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The analysis of real data by means of statistical methods with the aid of a software package common in industry and administration usually is not an integral part of mathematics studies, but it will certainly be part of a future professional work. The present book links up elements from time series analysis with a selection of statistical procedures used in general practice including the statistical software package SAS Statistical Analysis System). Consequently this book addresses students of statistics as well as students of other branches such as economics, demography and engineering, where lectures on statistics belong to their academic training. But it is also intended for the practician who, beyond the use of statistical tools, is interested in their mathematical background. Numerous problems illustrate the applicability of the presented statistical procedures, where SAS gives the solutions. The programs used are explicitly listed and explained. No previous experience is expected neither in SAS nor in a special computer system so that a short training period is guaranteed. This book is meant for a two semester course (lecture, seminar or practical training) where the first two chapters can be dealt with in the first semester. They provide the principal components of the analysis of a time series in the time domain. Chapters 3, 4 and 5 deal with its analysis in the frequency domain and can be worked through in the second term. In order to understand the mathematical background some terms are useful such as convergence in distribution, stochastic convergence, maximum likelihood estimator as well as a basic knowledge of the test theory, so that work on the book can start after an introductory lecture on stochastics. Each chapter includes exercises. An exhaustive treatment is recommended. This book is consecutively subdivided in a statistical part and an SAS-specific part. For better clearness the SAS-specific part, including the diagrams generated with SAS, always starts with a computer symbol, representing the beginning of a session at the computer, and ends with a printer symbol for the end of this session. This book is an open source project under the GNU Free Documentation License.
The analysis of real data by means of statistical methods with the aid of a software package common in industry and administration usually is not an integral part of mathematics studies, but it will certainly be part of a future professional work. The present book links up elements from time series analysis with a selection of statistical procedures used in general practice including the statistical software package SAS Statistical Analysis System). Consequently this book addresses students of statistics as well as students of other branches such as economics, demography and engineering, where lectures on statistics belong to their academic training. But it is also intended for the practician who, beyond the use of statistical tools, is interested in their mathematical background. Numerous problems illustrate the applicability of the presented statistical procedures, where SAS gives the solutions. The programs used are explicitly listed and explained. No previous experience is expected neither in SAS nor in a special computer system so that a short training period is guaranteed. This book is meant for a two semester course (lecture, seminar or practical training) where the first two chapters can be dealt with in the first semester. They provide the principal components of the analysis of a time series in the time domain. Chapters 3, 4 and 5 deal with its analysis in the frequency domain and can be worked through in the second term. In order to understand the mathematical background some terms are useful such as convergence in distribution, stochastic convergence, maximum likelihood estimator as well as a basic knowledge of the test theory, so that work on the book can start after an introductory lecture on stochastics. Each chapter includes exercises. An exhaustive treatment is recommended. This book is consecutively subdivided in a statistical part and an SAS-specific part. For better clearness the SAS-specific part, including the diagrams generated with SAS, always starts with a computer symbol, representing the beginning of a session at the computer, and ends with a printer symbol for the end of this session. This book is an open source project under the GNU Free Documentation License.
This volume brings together several authors from different areas of psychology and the neighbouring social sciences. Each one contributes their own perspective on the growing interest topic of subjective well-being. The aim of the volume is to present these divergent perspectives and to foster communication between the different areas. Split into three parts, this volume initially discusses the general perspectives of subjective well-being and addresses fundamental questions, secondly it discusses the dynamics of subjective well-being and more specific research issues to give a better understanding of the general phenomenon, and thirdly the book emphasizes the social context in which people experience and report their happiness and satisfaction. The book will be of great interest to social and clinical psychologists, students of psychology and sociology and health professionals.
The goal of the project was to establish knock down of mRNA in human mesenchymal stem cells. Since these cells are difficult to transfect, a viral approach is needed to achieve sufficient expression of e. g. shRNA in a high percentage of cells to allow for an efficient silencing of corresponding mRNAs. For this purpose for every gene product of interest, a number of shRNA clones have to be tested to detect an individual shRNA with sufficient efficacy. Lentiviral systems for shRNA approaches have recently become available. The principal advantage of the lentiviral system is that it allows gene silencing in nondividing cells and therefore expands the usefulness of the RNAi-based gene silencing system. Lentivirus-delivered shRNAs are capable of specific, highly stable and functional silencing of gene expression in a variety of cell types. Since the viral transfection of MSCs is a time consuming process that involves transfection of 293 FT cells plus transduction of target cells, for this thesis the following approach was chosen: genes of interest were checked for expression in 293FT cells by RT-PCR. These gene products can be silenced in 293FT cells simply by transfection of shRNA clones and efficacy was subsequently tested by RT-PCR. Beyond this thesis then the project can proceed with effective clones to transduce primary MSCs with individual shRNA clones identified as effective silencing tool in this thesis.
Surveys by the Universities of Wuerzburg and Berlin, starting in the 1970´s have revealed the existence of palaeolakes in remote areas in Niger. Initial research has shown that the sediments found are suitable for reconstructing its late quaternary palaeoenvironment. Although a high number of investigations focused on the succession of climatological conditions in the Central Sahara, some uncertainties still exist as the results show discontinuities and mostly are of low temporal and spatial
resolution.
Two expeditions in 2005 and 2006 headed to the northeastern parts of Niger to investigate the known remains of palaeolakes and search some new and undetected ones. Samples were taken at several study sites in order to receive a complete picture of the Late Quaternary environmental settings and to produce high-resolution proxies for palaeoclimate modelling.
