Refine
Is part of the Bibliography
- yes (974)
Year of publication
Document Type
- Doctoral Thesis (974) (remove)
Language
- English (753)
- German (220)
- Multiple languages (1)
Keywords
- Maus (37)
- Thrombozyt (32)
- T-Lymphozyt (29)
- Tissue Engineering (29)
- Dendritische Zelle (19)
- Taufliege (19)
- Genexpression (18)
- Angst (16)
- Entzündung (16)
- Myc (15)
- Signaltransduktion (15)
- Angststörung (14)
- Aufmerksamkeit (13)
- Drosophila (13)
- Staphylococcus aureus (13)
- Arteriosklerose (12)
- Biene (12)
- Candida albicans (12)
- G-Protein gekoppelte Rezeptoren (12)
- Immunologie (12)
- Kernspintomografie (12)
- Melanom (12)
- Schlaganfall (12)
- Serotonin (12)
- Fluoreszenzmikroskopie (11)
- Krebs <Medizin> (11)
- Mikroskopie (11)
- Stress (11)
- Epigenetik (10)
- GPCR (10)
- Microscopy (10)
- Regulation (10)
- Therapie (10)
- Thrombose (10)
- Transkriptionsfaktor (10)
- miRNS (10)
- ADHD (9)
- Apoptosis (9)
- DNS-Reparatur (9)
- Depression (9)
- Escherichia coli (9)
- Fluoreszenz-Resonanz-Energie-Transfer (9)
- Megakaryozyt (9)
- Motoneuron (9)
- Plasmozytom (9)
- Stammzelle (9)
- Tagesrhythmus (9)
- Zellskelett (9)
- Zellzyklus (9)
- platelets (9)
- Aspergillus fumigatus (8)
- Elektrophysiologie (8)
- Fuchsbandwurm (8)
- Furcht (8)
- Induzierte pluripotente Stammzelle (8)
- Konditionierung (8)
- Multiples Myelom (8)
- Neisseria meningitidis (8)
- Rezeptor (8)
- Spinale Muskelatrophie (8)
- Alzheimerkrankheit (7)
- Arzneimitteldesign (7)
- Biomarker (7)
- DNS-Schädigung (7)
- EEG (7)
- Genetik (7)
- Herzinfarkt (7)
- Herzinsuffizienz (7)
- Inhibitor (7)
- Kutikula (7)
- Lernen (7)
- Makrophage (7)
- Regulatorischer T-Lymphozyt (7)
- Small RNA (7)
- Synapse (7)
- Transcription (7)
- Transkription <Genetik> (7)
- Transplantat-Wirt-Reaktion (7)
- Verhalten (7)
- Zellkultur (7)
- dendritic cells (7)
- fMRI (7)
- Antigen CD28 (6)
- Bacteria (6)
- Bildgebendes Verfahren (6)
- Calcium (6)
- DNA damage (6)
- Diabetes mellitus (6)
- Entwicklung (6)
- Funktionelle Kernspintomografie (6)
- Hippocampus (6)
- Immuntherapie (6)
- Inflammation (6)
- Kognition (6)
- Lungenkrebs (6)
- MRI (6)
- MYC (6)
- Masernvirus (6)
- Molekularbiologie (6)
- Multiple Sklerose (6)
- Oxidativer Stress (6)
- Platelet (6)
- Platelets (6)
- Ratte (6)
- Thrombosis (6)
- Tiermodell (6)
- Transkriptomanalyse (6)
- Trypanosoma brucei (6)
- Ubiquitin (6)
- Virtuelle Realität (6)
- Zellmigration (6)
- Atherosclerosis (5)
- Aufmerksamkeits-Defizit-Syndrom (5)
- Autoantikörper (5)
- Bakterien (5)
- Biologie (5)
- Brain-derived neurotrophic factor (5)
- Cataglyphis (5)
- Chronobiologie (5)
- Cytoskeleton (5)
- Dendritic cells (5)
- Drosophila melanogaster (5)
- Dünndarm (5)
- Evolution (5)
- Gefühl (5)
- Genetics (5)
- Gephyrin (5)
- HIV (5)
- Immunsystem (5)
- In-vitro-Kultur (5)
- Inhibition (5)
- MAP-Kinase (5)
- Metabolismus (5)
- Monoklonaler Antikörper (5)
- Mutagenität (5)
- NFATc1 (5)
- Neurodegeneration (5)
- Neuroethologie (5)
- Polymorphismus (5)
- Resistenz (5)
- Schmerz (5)
- Transkription (5)
- Zelldifferenzierung (5)
- cancer (5)
- platelet (5)
- virtual reality (5)
- 3D-Druck (4)
- Actin (4)
- Anxiety (4)
- Aufmerksamkeitsdefizit-Syndrom (4)
- Aurora-A (4)
- Autoimmunität (4)
- B-Lymphozyt (4)
- Biofabrication (4)
- Biofilm (4)
- Bioinformatics (4)
- Biomaterial (4)
- Blut-Hirn-Schranke (4)
- Brustkrebs (4)
- CRISPR/Cas-Methode (4)
- CRISPR/Cas9 (4)
- Cadherine (4)
- Cancer (4)
- Chlamydia trachomatis (4)
- Chromatin (4)
- Chronophin (4)
- Darm (4)
- Dendritic cell (4)
- Dendritische Zellen (4)
- Einzelmolekülmikroskopie (4)
- Elektroencephalographie (4)
- Emotion (4)
- FRET (4)
- Fettsäurestoffwechsel (4)
- Fibroblastenwachstumsfaktor (4)
- Furchtgeneralisierung (4)
- Furchtkonditionierung (4)
- G-Protein gekoppelter Rezeptor (4)
- GPVI (4)
- Genotoxizität (4)
- Genregulation (4)
- Glucosetransportproteine (4)
- Graft-versus-host-disease (4)
- Herzmuskelzelle (4)
- Hämostase (4)
- Immunmodulation (4)
- Immunology (4)
- Immunreaktion (4)
- Immunsuppression (4)
- Infektion (4)
- Insulin (4)
- Interleukin 6 (4)
- Ionenkanal (4)
- Jugend (4)
- Kind (4)
- Knockout <Molekulargenetik> (4)
- MMB (4)
- MYCN (4)
- Malaria (4)
- Maschinelles Lernen (4)
- Mausmodell (4)
- Meeresschwämme (4)
- Mitochondrium (4)
- Mitose (4)
- Molekulargenetik (4)
- Myokardinfarkt (4)
- Natürliche Killerzelle (4)
- Neurobiologie (4)
- Neuroblastom (4)
- Neurowissenschaften (4)
- Opiatrezeptor (4)
- Panikstörung (4)
- Parkinson-Krankheit (4)
- Plasmodium falciparum (4)
- Posttranskriptionelle Regulation (4)
- Probiotikum (4)
- Proteasen (4)
- RNS-Bindungsproteine (4)
- Ribosom (4)
- SMN (4)
- Salmonella (4)
- Sepsis (4)
- Soziale Insekten (4)
- Stoffwechsel (4)
- TFIIH (4)
- Treg (4)
- TrkB (4)
- Tumor (4)
- Virulenz (4)
- Zelle (4)
- active zone (4)
- division of labor (4)
- genotoxicity (4)
- honeybee (4)
- inflammation (4)
- magnetic resonance imaging (4)
- measles virus (4)
- miRNA (4)
- microRNA (4)
- myocardial infarction (4)
- neuroblastoma (4)
- olfaction (4)
- regulation (4)
- 3D tissue model (3)
- ADHS (3)
- Adjuvans (3)
- Altern (3)
- Amygdala (3)
- Angiogenese (3)
- Angsterkrankungen (3)
- Animal model (3)
- Antibody (3)
- Antigen CD8 (3)
- Atherosklerose (3)
- B-MYB (3)
- B-Zell-Lymphom (3)
- Bacillus subtilis (3)
- Biochemie (3)
- Biodiversität (3)
- Bioinformatik (3)
- Biologische Uhr (3)
- Bioreaktor (3)
- Blutstammzelle (3)
- Blutstillung (3)
- CD1d (3)
- CD28 (3)
- CIDP (3)
- Campylobacter jejuni (3)
- Ceramid (3)
- Chemotherapie (3)
- Cyclo-AMP (3)
- Cytokine (3)
- Dimerisierung (3)
- E. coli Nissle 1917 (3)
- Echinococcus (3)
- Echinococcus multilocularis (3)
- Ecology (3)
- Electroencephalographie (3)
- Emotionsregulation (3)
- Endocytose (3)
- Endothel (3)
- Expansion Microscopy (3)
- Expositionstherapie (3)
- Extinktion (3)
- Fettzelle (3)
- Fibromyalgie (3)
- Fluorescence Microscopy (3)
- Gehirn (3)
- Gehirn-Computer-Schnittstelle (3)
- Genmutation (3)
- Genom (3)
- Geruch (3)
- Geruchssinn (3)
- Gewebekultur (3)
- Gewebemodell (3)
- Glioblastom (3)
- Glycinrezeptor (3)
- Helicasen (3)
- Helicobacter pylori (3)
- Herzhypertrophie (3)
- Heubacillus (3)
- Histone (3)
- Hyaliner Knorpel (3)
- Hyaluronsäure (3)
- Immuntoleranz (3)
- In vitro (3)
- Informationsverarbeitung (3)
- Knorpel (3)
- Komplement <Immunologie> (3)
- Koronare Herzkrankheit (3)
- Kristallstruktur (3)
- Kutikularwachs (3)
- Latrophilin (3)
- Lunge (3)
- MRSA (3)
- MRT (3)
- Magnetresonanztomographie (3)
- Massenspektrometrie (3)
- Megakaryocyte (3)
- Metagenom (3)
- Metalloproteinasen (3)
- Mitochondria (3)
- Miz1 (3)
- Molekulare Bildgebung (3)
- Multiproteinkomplex (3)
- Muscarinrezeptor (3)
- NIR-Spektroskopie (3)
- NMR-Tomographie (3)
- Nephroblastom (3)
- Nervennetz (3)
- Nervenzelle (3)
- Neuroanatomie (3)
- Neurogenese (3)
- Neuroinflammation (3)
- Neuronale Plastizität (3)
- Neuropathischer Schmerz (3)
- Neuropeptide (3)
- Neutrophiler Granulozyt (3)
- Non-coding RNA (3)
- Obesity (3)
- Opioide (3)
- Orientierung (3)
- PDXP (3)
- PET (3)
- Paniksyndrom (3)
- Parkinson's disease (3)
- Pathogenität (3)
- Pathophysiologie (3)
- Permeabilität (3)
- Phosphatase (3)
- Phosphoglykolatphosphatase (3)
- Phospholipide (3)
- Phosphorylierung (3)
- Physiologie (3)
- Pilzkörper (3)
- Plastizität (3)
- Pneumolysin (3)
- Proteinkinase D (3)
- Präfrontaler Cortex (3)
- Prävention (3)
- Psychische Störung (3)
- RNS (3)
- Raf-Kinasen (3)
- Rho-Proteine (3)
- Rhodopsin (3)
- Salmonella enterica (3)
- Schmerzforschung (3)
- Secretion (3)
- Sphingolipide (3)
- Stressreaktion (3)
- Structural Biology (3)
- T cell activation (3)
- T-Zelle (3)
- T-Zellen (3)
- Thrombozytenaggregation (3)
- Transpiration <Pflanzen> (3)
- Transposon (3)
- Tumorzelle (3)
- Typ 1 (3)
- Ubiquitinierung (3)
- Visuelle Aufmerksamkeit (3)
- Wundheilung (3)
- Zellkern (3)
- Zentralnervensystem (3)
- adrenocortical carcinoma (3)
- apoptosis (3)
- atherosclerosis (3)
- attention (3)
- cAMP (3)
- cell wall (3)
- circadian rhythms (3)
- cytoskeleton (3)
- dopamine (3)
- fear conditioning (3)
- gp130 (3)
- iPSC (3)
- ischemic stroke (3)
- learning (3)
- learning and memory (3)
- megakaryocyte (3)
- megakaryopoiesis (3)
- neurobiology (3)
- protease (3)
- regulatorische T-Zellen (3)
- signalling (3)
- super-resolution microscopy (3)
- translation (3)
- virulence (3)
- 3D cell culture (2)
- 3D-Zellkultur (2)
- 53BP1 (2)
- ALS (2)
- APOBEC3G (2)
- ASM (2)
- Acetylation (2)
- Ackerschmalwand (2)
- Actin-bindende Proteine (2)
- Actinomyceten (2)
- Actinomycetes (2)
- Adaptation (2)
- Adaptorproteine (2)
- Adenosinrezeptor (2)
- Adhesion GPCR (2)
- Adipogenesis (2)
- Adjuvant (2)
- Adrenalin (2)
- Adrenerger Rezeptor (2)
- Adventitia (2)
- Affekt (2)
- Analgesie (2)
- Angeborene Immunität (2)
- Angewandte Mikrobiologie (2)
- Antennallobus (2)
- Antiangiogenese (2)
- Antibiotikum (2)
- Antigen CD40 (2)
- Antigen CD95 (2)
- Antikörper (2)
- Aorta (2)
- Apis mellifera (2)
- Apoptose (2)
- Arabidopsis thaliana (2)
- Arbeitsgedächtnis (2)
- Arbeitsteilung (2)
- Arrestine (2)
- Aspergillus (2)
- Assoziation (2)
- Assoziatives Lernen (2)
- Astrozyt (2)
- Audiologie (2)
- Augenbewegung (2)
- Autoaggressionskrankheit (2)
- Autophagy (2)
- Aversive Konditionierung (2)
- Axon (2)
- B cells (2)
- B-Zellen (2)
- BAD (2)
- BCI (2)
- BOLD signal (2)
- BRET (2)
- Bacterial infection (2)
- Bakterielle Hirnhautentzündung (2)
- Bakterielle Infektion (2)
- Bakteriengift (2)
- Bauchspeicheldrüsenkrebs (2)
- Beta-1-Rezeptor (2)
- Beta-Rezeptor (2)
- Bildverarbeitung (2)
- Biogenese (2)
- Bioinks (2)
- Biomechanics (2)
- Biomedicine (2)
- Bioprinting (2)
- Bioreactor (2)
- Blickbewegung (2)
- Blut-Nerven-Barriere (2)
- Blutgerinnung (2)
- Bortezomib (2)
- Brain-computer interface (2)
- CD28 Superagonist (2)
- CD84 (2)
- CDH13 (2)
- COVID-19 (2)
- CRPS (2)
- CXCR4 (2)
- Calciumkanal (2)
- Calciumtransport (2)
- Camponotus floridanus (2)
- Cancer immunotherapy (2)
- Cardiomyocyte (2)
- Cartilage Tissue Engineering (2)
- Cell cycle (2)
- Cell migration (2)
- Cement (2)
- Ceramide (2)
- Cholesterinstoffwechsel (2)
- Chronische Niereninsuffizienz (2)
- Ciliary neurotrophic factor (2)
- Circadian Rhythms (2)
- Cochlear-Implantat (2)
- Colonkrebs (2)
- Compressed Sensing (2)
- Contactin-1 (2)
- Corpus amygdaloideum (2)
- Corti-Organ (2)
- Crosstalk (2)
- Cryptochrom (2)
- Cushing-Syndrom (2)
- Cuticle (2)
- Cuticular waxes (2)
- DNA Repair (2)
- DNA repair (2)
- DNA-Reparatur (2)
- DNS (2)
- DNS-Bindung (2)
- DNS-Doppelstrangbruch (2)
- DRG (2)
- DROSHA (2)
- Darmwandnervensystem (2)
- Deep sequencing (2)
- Diabetische Polyneuropathie (2)
- Diagnostik (2)
- Dichtegewichtung (2)
- Differentiation (2)
- Diffusionsgewichtete Magnetresonanztomografie (2)
- Dopamin (2)
- Dosimetrie (2)
- E. coli Nissle (2)
- EHEC (2)
- Echokardiographie (2)
- Einzelzellanalyse (2)
- Elektroencephalogramm (2)
- Elektrospinning (2)
- Emotionen (2)
- Emotionsverarbeitung (2)
- Encephalomyelitis (2)
- Endozytose (2)
- Enterobacteriaceae (2)
- Enzym (2)
- Epigenetic (2)
- Ereigniskorreliertes Potenzial (2)
- Erwachsener (2)
- Extrazelluläre Matrix (2)
- FKBP52 (2)
- Fabry-Krankheit (2)
- Farbensehen (2)
- Fettsucht (2)
- Fettsäurebiosynthese (2)
- Fitness (2)
- Fluconazol (2)
- Fluconazole (2)
- Fluorescence (2)
- Fluoreszenzkorrelationsspektroskopie (2)
- Fluoxetin (2)
- Frühdiagnostik (2)
- Förster Resonanz Energie Transfer (2)
- G-protein-coupled receptors (2)
- GABA-Rezeptor (2)
- Galectine (2)
- Gametogenese (2)
- Gastrointestinaltrakt (2)
- Gedächtnis (2)
- Gelenkknorpel (2)
- Generalisierung (2)
- Genomics (2)
- Gerinnungsfaktor XII (2)
- Glia (2)
- Glioblastoma (2)
- Gliom (2)
- Glukose (2)
- Glutamat-Decarboxylase (2)
- Glykosylierung (2)
- Golgi-Apparat (2)
- Graft-versus-host disease (2)
- Growth (2)
- Guanylatcyclase (2)
- GvHD (2)
- HUWE1 (2)
- Harnwegsinfektion (2)
- Hautleitfähigkeit (2)
- Hemostasis (2)
- Herz (2)
- Herzfrequenzvariabilität (2)
- Herzmuskel (2)
- Herzmuskelkrankheit (2)
- Herzschrittmacher (2)
- Hfq (2)
- High throughput screening (2)
- Hippo pathway (2)
- Hirnhautentzündung (2)
- Host-pathogen interaction (2)
