ischemic stroke (4)
- Propriozeption (3)
- Schlaganfall (3)
- neuroinflammation (3)
- Multiple Sklerose (2)
- Parkinson’s disease (2)
- Puppenhandillusion (2)
- biomarkers (2)
- cerebellar tDCS (2)
- deep brain stimulation (2)
- diabetic neuropathy (2)
- immunohistochemistry (2)
- neutrophils (2)
- skin biopsy (2)
- stroke (2)
- tMCAO (2)
- thrombo-inflammation (2)
- A53T mutation (1)
- A53T-Mutation (1)
- ADHD (1)
- ALS (1)
- ALS treatment (1)
- Amyotrophic Lateral Sclerosis (ALS) (1)
- Amyotrophic Lateral Sclerosis Assessment Questionnaire 5 (ALSAQ-5) (1)
- BB/OKL rats (1)
- Basal Ganglia (1)
- Basalganglien (1)
- Blut-Hirn-Schranke (1)
- Brain-derived neurotrophic factor (1)
- Caspr (1)
- Consortium to Establish a Registry for Alzheimer's Disease (1)
- Cortico-striatal projection neurons (1)
- Crespi effect (1)
- Diabetes mellitus (1)
- Diabetische Neuropathie (1)
- Dimethylfumarat (1)
- EuroQol Five Dimension Five Level Scale (EQ-5D-5L) (1)
- Fibromyalgia (1)
- Fibromyalgie (1)
- GABAergic neurons (1)
- Gefäßverschluss (1)
- Guillain-Barré syndrome (1)
- HMGB1 (1)
- HRUS (1)
- Hautbiopsie (1)
- Hirnblutung (1)
- Hornhaut (1)
- Idiopathisches Parkinson-Syndrom (1)
- IgG (1)
- IntelliCage (1)
- Intrathekale Applikation (1)
- Kognition (1)
- Körperwahrnehmung (1)
- LVO (1)
- Langerhans cells (1)
- Lebensqualität nach stroke (1)
- Lewy-Pathologie (1)
- Lewy-like pathology (1)
- Lokale Feldpotentialaktivität (1)
- Long COVID (1)
- MIBG scintigraphy (1)
- Mausmodell (1)
- Medium spiny neurons (1)
- Meningoenzephalitis (1)
- Mikroblutung (1)
- Morbus Parkinson (1)
- Motor learning (1)
- Motorisches Lernen (1)
- Multisensorische Integration (1)
- Muster (1)
- NOAC (1)
- Nervenbiopsie (1)
- Nervenultraschall (1)
- Neurofascin (1)
- Neurogeriatrie (1)
- Neuropsychologischer Test (1)
- Nucleus subthalamicus (1)
- Optikusnervenscheidendurchmesser (1)
- Parkinson (1)
- Parkinson Krankheit (1)
- Physiotherapie (1)
- Plastizität (1)
- Polyneuropathie (1)
- Prognostik (1)
- Ranvier-Schnürring (1)
- Resilienz (1)
- Revaskularisierung (1)
- SARS-CoV (1)
- SARS-CoV-2 (1)
- Sars-CoV-2 (1)
- Schlaganfall-Netzwerk (1)
- Score (1)
- Sonic hedgehog (1)
- Striatum (1)
- Stroke (1)
- Stroke Manager (1)
- Stroke-Unit (1)
- Synaptic plasticity (1)
- Synuclein <alpha-> (1)
- T-cells (1)
- T-lymphocytes (1)
- TIND (1)
- Telemedizin (1)
- Thrombektomie (1)
- Tiermodell (1)
- Tourette syndrome (1)
- Triamcinolon (1)
- TrkB (1)
- Type 1 diabetes (1)
- Ultraschall (1)
- Ultraschalldiagnostik (1)
- Umfragestudie (1)
- Vitamin D (1)
- Vitamin D-Mangel (1)
- Volon A (1)
- Western blot (1)
- Wiederbelebung (1)
- XAV-939 (1)
- acid sphingomyelinase (1)
- acute ischemic stroke (1)
- albumin (1)
- algorithm (1)
- alpha-7 nicotinic acetylcholine receptor (1)
- alpha‐synuclein (1)
- alpha‐synuclein propagation (1)
- alpha‐synuclein seeding (1)
- amyotrophe Lateralsklerose (1)
- amyotrophic lateral sclerosis (ALS) (1)
- antidepressants (1)
- antimicrobial stewardship (1)
- anxiety (1)
- assistive devices (1)
- attenuation of disease (1)
- bacterial co-infection (1)
- balance (1)
- barrier (1)
- basal forebrain cholinergic neurons (1)
- biopsy (1)
- blood brain barrier (1)
- blood–brain barrier (1)
- cardiac imaging (1)
- caregiver burden (1)
- cerebral ischemia (1)
- cerebrovascular disorders (1)
- choline acetyltransferase (1)
- chronic stimulation (1)
- chronische Multiple Sklerose (1)
- clinical approach (1)
- clinical decision-support (1)
- clinical phenotype (1)
- closed head injury (1)
- collateral circulation (1)
- comprehension (1)
- computed tomography (1)
- contact-kinin system (1)
- corneal confocal microscopy (1)
