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- Remote Sensing (7)
- SMN (7)
- Spinale Muskelatrophie (7)
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- algorithm (7)
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- immunofluorescence (7)
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- immunoprecipitation (7)
- latency (7)
- locomotion (7)
- luciferase (7)
- macrophage (7)
- mapping (7)
- mechanotransduction (7)
- meta-analysis (7)
- methylation (7)
- microenvironment (7)
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- 1 (4)
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- Perylenbisdicarboximide <Perylen-3,4:9,10-bis(dicarboximide)> (4)
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- neurite outgrowth (2)
- neurodevelopmental disorders (2)
- neuroendocrine tumor (NET) (2)
- neurofilaments (2)
- neuron (2)
- neuronal ceroid lipofuscinosis (2)
- neuronal dendrites (2)
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- neurotransmission (2)
- neurotransmitter release (2)
- neutral sphingomyelinase-2 (2)
- neutralino (2)
- neutrino astronomy (2)
- neutrino emission (2)
- neutrino telescope (2)
- neutrinos (2)
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- next generation sequencing (NGS) (2)
- nicht-kartesische Bildgebung (2)
- nicht-kovalente Wechselwirkungen (2)
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- nilotinib (2)
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- nociception (2)
- nomenclature (2)
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- normal distribution (2)
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- nucleotide sequence (2)
- nude-mice (2)
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- numerical hydrodynamics (2)
- nurse bee (2)
- nurses (2)
- o-methoxy-sila-hexocyclium (2)
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- object-based image analysis (2)
- observer (2)
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- occupational medicine/industrial medicine (2)
- oculomotor control (2)
- oestrogen receptor signalling (2)
- office-workers (2)
- oil palm (2)
- older adults (2)
- olfaktorisches Lernen (2)
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- onset (2)
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- organische Solarzellen (2)
- origin (2)
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- orthopedics (2)
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- osteonecrosis of the jaw (2)
- osteopontin (2)
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- outer membrane protein (2)
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- outer-membrane proteins (2)
- outpatients (2)
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- oxidative addition (2)
- oxygen reduction reaction (2)
- oxygen uptake (2)
- oxytocin (2)
- p-Halbleiter (2)
- p34 (2)
- p38 MAP kinase (2)
- p44 (2)
- p90 ribosomal S6 kinase (2)
- pCa (2)
- pICln (2)
- paediatric patients (2)
- paediatrics (2)
- pain regulation (2)
- pain sensation (2)
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- parallel imaging (2)
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- patient-specific (2)
- pattern (2)
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- penicillin hypersensitivity (2)
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- photoinduzierter Elektronentransfer (2)
- photolysis (2)
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- photon-counting (2)
- photoreceptor (2)
- photoreceptors (2)
- photoswitchable organic fluorophores (2)
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- planning (2)
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- plant cuticle (2)
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- power training (2)
- pp Collisions (2)
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- rice (2)
- ring expansion (2)
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- root (2)
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- see (2)
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- sentinel-2 (2)
- septic (2)
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- shedding (2)
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- sizing (2)
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- speech (2)
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- spermatocytes (2)
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- succession (2)
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- supervisors (2)
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- supramolekulare Chemie (2)
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- synapsis (2)
- synaptische Proteine (2)
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- syndrome (2)
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- tolerability (2)
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- tracking (2)
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- transcranial magnetic stimulation (2)
- transcription factor MIZ-1 (2)
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- type VII secretion system (2)
- tyramine (2)
- tyrosine (2)
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- ultrafast spectroscopy (2)
- ultrafiltration (2)
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- umbilical hernia (2)
- unconventional superconductivity (2)
- unexpressed needs (2)
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- universal prevention (2)
- universality (2)
- unmanned aerial vehicles (2)
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Synaptophysin: a substrate for the protein tyrosine kinase pp60c-src in intact synaptic vesicles
(1990)
Expression of pp60 c-src, the first well defined proto-oncogene product, is developmentally regulated and tissue-specific, with neuronal tissues displaying high amounts of the c-src encoded pp60 c-src kinase activity. In the central nervous system pp60 s-src is preferentially expressed in regions characterized by a high content of grey matter and elevated density of nerve terminals. In this study we show for the first time a direct interaction between pp60 c-src and synaptophysin as a physiological target protein in neurons by demonstrating that endogenous pp60 c-src is able to phosphorylate synaptophysin (p38). p38 is a major constituent of the synaptic vesicle membrane protein and is thought to play a key role in the exocytosis of small synaptic vesicles and possibly small clear vesicles in neuroendocrine cells.
0-2A progenitor cells give rise to both oligodendrocytes and type-2 astrocytes in vitro. Whereas oligodendrocyte differentiation occurs constitutively, type-2 astrocyte differentiation requires extracellular signals, one of which is thought to be ciliary neurotrophic factor (CNTF). CNTF, however, is insufficient by itself to induce the development of stable type-2 astrocytes. In this report we show the following: (a) that molecules associated with the extracellular matrix (ECM) cooperate with CNTF to induce stable type-2 astrocyte differentiation in serumfree cultures. The combination of CNTF and the ECM-associated molecules thus mimics the effect of FCS, which has been shown previously to induce stable type-2 astrocyte differentiation in vitro. (b) Both the ECM-associated molecules and CNTF act directly on 0-2A progenitor cells and can induce them to differentiate prematurely into type-2 astrocytes. (c) ECM-associated molecules also inhibit oligodendrocyte differentiation, even in the absence of CNTF, but this inhibition is not sufficient on its own to induce type-2 astrocyte differentiation. (d) Whereas the effect of ECM on oligodendrocyte differentiation is mimicked by basic fibroblast growth factor (bFGF), the effect of ECM on type-2 astrocyte differentiation is not. (e) The ECM-associated molecules that are responsible for inhibitin~ oligodendrocyte differentiation and for cooperating with CNTF to induce type-2 astrocyte differentiation are made by non-glial cells in vitro. (f) Molecules that have these activities and bind to ECM are present in the optic nerve at the time type-2 astrocytes are thought to be developing.
no abstract available
To study the activation of HIV by human spumaretrovirus (HSRV) the long terminal repeats (LTRs) of HSRV, HIVl and HIV2 were examined with respect to their ability to function as transcriptional promoters in virus infected and uninfected cells. Transient transfections using plasmids in which the L TRs of the three viruses were coupled to the bacterial chloramphenicol acetyltransferase (CA T) gene revealed (i) the level of cat gene expression directed by the HSRV LTR was markedly increased in HSRV infected cells compared to uninfected cells, (ii) cat gene expression driven by the HIV1 LTR, but not by the HIV2 LTR could be enhanced upon HSRV infection, whereas (iii) neither in HIV1 nor in HIV2 infected cells an effect on HSRV LTR driven cat geneexpression was detected.
A 42 m drilling was pertormed in the depresalon of Bilma, Xawar, NE-Niger. The sediment and pollen records show that after an initial deposition of dune sands there were repeated lake phases which terminated by desiccation and consolidation of spring mounds. The pollen record indicates a continuous presence of savanna vegetation. The record probably covers the period between the Upper Pleistocene and the Late Holocene. The climate was characterised by a monssonal summer rain regime giving effective rain fall of about 450-500 mm per year. Groundwater recharge was possible but estimates of the amount of water resources are difficult because of the karstic system of the escarpment and the nearly unknown hydrogeological situation.