- Hydrogel (2)
- Hypertrophie (2)
- Hypothalamus (2)
- Hypoxia (2)
- Hypoxie (2)
- Immunisierung (2)
- Immunological synapse (2)
- Immunotherapy (2)
- Impfung (2)
- Induced pluripotent stem cells (2)
- Infektionsmodell (2)
- Inhibitorische Synapse (2)
- Inhibitory synapse (2)
- Innate immunity (2)
- Innere Uhr (2)
- Insekten (2)
- Interaktion (2)
- Interferon (2)
- Interferon <gamma-> (2)
- Interleukin 2 (2)
- Intrazellulärraum (2)
- Invasion (2)
- Ischemic stroke (2)
- Japankärpfling (2)
- K-Ras (2)
- Kardiologie (2)
- Kardiomyozyt (2)
- Keratinozyt (2)
- Kernspintomographie (2)
- Klimaänderung (2)
- Knochen-Morphogenese-Proteine (2)
- Knochenmark (2)
- Knochenmarktransplantation (2)
- Knockout (2)
- Knockout-Maus (2)
- Komplement C5a (2)
- Konfokale Mikroskopie (2)
- Kontextkonditionierung (2)
- Kostimulation (2)
- Kraniosynostose (2)
- Krankheit (2)
- Krebsforschung (2)
- Krebsimmuntherapie (2)
- LC-MS (2)
- Lactatdehydrogenase (2)
- Larve (2)
- Learning (2)
- Leishmania (2)
- Leishmania major (2)
- Leishmaniose (2)
- Lidschlag (2)
- Lipide (2)
- Lung (2)
- Lysosom (2)
- Macrophages (2)
- Magnetische Resonanz (2)
- Malaria tropica (2)
- Manisch-depressive Krankheit (2)
- Marine sponges (2)
- Mechanosensation (2)
- Medizinphysik (2)
- Megakaryopoese (2)
- Melt Electrowriting (2)
- Meningitis (2)
- Mensch (2)
- Merkel cell carcinoma (2)
- Mesenchymzelle (2)
- Metabolomik (2)
- Metastase (2)
- Methylierung (2)
- Mikrotubuli (2)
- Monarchfalter (2)
- Motoneuron-Krankheit (2)
- Motorisches Lernen (2)
- Multidrug-Resistenz (2)
- Multiple Myeloma (2)
- Mutation (2)
- Myatrophische Lateralsklerose (2)
- N-MYC (2)
- N-Myc (2)
- NFAT (2)
- NNMT (2)
- Na+/K+-ATPase (2)
- NaV1.9 (2)
- Nahrungserwerb (2)
- Nanoparticles (2)
- Natriumkanal (2)
- Navigation (2)
- Neisseria gonorrhoeae (2)
- Nervendegeneration (2)
- Nervensystem (2)
- Nestbau (2)
- Neuralgie (2)
- Neurofascin (2)
- Neuromodulation (2)
- Neuropathie (2)
- Neuroscience (2)
- Neutrophils (2)
- Nicht-kleinzelliges Bronchialkarzinom (NSCLC) (2)
- Nociceptor (2)
- Nozizeptor (2)
- Nuklearmedizin (2)
- Nukleotid-Exzisions-Reparatur (2)
- Olfaction (2)
- Oligomerisation (2)
- Oncostatin M (2)
- Onkogen (2)
- Optogenetik (2)
- Organische Synthese (2)
- Organoid (2)
- Osteogenesis (2)
- Oxidative stress (2)
- P300 (2)
- PVM (2)
- Parathormon (2)
- Peptide (2)
- Peptidsynthese (2)
- Peyer's patch (2)
- Pflanzen (2)
- Pflanzenschutzmittel (2)
- Phosphatasen (2)
- Phospholipase D (2)
- Phylogenie (2)
- Phänologie (2)
- Plant Protection (2)
- Plant cuticle (2)
- Plasmamembran (2)
- Polyneuropathie (2)
- Positronen-Emissions-Tomographie (2)
- Post-transcriptional regulation (2)
- Probiotic (2)
- Progenitor (2)
- Prognose (2)
- Proliferation (2)
- Protein (2)
- Protein-Protein-Wechselwirkung (2)
- Proteine (2)
- Proteinsynthese (2)
- Proteintyrosinphosphatase (2)
- Proteolyse (2)
- Proteom (2)
- Psychologie (2)
- RNA (2)
- RNA helicase (2)
- RNA modifications (2)
- RNA polymerase II (2)
- RNS-Interferenz (2)
- RNS-Viren (2)
- ROS (2)
- RS1 (2)
- Radionuklid (2)
- Ranvier-Schnürring (2)
- Regenerative Medizin (2)
- Resilienz (2)
- Rheumatoid arthritis (2)
- RhoA (2)
- Ribosome (2)
- Risikofaktoren (2)
- Röntgenkristallographie (2)
- SARS-CoV-2 (2)
- SGLT1 (2)
- SOCE (2)
- SPECT (2)
- Salmonella Typhimurium (2)
- Salmonella typhimurium (2)
- Schlaf (2)
- Schwertkärpfling (2)
- Schädel-Hirn-Trauma (2)
- Screening (2)
- Sekundärkrankheit (2)
- Sekundärmetabolit (2)
- Sequenzanalyse (2)
- Serotonerge Nervenzelle (2)
- Signalkette (2)
- Sinneszelle (2)
- Sozialangst (2)
- Soziale Wahrnehmung (2)
- Sphingomyelin (2)
- Spinal Muscular Atrophy (2)
- Spred-Proteine (2)
- Staphylococcus (2)
- Stickstoff (2)
- Streptococcus pneumoniae (2)
- Symbiose (2)
- Synthese (2)
- T cells (2)
- T-Lymphozyten-Rezeptor (2)
- TFIIIC (2)
- TLR3 (2)
- TNF (2)
- TWEAK (2)
- Therapieresistenz (2)
- Thrombo-inflammation (2)
- Thrombopoiesis (2)
- Tissue engineering (2)
- Toleranz (2)
- Toll-like-Rezeptoren (2)
- Transcriptome (2)
- Transforming Growth Factor beta (2)
- Transgener Organismus (2)
- Transkriptom (2)
- Tuberkelbakterium (2)
- Tumor-Nekrose-Faktor (2)
- Turbo Spin Echo (2)
- Ubiquitin-Protein-Ligase (2)
- VSG (2)
- Vaccine (2)
- Wahrnehmung (2)
- Wilms tumor (2)
- Wirkstoffdesign (2)
- X-ray crystallography (2)
- Xiphophorus (2)
- Zebrabärbling (2)
- Zebrafish (2)
- Zellteilung (2)
- Zellwand (2)
- Zement (2)
- Zink-Finger-Proteine (2)
- adipocytes (2)
- adult neurogenesis (2)
- amygdala (2)
- antennal lobe (2)
- anxiety (2)
- anxiety disorders (2)
- autophagy (2)
- bee (2)
- behavior (2)
- behaviour (2)
- biased agonism (2)
- bioinformatics (2)
- biology (2)
- biomedical applications (2)
- biomedicine (2)
- bioreactor (2)
- blood brain barrier (2)
- bone marrow (2)
- calcium (2)
- cardiac hypertrophy (2)
- cell (2)
- ceramide (2)
- chlamydia (2)
- cytokines (2)
- cytokinesis (2)
- deep brain stimulation (2)
- dendritic cell (2)
- dendritische Zelle (2)
- depression (2)
- development (2)
- developmental differentiation (2)
- diet (2)
- dosimetry (2)
- drug development (2)
- ecology (2)
- electron microscopy (2)
- electrophysiology (2)
- emotion (2)
- emotion processing (2)
- emotion regulation (2)
- endosomal trafficking (2)
- endothelial cells (2)
- epigenetics (2)
- evolution (2)
- experimental autoimmune encephalomyelitis (2)
- expression (2)
- extracellular matrix (2)
- fMRI time series (2)
- fear extinction (2)
- fear generalization (2)
- foxtapeworm (2)
- funktionelle Kernspintomographie (2)
- gamma-H2AX (2)
- genetics (2)
- genomics (2)
- gephyrin (2)
- glucose (2)
- hippocampus (2)
- host-pathogen interaction (2)
- immunologische Synapse (2)
- in vitro (2)
- infection (2)
- inflammatory pain (2)
- intestinal in vitro model (2)
- kinase (2)
- lipid rafts (2)
- lung cancer (2)
- malaria (2)
- mass spectrometry (2)
- medical physics (2)
- melanoma (2)
- mesenchymal stem cells (2)
- metabolism (2)
- metagenomics (2)
- mitosis (2)
- mitotic gene expression (2)
- motoneuron (2)
- mouse model (2)
- multi-unit recording (2)
- multiple myeloma (2)
- neuroethology (2)
- neuropathy (2)
- nuclear medicine (2)
- oligomerization (2)
- p53 (2)
- pancreas (2)
- peptide (2)
- perception (2)
- phosphatase (2)
- receptor (2)
- regulatory T cells (2)
- regulatory t cells (2)
- resistance (2)
- serotonergic system (2)
- shRNA (2)
- signal transduction (2)
- single particle tracking (2)
- skin equivalent (2)
- small RNA (2)
- snRNP (2)
- social anxiety (2)
- social attention (2)
- social insects (2)
- sphingolipids (2)
- spontaneous blinks (2)
- stress (2)
- stroke (2)
- symbiosis (2)
- synaptic plasticity (2)
- t cells (2)
- tDCS (2)
- targeted therapy (2)
- thrombopoiesis (2)
- tissue engineering (2)
- transcription (2)
- transkranielle Gleichstromstimulation (2)
- vascularization (2)
- virtuelle Realität (2)
- wild bees (2)
- working memory (2)
- wound healing (2)
- Ökologie (2)
- Übergewicht (2)
- "Lipid Rafts" (1)
- (hem)ITAM signaling (1)
- 13C-isotopologue profiling (1)
- 177Lu-OPS201 (1)
- 18S rRNA (1)
- 2-point Dixon (1)
- 3 D bioprinting (1)
- 3-D liver model (1)
- 3D Gewebemodelle (1)
- 3D Modell (1)
- 3D Printing (1)
- 3D Tumormodell (1)
- 3D model (1)
- 3D models (1)
- 3D muscle (1)
- 3D spheroid culture (1)
- 3D-Elektrode (1)
- 3D-Gewebemodell (1)
- 3D-Kultur (1)
- 3D-Modell (1)
- 4-HNE (1)
- 5-FU (1)
- 5`-UTR (1)
- 68Ga-OPS202 (1)
- 7 T (1)
- 7SK (1)
- 7T (1)
- A-RAF (1)
- A2B adenosine receptor (1)
- A2BAR (1)
- AAC (1)
- ABC-Transporter (1)
- ACC (1)
- ACL (1)
- ADGRL3 (1)
- ADORA2A (1)
- ADP (1)
- AI (1)
- AMPK (1)
- AMP‐activated protein kinase (1)
- ARF6 GTPase (1)
- ASM-Inhibition (1)
- ATF5 (1)
- ATGL (1)
- ATR-FTIR (1)
- ATRA (1)
- Absorbed Doses (1)
- Accelerated imaging (1)
- Acetylcholinrezeptor (1)
- Acetylierung (1)
- Acid adaptation (1)
- Actin Dynamics (1)
- Actin binding proteins (1)
- Actin cytoskeleton-related protein (1)
- Actinomyces (1)
- Acute myeloid leukemia (AML) (1)
- Acyrthosiphon pisum (1)
- Adapterprotein (1)
- Adenomatous-polyposis-coli-Protein (1)
- Adenosine receptors (1)
- Adhesion and Invasion (1)
- Adhesion and degranulation promoting adapter protein (1)
- Adhesion-GPCR (1)
- Adhesive Hydrogels (1)
- Adhärenz (1)
- Adhäsion (1)
- Adipose (1)
- Adipose Tissue Engineering (1)
- Adipose-Derived Stromal/Stem Cells (1)
- Adipositas (1)
- Administered Activities (1)
- Adrenergic receptor (1)
- Adrenocortical Carcinoma (1)
- Adrenokortikales Karzinom (1)
- Adulte Neurogenese (1)
- Adultschlupfes (1)
- Advanced Therapy Medicinal Products (ATMP) (1)
- Affinity probe (1)
- Agaphelin (1)
- Agarose (1)
- Aggregation (1)
- Agoraphobie (1)
- Agrobacterium vitis (1)
- Aiolos (1)
- Airway epithelia (1)
- Aktive Implantate (1)
- Aktivierung <Physiologie> (1)
- Aktivierungsenergie (1)
- Aktivitätstest (1)
- Akute lymphatische Leukämie (1)
- Akute myeloische Leukämie (1)
- Akzeptanz (1)
- Akzeptanz- und Commitment Therapie (1)
- Algorithmus (1)
- Aliphatics (1)
- Alkaloid (1)
- Allergie (1)
- Allergy (1)
- Allgemeine Zelle (1)
- Alloantigen (1)
- Alloantigen Expression (1)
- Allogene Zelle (1)
- Allogenic hematopoietic stem cell transplantation (1)
- Allosterie (1)
- Alpaca (1)
- Alpha Neurofeedback (1)
- Alpha-Aktivität (1)
- Alternative polyadenylation (1)
- Alternative zum Tierversuch (1)
- Alveolar Echinococcosis (1)
- Alveoläre Echinokokkose (1)
- Alzheimer's Dementia (1)
- Alzheimer's disease (1)
- Alzheimer`s disease (1)
- AmGr1, AmGr2, AmGr3 (1)
- Ambrosia beetles (1)
- Ambrosiakäfer (1)
- Ameise (1)
- Ameisen (1)
- Ameisenstaat (1)
- Aminobisphosphonat (1)
- Aminobisphosphonate (1)
- Aminobuttersäure <gamma-> (1)
- Ammoniumpermease (1)
- Amphibien (1)
- Amyotrophe Lateralsklerose (1)
- Amyotrophic lateral sclerosis (1)
- Analyse (1)
- Anaphylatoxine (1)
- Anaphylatoxinrezeptoren (1)
- Anastomoseninsuffizienz (1)
- Ancistrocladaceae (1)
- Ancistrocladus (1)
- Androstadienon (1)
- Aneuploidy (1)
- Angewandte Toxikologie (1)
- Angiogenesis (1)
- Angiotensin II (1)
- Angst als Eigenschaft (1)
- Angst als Zustand (1)
- Angsterkrankung (1)
- Angstreaktionen (1)
- Angstsensitivität (1)
- Angstverhalten (1)
- Animal behavior IntelliCage system (1)
- Animales Nervensystem (1)
- Anisotropic structures (1)
- Annotation (1)
- Anoikis (1)
- Anpassung (1)
- Ant (1)
- Anthocyane (1)
- Anthropocene (1)
- Anti-CD52-Antikörper (1)
- Anti-infective (1)
- Antibiotic (1)
- Antibodies (1)
- Antifungal (1)
- Antigen CD3 (1)
- Antigen CD4 (1)
- Antigen CD44 (1)
- Antigen presentation (1)
- Antigen recognition (1)
- Antigenpräsentation (1)
- Antigenrezeptor (1)
- Antikörper-Antwort (1)
- Antimicrobial activities (1)
- Antimicrobial activity (1)
- Antimicrobial proteins (1)
- Antimikrobielle Aktivitäten (1)
- Antimikrobieller Wirkstoff (1)
- Antimykotika (1)
- Antimykotikum (1)
- Antioxidantien (1)
- Antivirale Substanzen (1)
- Antworthemmung (1)
- Antwortverhalten (1)
- Anxiety Disorders (1)
- Anxiety disorder (1)
- Anxiety disorders (1)
- Aortenaneurysma (1)
- Apallisches Syndrom (1)
- Aplysina aerophoba (1)
- Apolipoprotein E (1)
- Approved immunomodulators (1)
- Archaea (1)
- Archaebakterien (1)
- Arginine (1)
- Arid biomes (1)
- ArsZ (1)
- Artefakt (1)
- Artenreichtum (1)
- Arterielles Blut (1)
- Artery Models (1)
- Artesunate (1)
- Arthrose (1)
- Arthrosis deformans (1)
- Arzneimittel (1)
- Arzneimittelzulassung (1)
- Aspartatprotease (1)
- Aspergillose (1)
- Aspergillosis (1)
- Associative learning (1)
- Assoziatives Gedächtnis (1)
- AstA (1)
- Atemwege (1)
- Atemwegsschleimhaut (1)
- Atherogenese (1)
- Atmungsinsuffizienz (1)
- Atomic-force-microscopy (1)
- Atriales natriuretisches Hormon (1)
- Atta vollenweideri (1)
- Attention (1)
- Attention deficit / hyperactivity disorder (1)
- Attentional Avoidance (1)
- Attentional Bias (1)
- Attentional bias (1)
- Attraction (1)
- Attraktion (1)
- AuNPs (1)
- Auditorische Neuropathie (1)
- Auditorischer Kortex (1)
- Aufmerksamkeitsprozesse (1)
- Aurora B (1)
- Aurora-A-MYCN-Komplex (1)
- Ausbreitungsverhalten (1)
- Aussterbedynamik (1)
- Autoantigen (1)
- Autofocus (1)
- Autoimmunity (1)
- Autoinhibition (1)