- decreasing autonomy (1)
- depression (1)
- diagnosis (1)
- diagnostic markers (1)
- directional deep brain stimulation (1)
- dystonia (1)
- echocardiography (1)
- edoxaban (1)
- electrophysiology (1)
- essential tremor (1)
- experimental stroke (1)
- expert opinion (1)
- fibromyalgia sydrome (1)
- finger-tapping task (1)
- functional status (1)
- future directions (1)
- gait (1)
- gene-environment interaction (1)
- gephyrin (1)
- glycine receptor (1)
- glycoprotein receptor Ib (1)
- health-related quality of life (1)
- health-related quality of life (HRQoL) (1)
- hemorrhagic transformation (1)
- hyperekplexia (1)
- hypoxic-ischemic encephalopathy (1)
- hypoxische Enzephalopathie (1)
- image-guided programming (1)
- immunomodulation (1)
- induced pluripotent stem cells (1)
- infantile neuronal ceroid lipofuscinosis (1)
- inflammation (1)
- inflammatory neuropathy (1)
- informal caregiving (1)
- informed consent (1)
- internal medicine (1)
- interview (1)
- intrathecal (1)
- intrathekal (1)
- iron (1)
- iron dyshomeostasis (1)
- ischemic penumbra (1)
- large vessel occlusion (1)
- leukocytes (1)
- macrophages (1)
- magnetic resonance imaging (1)
- major depression (1)
- mechanical thrombectomy (1)
- medial ganglionic eminence (1)
- medikamentöse Sekundärprävention bei stroke (1)
- mesencephalic locomotor region (1)
- middle cerebral artery occlusion (1)
- mixed methods (1)
- motor learning (1)
- mouse model (1)
- multiple sclerosis (1)
- multiple system atrophy (1)
- multisensorische Integration (1)
- multisensory integration (1)
- nerve biopsy (1)
- nerve tumor (1)
- neurocritical care (1)
- neurodegeneration (1)
- neuroleukemiosis (1)
- neurological (1)
- neurological complications (1)
- neurological examination (1)
- neuropathy (1)
- node of Ranvier (1)
- object recognition memory (1)
- on-site examination (1)
- optic nerve sheath diameter (1)
- outcomes (1)
- pain (1)
- pandemic (1)
- pathogenesis (1)
- pathophysiology (1)
- patient triage (1)
- pattern (1)
- peripheral nervous system (1)
- peripheral neuropathy (1)
- photothrombotic stroke (1)
- platelets (1)
- polyneuropathy (1)
- population-based (1)
- preceding infections (1)
- predictive coding (1)
- preventive treatment (1)
- progressive multiple sclerosis (1)
- psychological support (1)
- psychosocial resilience (1)
- purmorphamine (1)
- quality of life (QoL) (1)
- randomized controlled double-blind study (1)
- regulatory T cells (1)
- resilience (1)
- risk of fall (1)
- risk stratification (1)
- rubber hand illusion (1)
- sciatic nerve (1)
- second hit (1)
- skin punch biopsy (1)
- small fiber neuropathy (1)
- small fiber pathology (1)
- socioeconomic status (1)
- somatic resilience (1)
- sphingolipids (1)
- split-belt treadmill (1)
- startle disease (1)
- stress (1)
- stroke networks (1)
- stroke unit (1)
- subthalamic nucleus (1)
- survey (1)
- symptom-specific treatment (1)
- tDCS (1)
- target considerations (1)
- task retention (1)
- telemedicine (1)
- tetrahydroisoquinoline derivates (1)
- thromboemboli (1)
- thrombosis (1)
- tics (1)
- timing (1)
- transient ischemic attack (1)
- treatment-induced neuropathy in diabetes (TIND) (1)
- tremor (1)
- triamcinolone acetonide (1)
- α-Synuclein (1)
- α-synuclein (1)
- “bulbar-onset” ALS (bALS) (1)
- “limb-onset” ALS (lALS) (1)
Institute
- Neurologische Klinik und Poliklinik (54) (remove)
Schriftenreihe
EU-Project number / Contract (GA) number
- 825575 (1)
Background
To characterise the longitudinal dynamics of C-reactive protein (CRP) and Procalcitonin (PCT) in a cohort of hospitalised patients with COVID-19 and support antimicrobial decision-making.