The most valuable and best-investigated study site is the sebkha of Seggedim, where a core of 15 meters length could be extracted which revealed a composition of high-resolution sections. Stratigraphical, structural and geochemical investigations as well as the analysis of thin sections allow the characterization of different environmental conditions from Early to Mid Holocene. Driven by climate and hydrogeological influence, the water body developed from a water pond of several metres depth within a stable, grass and shrub vegetated landscape, to an alternating freshwater lake in a more dynamic environmental setting. Radiocarbon dates set the beginning of the stage at about 10.6 ka cal BP, with an exceptionally stable regime to 6.6 ka cal BP (at 12.6 metres’ depth), when a major change in the sedimentation regime of the basin is recorded in the core. Increased erosion, likely due to decreased vegetation cover within the basin, led to the siltation/filling of the lake within a few hundred years and the subsequent development of a sebkha/salt pan due to massive evaporation. Due to the lack of dateable material in the upper core section, the termination of the lake stage and the onset of the subsequent sebkha stage cannot be determined precisely but can be narrowed to a period around 6 ka BP.
The results obtained from the core are compared with those from terrestrial and lacustrine sediments from outside the depression, situated a few hundred kilometres further to the north. These supplementary study sites are required to validate the information obtained from the coring. Within the plateau landscape of Djado, Mangueni and Tchigai, two depressions and a valley containing lacustrine deposits, were investigated for palaeoenvironmental reconstruction. Depending on modifying local factors, these sediment archives were of shorter existence than IX the lake, but reveal additional information about the landscape dynamics from Early to Mid Holocene.
A damming situation within a small tributary at Enneri Achelouma led to lacustrine sedimentation conditions at Early Holocene in the upper reaches of the valley. The remnants of the lacustrine accumulations show distinct changes in the environmental conditions within the small catchment, as the archive immediately responded to local climate-induced changes of precipitation. Radiocarbon dating of the deposited sediments revealed ages from 8780 ± 260 cal a BP to 9480 ± 80 cal a BP.
The sites of Yoo Ango and Fabérgé show a completely different sedimentation milieu as they consist of basins within the foothills of the Tchigai. The study sites show increased catchment sizes, probably extending towards the Tchigai massif and are most likely influenced by groundwater charge. The widespread occurrence of wind shaped relicts and the limited amount of lacustrine remnants indicate a generally high aeolian activity in both areas. Only in wind sheltered spots, parts of the lacustrine sequences were preserved, that show ages spanning from Early to Mid Holocene (9440 ± 140 cal a BP – 6810 ±140 cal a BP) and give additional evidence of fires from pre-LGM periods. Although intensively weathered, all profiles indicate distinct changes in the sedimentation conditions by alternating geochemical values and the mineralogical composition.
The information obtained from the records investigated in this work confirms the heterogeneity of reconstructed environmental succession in the Central Sahara. The Mid Holocene rapid (within decades) and uniform development from more humid to extremely arid environmental conditions cannot be confirmed for the Central Sahara. In addition, a division of Early and Mid Holocene wet periods cannot be confirmed, either. Actually, the evidences obtained from the palaeoenvironmental reconstructions revealed major variations in the timing and extend of lacustrine and aeolian periods. Evidently, a transitional time has existed between 7 to 5 ka BP where alternating influences prevailed. This is indicated by the varying sedimentation conditions in the Seggedim depression as well as the evidence of soil properties on a fossil dune, with a time of deposition dated to 6200 ± 400 cal a BP and the removal of lacustrine Sediments at the Seeterrassental at Mid Holocene. In respect to provide a complete picture of landscape succession and to avoid misinterpretation, the investigation of several dissimilar spots within a designated study area is prerequisite for further investigations.
The analysis of real data by means of statistical methods with the aid of a software package common in industry and administration usually is not an integral part of mathematics studies, but it will certainly be part of a future professional work. The present book links up elements from time series analysis with a selection of statistical procedures used in general practice including the statistical software package SAS. Consequently this book addresses students of statistics as well as students of other branches such as economics, demography and engineering, where lectures on statistics belong to their academic training. But it is also intended for the practician who, beyond the use of statistical tools, is interested in their mathematical background. Numerous problems illustrate the applicability of the presented statistical procedures, where SAS gives the solutions. The programs used are explicitly listed and explained. No previous experience is expected neither in SAS nor in a special computer system so that a short training period is guaranteed. This book is meant for a two semester course (lecture, seminar or practical training) where the first three chapters can be dealt within the first semester. They provide the principal components of the analysis of a time series in the time domain. Chapters 4, 5 and 6 deal with its analysis in the frequency domain and can be worked through in the second term. In order to understand the mathematical background some terms are useful such as convergence in distribution, stochastic convergence, maximum likelihood estimator as well as a basic knowledge of the test theory, so that work on the book can start after an introductory lecture on stochastics. Each chapter includes exercises. An exhaustive treatment is recommended. Chapter 7 (case study) deals with a practical case and demonstrates the presented methods. It is possible to use this chapter independent in a seminar or practical training course, if the concepts of time series analysis are already well understood. This book is consecutively subdivided in a statistical part and an SAS-specific part. For better clearness the SAS-specific parts are highlighted. This book is an open source project under the GNU Free Documentation License.