- Automatische Klassifikation (1)
- Autophagie (1)
- Autophagie <Physiologie> (1)
- Autophagosom (1)
- Autophagozytose (1)
- Autoproteolysis (1)
- Autotransporter (1)
- Autotransporterprotein (1)
- Awareness (1)
- Axon Branching (1)
- B Lymphocytes (1)
- B-Lymphozyten (1)
- B0 (1)
- B0 correction (1)
- B0-Korrektur (1)
- B7-H1 (1)
- BCG (1)
- BCL-2 Familie (1)
- BCL-2 family (1)
- BCMA (1)
- BDNF (1)
- BDNF stimulation (1)
- BH3-only proteins (1)
- BIN2 (1)
- BMP (1)
- BMP signaling pathway (1)
- BMP-2 (1)
- BMP-Signaltransduktionsweg (1)
- BMP2 (1)
- BMS-5 (1)
- BRAF (1)
- BRCA1 (1)
- BTB domain (1)
- BTN3A1 and Phospho-antigen presentation (1)
- Bach (1)
- Bacteria-Host Cell Interaction (1)
- Bacterial Toxins (1)
- Bacterial community analysis (1)
- Bacterial meningitis (1)
- Bacteroides thetaiotaomicron (1)
- Baff (1)
- Baghdadite (1)
- Bahnung (1)
- Bakterielle Nanocellulose (1)
- Bakterienzellwand (1)
- Bakteriophagen (1)
- Bandwürmer (1)
- Bariatric surgery (1)
- Barth Syndrome (1)
- Barth syndrome (1)
- Basal Ganglia (1)
- Basalganglien (1)
- Basalmembran (1)
- Basement membrane (1)
- Batten disease (1)
- Bauchspeicheldrüse (1)
- Baumphysiologie (1)
- Bcl-2-Proteinfamilie (1)
- Bed nucleus of stria terminalis (1)
- Behavior (1)
- Behaviour (1)
- Benzimidazolderivate (1)
- Benzoate (1)
- Benzoate degradation (1)
- Beschleunigte Bildgebung (1)
- Bestimmung des Relaxations-Parameters in der Magnetresonanztomografie (1)
- Bestrahlung (1)
- Bestärkendes Lernen <Künstliche Intelligenz> (1)
- Bestäubung (1)
- Bestäubung Pollination Honigbiene Hummel (1)
- Beta-1-receptor (1)
- Beta-2-Rezeptor (1)
- Beta-Adrenergic Receptor (1)
- Beta-Adrenozeptor (1)
- Bevacizumab (1)
- Bewegungsstörung (1)
- Bienen <Familie> (1)
- Bienen Dressur Lernen (1)
- Bierhefe (1)
- Bildanalyse (1)
- Bildartefakte (1)
- Bildbearbeitung (1)
- Bilderzeugung (1)
- Bildgebung intakten Knochens (1)
- Bimolekulare Lipidschicht (1)
- Bindegewebe (1)
- BioVaSc (1)
- Biochemische Analyse (1)
- Biochemistry (1)
- Biodistribution (1)
- Biodiversity assessment (1)
- Biodiversity conservation (1)
- Biofabrikation (1)
- Biofilm formation (1)
- Biofilmarchitektur (1)
- Biofilms (1)
- Bioink (1)
- Biokinetics (1)
- Biolayerinterferometrie (1)
- Biologie / Zellbiologie (1)
- Biologischer Abbau (1)
- Biologisches Modell (1)
- Biology (1)
- Bioluminescence resonance energy transfer (1)
- Biolumineszenzmessung (1)
- Biomechanik (1)
- Bioprozessmethode (1)
- Bioreaktorplattform (1)
- Biosynthese der aromatischen Aminosäuren (1)
- Biosynthese-Genclustern (1)
- Bipolar (1)
- Bipolar Disorder (1)
- Bisphosphonate (1)
- Bitopic Ligands (1)
- Bitopische Liganden (1)
- Blick (1)
- Blickinteraktion (1)
- Blimp-1 (1)
- Blinatumomab (1)
- Blood nerve barrier (1)
- Blumeria graminis (1)
- Blut-Liquor-Schranke (1)
- Blut-Rückenmarkschranke (1)
- Blutgefäßsystem (1)
- Blutgerinnungsfaktor XII (1)
- Bluthirnschranke (1)
- Bone (1)
- Bone Marrow Dosimetry (1)
- Bone Quantification (1)
- Bone marrow stromal cell (1)
- Bone marrow stromal cell (BMSC) (1)
- Bone marrow transplantation (1)
- Bone morphogenetic protein 2 (1)
- Bone morphogenetic proteins (1)
- Bone regeneration (1)
- Bone-replacement (1)
- Bordetella (1)
- Borkenkäfer (1)
- Borneo (1)
- Borrelia (1)
- Bovine Mastitis (1)
- Brain (1)
- Brain derived neurotorphic factor (1)
- Brain endothelial cells (1)
- Brownsche Bewegung (1)
- Bruchpilot (1)
- Brustdrüsenentzündung (1)
- Burkholderia (1)
- Burkholderia pseudomallei (1)
- Burkitt Lymphom (1)
- Burkitt Lymphoma (1)
- Butyrophilin (1)
- Bäckerhefe (1)
- Bärtierchen (1)
- C. albicans (1)
- C. elegans (1)
- C/EBP (1)
- C1-inibitor (1)
- C5aR1-Antagonist (1)
- CA3 (1)
- CAMP production (1)
- CAR T Zellen (1)
- CAR T-Zelltherapie (1)
- CAR T-cells (1)
- CAR-T cell (1)
- CAR-T-Zell-Therapie (1)
- CCR4 (1)
- CD150 (1)
- CD28 Molekül (1)
- CD28 Superagonisten (1)
- CD28 antigen (1)
- CD28-SA (1)
- CD28-Superagonist (1)
- CD28-superagonist (1)
- CD4 T-Zellen (1)
- CD4 positiv T cells (1)
- CD4+ (1)
- CD4+ T cell activation (1)
- CD40 gerichteter bifunktioneller scFv-TRAIL Fusionsproteine (1)
- CD40-targeted bifunctional scFv-TRAIL fusion proteins (1)
- CD44 (1)
- CD8 Effektorfunktionen (1)
- CD8 Gedächtnisreaktionen (1)
- CD8 T cell (1)
- CD8 T-Zelle (1)
- CD8 T-Zellen (1)
- CD8+ T cells (1)
- CD8+ T-Zellen (1)
- CD95 (1)
- CD95L (1)
- CDC42 (1)
- CDK4 Inhibitor (1)
- CDK4 inhibitor (1)
- CDR1-Effluxpumpe (1)
- CIP2A (1)
- CLEC-2 (1)
- CLEC16A (1)
- CMT1A (1)
- CMV (1)
- CNBP (1)
- COMT polymorphism (1)
- CRHR1 (1)
- CRISPR Cas9 (1)
- CRISPR Cas9 system (1)
- CTLA-4 (1)
- CVT (1)
- CX-5461 (1)
- CXCL13 (1)
- CXCR5 (1)
- CYP24A1 (1)
- CYP7A1 (1)
- CaCo-2 cell (1)
- Cadherin 13 (1)
- Cadherin-13 (1)
- Caenorhabditis elegans (1)
- Calcium Phosphate (1)
- Calcium phosphate-based biomaterials (1)
- Calcium signalling (1)
- Calcium-bindende Proteine (1)
- Calciumhomöostase (1)
- Calciumphosphat (1)
- Camponotus (1)
- Camponotus rufipes (1)
- Cancer Immune Therapy (1)
- Cancer Metabolism (1)
- Cancer biology (1)
- Carabid beetles (1)
- Carcinogenese (1)
- Cardiac (1)
- Cardiac Efficiency (1)
- Cardiac MRI (1)
- Cardiac hypertrophy (1)
- Cardiac imaging (1)
- Cardiolipin (1)
- Cardiomyocytes (1)
- Cardiomyopathy (1)
- Carotis Intima Media Dicke (1)
- Cartiage Integration (1)
- Cartilage (1)
- Cartilage Regeneration (1)
- Cartilage defect (1)
- Cas9 (1)
- Caspr-1 (1)
- Catechol-0-Methyltransferase (1)
- Catechol-O-Methyltransferase (1)
- Catecholmethyltransferase <Catechol-0-Methyltransferase> (1)
- Cation Homeostasis (1)
- Caveolin-1 (1)
- Ccr4-Not (1)
- Cdh13 (1)
- Celecoxib (1)
- Cell (1)
- Cell Cycle (1)
- Cell Sheet Engineering (1)
- Cell adhesion (1)
- Cell culture (1)
- Cell differentiation (1)
- Cell line (1)
- Cell-Assisted Lipotransfer (1)
- Cells (1)
- Cellular invasion (1)
- Ceramides (1)
- Cerebrospinal fluid (CSF) (1)
- ChIP-Seq (1)
- ChIP-sequencing (1)
- Chaetomium thermophilum (1)
- Chain-length distribution (1)
- Characterization (1)
- Charcot-Marie-Tooth 1A (1)
- Chemische Synapsen (1)
- Chemokin CXCL10 (1)
- Chemokin CXCL12 (1)
- Chemokine (1)
- Chemokine receptors (1)
- Chemoresistenz (1)
- Chemotaxis (1)
- Chemotherapeutic resistance (1)
- Children (1)
- Chimeric Antigen Receptor (1)
- Chimeric antigen receptor (1)
- Chimeric antigen receptor (CAR) (1)
- Chimpanzee (1)
- Chimärer Antigenrezeptor (1)
- Chirurgie (1)
- Chlamydia (1)
- Chlamydienkrankheit (1)
- Cholesterintransporter (1)
- Chondrogenic Differentiation (1)
- Chordontonal organ (1)
- Chromatinremodeling (1)
- Chromatinremodelling (1)
- Chromosom 6 (1)
- Chromosome 6 (1)
- Chronic Mild Stres (1)
- Chronisch-myeloische Leukämie (1)
- Chronische Nierenerkrankung (1)
- Chronischer Schmerz (1)
- Chylomicron (1)
- Chylomicrons (1)
- Circadian (1)
- Circadian Clock (1)
- Circadian clock (1)
- Circadiane Uhr (1)
- Circadianer Rhythmus (1)
- Citalopram (1)
- Claudin (1)
- Click-Chemie (1)
- Climate change (1)
- Clonal competition assay (1)
- Clostridium difficile (1)
- Cluster (1)
- Co-Analgetika (1)
- Co-Kultur (1)
- Co-culture (1)
- Co-culture system (1)
- CoQ10 (1)
- Coactosin-like (1)
- Coffin-Lowry syndrome (1)
- Cofilin (1)
- Cognition (1)
- Cognitive Distortions (1)
- Collagen gels (1)
- Colliculus inferior (1)
- Collybistin (1)
- Colon cancer (1)
- Commensalism (1)
- Comorbidity (1)
- Comoé National Park (1)
- Complement system (1)
- Complex Regional Pain Syndrome (1)
- Complexes (1)
- Complexome (1)
- Compound eyes (1)
- Compressed sensing (1)
- Computational Fluid Dynamics (1)
- Computational drug design (1)
- Computersimulation (1)
- Computerunterstütztes Verfahren (1)
- Conditioning (1)
- Contact-Kinin System (1)
- Contrast Agent Bolus Based Perfusion Magnetic Resonance Imaging (1)
- Convolutional Neural Network (1)
- Coronary heart disease (1)
- Correlative microscopy (1)
- Cortico-striatal projection neurons (1)
- Corticoliberin (1)
- Counting (1)
- Coxiella burnetii (1)
- Craniosynostosis (1)
- Craving (1)
- CsrA (1)
- Cul4b (1)
- Cuticular transpiration (1)
- Cuticular water permeabilities (1)
- Cyanobacteria (1)
- Cyanobakterien (1)
- Cyclic peptides (1)
- Cyclics (1)
- Cystein (1)
- Cysteinproteasen (1)
- Cytologie (1)
- Cytomegalie-Virus (1)
- Cytoplasma (1)
- Cytotoxic T cell (1)
- D-4F (1)
- DC (1)
- DC/T-Zell-Konjugate (1)
- DEQCT (1)
- DExD/H box protein (1)
- DG diacyglycerol (1)
- DGCR8 (1)
- DHX30 (1)
- DNA Barcoding (1)
- DNA Damage (1)
- DNA Doppelstrangbrüche (1)
- DNA Schaden (1)
- DNA Sekundärstruktur (1)
- DNA double strand breaks (1)
- DNA lesion (1)
- DNA methylation (1)
- DNA secondary structure (1)
- DNA-Methylierung (1)
- DNA-Schaden (1)
- DNA-Schäden (1)
- DNS-Bindungsproteine (1)
- DNS-Schaden (1)
- DNS-Sequenz (1)
- DOT1 (1)
- DREAM (1)
- DREAM complex (1)
- DSIF (1)
- DTI (1)
- DUB Mutante (1)
- DYT-TOR1A (1)
- Danaus plexippus (1)
- Danio rerio (1)
- Darmepithel (1)
- Darmflora (1)
- Dasatinib (1)
- Datenbank (1)
- Decapping (1)
- Deep-sequencing (1)
- Deeplearning (1)
- Defensine (1)
- Defäkographie (1)
- Deletion (1)
- Denaturierende Gradienten-Gelelektrophorese (1)
- Denaturing Gradient Gel Electrophoresis (1)
- Density Weighting (1)
- Deoxyribozymes (1)
- Dephosphorylierung (1)
- Depletion (1)
- Dereplicaiton (1)
- Desmoglein 2 (1)
- Desmoglein 3 (1)
- Desmogleine (1)
- Desmosom (1)
- Deubiquitination (1)
- Development (1)
- Dexamethason (1)
- Diabetes (1)
- Diabetes Typ 1 (1)
- Diabetes mellitus Typ 1 (1)
- Diabetic painful neuropathy (1)
- Diabetic polyneuropathy (1)
- Diagnostic Imaging Exams (1)
- Dickdarmkrebs (1)
- Differential scanning calorimetry (1)
- Differentielle Genexpression (1)
- Differentielle Ressourcenallokation (1)
- Differenzierung (1)
- Differenzierungszustand (1)
- Diffusion (1)
- Diffusion Tensor Imaging (1)
- Diffusion coefficient (1)
- Dihydrooxazole (1)
- Dilated cardiomyopathy (1)
- Dimension 3 (1)
- Dimere (1)
- Dimeric Naphthylisoquinoline Alkaloids (1)
- Diphenylether (1)
- Dispersal (1)
- Disulfidbrücken (1)
- Diversifikation <Biologie> (1)
- Diversity (1)
- Dolutegravir (1)
- Domäne <Biochemie> (1)
- Domänenprotein (1)
- Dopamin-Transporter (1)
- Dopamine transporter (1)
- Dopaminstoffwechsel (1)
- Dopamintransporter (1)
- Dorsal Root Ganglion (1)
- Dorsal root ganglion (1)
- Dosimetry (1)
- Double Negative B cells (1)
- Droseraceae (1)
- Drosophila Larva (1)
- Drosophila Larve (1)
- Drosophila Myc transcription growth PAF1 (1)
- Drug delivery system (DDS) (1)
- Drug resistance (1)
- Drug targets (1)
- Drug testing (1)
- Dual RNA-seq (1)
- Dual RNA-seq data analysis (1)
- Dual-setting (1)
- Dualstere Liganden (1)
- Dualsteric Ligands (1)
- Duodenal Jejunal Bypass (1)
- Duplikation (1)
- Durchflusscytometrie (1)
- Dynabeads (1)
- Dynamic MR imaging (1)
- Dynamics of ribosome assembly (1)
- Dynamik (1)
- Dynamik von Membranrezeptoren (1)
- Dynamische MR-Bildgebung (1)
- Dynein Light Chain (1)
- Dystonie (1)
- Dürrestress (1)
- E.coli Nissle 1917 (1)
- E1 inhibitoren (1)
- E1 inhibitors (1)
- E2 (1)
- EAE (1)
- ECAP (1)
- ECG-gated PET (1)
- ELISA (1)
- EMT (1)
- ER dynamics in axon terminals (1)
- ERK (1)
- Eap (1)
- Early-Life Stress (1)
- Echo Planar Imaging (1)
- Echo planar imaging (1)
- Echocardiography (1)
- Echoplanar-Bildgebung (1)
- Echtzeit (1)
- Echtzeitbildgebung (1)
- Ecological Momentary Assessment (1)
- Ecological Momentary Assessments (1)
- Ecosystem services (1)
- Effect anticipation (1)
- Effektantizipation (1)
- Efflux pump (1)
- Effluxpumpen (1)
- Eierstockkrebs (1)
- Eierstocktumor (1)
- Einfühlung (1)
- Einfühlung <Motiv> (1)
- Eingeweidewürmer (1)
- Einsamkeit (1)
- Einzel-Molekül (1)
- Einzelpartikelverfolgung (1)
- Einzelzellgelelektrophorese (1)
- Electrochemical Impedance Spectroscopy (1)
- Electrode (1)
- Electroencephalography (1)
- Electromyography (1)
- Electrophysiology (1)
- Elektroakupunktur (1)
- Elektrode (1)
- Elektromyographie (1)
- Elektronencephalographie (1)
- Elektrospinnen (1)
- Elektrostimulation (1)
- Elektrotherapie (1)
- Elevated Plus-Maze (1)
- Elongation (Transkription) (1)
- Embryo (1)
- Embryonale Stammzelle (1)
- Emotionale Informationsverarbeitung (1)