Methods
Longitudinal CRP and PCT concentrations and trajectories of 237 hospitalised patients with COVID-19 were modelled. The dataset comprised of 2,021 data points for CRP and 284 points for PCT. Pairwise comparisons were performed between: (i) those with or without significant bacterial growth from cultures, and (ii) those who survived or died in hospital.
Results
CRP concentrations were higher over time in COVID-19 patients with positive microbiology (day 9: 236 vs 123 mg/L, p < 0.0001) and in those who died (day 8: 226 vs 152 mg/L, p < 0.0001) but only after day 7 of COVID-related symptom onset. Failure for CRP to reduce in the first week of hospital admission was associated with significantly higher odds of death. PCT concentrations were higher in patients with COVID-19 and positive microbiology or in those who died, although these differences were not statistically significant.
Conclusions
Both the absolute CRP concentration and the trajectory during the first week of hospital admission are important factors predicting microbiology culture positivity and outcome in patients hospitalised with COVID-19. Further work is needed to describe the role of PCT for co-infection. Understanding relationships of these biomarkers can support development of risk models and inform optimal antimicrobial strategies.
Guillain-Barré syndrome after SARS-CoV-2 infection in an international prospective cohort study
(2021)
In the wake of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, an increasing number of patients with neurological disorders, including Guillain-Barré syndrome (GBS), have been reported following this infection. It remains unclear, however, if these cases are coincidental or not, as most publications were case reports or small regional retrospective cohort studies. The International GBS Outcome Study is an ongoing prospective observational cohort study enrolling patients with GBS within 2 weeks from onset of weakness. Data from patients included in this study, between 30 January 2020 and 30 May 2020, were used to investigate clinical and laboratory signs of a preceding or concurrent SARS-CoV-2 infection and to describe the associated clinical phenotype and disease course. Patients were classified according to the SARS-CoV-2 case definitions of the European Centre for Disease Prevention and Control and laboratory recommendations of the World Health Organization. Forty-nine patients with GBS were included, of whom eight (16%) had a confirmed and three (6%) a probable SARS-CoV-2 infection. Nine of these 11 patients had no serological evidence of other recent preceding infections associated with GBS, whereas two had serological evidence of a recent Campylobacter jejuni infection. Patients with a confirmed or probable SARS-CoV-2 infection frequently had a sensorimotor variant 8/11 (73%) and facial palsy 7/11 (64%). The eight patients who underwent electrophysiological examination all had a demyelinating subtype, which was more prevalent than the other patients included in the same time window [14/30 (47%), P = 0.012] as well as historical region and age-matched control subjects included in the International GBS Outcome Study before the pandemic [23/44 (52%), P = 0.016]. The median time from the onset of infection to neurological symptoms was 16 days (interquartile range 12–22). Patients with SARS-CoV-2 infection shared uniform neurological features, similar to those previously described in other post-viral GBS patients. The frequency (22%) of a preceding SARS-CoV-2 infection in our study population was higher than estimates of the contemporaneous background prevalence of SARS-CoV-2, which may be a result of recruitment bias during the pandemic, but could also indicate that GBS may rarely follow a recent SARS-CoV-2 infection. Consistent with previous studies, we found no increase in patient recruitment during the pandemic for our ongoing International GBS Outcome Study compared to previous years, making a strong relationship of GBS with SARS-CoV-2 unlikely. A case-control study is required to determine if there is a causative link or not.
Purpose
Over the course of COVID-19 pandemic, evidence has accumulated that SARS-CoV-2 infections may affect multiple organs and have serious clinical sequelae, but on-site clinical examinations with non-hospitalized samples are rare. We, therefore, aimed to systematically assess the long-term health status of samples of hospitalized and non-hospitalized SARS-CoV-2 infected individuals from three regions in Germany.