- Emotionales Verhalten (1)
- Empfindlichkeit (1)
- Endobrachyösophagus (1)
- Endocytosis (1)
- Endogenous clock (1)
- Endokrinologie (1)
- Endophenotype (1)
- Endophänotyp (1)
- Endophänotypen (1)
- Endoplasmatisches Retikulum (1)
- Endorganschaden (1)
- Endosomes (1)
- Endothelium (1)
- Endothelzelle (1)
- Enoyl-Reduktase (1)
- Enoyl-acyl-carrier-protein-Reductase (1)
- Enoyl-acyl-carrier-protein-Reductase <Enoyl-[acyl-carrier-protein]-Reductase> (1)
- Enterische Glia (1)
- Enterisches Nervensystem (1)
- Enterohemorrhagic Escherichia coli (1)
- Entscheidungsverhalten (1)
- Entwicklung chimärer Antigenrezeptor T-Zellen (1)
- Entzündungschmerz (1)
- Entzündungsreaktion (1)
- Entzündungsschmerz (1)
- Enzymaktivierung (1)
- Enzyminhibitor (1)
- Eosinophiler Granulozyt (1)
- EphA2 (1)
- Ephrin ligand (1)
- Ephrine (1)
- Epidemiologie (1)
- Epigenetische Mechanismen (1)
- Epithel (1)
- Epithelial layer (1)
- Epithelial lineage (1)
- Epithelial-mesenchymale Transition (1)
- Epithelzelle (1)
- Erk1/2 (1)
- Erkennung (1)
- Erregbarkeit (1)
- Esophageal adenocarcinoma (1)
- Esophageal disease (1)
- Essgewohnheit (1)
- Essstörung (1)
- Essverhalten (1)
- Estrogens (1)
- Excitatory/inhibitory imbalance (1)
- Excitotoxicity (1)
- Exon Array (1)
- Expansion microscopy (1)
- Expansionsmikroskopie (1)
- Experimental Autoimmune Encephalomyelitis (EAE) (1)
- Experimentelle Autoimmune Enzephalomyelitis (1)
- Experimentelle Autoimmune Enzephalomyelitis (EAE) (1)
- Experimentelle autoimmune Enzephalomyelitis (1)
- Experimentellen Autoimmun-Enzephalomyelitis (1)
- Experimenteller Schlaganfall (1)
- Explainable AI (1)
- Explainable Artificial Intelligence (1)
- Explorationsverhalten (1)
- Exposition (1)
- Expositionslernen (1)
- Exposure treatment (1)
- Expression (1)
- Extracellular Matrix (1)
- Extracellular Vesicles (1)
- Extracellular matrix proteins (1)
- Extrazellulärmatrix (1)
- Exzitatorische Synapse (1)
- Eye irritation (1)
- FAS (1)
- FAS-II (1)
- FAT10ylation (1)
- FBXO6 (1)
- FCS (1)
- FGF (1)
- FGF Signaling (1)
- FLT3 inhibitor (1)
- FMMs (1)
- FMS-like tyrosine kinase 3 (FLT3) (1)
- FOXM1 (1)
- FOXP2 (1)
- FP635 (1)
- FRAP (1)
- FRET sensors (1)
- FT-IR-Spektroskopie (1)
- FabI (1)
- FabV (1)
- Fabry disease (1)
- Factor XII (1)
- Faktor XII (1)
- Fanconi Anemia (1)
- Fanconi-Anämie (1)
- Farnesyl Pyrophosphate Synthase (1)
- Farnesylpyrophosphatsynthase (FPPS) (1)
- Fas-Ligand (1)
- Fat Quantification (1)
- FcgR (1)
- FeS cluster (1)
- Fear (1)
- Fear Conditioning (1)
- Fear Extinction (1)
- Fear Generalization (1)
- Fear Learning (1)
- Fear conditioning (1)
- Fear generalization (1)
- Feedforward loop (1)
- FemX (1)
- Ferroptosis (1)
- Fertilization in angiosperm (1)
- Fettgewebe (1)
- Fettleber (1)
- Fettsäure-Synthase (1)
- Fibroblast (1)
- Fibroblasts (1)
- Fibromyalgia (1)
- Fibromyalgia syndrome (1)
- Fibromyalgiesyndrom (1)
- Fibrose (1)
- Filter (1)
- Flagelle (1)
- Flavonoide (1)
- Flavonoids (1)
- Flippase (1)
- Flotillin (1)
- Flow (1)
- Flugzeitmassenspektrometrie (1)
- FluidFM (1)
- Fluorescence Correlation Spectroscopy (1)
- Fluorescence Resonance Energy Transfer (1)
- Fluorescence correlation spectroscopy (1)
- Fluorescence microscopy (1)
- Fluorescence-resonance-energy-transfer (1)
- Fluorescent probes (1)
- Fluoreszenz (1)
- Fluoreszenzproteine (1)
- Fluoreszenzsonde (1)
- Fluoreszenzspektroskopie (1)
- Fluoxetine (1)
- Fluss (1)
- Foamyviren (1)
- Folliculin (1)
- Forkhead Transcription Factors (1)
- Forkhead-Box-Proteine (1)
- Fox tapeworm (1)
- FoxO transcription factors (1)
- Foxo1 (1)
- Foxp3+CD4+ regulatorische T-Zelle (1)
- Foxp3+CD4+ regulatory T cell (1)
- Fragebogen (1)
- Fragmentscreening (1)
- Französische Feldwespe (1)
- Freezing (1)
- Freies Molekül (1)
- Fremdkörpermodell (1)
- Frizzled 5 (1)
- Frontal asymmetry (1)
- Froschlurche (1)
- Fructosebisphosphat-Aldolase (1)
- Fruit (1)
- Frühe Gene (1)
- Function (1)
- Functional analyses (1)
- Functioning Assessment Short Test (1)
- Funktionelle Annotation (1)
- Funktionelle Bildgebung (1)
- Funktionelle Kernspintomographie (1)
- Funktionsausfälle (1)
- Furagieraktivität (1)
- Furchkonditionierung (1)
- Furchtentwicklung (1)
- Furchtextinktion (1)
- Fusarium (1)
- Fusobacterium nucleatum (1)
- Förster Resonance Energy Transfer (1)
- G Protein-Coupled Receptor (1)
- G Protein-Coupled Receptors (1)
- G Protein-coupled receptor (1)
- G glycoprotein (1)
- G protein coupled receptor (1)
- G protein-coupled receptor kinase (1)
- G protein-coupled receptor kinase 2 (GRK2) (1)
- G protein-coupled receptors (1)
- G protein-gekoppelte Rezeptor Kinase 2 (GRK2) (1)
- G-Protein (1)
- G-Protein gekoppelte Rezeptor (1)
- G-Protein-gekoppelte Rezeptoren (1)
- G-protein (1)
- G-quadruplex (1)
- G2/M genes (1)
- GABA (1)
- GABA A Receptors (1)
- GABA A Rezeptoren (1)
- GABA receptor (1)
- GABA(A) receptor (1)
- GABAA-Rezeptor (1)
- GABAerge Nervenzelle (1)
- GAD1 (1)
- GAD65 (1)
- GAS2L3 (1)
- GC1 cells (1)
- GDF-15 (1)
- GLA KO mouse model (1)
- GLP-1 (1)
- GMP (1)
- GPCR dimerisation (1)
- GPCR nanodomains (1)
- GPCR signaling (1)
- GRM8 (1)
- GWAS (1)
- Ga-68-labelled Peptides (1)
- Galactosidase <alpha-> (1)
- Galectin 1 (1)
- Gambler's Fallacy (1)
- Gametocyt (1)
- Gametozyt (1)
- Ganzkörperbestrahlung (1)
- Gap Junction (1)
- Gas chromatography (1)
- Gaschromatographie (1)
- Gastroesophageal reflux (1)
- Gastrointestinal tract (1)
- Gauss Prozess Klassifikation (1)
- Gaussian Process Classification (1)
- Gaze interaction (1)
- Gb3 accumulation (1)
- Gefrierstrukturierung (1)
- Gefäßalter (1)
- Gefäßwand (1)
- Gefäßwand-residente Stamm- und Vorläuferzellen (1)
- Gehirn-Computer Schnittstelle (1)
- Geißel <Biologie> (1)
- Gelernte Hilflosigkeit (1)
- Gemcitabin (1)
- Gen BRCA 1 (1)
- Gen Umweltinteraktion (1)
- Gen notch (1)
- Gen-Umwelt Interaktion (1)
- Gene by Environment (1)
- Gene expression regulation (1)
- Gene regulation (1)
- Gene therapy (1)
- General Transcription Factor II H (1)
- General amplifier model (1)
- Generalization (1)
- Genetic etiology (1)
- Genome Annotation (1)
- Genome Instability (1)
- Genome editing (1)
- Genomeditierung (1)
- Genomic Selection (1)
- Genomik (1)
- Genotoxicity (1)
- Genotyping (1)
- Gentoxizität (1)
- Geomagnetic Field (1)
- Gerinnungsfaktor (1)
- Germination and differentiation (1)
- Germinative Zellen (1)
- Geruchswahrnehmung (1)
- Geschlechtsunterschiede (1)
- Geschmack (1)
- Gestational diabetes (1)
- Gestationsdiabetes (1)
- Gewebe (1)
- Gewebemodelle (1)
- Glatte Muskulatur (1)
- Glatter Krallenfrosch (1)
- Glioblastomtherapie (1)
- Glioma (1)
- Global change (1)
- Glottoplastik (1)
- Glucocorticoids (1)
- Glucose Starvation (1)
- Glucose metabolism (1)
- Glucosetransport (1)
- Glucosetransporter (1)
- Glukosemetabolismus (1)
- Glukosetransporter -1 (1)
- Glutamin (1)
- Glutathion (1)
- Glycerin-3-phosphat (1)
- Glycerinphosphate (1)
- Glycin (1)
- Glycine Receptors (1)
- Glycocalyx (1)
- Glycolipid (1)
- Glycophyten (1)
- Glycoprotein GPV (1)
- Glycoprotein hormone (1)
- Glykane (1)
- Glykobiologie (1)
- Glykokalyx (1)
- Glykomodifizierung (1)
- Glykosyltransferase (1)
- Glyzin Rezeptoren (1)
- Glyzinrezeptor (1)
- Glücksspiel (1)
- Gold Nanoparticles (1)
- Golgi apparatus (1)
- Gonococcal invasion (1)
- Grad-seq (1)
- Gradient System Transfer Function (1)
- Graft versus Host Disease (1)
- Graft versus Host disease (1)
- Graft versus host disease (1)
- Graft-versus-host disease (GvHD) (1)
- Graft-versus-leukemia (1)
- Gram-positive (1)
- Gram-positive bacteria (1)
- Granulozyten (1)
- Growth-differentiation Factor 15 (1)
- Guanin Nukleotid Austauschfaktor (1)
- Guanine nucleotide exchange factor (GEF) (1)
- Guaninnucleotid-Austauschfaktoren (1)
- Guanylyl cyclase A (1)
- Guillain-Barré-Syndrom (1)
- GvL (1)
- Gvhd (1)
- H2A.Z (1)
- HAD phosphatase (1)
- HASH (1)
- HBD2 (1)
- HCMV (1)
- HD5 (1)
- HDAC (1)
- HECTD1 (1)
- HERV (1)
- HFpEF (1)
- HIF1alpha (1)
- HIV Drug resistance (1)
- HIV South Africa (1)
- HIV-1 (1)
- HIV-1 Vif (1)
- HIV-associated neurocognitive disorder (HAND) (1)
- HIV-assoziierte neurokognitive Störung (HAND) (1)
- HLA-G (1)
- HMBPP (1)
- HNE (1)
- HP1432, Hpn2 (1)
- HPLC-MS (1)
- HRV (1)
- HSF1 (1)
- HST1 (1)
- HSV-1 (1)
- Haarzelle (1)
- Habituationstraining (1)
- Haemostasis (1)
- Haloacid dehalogenase (1)
- Halophyten (1)
- Halophytes (1)
- Harze (1)
- Hautkrebs (1)
- Hautmodell (1)
- Hautverbrennung (1)
- Heart (1)
- Heart Failure (1)
- Heart Period (1)
- Heart development (1)
- Heart failure (1)
- Heat shock protein 90 (1)
- Heat stress (1)
- Heilmittel (1)
- Heilung (1)
- Heißhunger (1)
- Helferzelle (1)
- Helicase (1)
- Helikasen (1)
- Helminths (1)
- Hematopoietic Cell Transplantation (1)
- Hematopoietic Stem Cell (1)
- Hematopoietic cell transplantation (1)
- Hemmung der Proliferation schnell wachsender Krebszellen (1)
- Hemodynamics (1)
- Hemofiltration (1)
- Heparin (1)
- Hereditary spastic paraplegia (1)
- Hereditäre spastsiche Paraplegie (1)
- Herpes (1)
- Herpes simplex Virus DUB C65A (1)
- Herpes simplex virus C65A (1)
- Herpesviren (1)
- Herpesviruses (1)
- Herz-Kreislauf-Erkrankung (1)
- Herzbildgebung (1)
- Herzfrequenz (1)
- Herzfunktion (1)
- Herzruptur (1)
- Heterogenität von Mikroorganismen (1)
- Hey Proteine (1)
- Hey proteins (1)
- Hi-C (1)
- Hic-5 (1)
- Hidden Markov Model (1)
- Hidden-Markov-Modell (1)
- High-thropughput screening (1)
- Himmelskompass (1)
- Hippokampus (1)
- Hirnendothelzellen (1)
- Hirnhaut (1)
- Hirnstimulation (1)
- Histatin 5 (1)
- Histon-Deacetylase (1)
- Histon-Methyltransferase (1)
- Histonacetyltransferase (1)
- Histone Acetylation (1)
- Histone modification (1)
- Histone variant (1)
- Histones (1)
- Hitzeschock Proteine (1)
- Hitzeschock-Proteine (1)
- Hitzeschockprotein 90 (1)
- Hitzeschocktranskriptionsfaktor (1)
- Hitzestress (1)
- Hochauflösende Mikroskopie (1)
- Hochauflösungsmikroskopie (1)
- Hochdurchsatz-Screening (1)
- Hochdurchsatzsequenzierung (1)
- Holobiont (1)
- Homing (1)
- Homöostase (1)
- Honeybee (1)
- Honigbiene (1)
- Honigbienen (1)
- Hormone Receptor Signaling (1)
- Hornhaut (1)
- Hornhautinfektionen (1)
- Hospitalismus <Hygiene> (1)
- Host Colonization (1)
- Host Genome Integrity (1)
- Host defense (1)
- Hot Hand Fallacy (1)
- Huh6 (1)
- Human Herpesvirus 6 (1)
- Human Transcriptome (1)
- Human-pathogenic (1)
- Humanes Herpesvirus 6 (1)
- Humanparasitologie (1)
- Huwe1 (1)
- Hyaluronic Acid (1)
- Hyaluronic acid (1)
- Hybrid-Molecules (1)
- Hydrocortison (1)
- Hydrogels (1)
- Hyperactivity (1)
- Hyperekplexie (1)
- Hypertension (1)
- Hypertrophy (1)
- Hyrogels (1)
- Hämatopoetische Stammzellen (1)
- Hämatopoetische Stammzelltransplantation (1)
- Hämodynamik (1)
- Hämophilie A (1)
- Hämsotase (1)
- Höhenangst (1)
- Hörbahn (1)
- Hörrinde (1)
- ICP22 (1)
- IE3 (1)
- IEG (1)
- IFN-g (1)
- IFNAR (1)
- IKZF1 (1)
- IKZF3 (1)
- IL-12p70 (1)
- IL-2 (1)
- IL-23 (1)
- IL-4 (1)
- IL-4 Rezeptor alpha (1)
- IL-4 receptor alpha chain (1)
- IL-6 Inhibition (1)
- IMP1/ZBP1 (1)
- IP6 (1)
- IPP (1)
- IRAK2 (1)
- ITAM (1)
- ITAM-signalling (1)
- IVIG (1)
- Ibrutinib (1)
- Ideomotor gaze control (1)
- Ideomotorik (1)
- Ideomotorische Blickkontrolle (1)
- IgG-Subklasse (1)
- Ighmbp2 (1)
- Ikaros (1)
- Ileal Trasposition (1)
- Illumina HiSeq (1)
- Image Processing (1)
- Image Quality (1)
- Immunaktivierung (1)
- Immunantwort (1)
- Immune Checkpoint Therapy (1)
- Immune System (1)
- Immune Thrombocytopenia (1)
- Immune activation (1)
- Immune cell assays (1)
- Immune cells (1)
- Immunglobulin G (1)
- Immunität <Medizin> (1)
- Immunkardiologie (1)
- Immunocardiology (1)
- Immunologe (1)
- Immunomodulation (1)
- Immunophilin (1)
- Immunosuppressant (1)
- Immunozyt (1)
- Immunsuppressiva (1)
- Immunthrombozytopenie (1)
- Immunzellassays (1)
- Immunzellrekrutierung (1)
- Impfstoff (1)
- Implantatentwicklung (1)
- Impulsivität (1)
- In vitro models (1)
- In vivo Imaging (1)
- Individual based model (IBM) (1)
- Individualisierte Medizin (1)
- Infection imaging (1)
- Infection models (1)
- Infectious diseases (1)
- Infektiologie (1)
- Infektionsbildgebung (1)
- Infektionsbiologie (1)
- Infektionsprozess (1)