Methods
The present paper describes the COVIDOM-study within the population-based cohort platform (POP) which has been established under the auspices of the NAPKON infrastructure (German National Pandemic Cohort Network) of the national Network University Medicine (NUM). Comprehensive health assessments among SARS-CoV-2 infected individuals are conducted at least 6 months after the acute infection at the study sites Kiel, Würzburg and Berlin. Potential participants were identified and contacted via the local public health authorities, irrespective of the severity of the initial infection. A harmonized examination protocol has been implemented, consisting of detailed assessments of medical history, physical examinations, and the collection of multiple biosamples (e.g., serum, plasma, saliva, urine) for future analyses. In addition, patient-reported perception of the impact of local pandemic-related measures and infection on quality-of-life are obtained.
Results
As of July 2021, in total 6813 individuals infected in 2020 have been invited into the COVIDOM-study. Of these, about 36% wished to participate and 1295 have already been examined at least once.
Conclusion
NAPKON-POP COVIDOM-study complements other Long COVID studies assessing the long-term consequences of an infection with SARS-CoV-2 by providing detailed health data of population-based samples, including individuals with various degrees of disease severity.
Trial registration
Registered at the German registry for clinical studies (DRKS00023742).
Hintergrund und Ziel
Telemedizinische Schlaganfall-Netzwerke tragen dazu bei, die Schlaganfallversorgung und insbesondere den Zugang zu zeitkritischen Schlaganfalltherapien in vorrangig strukturschwachen, ländlichen Regionen zu gewährleisten. Ziel ist eine Darstellung der Nutzungsfrequenz und regionalen Verteilung dieser Versorgungsstruktur.
Methoden
Die Kommission „Telemedizinische Schlaganfallversorgung“ der Deutschen Schlaganfall-Gesellschaft führte eine Umfragestudie in allen Schlaganfall-Netzwerken durch.
Ergebnisse
In Deutschland sind 22 telemedizinische Schlaganfall-Netzwerke aktiv, welche insgesamt 43 Zentren (pro Netzwerk: Median 1,5, Interquartilsabstand [IQA] 1–3) sowie 225 Kooperationskliniken (pro Netzwerk: Median 9, IQA 4–17) umfassen und an einem unmittelbaren Zugang zur Schlaganfallversorgung für 48 Mio. Menschen teilhaben. Im Jahr 2018 wurden 38.211 Telekonsile (pro Netzwerk: Median 1340, IQA 319–2758) durchgeführt. Die Thrombolyserate betrug 14,1 % (95 %-Konfidenzintervall 13,6–14,7 %), eine Verlegung zur Thrombektomie wurde bei 7,9 % (95 %-Konfidenzintervall 7,5–8,4 %) der ischämischen Schlaganfallpatienten initiiert. Das Finanzierungssystem ist uneinheitlich mit einem Vergütungssystem für die Zentrumsleistungen in nur drei Bundesländern.
Diskussion
Etwa jeder 10. Schlaganfallpatient wird telemedizinisch behandelt. Die telemedizinischen Schlaganfall-Netzwerke erreichen vergleichbar hohe Lyseraten und Verlegungen zur Thrombektomie wie neurologische Stroke-Units und tragen zur Sicherstellung einer flächendeckenden Schlaganfallversorgung bei. Eine netzwerkübergreifende Sicherstellung der Finanzierung und einheitliche Erhebung von Qualitätssicherungsdaten haben das Potenzial diese Versorgungsstruktur zukünftig weiter zu stärken.
Inflammatory mechanisms in the pathophysiology of diabetic peripheral neuropathy (DN) — new aspects
(2021)
The pathogenesis of diabetic neuropathy is complex, and various pathogenic pathways have been proposed. A better understanding of the pathophysiology is warranted for developing novel therapeutic strategies. Here, we summarize recent evidence from experiments using animal models of type 1 and type 2 diabetes showing that low-grade intraneural inflammation is a facet of diabetic neuropathy. Our experimental data suggest that these mild inflammatory processes are a likely common terminal pathway in diabetic neuropathy associated with the degeneration of intraepidermal nerve fibers. In contrast to earlier reports claiming toxic effects of high-iron content, we found the opposite, i.e., nutritional iron deficiency caused low-grade inflammation and fiber degeneration while in normal or high non-heme iron nutrition no or only extremely mild inflammatory signs were identified in nerve tissue. Obesity and dyslipidemia also appear to trigger mild inflammation of peripheral nerves, associated with neuropathy even in the absence of overt diabetes mellitus. Our finding may be the experimental analog of recent observations identifying systemic proinflammatory activity in human sensorimotor diabetic neuropathy. In a rat model of type 1 diabetes, a mild neuropathy with inflammatory components could be induced by insulin treatment causing an abrupt reduction in HbA1c. This is in line with observations in patients with severe diabetes developing a small fiber neuropathy upon treatment-induced rapid HbA1c reduction. If the inflammatory pathogenesis could be further substantiated by data from human tissues and intervention studies, anti-inflammatory compounds with different modes of action may become candidates for the treatment or prevention of diabetic neuropathy.