- Infektionsstudien (1)
- Inferior colliculus (1)
- Inflamamtion (1)
- Inflammatory Pain (1)
- Inflammatory pain (1)
- Informationsnutzung (1)
- Infrared radiation (1)
- Inhibitory-postsynapse (1)
- Injectability (1)
- Insect (1)
- Insekt (1)
- Insektenstaaten (1)
- Instrumental Activities of Daily Living (1)
- Insulin-like Growth (1)
- Insulin-like-Growth-Factor-Binding-Protein-5 (1)
- Insulinresistenz (1)
- Integrase inhibitor (1)
- Integrated Defensive States (1)
- Integrin (1)
- Integrine (1)
- Interaction analysis (1)
- Interaction of 7SK with the Smn complex modulates snRNP production (1)
- Interaktionsrezeptor (1)
- Interferon <Gamma-> (1)
- Interferonrezeptor (1)
- Interleukin (1)
- Interleukin 12 (1)
- Interleukin 17 (1)
- Interleukin 5 (1)
- Interleukin-4 Antagonist (1)
- Interleukine (1)
- Internal Dosimetry (1)
- Internalisierende Störung (1)
- Intestinal metaplasia (1)
- Intestinal stem cell (1)
- Intracellular bacteria (1)
- Intracellular virulence (1)
- Intratumorale Heterogenität (1)
- Intravoxel Incoherent Motion (1)
- Intrazelluläre Bakterien (1)
- Intrinsische Gerinnungskaskade (1)
- Ion channel function (1)
- Ionisierende Strahlung (1)
- Irradiation (1)
- Ischemia (1)
- Ischämischer Schlaganfall (1)
- Isolation (1)
- Isolation and Characterization (1)
- Isomer (1)
- Isopentenyl pyrophosphate (IPP) (1)
- Isopentenyl-pyrophosphat (IPP) (1)
- Isoprenoid Synthesis (1)
- Isoprenoide (1)
- Isoprenoidsynthese (1)
- Ixolaris (1)
- JNCL (1)
- JNK (1)
- JURKAT-Zelle (1)
- Judgment (1)
- Jugendliche (1)
- Jun (1)
- K-RAS (1)
- K5 capsule (1)
- KDELR2 (1)
- Kaliumkanal (1)
- Kallikrein-Kinin-System (1)
- Kardiale MR-Bildgebung (1)
- Kardiovaskuläre Krankheit (1)
- Karotis-Intima-Media-Dicke (1)
- Kation (1)
- Kationen-Homöostase (1)
- Kehlkopfchirurgie (1)
- Keimzentrumsreaktion (1)
- Kern (1)
- Kidney (1)
- Kilimandscharo (1)
- Kinase (1)
- Kinase signaling (1)
- Kinasen (1)
- Kinder (1)
- Kinderpsychiatrie (1)
- Kinderschlaf (1)
- Kindesalter (1)
- Kindheit und Jugend (1)
- Kinetik (1)
- Klassifikations- und Regressionsbaum (1)
- Klassische Konditionierung (1)
- Kleine Proteine (1)
- Kleinkern (1)
- Kleinkind (1)
- Klima (1)
- Klimawandel (1)
- Klinischer Behandlungspfad (1)
- Kniegelenkarthrose (1)
- Knochenbildung (1)
- Knochenersatz (1)
- Knochenmarkzelle (1)
- Knochenmetastase (1)
- Knochenmetastasen (1)
- Kofaktorbindung (1)
- Koffein (1)
- Kognitive Beeinträchtigung (1)
- Kognitive Inhibition (1)
- Kognitive Störung (1)
- Kognitiver Prozess (1)
- Kognitives Lernen (1)
- Kohlendioxid (1)
- Kohlenhydrate (1)
- Kohlenstoff (1)
- Kohlenstofffaser (1)
- Kohlenstoffstoffwechsel (1)
- Kohlenwasserstoffe (1)
- Kollektive Invasion (1)
- Kolloid (1)
- Kolonieerkennung (1)
- Kolonkarzinom (1)
- Kommunikation (1)
- Kommunikationshilfe (1)
- Komorbidität (1)
- Kompass (1)
- Komplement (1)
- Komplement C3a (1)
- Komplement C5a Rezeptor 1 (1)
- Komplementsystem (1)
- Komplexauge (1)
- Komplexes regionales Schmerzsyndrom (1)
- Komprimierte Abtastung (1)
- Kongestive Herzmuskelkrankheit (1)
- Kongo (1)
- Konnektivitätsschätzung (1)
- Konsolidierung (1)
- Kontingenz (1)
- Kontrastmittel (1)
- Kontrastmittel-gestützte MRT-Perfusionsmessung (1)
- Kontrolle (1)
- Kopfschmerz (1)
- Kopienzahlvariation (1)
- Korrelative Mikroskopie (1)
- Krebs (1)
- Kristallographie (1)
- Kryokonservierung (1)
- Kuh (1)
- Körperachsen (1)
- Körperliche Leistungsfähigkeit (1)
- Künstliche Ingelligenz (1)
- Künstliche Intelligenz (1)
- L-typ Calciumkanal Antagonist (1)
- LAD (1)
- LASP1 (1)
- LASP1 (LIM and SH3 Protein 1) (1)
- LASP1 (LIM und SH3 Protein 1) (1)
- LAT2 (1)
- LIMK (1)
- LIS (1)
- LPS (1)
- LPS Biosynthese (1)
- LV Function (1)
- Labeling (1)
- Lactobacillus reuteri (1)
- Lambdoide Prophagen (1)
- Langerhans cells (1)
- Langzeitgedächtnis (1)
- Lasermikrodissektion (1)
- Lasiocarpin (1)
- Lateral root development (1)
- Latrophilin receptor (1)
- Latrophilin-3 (1)
- Ldlr-Knockout (1)
- Leaf (1)
- Learning & Memory (1)
- Learning Walk (1)
- Learning walk (1)
- Lebendzellmikroskopie (1)
- Lebensmittelchemie (1)
- Lebensqualität (1)
- Leber-Metabolismus (1)
- Leberepithelzelle (1)
- Leichte kognitive Beeinträchtigung (1)
- Leitlinien (1)
- Lenalidomid (1)
- Lentiviral transgenesis (1)
- Leptomeningeal cells (1)
- Leptomeningealzellen (1)
- Lernverhalten (1)
- Letalität (1)
- Leukaemia-inhibitory factor (1)
- Lgr5 (1)
- Library Screening (1)
- Library of Phytochemicals (1)
- Library of plant species (1)
- Licht (1)
- Lichtblattmikroskopie (1)
- Lichtscheibenmikroskopie (1)
- Licl (1)
- Ligand <Biochemie> (1)
- Ligand uncaging (1)
- Light Sheet Fluorescence Microscopy (1)
- Light sheet microscopy (1)
- Lipid Raft (1)
- Lipid Rafts (1)
- Lipid Transfer Protein (1)
- Lipidom (1)
- Lipidomics (1)
- Lipidomik (1)
- Lipidumbau (1)
- Lipolysis (1)
- Liquor (1)
- Locomotor activity (1)
- Lokalanästhesie (1)
- Luftfeuchtigkeit (1)
- Lung Cancer metastasis (1)
- Lung cancer (1)
- Lung squamous cancer cells (1)
- Lungenentzündung (1)
- Lungentumor (1)
- Lurche (1)
- Lysin-Oxidase (1)
- Lysosome (1)
- Lysyl oxidases (1)
- Lysyloxidasen (1)
- Ländlicher Raum (1)
- M1 Muscarinic Receptor (1)
- MAP kinase (1)
- MAX (1)
- MCMV (1)
- MDR1 (1)
- MDSC (1)
- MDSCs (1)
- MEK5/ERK5 (1)
- MEK5/ERK5 cascade (1)
- MET-T-box riboswitch (1)
- MGMT (1)
- MIPs (1)
- MIZ1 (1)
- MLN7243 (1)
- MM (1)
- MMB complex (1)
- MMN (1)
- MMP (Matrix-Metalloproteasen) (1)
- MMP (Matrix-Metalloproteases) (1)
- MND (1)
- MRR1 (1)
- MS2-affinity purification and RNA-seq (1)
- MT02 (1)
- MYCN-amplified (1)
- Machine Learning (1)
- Macromolecular machine (1)
- Macrophage (1)
- Macrophage extracellular traps (1)
- Macrophytes (1)
- Magen (1)
- Magenchirurgie (1)
- Magenkrankheit (1)
- Magenkrebs (1)
- Magnetic Resonance Imaging (1)
- Magnetic Resonance Relaxometry (1)
- Magnetic resonance imaging (1)
- Magnetresonanz-Relaxometrie (1)
- Major depression (1)
- Makrokolonie (1)
- Makrophagen (1)
- Makrophyten (1)
- Malignant melanoma (1)
- Mamma carcinoma (1)
- Mammakarzinom (1)
- Mantle cell lymphoma (1)
- Marine natural products (1)
- Marine sponge (1)
- Marine sponge-derived actinomycetes (1)
- Marker (1)
- Marketing authorisation of pharmaceuticals (1)
- Marrow (1)
- Masern (1)
- Masern-Virus (1)
- Masernvirus-Infektion (1)
- Mass Spectrometry (1)
- Mass spectrometry (1)
- Massenspektrometrie/Proteomics (1)
- Masspectrometry (1)
- Mast cells (1)
- Mastzelle (1)
- Mathematical modeling (1)
- Mathematische Modellierung (1)
- Matrix-Metalloprotease (1)
- Matrix-Metalloproteasen (1)
- Matrix-Metalloproteinase (1)
- Mauerbiene (1)
- Mc4r (1)
- Measles virus (1)
- Mechanical deformation (1)
- Mechanisms of Social Attention (1)
- Mechanismus (1)
- Mechanistic model (1)
- Mechanorezeptor (1)
- Medaka (1)
- Mediator Komplex (1)
- Medium spiny neurons (1)
- Medizinprodukt (1)
- Medizintechnik (1)
- Medulloblastom (1)
- Megakaryocytes (1)
- Megakaryozytopoese (1)
- Mek5/Erk5-Signalweg (1)
- Melanin (1)
- Melanin release (1)
- Melanoma (1)
- Melanophor (1)
- Melt electrowriting (1)
- Membrane Receptor Dynamics (1)
- Membrane transporters (1)
- Membranlipide (1)
- Membranrezeptor (1)
- Membrantransporter (1)
- Memory (1)
- Memory B cells (1)
- Menaquinon-BIosynthese (1)
- Menaquinone Biosynthesis (1)
- Meninges (1)
- Meningokokken-Sepsis (1)
- Meniskus (1)
- Meniskusimplantat (1)
- Meniskustransplantation (1)
- Merkel cell polyomavirus (1)
- Merkelzellkarzinom (1)
- Mesenchymal Stem Cell (1)
- Mesenchymal Stromal Cell (1)
- Mesenchymal Stromal Cells (1)
- Mesenchymal stem cell (1)
- Mesenchymal stromal cells (1)
- Mesenchymale Stammzelle (1)
- Mesenchymale Stromazelle (1)
- Messenger-RNS (1)
- Meta-barcoding (1)
- Metabolic Glycoengineering (1)
- Metabolic Labeling (1)
- Metabolism (1)
- Metabolite von Morphin (1)
- Metabolites of morphine (1)
- Metabolomics (1)
- Metagenomics (1)
- Metalloprotease (1)
- Metalloproteasen (1)
- Metalloproteases (1)
- Metalloproteinase (1)
- Metapopulation (1)
- Metastasierung (1)
- Metatranscriptomics (1)
- Methioninbiosynthese (1)
- Method development (1)
- Methodenentwicklung (1)
- Methylphenidat (1)
- Methyltransferase (1)
- Mevalonate Pathway (1)
- MgrB (1)
- MicF (1)
- MicroRNA (1)
- MicroRNAs (1)
- Microarray (1)
- Microbial community (1)
- Microbiota (1)
- Microglia (1)
- Micronucleus (1)
- Microvesicle (1)
- Microwave Assisted Extraction (1)
- Migraine (1)
- Migration (1)
- Migräne (1)
- Mikroarray basierte vergleichende Genomhybridisierung (Array-CGH) (1)
- Mikrobiota (1)
- Mikroglia (1)
- Mikroglomeruli (1)
- Mikrokerne (1)
- Mikroorganismus (1)
- Mikrotubuli-assoziiertes Protein (MAP) (1)
- Mikrotubulus (1)
- Mimik (1)
- Mitochondrien (1)
- Mittelohrimplantat (1)
- Mobile Crowdsensing (1)
- Mobile Health (1)
- Mobiles Endgerät (1)
- Mobilfunkstrahlung (1)
- Moco biosynthesis (1)
- Model (1)
- Model Based Reconstruction Algorithms in Magnetic Resonance Imaging (1)
- Model Organism (1)
- Model simulation (1)
- Modell (1)
- Modellbasierte-Rekonstruktionsalgorithmen in der Magnetresonanztomografie (1)
- Modellierung (1)
- Modellorganismus (1)
- Modellsystem (1)
- Moderator (1)
- Modification (1)
- Modifizierung (1)
- ModulationTregs (1)
- Molecular Pharmacology (1)
- Molecular Radiotherapy (1)
- Molekulare Zielstrukturen (1)
- Mongolische Rennmaus (1)
- Monitoring (1)
- Monoklonale Gammopathie (1)
- Monoklonaler Antikoerper (1)
- Monoklonaler bispezifischer Antikörper (1)
- Monozyt (1)
- Moonlight (1)
- Moosfaserterminalen (1)
- Morbus Alzheimer (1)
- Morbus Fabry (1)
- Morphin (1)
- Morphology (1)
- Morris Water Maze (1)
- Motivation (1)
- Motoneuron diseases (1)
- Motoneuronenerkrankung (1)
- Motoneurons (1)
- Motor Memory (1)
- Motor learning (1)
- Motor neuron disease (1)
- Motorische Endplatte (1)
- Motorisches Gedächtnis (1)
- Mouse Model (1)
- Mrap2 (1)
- Mrr1 (1)
- MscS (1)
- Mucorales (1)
- Mucormycosis (1)
- Mucormykose (1)
- Multi-Unit Aufnahmen (1)
- Multicellular aggregates (1)
- Multidrug-Resistance-Related Proteine (1)
- Multidrugresistant (1)
- Multilayered skin tissue model (1)
- Multiphotonenmikroskopie (1)
- Multiple Sclerosis (1)
- Multiple myeloma (1)
- Multizellulären Bakteriengemeinschaften (1)
- Mundschleimhautzellen (1)
- Murine models of thrombosis and haemostasis (1)
- Muskelin (1)
- Muskelzelle (1)
- Mustererkennungsrezeptoren (1)
- Myb-MuvB complex (1)
- Mycobacterium tuberculosis (1)
- Mycobacterium tuberculosis InhA (1)
- Myeloblast (1)
- Myeloid (1)
- Myeloid-derived suppressor cells (1)
- Myeloide Suppressorzellen (1)
- Myelom (1)
- Myeloma (1)
- Myocardial Work (1)
- Myocardial infarction (1)
- Myokardiale Deformation (1)
- Myokarditis (1)
- Myosin IIA (1)
- Myrmecology (1)
- N-RAS (1)
- N2pc (1)
- N400 (1)
- NA (1)
- NAFLD (1)
- NEDMIAL (1)
- NES (1)
- NF-kB (1)
- NF-kappaB (1)
- NFATc3 (1)
- NHERF (1)
- NK (1)
- NK cell (1)
- NK-DC cross-talk (1)
- NKT (1)
- NLS (1)
- NMJ (neuromuscular junction) (1)
- NMR (1)
- NNMT activity assay (1)
- NO-GC (1)
- NOS-I (1)
- NOS1AP (1)
- NOTES <Chirurgie> (1)
- NRF2 (1)
- NSM2 (1)
- NTRK fusions (1)
- NaV1.9. oxidized phospholipids (1)
- Nachtschattengewächse (1)
- Nahrung (1)
- Nahrungsaufnahme (1)
- Nanofabrication (1)
- Nanofabrikation (1)
- Nanofaser (1)
- Nanomedicine (1)
- Nanomedizin (1)
- Nanopartikel (1)
- Nanotubes (1)
- Naphthalinderivate (1)
- Naphthochinonen (1)
- Naphthoquinones (1)
- Naphthylisochinolinalkaloide (1)
- Naphthylisoquinoline (1)
- Narrow escape problem (1)
- Nasenschleimhaut (1)
- Natrium-Kalium-Pumpe (1)
- Natrium-abhängigen Glukosetransporter-1 (1)
- Natriumoxamat (1)
- Natural pest control (1)
- Natural products (1)
- Nature-Insipired Synthesis (1)
- Naturschutz (1)
- Naturstoff (1)
- Near Miss (1)
- Nebenniere (1)
- Nebennierenrindenkarzinom (1)
- Nebennierenrindenkrebs (1)
- Nebennierentumor (1)
- Nectin4 (1)
- Neogenin-1 (1)
- Nephrogenese (1)
- Nerven (1)
- Nervenstimulation (1)
- Netrin-1 (1)
- Netzhaut (1)
- Netzwerkanalyse (1)
- Neuartige Arzneimittel (1)
- Neural Stem cells (1)
- Neurobiology (1)
- Neuroblastoma (1)
- Neurodegenerative Erkrankung (1)
- Neurodevelopment (1)
- Neurodevelopmental Disorder (1)
- Neurodevelopmental diseases (1)
- Neuroepigenomics (1)
- Neuroethology (1)
- Neurofeedback (1)
- Neurofilament (1)
- Neurogenesis (1)
- Neurogenetik (1)
- Neuroligin 2 (1)
- Neuromuskuläre Endplatte (1)
- Neuronale Stammzellen (1)
- Neuronales visuelles System (1)
- Neuropathic Pain (1)
- Neuropathic pain (1)
- Neuropathologie (1)
- Neuropathy (1)
- Neuropeptid S Rezeptor Gen (1)
- Neuropeptid Y (1)
- Neuropeptidom (1)
- Neurophysiologie (1)
- Neuroplasticity (1)
- Neuroprotection (1)
- Neuroprotektivum (1)
- Neurotransmitter Receptors (1)
- Neurotransmitter Rezeptoren (1)
- Neurotransmitter-Rezeptor (1)
- Neurotrophic factors (1)
- Neutrophil (1)
- Neutrophil granulocyte (1)
- Neutrophil granulocytes interaction (1)
- Newman strain sae (1)
- Next Generation Sequencing (NGS) (1)
- Nicht-kartesische Bildgebung (1)
- Nicht-kleinzelliges Bronchialkarzinom (1)
- Nichtionisierende Strahlung (1)
- Nichtstrukturproteine (1)
- Nicotiana tabacum (1)
- Niere (1)
- Nierenversagen (1)
- Nimodipin (1)
- Nitrogen (1)
- Nodo-Paranodopathie (1)
- Non-Hodgkin-Lymphom (1)
- Non-conventional T cell (1)
- Non-invasive imaging (1)
- Non-ribosomal peptide synthetase (1)
- Non-viral genome engineering (1)
- Noonan-Syndrom (1)
- Noradrenalin (1)
- Noradrenalinstoffwechsel (1)
- Nosocomial Infections (1)
- Nosokomiale Infektionen (1)
- Notch Signalweg (1)
- Notch signalling (1)
- Nozizeption (1)
- Nuclar Medicine (1)
- Nuclear Factor of Activated T cells (NFAT) (1)
- Nuclear Medicine (1)
- Nuclear imaging (1)
- Nuclease (1)
- Nucleasen (1)
- Nucleotide excision repair (1)
- Nucleotide-Excision-Repair (1)
- Nucleus subthalamicus (1)
- Nuklearfaktor Kappa B (1)
- Nukleäre Hormonrezeptoren (1)
- Numerische Fluidmechanik (1)
- O(6)-Methylguanine-DNA Methyltransferase (1)
- OCT1 (1)
- OIS (1)
- OSM (1)
- OSMR (1)
- Oberflächenproteine der Sexualstadien (1)
- Olfaktion (1)
- Olfaktorik (1)
- Oligomerization (1)
- OmoMYC (1)
- Onchocerca volvulus (1)
- Onchozerkose (1)
- Oncogenes (1)
- Oncolytic Virotherapy (1)
- Onkologie (1)
- Onkolyse (1)
- Oozyte (1)
- Open chromatin (1)
- Opioidpeptide (1)
- Optimal foraging (1)
- Optogenetics (1)
- Orai1 (1)
- Organ of Corti (1)
- Organoids (1)
- Orientia tsutsugamushi (1)
- Osmr-Knockout (1)
- Osteoporose (1)
- OxPL (1)
- Oxidative Stress (1)
- Oxidized Phospholipids (1)
- Oxidized phospholipids (1)
- Oxygen partial pressure (1)
- Oxytocin (1)
- Oxytosis (1)
- P4-ATPase (1)
- PAF1c (1)
- PAR-CLIP (1)
- PD-L1 (1)
- PDE (1)
- PDI (1)
- PE Phosphoethanolamine (1)
- PEG (1)
- PER (1)
- PG neurons (1)
- PGE2 (1)
- PHMB (1)
- PI3K (1)
- PKA signaling (1)
- PLEKHG5 (1)
- PLP phosphatase (1)
- PP2A (1)
- PRKACA (1)
- PROTAC (1)
- PRR (1)
- PTH1R (1)
- PTMs (1)
- PTPN22 (1)
- PacBio sequencing (1)
- Palbociclib (1)
- Panic Disorder (1)
- Panik (1)
- Pankreas (1)
- Paranodopathie (1)
- Parasitology (1)
- Parc National de la Comoé (1)
- Parkinson Krankheit (1)
- Partial Agonists (1)
- Partialagonismus (1)
- Paternal age and BMI effects (1)
- Pathogene Bakterien (1)
- Pathogenese (1)
- Pathogenesis (1)
- Pathogenicity (1)
- Pathogens (1)
- Pathologie (1)
- Pathology (1)
- Pathophysiologische Mechanismen (1)
- Patienten-orientierte Versorgung (1)
- Patientenklassifikation (1)
- Patientenorientierte Medizin (1)
- Pattern recognition receptors (1)
- Pattern-Recognition-Receptors (1)
- Patulin (1)
- Pediatric Nuclear Medicine (1)
- Pediatric Patients (1)
- Pemphigus (1)
- Peptides (1)
- Perforation <Medizin> (1)
- Perforine (1)
- Perfusion Bioreactor (1)
- Perianova, Irina (1)
- Periaqueductal gray (1)
- Period2 (1)
- Peripheral eosinophils (1)
- Periphere Analgesie (1)
- Peripheres Nervensystem (1)
- Permeability (1)
- Permeation (1)
- Peroxisomen-Proliferator-aktivierter Rezeptor (1)
- Persistence (1)
- Pertussis (1)
- Pesticide (1)
- Peyersche Plaques (1)
- Pflanzen-Bienen-Netzwerke (1)
- Pflanzenaussterben (1)
- Pflanzenhydraulik (1)
- Pflanzenzelle (1)
- Pflanzenzellkulturen (1)
- Pflanzenökologie (1)
- PhD thesis pharmacology (1)
- Pharmaceutische Biologie (1)
- Pharmacology (1)
- Pharmakodynamik (1)
- Phasenvariation (1)
- Phenotypic switch (1)
- Pheromon (1)
- Phonochirurgie (1)
- Phosphatidylinositolkinase <Phosphatidylinositol-3-Kinase> (1)
- Phosphoantigen (1)
- Phosphodiesterase (1)
- Phosphoglykolat (1)
- Phosphoglykolat-Phosphatase (1)
- Phospholamban (1)
- Phosphorylation (1)
- Photoreceptor (1)
- Photoswitch (1)
- Phyllosphere (1)
- Phyllosphäre (1)
- Phylogeny (1)
- Pilze (1)
- PinT (1)
- Plant Biology (1)
- Plant Ecology (1)
- Plant cell cultures (1)
- Plant extracts (1)
- Plant hydraulic (1)
- Plants (1)
- Plasmonic (1)
- Plastin 3 (1)
- Platelet activating Factor (1)
- Platelet count (1)
- Platelet granules (1)
- Platelet-Membranglykoprotein p62 (1)
- Platy (1)
- Pluripotenz (1)
- Pmn mutant mouse (1)
- Pneumoviruses (1)
- Point Spread Function (1)
- Polistes (1)
- Pollen (1)
- Polo-like kinase 1 (1)
- Poly(2-oxazoline) (1)
- Poly(2-oxazoline)s (1)
- Poly(glycidol) (1)
- Polyadenylierung (1)
- Polyethism (1)
- Polymer Science (1)
- Polymere (1)
- Polymers (1)
- Polyphosphate (1)
- Polysaccharide (1)
- Polysaccharide intercellular adhesin (PIA) (1)
- Pore (1)
- Pore formation (1)
- Pore-formation (1)
- Porenbildung (1)
- Porifera (1)
- Porins (1)
- Positron emission tomography (1)
- Positronen-Emissions-Tomografie (1)
- Posttranslationale Änderung (1)
- Powdery mildew fungus (1)
- Pra1 (1)
- Preclinical studies (1)
- Prefrontal cortex (1)
- Prefrontalt Cortex (1)
- Primaten (1)
- Primär-basierte immortalisierte Zelllinie (1)
- Primäre Ziliendyskinesie (1)
- Primärelement (1)
- Primärprevention (1)
- Primärtumor (1)
- Primärzellen (1)
- ProQ (1)
- Problem Gambling (1)
- Processing fluency (1)
- Profilin (1)
- Programmed Cell Death 1 (1)
- Programmed Cell Death Ligand 1 (1)
- Promotor (1)
- Prosoziales Verhalten (1)
- Prostaglandin E2 (1)
- Protease (1)
- Proteaseaktivität (1)
- Proteaseinhibitor (1)
- Proteases (1)
- Proteasom (1)
- Proteasomaler Abbau (1)
- Proteasome (1)
- Protein Disulfid Isomerase (1)
- Protein Kinase D2 (1)
- Protein TRPC6 (1)
- Protein chemistry (1)
- Protein crosslinking (1)
- Protein folding (1)
- Protein interactions (1)
- Protein interactor (1)
- Protein purification (1)
- Protein-Protein Interaktion (1)
- Protein-Protein-Interaktion (1)
- Protein-Tyrosin-Kinasen (1)
- Proteinen mit antimikrobieller Wirkung (1)
- Proteinfaltung (1)
- Proteininteraktion (1)
- Proteininteraktionen (1)
- Proteinkinase A (1)
- Proteinkinase C (1)
- Proteinmodifizierung (1)
- Proteinquervernetzungen (1)
- Proteolysis (1)
- Proteolysis-Targeting-Chimera (1)
- Proteomics (1)
- Prozessierung (1)
- Prädiktoren und Korrelate (1)
- Präklinische Bildgebung (1)
- Präklinische Studien (1)
- Pränatale Entwicklung (1)
- Präzisionsmedizin (1)
- Pseudouridin (1)
- Psoriasis (1)
- Psychische Belastung (1)
- Psychische Gesundheit (1)
- Psychobiologie (1)
- Psychotherapie (1)
- Ptpn22 (1)
- Puberty (1)
- Pubertät (1)
- Pulswelle (1)
- Punktmutation (1)
- Purinozeptor (1)
- Pyridoxal 5'-phosphate phosphatase (1)
- Pyridoxalphosphat (1)
- Pyrrolidinderivate (1)
- Pyrrolidine carboxamides (1)
- Pyrrolizidinalkaloide (1)
- QPCR (1)
- QTOF (1)
- Quadruplex-DNS (1)
- Qualität (1)
- Qualitätsindikator (1)
- Qualitätssicherung (1)
- Quantifizierung (1)
- Quantitation (1)
- Quantitative Genetics (1)
- Quartäre Bisnaphthalimide (1)
- Quaternary Bisnaphthalimide (1)
- RAF (1)
- RAF Kinasen (1)
- RAMP (1)
- REDD1 (1)
- REST-Complex (1)
- RESTORE protocol (1)
- RIL-seq (1)
- RIM1α (1)
- RNA Abbau (1)
- RNA G-quadruplex (1)
- RNA Sequencing (1)
- RNA binding potein CNBP (1)
- RNA binding proteins (1)
- RNA decay (1)
- RNA metabolism (1)
- RNA protein interactions (1)
- RNA secondary structures (1)
- RNA sequencing (1)
- RNA structures (1)
- RNA virus (1)
- RNA-Protein Interaktom (1)
- RNA-RNA interactions (1)
- RNA-Seq (1)
- RNA-Sequenzierung (1)
- RNA-bindendes Protein (1)
- RNA-binding protein (1)
- RNA-binding proteins (1)
- RNA-protein interactome (1)
- RNAi (1)
- RNS Polymerase I (1)
- RNS-Polymerase II (1)
- RNS-Spleißen (1)
- ROR2 (1)
- RS-Virus (1)
- RS1 Peptides (1)
- RS1 derived peptides (1)
- RSK2 (1)
- RSV (1)
- RYGB (1)
- Rac1 (1)
- Radiale MR-Bildgebung (1)
- Radiation Protection (1)
- Radiation-associated Cancer Risk (1)
- Radiologische Diagnostik (1)
- Radionuklidtherapie (1)
- Raf <Biochemie> (1)
- Raf Kinase Inhibitor Protein (RKIP) (1)
- Raf kinase inhibitor protein (1)
- Raf1 (1)
- Random Forest (1)
- Random-walk simulations (1)
- Raphe (1)
- Raphe Kerne (1)
- Rasterionenmikroskop (1)
- Rasterkraft-Mikroskopie (1)
- Rauch (1)
- Rbm8a (1)
- Read-through transcription (1)
- Reaktive Sauerstoffspezies (1)
- Real-time imaging (1)
- RecQ helicase (1)
- Receptor (1)
- Receptor Anchoring (1)
- Receptor dynamics (1)
- Receptor internalization (1)
- Receptor signaling (1)
- Recombinant defensins (1)
- Recycling- Endosomen (1)
- Red Sea (1)
- Regenerative Medicine (1)
- Regulation of Gene Expression (1)
- Regulator of G protein signaling 2 (1)
- Regulatorische T-Zellen (1)
- Regulatory T Cells (1)
- Regulatory T-cell (1)
- Rekombinante DNS (1)
- Rekonsolidierung (1)
- Rekonstruktion (1)
- Relaxation Parameter Mapping in Magnetic Resonance Imaging (1)
- Remission (1)
- Remodeling (1)
- Renaturierung <Ökologie> (1)
- Repeats (1)
- Reperfusion (1)
- Reporter Cells (1)
- Reporterzellen (1)
- Repression (1)
- Repression <Genetik> (1)
- Reproducibility challenges (1)
- Reprogrammming (1)
- Rescue behaviour (1)
- Resistance (1)
- Resistenzmechanismen (1)
- Respiratorisches System (1)
- Response Inhibition (1)
- Ressourcenallokation (1)
- Restriktionsenzym (1)
- Resveratrol (1)
- Retinales S-Antigen (1)
- Retinoesäure (1)
- Retinoic acid (1)
- Reverse Transkriptase (1)
- Rezeptor Verankerung (1)
- Rezeptor-Tyrosinkinasen (1)
- Rezeptorblocker (1)
- Rezeptorpharmakologie (1)
- Rezidiv (1)
- Rgs2 (1)
- Rheologie (1)
- Rheology (1)
- Rheumatoider arthritis (1)
- Rhizopus arrhizus (1)
- Rho GTPase (1)
- Rho GTPasen (1)
- Rho GTPasw (1)
- Rho-GTPasen (1)
- Rho-Kinasen (1)
- RhoGTPase (1)
- Rhodopseudomonas palustris (1)
- Rhodopsin 7 (1)
- Ribonuclease H2 (1)
- Riboregulation (1)
- Ribosomale RNA (1)
- Ribosome biogenesis (1)
- Ribosome profiling (1)
- Ribozymes (1)
- Riesensynapsen (1)
- Risk Assessment (1)
- Rituximab (1)
- Rodents (1)
- Rodung (1)
- Roscovitine (1)
- Rossameise (1)
- Rotes Meer (1)
- Rothmund-Thomson-Syndrome (1)
- Rupturen (1)
- Räumliches Gedächtnis (1)
- SAP2 (1)
- SCV maturation (1)
- SEPHCHC Synthase (1)
- SERCA2a (1)
- SET7 (1)
- SGLT (1)
- SIS-muc (1)
- SIX1 (1)
- SLC2A3 (1)
- SLFN5 (1)
- SMARD1 (1)
- SMN complex (1)
- SNAP-Rezeptor (1)
- SNPs (1)
- SOC (1)
- SOD1 (1)
- SPECT/CT (1)
- SR proteins (1)
- SREBP (1)
- STAAB Cohort Study (1)
- STAAB study (1)
- STAAB-Studie (1)
- STD patients (1)
- STEC (1)
- STED (1)
- STIM2 (1)
- STP1 (1)
- SUMOylation (1)
- SWI/SNF (1)
- Saatgutbeizung (1)
- Saccharomyces cerevisiae (1)
- Salmonellose (1)
- Samenschale (1)
- Sandminen (1)
- Sap47 (1)
- Satellite glial cell (1)
- Sauerstoffkonzentration (1)
- Saure Sphingomyelinase (1)
- Scaffold bone implant (1)
- Scherstress (1)
- Schilddrüse (1)
- Schimmelpilze (1)
- Schimpanse (1)
- Schizosaccharomyces pombe (1)
- Schlafstörung (1)
- Schlaganfallversorgung (1)
- Schließzellfunktion (1)
- Schmerztherapie (1)
- Schmetterlinge (1)
- Schnelle MR-Bildgebung (1)
- Schreckreaktion (1)
- Schuppenflechte (1)
- Schwamm (1)
- Schwämme (1)
- Sehen (1)
- Sekretion (1)
- Sekretion von Aspartatproteasen (1)
- Sekundäre Inflammation (1)
- Sekundärprävention (1)
- Sekundärstruktur (1)
- Selbstregulation (1)
- Selective extraction (1)
- Selektiver Serotonin Wiederaufnahmehemmer / SSRI (1)
- Senecionin (1)
- Seneciphyllin (1)
- Seneszenz (1)
- Sensory Gating (1)
- Sequence Analysis (1)
- Sequence-Structure (1)
- Sequenz (1)
- Sequenzanalyse <Chemie> (1)
- Sequenzdaten (1)
- Sequenzwiederholung (1)
- Serinprotease (1)
- Serotonin Transporter (1)
- Serotonin transporter (1)
- Serotonin-Reuptake-Hemmer (1)
- Serotonin-Wiederaufnahmehemmer (1)
- Serotonindefizienz (1)
- Serotonintransporter (1)
- Sertralin (1)