Patients with atrial fibrillation and previous ischemic stroke (IS) are at increased risk of cerebrovascular events despite anticoagulation. In these patients, treatment with non-vitamin K oral anticoagulants (NOAC) such as edoxaban reduced the probability and severity of further IS without increasing the risk of major bleeding. However, the detailed protective mechanism of edoxaban has not yet been investigated in a model of ischemia/reperfusion injury. Therefore, in the current study we aimed to assess in a clinically relevant setting whether treatment with edoxaban attenuates stroke severity, and whether edoxaban has an impact on the local cerebral inflammatory response and blood–brain barrier (BBB) function after experimental IS in mice. Focal cerebral ischemia was induced by transient middle cerebral artery occlusion in male mice receiving edoxaban, phenprocoumon or vehicle. Infarct volumes, functional outcome and the occurrence of intracerebral hemorrhage were assessed. BBB damage and the extent of local inflammatory response were determined. Treatment with edoxaban significantly reduced infarct volumes and improved neurological outcome and BBB function on day 1 and attenuated brain tissue inflammation. In summary, our study provides evidence that edoxaban might exert its protective effect in human IS by modulating different key steps of IS pathophysiology, but further studies are warranted.
It remains unclear if principal components of the local cerebral stroke immune response can be reliably and reproducibly observed in patients with acute large-vessel-occlusion (LVO) stroke. We prospectively studied a large independent cohort of n = 318 consecutive LVO stroke patients undergoing mechanical thrombectomy during which cerebral blood samples from within the occluded anterior circulation and systemic control samples from the ipsilateral cervical internal carotid artery were obtained. An extensive protocol was applied to homogenize the patient cohort and to standardize the procedural steps of endovascular sample collection, sample processing, and laboratory analyses. N = 58 patients met all inclusion criteria. (1) Mean total leukocyte counts were significantly higher within the occluded ischemic cerebral vasculature (I) vs. intraindividual systemic controls (S): +9.6%, I: 8114/µL ± 529 vs. S: 7406/µL ± 468, p = 0.0125. (2) This increase was driven by neutrophils: +12.1%, I: 7197/µL ± 510 vs. S: 6420/µL ± 438, p = 0.0022. Leukocyte influx was associated with (3) reduced retrograde collateral flow (R\(^2\) = 0.09696, p = 0.0373) and (4) greater infarct extent (R\(^2\) = 0.08382, p = 0.032). Despite LVO, leukocytes invade the occluded territory via retrograde collateral pathways early during ischemia, likely compromising cerebral hemodynamics and tissue integrity. This inflammatory response can be reliably observed in human stroke by harvesting immune cells from the occluded cerebral vascular compartment.
Based on recent findings that show that depletion of factor XII (FXII) leads to better posttraumatic neurological recovery, we studied the effect of FXII-deficiency on post-traumatic cognitive and behavioral outcomes in female and male mice. In agreement with our previous findings, neurological deficits on day 7 after weight-drop traumatic brain injury (TBI) were significantly reduced in FXII\(^{−/−}\) mice compared to wild type (WT) mice. Also, glycoprotein Ib (GPIb)-positive platelet aggregates were more frequent in brain microvasculature of WT than FXII\(^{−/−}\) mice 3 months after TBI. Six weeks after TBI, memory for novel object was significantly reduced in both female and male WT but not in FXII\(^{−/−}\) mice compared to sham-operated mice. In the setting of automated home-cage monitoring of socially housed mice in IntelliCages, female WT mice but not FXII\(^{−/−}\) mice showed decreased exploration and reacted negatively to reward extinction one month after TBI. Since neuroendocrine stress after TBI might contribute to trauma-induced cognitive dysfunction and negative emotional contrast reactions, we measured peripheral corticosterone levels and the ration of heart, lung, and spleen weight to bodyweight. Three months after TBI, plasma corticosterone levels were significantly suppressed in both female and male WT but not in FXII\(^{−/−}\) mice, while the relative heart weight increased in males but not in females of both phenotypes when compared to sham-operated mice. Our results indicate that FXII deficiency is associated with efficient post-traumatic behavioral and neuroendocrine recovery.