- Setting Control (1)
- Sexuelle Entwicklung (1)
- Sezernierte Faktoren (1)
- Sglt1 (1)
- Shear Stress (1)
- Shigella (1)
- Shigella flexneri (1)
- Shimming (1)
- Sialoadhesin (1)
- Signal-Übertragung (1)
- Signaling (1)
- Signalregenerierung (1)
- Silica precursor (1)
- Simulation (1)
- Single Particle Tracking (1)
- Single-cell RNA Sequencing (1)
- Single-cell RNA-sequencing (1)
- Single-molecule (1)
- Sinusthrombose (1)
- Skin (1)
- Skin Tissue Engineering (1)
- Skin conductance (1)
- Sleep (1)
- Sleep in children (1)
- Sleeping Beauty Transposon System (1)
- Sleeping Beauty transposon (1)
- Smad (1)
- Small angle X-ray scattering (1)
- Small intestine (1)
- Small non-messenger RNS (1)
- Small nuclear RNP (1)
- Small-angle X-ray Scattering (1)
- Smoke (1)
- SnRK1-bZIP complex (1)
- Snap25 (1)
- Social Buffering (1)
- Social Distancing (1)
- Social action effects (1)
- Social buffering (1)
- Sociomotor gaze control (1)
- Sodium dependent glucose transporter-1 (1)
- Sol-gel (1)
- Solanaceae (1)
- Solanum species (1)
- Solid-phase peptide synthesis (1)
- South Africa (1)
- Soziale Handlungseffekte (1)
- Soziale Phobie (1)
- Sozialer Kontakt (1)
- Soziobiologie (1)
- Soziomotorische Blickkontrolle (1)
- Spatial heterogeneity (1)
- Spatiotemporal analysis (1)
- Specialized pro resolving mediators (1)
- Species richness (1)
- Speckle Tracking (1)
- Speicheldrüse (1)
- Sphingolipidstoffwechsel (1)
- Sphingomyelinase (1)
- Sphingomyelinphosphodiesterase (1)
- Sphingosine-1-phosphate (1)
- Sphingosine-1-phosphats (1)
- Spielsucht (1)
- Spinal muscular Atrophy (1)
- Spinal muscular atrophy (1)
- Spinal muscular atrophy (DLC) (1)
- Spinalganglion (1)
- Spirale (1)
- Spleen tyrosine kinase (1)
- Spliceosome (1)
- Splicing (1)
- Spo0A (1)
- Sponge diseases (1)
- Sponges (1)
- Sporenbildung (1)
- Sporulation (1)
- Spumaviren (1)
- Squamous cell carcinoma (1)
- Ssl1 (1)
- Stack-of-Stars Sequenz (1)
- Stack-of-Stars sequence (1)
- Stammzellen (1)
- Stammzelltransplantation (1)
- Staphylococci (1)
- Staphylococcus epidermidis (1)
- Stat3 (1)
- Stat5 (1)
- Stathmin (1)
- Staupevirus (1)
- SteC (1)
- Stechameisen (1)
- Stem Cells (1)
- Stem cells (1)
- Sterblichkeit (1)
- Steroide (1)
- Steroidhormon (1)
- Stickstoffkontrolle (1)
- Stickstoffmetabolismus (1)
- Stickstoffmonoxid-Synthase (1)
- Stickstoffwechsel (1)
- Stiff person syndrome (1)
- Stiff-Person Syndrom (1)
- Stiff-person syndrome (1)
- Stimmbandchirurgie (1)
- Stimmerhöhung (1)
- Stimulation (1)
- Stimulationsversuche (1)
- Stk (1)
- Stofftransport <Biologie> (1)
- Stoffwechselinhibitoren (1)
- Store-Operated (1)
- Stp (1)
- Strahlenpilze (1)
- Streptomyces (1)
- Stressresistenz (1)
- Striatum (1)
- Stroke (1)
- Stroke Unit (1)
- Stroop-Verfahren (1)
- Structural elucidation (1)
- Structural organisation (1)
- Structure-based (1)
- Structured Illumination Microscopy (1)
- Struktur (1)
- Struktur-basiertes Wirkstoff Design (1)
- Strukturanalyse (1)
- Strukturbiologie (1)
- Strumpellin (1)
- Störabstand (1)
- Störung des Sozialverhaltens (1)
- Subitizing (1)
- Subtyp C (1)
- Sumo (1)
- Sumoylierung (1)
- Super-Resolution Microscopy (1)
- Super-resolution microscopy (1)
- Super-resolution microsopy (1)
- Superhochauflösende Mikroskopie (1)
- Superparamagnetische Eisenoxid Kontrastmittel (1)
- Superresolution microscopy (1)
- Suppressorzelle (1)
- Survival Motor Neuron (1)
- Suspensionskultur (1)
- Syap1 (1)
- Symbionts (1)
- Symbiosis (1)
- Synapse-associated protein (1)
- Synapsen assoziiert (1)
- Synapses (1)
- Synapsine (1)
- Synaptic plasticity (1)
- Synaptische Plastizität (1)
- Synaptische Transmission (1)
- Synaptische Vesikel (1)
- Synchronitätsmessung (1)
- Syncytin (1)
- Synthesis (1)
- Systematik (1)
- Systembiologie (1)
- Säugerzellen (1)
- Säugetiere (1)
- Südafrika (1)
- Südostasien (1)
- T Helper Cell (1)
- T Lymphocyte (1)
- T Zell Selektion (1)
- T Zellen (1)
- T cell (1)
- T cell cytotoxicity (1)
- T cell engaging Antibody (1)
- T cell homing (1)
- T cell receptor (1)
- T cell selection (1)
- T cell specificity (1)
- T zellen (1)
- T-Zell-Aktivierung (1)
- T-Zellaktivierung (1)
- T-Zellhoming (1)
- T-Zellmigration (1)
- T-cell (1)
- T-cell engineering (1)
- T-cell therapy (1)
- TAC (1)
- TCTP (1)
- TGF-ß (1)
- TGF-β (1)
- TGN1412 (1)
- TH2 Immunantwort (1)
- TLR signaling (1)
- TMEM16F (1)
- TP53 (1)
- TP53 lesions (1)
- TRAIL mutants (1)
- TRPA1 (1)
- TRPA1 channel (1)
- TRPC (1)
- TRPC-Ionenkanäle (1)
- TRPC3 (1)
- TRPC6 (1)
- TRPM7 kinase (1)
- TRPV1 (1)
- TRRAP (1)
- TT-Fields (1)
- TTF (1)
- Tabakkonsum (1)
- Tageslänge (1)
- Tagesrhythmik (1)
- Tamoxifen (1)
- Tansania (1)
- Tanzania (1)
- Tapeworm (1)
- Targeted therapy (1)
- Tc-99m-MAG3 Scans (1)
- Telomer <Molekulargenetik> (1)
- Telomerase (1)
- Temperatur (1)
- Temperaturabhängigkeit (1)
- Temporal heterogeneity (1)
- Temporal predictability (1)
- Terahertzbereich (1)
- Terahertzstrahlung (1)
- Terpene (1)
- Test system (1)
- Tfb4 (1)
- Thebain (1)
- Theoretical Ecology (1)
- Theory of Mind (1)
- Therapeutical application (1)
- Therapieoutcome (1)
- Therapiesimulation (1)
- Therapy (1)
- Thermoregulation (1)
- Thermoresponsive Polymere (1)
- Thermotoleranz (1)
- Theta Burst Stimulation (1)
- Thigmotaxis (1)
- Think/No-Think (1)
- Thiolase (1)
- Thiostrepton (1)
- Thrombin (1)
- Thromboinflammation (1)
- Thrombopoese (1)
- Thrombozyten (1)
- Thrombozytenfunktion (1)
- Thrombozytenfunktionsanalyse (1)
- Thrombozytopathie (1)
- Thrombozytopenie (1)
- Thrombozytopoese (1)
- Thrombus (1)
- Thymocytes (1)
- Thymosin b4 (1)
- Thymus (1)
- Tierphysiologie (1)
- Tight Junction Proteins (1)
- Tight junction (1)
- Tight-Junction-Protein (1)
- Time-of-flight (1)
- Timing (1)
- Tissue staining (1)
- Tobacco smoking (1)
- Tolerance (1)
- Toleranz <Biologie> (1)
- Toxin (1)
- TraDIS (1)
- Tracer (1)
- Trailmaking Test (1)
- Transcranial Magnetic Stimulation (1)
- Transcription Factor (1)
- Transcription factor (1)
- Transgenic mice (1)
- Transkriptomik anlyze (1)
- Translation <Genetik> (1)
- Transmission (1)
- Transmissionsblockierende Impfstoffe (1)
- Transpiration barrier (1)
- Transplantatabstoßung (1)
- Transportbarriere (1)
- Transporters (1)
- Transsexualismus (1)
- Transthorakale Echokardiographie (1)
- Trauma (1)
- Traumatic neuropathy (1)
- Tree physiology (1)
- Trem2 (1)
- Trend (1)
- Trennungsangst (1)
- Triclosan (1)
- Triglyceride (1)
- Tripartite Model (1)
- Trockenstress (1)
- Trophic Factors (1)
- Tropomyosin receptor kinase B (1)
- TruD (1)
- Trypanosoma (1)
- Trypanosoma Brucei (1)
- Trypanosoma brucei brucei (1)
- Trypanosomiasis (1)
- Tryptophan hydroxylase (1)
- Tryptophan hydroxylase 2 (1)
- Tuberkulose (1)
- Tumor Treating Fields (1)
- Tumor microenvironment (1)
- Tumor-Nekrose-Faktor <alpha> (1)
- Tumorangiogenese (1)
- Tumorgefäßmorphologie (1)
- Tumorhypoxie (1)
- Tumorimmunologie (1)
- Tumormetabolismus (1)
- Tumortherapiefeld (1)
- Tumorwachstum (1)
- Tumorzellen (1)
- Tumour (1)
- Twilight (1)
- Typ 2 (1)
- Type 1 Diabetes (1)
- Type 1 diabetes (1)
- Type II-C CRISPR/Cas (1)
- Type VIIb secretion system (1)
- Tyrosinkinaseinhibitor (1)
- U snRNPs (1)
- U1 snRNA (1)
- UBA6 (1)
- UBE2S (1)
- UBE2Z (1)
- UNC5B (1)
- UPEC (1)
- USA300 (1)
- USP (1)
- USP28 (1)
- Ubiquitin activating eznyme 1 (1)
- Ubiquitin system (1)
- Ubiquitin-PA (1)
- Ubiquitin-aktivierende Enzym 1 (1)
- Ubiquitin-conjugating enzyme (1)
- Ubiquitylation (1)
- Ultrahigh field (1)
- Ultraschall (1)
- Ultrashort echo time - UTE (1)
- Unidirectional Freezing (1)
- Untertyp (1)
- Uremic cardiomyopathy (1)
- Urinary tract infection (1)
- Urteilen (1)
- Urämie (1)
- Urämische Kardiomyopathie (1)
- VCAM (1)
- VE-Cadherin (1)
- VE-PTP (1)
- VLA-1 (1)
- VSMC (1)
- VW-SCs (1)
- Vaccinia-Virus (1)
- Vagus (1)
- Vagusnervstimulation (1)
- Vakuole (1)
- Vakzinen (1)
- Validierung (1)
- Validierungsstudie (1)
- Validität (1)
- Valscularization (1)
- Variant Surface Glycoprotein (1)
- Variants (1)
- Vascular system (1)
- Vaskularisation (1)
- Vaskularisierung (1)
- Vaskuläre Integrität (1)
- Vasopressin (1)
- Venusfliegenfalle (1)
- Verbreitungsökologie (1)
- Verhaltenplastizität (1)
- Verhaltenskontrolle (1)
- Verhaltensplastizität (1)
- Verhaltensstörung (1)
- Vermehrung (1)
- Vermeidungsreaktion (1)
- Vermeidungsverhalten (1)
- Vernetzung <Chemie> (1)
- Versorgungsqualität (1)
- Verweildauer (1)
- Verwundbarkeit (1)
- Very-long-chain aliphatic (1)
- Vesikel (1)
- Vesikelbildung (1)
- Vessel wall (1)
- Vg9Vd2 T Zellaktivierung (1)
- Vg9Vd2 T cell (1)
- Vgamma9Vdelta2 T cell (1)
- Vgamma9Vdelta2 T cells (1)
- Vibrationstraining (1)
- Vielfalt (1)
- Virologische Synapse (1)
- Virology (1)
- Virulenzfaktor (1)
- Virus infection (1)
- Virus-Transmission (1)
- Virusreplikation (1)
- Visual attention (1)
- Visuelle Orientierung (1)
- Visuelle Wahrnehmung (1)
- Visuelles Gedächtnis (1)
- Visuelles System (1)
- Vitamin D (1)
- Vitamin D-Rezeptor (1)
- Vitamin D3 (1)
- Voltage-Clamp-Methode (1)
- Vorhersage (1)
- Vorläufer (1)
- Vulnerable plaque (1)
- Vγ9Vδ2 T cells (1)
- WASH complex (1)
- WNT (1)
- Wachstum (1)
- Wachstumsfaktor (1)
- Waiting Impulsivity (1)
- Warburg, Otto (1)
- Warburg-Effekt (1)
- Wasser Fett Trennung (1)
- Wasted Work (1)
- Water stress (1)
- Web services (1)
- Wechselwirkungen (1)
- Weinrebe (1)
- Wildbienen (1)
- Wilms Tumor (1)
- Wilms tumor protein 1 (1)
- Wilms-Tumor (1)
- Wirbelströme (1)
- Wirkstoff (1)
- Wirkstofftestung (1)
- Wirt-Erreger Interaktion (1)
- Wirtszelle (1)
- Wnt-Proteine (1)
- Wnt-Signalweg (1)
- Wnt-pathway (1)
- Wurzelhalsgalle (1)
- Würmer (1)
- Wüstenpflanze (1)
- X-ray Crystallography (1)
- X-ray diffraction (1)
- XPD (1)
- Xenograft (1)
- Xeroderma pigmentosum (1)
- Xerostomie (1)
- Xiphophorus Melanom (1)
- Xmrk (1)
- YAP (1)
- YB-1 (1)
- Yb1 (1)
- Yeast (1)
- Yersinia (1)
- Yersinia pestis (1)
- YnaI (1)
- ZFAND1 (1)
- Zebrafisch (1)
- Zeitgeber (1)
- Zell Migration (1)
- Zell-Migration (1)
- Zelladhäsion (1)
- Zellfilamente (1)
- Zellkernarchitektur (1)
- Zellkontakt (1)
- Zelllinie (1)
- Zellteilung (Zytokinese) (1)
- Zelltod (1)
- Zelltransport (1)
- Zielstruktur (1)
- Zink-Cluster-Transkriptionsfaktoren (1)
- Zytokin (1)
- Zytokingenpolymorphismus (1)
- Zytoskelett (1)
- Zytoskelettreorganisation (1)
- Zählen (1)
- aGPCR (1)
- acceptance-based strategies (1)
- acid sphingomyelinase (1)
- actin cytoskeleton (1)
- actin-binding proteins (1)
- actinomycetes (1)
- acute brain slices (1)
- acute lymphoblastic leukaemia (1)
- adhesion (1)
- adhesion-GPCR (1)
- adipogenic differentiation (1)
- adipose (1)
- adipose-derived (1)
- adolescents (1)
- adrenal gland (1)
- adrenal incidentaloma (1)
- adrenerge Rezeptoren (1)
- adrenergic receptor (1)
- adrenergic receptors (1)
- adrenocortical adenoma (1)
- adult ADHD (1)
- adult attention deficit hyperactivity disorder (aADHD) (1)
- adulte Neurogenese (1)
- aggressive behavior (1)
- aging (1)
- airflow (1)
- airways (1)
- akute lymphatische Leukämie bei Kindern (1)
- alfa-cyano-4-hydroxycinnamat (1)
- alkaloids (1)
- allogen (1)
- allogeneic stem cell transplantation (1)
- allogenic (1)
- allogenic stem cell transplantation (1)
- allografts (1)
- alltägliche Funktionsfähigkeit (1)
- alpha-IIb beta-3 (1)
- alternative intronic polyadenylation (1)
- ammonium (1)
- ammonium permease (1)
- amphibia (1)
- amphiphysin (1)
- amyotrophic lateral sclerosis (1)
- anaerobe (1)
- analysis (1)
- anaphylatoxin receptors (1)
- androstadienone (1)
- anoikis (1)
- anterior insula (1)
- anthocyanins (1)
- anti-hDEC205-WT1 antibody fusion protein (1)
- anti-infective (1)
- antigen (1)
- antigenic variation (1)
- antileukemia vaccine (1)
- antimicrobial (1)
- antithrombotic (1)
- antivirale Gene (1)
- anxiety conditioning (1)
- arf (1)
- aromatic amino acid biosynthesis (1)
- articular cartilage progenitor cells (1)
- artificial diet (1)
- artificial human skin (1)
- artifizielle Aktivierung (1)
- artifizielle Hautmodelle (1)
- asialoGM1 (1)
- aspartic protease (1)
- assembly (1)
- association studies (1)
- asymptomatic bacteriuria (1)
- atomic force microscopy (1)
- atopic diseases (1)
- atrial natriuretic peptide (1)