Treatment-induced neuropathy in diabetes (TIND) — Developing a disease model in type 1 diabetic rats
(2021)
Treatment-induced neuropathy in diabetes (TIND) is defined by the occurrence of an acute neuropathy within 8 weeks of an abrupt decrease in glycated hemoglobin-A1c (HbA1c). The underlying pathogenic mechanisms are still incompletely understood with only one mouse model being explored to date. The aim of this study was to further explore the hypothesis that an abrupt insulin-induced fall in HbA1c may be the prime causal factor of developing TIND. BB/OKL (bio breeding/OKL, Ottawa Karlsburg Leipzig) diabetic rats were randomized in three groups, receiving insulin treatment by implanted subcutaneous osmotic insulin pumps for 3 months, as follows: Group one received 2 units per day; group two 1 unit per day: and group three 1 unit per day in the first month, followed by 2 units per day in the last two months. We serially examined blood glucose and HbA1c levels, motor- and sensory/mixed afferent conduction velocities (mNCV and csNCV) and peripheral nerve morphology, including intraepidermal nerve fiber density and numbers of Iba-1 (ionized calcium binding adaptor molecule 1) positive macrophages in the sciatic nerve. Only in BB/OKL rats of group three, with a rapid decrease in HbA1c of more than 2%, did we find a significant decrease in mNCV in sciatic nerves (81% of initial values) after three months of treatment as compared to those group three rats with a less marked decrease in HbA1c <2% (mNCV 106% of initial values, p ≤ 0.01). A similar trend was observed for sensory/mixed afferent nerve conduction velocities: csNCV were reduced in BB/OKL rats with a rapid decrease in HbA1c >2% (csNCV 90% of initial values), compared to those rats with a mild decrease <2% (csNCV 112% of initial values, p ≤ 0.01). Moreover, BB/OKL rats of group three with a decrease in HbA1c >2% showed significantly greater infiltration of macrophages by about 50% (p ≤ 0.01) and a decreased amount of calcitonin gene related peptide (CGRP) positive nerve fibers as compared to the animals with a milder decrease in HbA1c. We conclude that a mild acute neuropathy with inflammatory components was induced in BB/OKL rats as a consequence of an abrupt decrease in HbA1c caused by high-dose insulin treatment. This experimentally induced neuropathy shares some features with TIND in humans and may be further explored in studies into the pathogenesis and treatment of TIND.
The objective of this study was to examine the therapeutic potential of multiple sessions of training on a split-belt treadmill (SBT) combined with cerebellar anodal transcranial direct current stimulation (tDCS) on gait and balance in People with Multiple Sclerosis (PwMS). Twenty-two PwMS received six sessions of anodal (PwMS\(_{real}\), n = 12) or sham (PwMS\(_{sham}\), n = 10) tDCS to the cerebellum prior to performing the locomotor adaptation task on the SBT. To evaluate the effect of the intervention, functional gait assessment (FGA) scores and distance walked in 2 min (2MWT) were measured at the baseline (T0), day 6 (T5), and at the 4-week follow up (T6). Locomotor performance and changes of motor outcomes were similar in PwMS\(_{real}\) and PwMS\(_{sham}\) independently from tDCS mode applied to the cerebellum (anodal vs. sham, on FGA, p = 0.23; and 2MWT, p = 0.49). When the data were pooled across the groups to investigate the effects of multiple sessions of SBT training alone, significant improvement of gait and balance was found on T5 and T6, respectively, relative to baseline (FGA, p < 0.001 for both time points). The FGA change at T6 was significantly higher than at T5 (p = 0.01) underlining a long-lasting improvement. An improvement of the distance walked during the 2MWT was also observed on T5 and T6 relative to T0 (p = 0.002). Multiple sessions of SBT training resulted in a lasting improvement of gait stability and endurance, thus potentially reducing the risk of fall as measured by FGA and 2MWT. Application of cerebellar tDCS during SBT walking had no additional effect on locomotor outcomes.