- attributable fraction (1)
- attributable risk (1)
- auditorisch (1)
- auditory (1)
- auditory pathway (1)
- autoantibodies (1)
- autoantibody (1)
- autoimmunity (1)
- autophagocytose (1)
- autophagocytosis (1)
- autophagosome (1)
- autotransporter (1)
- bSSFP (1)
- bac-genomics-scripts (1)
- bacterial cancer therapy (1)
- bacterial fatty-acid biosynthesis (1)
- bacterial lipid rafts (1)
- bacterial nanocellulose (1)
- bacterial tumor targeting (1)
- bakterielle Flora (1)
- balanced steady state free precession (1)
- bark beetles (1)
- bee microbiota (1)
- bee-associated bacteria (1)
- bee-lining (1)
- bees (1)
- behavioral maturation (1)
- behavioral rhythms (1)
- beige adipocytes (1)
- benzimidazole (1)
- bestäuberfreundliche Pflanzen (1)
- beta actin (1)
- beta cell (1)
- beta-Arrestin2 (1)
- beta-Catenin (1)
- beta-adrenerge Signalwege (1)
- bicuculline (1)
- bilateral BAS model (1)
- binding mode (1)
- biochemistry (1)
- biodistribution (1)
- biodiversity (1)
- biofabrication (1)
- biofilm architecture (1)
- bioimage analysis (1)
- bioink (1)
- biokinetics (1)
- biolayerinterferometry (1)
- biological scaffolds (1)
- bioluminescence imaging (1)
- biomaterials (1)
- bioprocessing (1)
- bioreactor plattform (1)
- biosynthetic gene clusters (1)
- bipolar disorder (1)
- bipolare Störung (1)
- bispecific (1)
- bispezifisch (1)
- bitter taste (1)
- blood (1)
- blood cerebrospinal fluid barrier (1)
- blood glucose regulation (1)
- blood nerve barrier (1)
- blood-brain barrier (1)
- body axis (1)
- bone marrow niche (1)
- bone marrow transplantation (1)
- bone metastases (1)
- bone regeneration (1)
- brain (1)
- brood rearing (1)
- building behavior (1)
- bumblebee*s (1)
- burn wound (1)
- butyrophilin 3A (1)
- c-Jun Phosphorylierung (1)
- c-myc (1)
- cAMP signaling (1)
- cadherin-13 (1)
- caffeine (1)
- calcium activity (1)
- calcium homeostasis (1)
- calcium imaging (1)
- cancer therapy (1)
- candida (1)
- candida albicans (1)
- canine (1)
- carbon dioxide (1)
- cardiac imaging (1)
- cardiac magnetic resonance imaging (1)
- cardiac tissue (1)
- cardiac tissue engineering (1)
- cardiovascular (1)
- carnivorous plants (1)
- cartilage (1)
- cartilage regeneration (1)
- cd28 superagonists (1)
- cell adhesion (1)
- cell cycle (1)
- cell filaments (1)
- cell migration (1)
- cell therapy (1)
- cellular model (1)
- cellular-trafficking (1)
- central complex (1)
- chaperone (1)
- chemotherapy (1)
- children (1)
- chimeric antigen receptor (1)
- chlamydia trachomatis (1)
- chondrogene Differenzierung (1)
- chromatin accessibility (1)
- chromosome conformation capture (1)
- chronic kidney disease (1)
- chronic pain (1)
- chronophin (1)
- cine loop (1)
- circadian clock (1)
- circadian clocks (1)
- circuitopathies (1)
- claudin-12 (1)
- climate change (1)
- climate control (1)
- clock genes (1)
- closing of chromatin (1)
- co-culture (1)
- co-dependent expression (1)
- co-infection (1)
- coagulation factor XII (1)
- cochlea implant (1)
- cofactorbinding (1)
- cognitive decline (1)
- cognitive deficits (1)
- cognitive inhibition (1)
- cognitive remediation (1)
- cohesin (1)
- collective invasion (1)
- collybistin (1)
- colony recognition (1)
- color vision (1)
- comet assay (1)
- compartments (1)
- compound eyes (1)
- compressed sensing (1)
- conditional Knockout (1)
- confocal microscopy (1)
- conformational activation (1)
- context conditioning (1)
- contextual conditioning (1)
- contingency awareness (1)
- control (1)
- convolutional neural network (1)
- corneal confocal microscopy (1)
- coronary heart disease (1)
- correlation (1)
- cryokonservation (1)
- crystal structure (1)
- ctr (1)
- cushing's syndrome (1)
- cuticular hydrocarbons (1)
- cuticular leaf wax (1)
- cuticular transpiration barrier (1)
- cuticular water permeability (1)
- cuticular waxes (1)
- cyclase-associated protein (1)
- cyclase-associated protein 2 (1)
- cyclo-AMP (1)
- cytokine release syndrome (1)
- cytoskeletal reorganisation (1)
- dCIRL (1)
- dSTORM (1)
- decellularization (1)
- decision-making (1)
- defense (1)
- degeneratives Nervengewebe (1)
- delipidation (1)
- dendritic cells (1)
- dendritic cell-targeting (1)
- density weighting (1)
- desert plant (1)
- deubiquitinase (1)
- dexamethasone suppression test (1)
- diabetic cardiomyopathy (1)
- diagnostic Microarray (1)
- diagnostic accuracy (1)
- diagnostics (1)
- diagnostischer Microarray (1)
- diastolic dysfunction (1)
- differential RNA-seq (1)
- differential coverage binning (1)
- differential geneexpression (1)
- differentiation status (1)
- differenzielle Genexpression (1)
- dilated cardiomyopathy with ataxia (DCMA) (1)
- dimerer Naphthylisochinolin-Alkaloide (1)
- disease model (1)
- dispersal (1)
- distance (1)
- distribution (1)
- disulfide bonds (1)
- diversity (1)
- double-strand break repair (1)
- drift-diffusion model (1)
- drug (1)
- drug repurposing (1)
- dual RNA-seq (1)
- early detection (1)
- early neural precursors (1)
- early-life stress (1)
- early-onset isolated dystonia (1)
- eating behavior (1)
- eating disorders (1)
- echocardiography (1)
- ecoli_VF_collection (1)
- ecological validity (1)
- ectopic bone formation (1)
- ectopic release (1)
- effector protein (1)
- efflux pump (1)
- electroacupuncture (1)
- electrode scaffold (1)
- electroencephalogram (1)
- electron cryomicroscopy (1)
- electron tomography (1)
- electrospinning (1)
- embryonale Maus (1)
- emojis (1)
- emotional (1)
- emotional feedback (1)
- emotional information processing (1)
- emotional interference (1)
- emotional processing (1)
- emotionale Anspannung (1)
- emotionale Interferenz (1)
- emotions (1)
- endocytic recycling (1)
- endocytosis (1)
- endophyte (1)
- enhancers (1)
- enoyl ACP reductase (1)
- enoyl reductase (1)
- enoyl-ACP reductase (1)
- entero-aggregative-haemorrhagic Escherichia coli (EAHEC) (1)
- enteroinvasive (1)
- eosinophil (1)
- epidemiology (1)
- epigenetic (1)
- epithelial to mesenchymal transition (1)
- epithelial-mesenchymal transition (1)
- ereigniskorreliertes Potential (1)
- etiology (1)
- evozierte Potentiale (1)
- exotische Pflanzen (1)
- experimentelle autoimmune Enzephalomyelitis (1)
- exposition training (1)
- exposure therapy (1)
- extinction (1)
- extinction dynamics (1)
- extracellular signal–regulated kinases 1/2 (1)
- extrazelluläre Matrix (1)
- eye contact (1)
- eye tracking (1)
- eye-tracking (1)
- eyetracking (1)
- fabry disease (1)
- facial expressions (1)
- fast MR imaging (1)
- fatty acid biosynthesis (1)
- fatty acid synthesis (1)
- fear potentiated startle response (1)
- feasibility (1)
- feral bees (1)
- fgf (1)
- fibroblast growth factors (1)
- fibromyalgia sydrome (1)
- filtering (1)
- fitness (1)
- flagellum (1)
- fluorescence imaging (1)
- fluorescence microscopy (1)
- fluorescence resonance energy transfer (1)
- fluorescence resonance energy transfer (FRET) (1)
- flytrap (1)
- fmri activity (1)
- foamy viruses (1)
- follicular regulatory T cell (1)
- follikuläre regulatorische T-Zelle (1)
- food craving (1)
- forager (1)
- foraging (1)
- foraging activity (1)
- forest landscape (1)
- fragment screening (1)
- frameshifting (1)
- freezing of gait (1)
- frequency modulation (1)
- frogs (1)
- fruit cuticle (1)
- frühe neurale Vorläufer (1)
- functional connectivity (1)
- functional imaging (1)
- functional membrane microdomains (1)
- functional modules (1)
- functional neuroimaging (1)
- functional resting-state connectivity (1)
- functional selectivity (1)
- functional studies (1)
- fungal endophytes of grasses (1)
- fungi (1)
- fungus (1)
- funktionale Bildgebung (1)
- funktionelle Magnetresonanztomographie (1)
- funktionelle Module (1)
- funktionelle Resting-State Konnektivität (1)
- g-factor (1)
- gait analysis (1)
- gait initiation (1)
- gametocyt (1)
- gametocyte (1)
- gametogenesis (1)
- gamma delta T cells (1)
- gastrointestinal infection (1)
- gastronintestinal microbiota (1)
- gene environment interaction (1)
- gene-environmental interaction (1)
- genetic cytokine polymorphism (1)
- genetic modification (1)
- genetic screen (1)
- genome stability (1)
- genomic damage (1)
- genomic imaging (1)
- genomische Schäden (1)
- genotoxic agents (1)
- genotoxische Agenzien (1)
- gepaarte Vagusnerv-Stimulation (1)
- germinal center (1)
- germinative cell (1)
- gezielte Therapie (1)
- glutamate decarboxylase 65 (1)
- glycine receptor (1)
- glycine receptor autoantibodies (1)
- glycophytes (1)
- glycoprotein GPV (1)
- gonococcal (1)
- gonococcal infection (1)
- grass (1)
- guanine nucleotide exchange factor (1)
- guanylyl cyclase (GC) (1)
- guard cells (1)
- gustation (1)
- habitat (1)
- haloacid dehalogenase phosphatase (1)
- hearing (1)
- heart failure (1)
- heat shock proteins (1)
- hematopoiesis (1)
- hereditary spastic paraplegia (1)
- hiPSC aggregation (1)
- hibernation (1)
- high-pressure freezing/freeze substitution (1)
- high-throughput sequencing (1)
- histone variants (1)
- hnRNP (1)
- hnRNP R (1)
- homeostasis (1)
- homoFRET (1)
- honey bee density (1)
- honey bees (1)
- honeybee*s (1)
- honeybees (1)
- host colonization (1)
- huh6 (1)
- human (1)
- human adipose tissue (1)
- human chromosome 6 (1)
- human factor H (1)
- human induced pluripotent stem cells (1)
- human intestinal epithelium (1)
- human parthenogenetic neural stem cells (1)
- human parthenogenetic stem cells (1)
- human plasma (1)
- human primary cells (1)
- humanen induzierte pluripotente Stammzellen (1)
- humaner Faktor H (1)
- humans (1)
- hyaline cartilage (1)
- hyaluronic acid (1)
- hybrid (1)
- hybrid assembly (1)
- hydrogel (1)
- hyperekplexia (1)
- iNKT cell (1)
- iPSC-derived CMs (iPSC-CMs) (1)
- iPSCs (1)
- icaADBC (1)
- imaging (1)
- immediate early genes (1)
- immune escape (1)
- immune evasion (1)
- immune response (1)
- immune system (1)
- immunologic tolerance (1)
- immunological synapse (1)
- imprinting. (1)
- imunology (1)
- in situ microscopy (1)
- in vitro Kulturmodelle (1)
- in vitro Modelle (1)
- in vitro Testmodell (1)
- in vitro Testsystem (1)
- in vitro model (1)
- in vitro model system of inherited cardiomyopathies (1)
- in vitro neural differentiation (1)
- in vitro-Testsystem (1)
- in vivo study (1)
- induced pluripotent stem cells (1)
- induced pluripotent stem cells (iPSCs) (1)
- induzierte Phosphatasen MKP-1 und MKP-2 (1)
- infection biology (1)
- infectionmodel (1)
- infectionprocess (1)
- inferior frontal gyrus (1)
- inferiore frontale Gyrus (1)
- inflammatorische Gewebeschäden (1)
- influenza A virus (1)
- information processing (1)
- information use (1)
- inherited macrothrombocytopenia (1)
- inhibitor residence time (1)
- inhibitory postsynapse (1)
- innate immunity (1)
- insect visual learning (1)
- insects (1)
- insertion-site deep sequencing (1)
- instrumentelle Aktivitäten des täglichen Lebens (1)
- insulin (1)
- insulin resistance (1)
- intact bone imaging (1)
- integrins (1)
- interaction stress and circadian system (1)
- interactions (1)
- interferon (1)
- interleukin-5 signaling (1)
- internal dosimetry (1)
- interphase gap (1)
- interpulse interval (1)
- intestinal mucus (1)
- intestine (1)
- intracellular calcium release (1)
- intracellular domain (1)
- intraoperative Ankopplungseffizienz (1)
- intravenöse Immunglobuline (1)
- intrazelluläre Domäne (1)
- invariant NKT cells (1)
- invariante NKT Zellen (1)
- invasive meningococcal diseases (1)
- invasive pulmonary aspergillosis (1)
- ion channel (1)
- iron oxide contrast agent (1)
- ischemia reperfusion injury (1)
- ischämischer Schlaganfall (1)
- islets of Langerhans (1)
- jasmonate (1)
- juvenile hormone (1)
- kardiales Gewebe (1)
- kardiales Tissue Engineering (1)
- kardiovaskuläre Risikofaktoren (1)
- kidney development (1)
- kinesin (1)
- knockout (1)
- knockout-mice (1)
- kognitive Defizite (1)
- kognitive Remediation (1)
- kolorektale Karzinomzelllinien (1)
- konventionelle CD4 T Zellen (1)
- koronare Herzerkrankung (1)
- kutikuläre Kohlenwasserstoffe (1)
- kutikuläre Wasserpermeabilität (1)
- kutikuläres Blattwachs (1)
- l-type calcium channel antagonist (1)
- labeling techniques (1)
- lambdoid phage resistance (1)
- lambdoid prophage (1)
- lasiocarpine (1)
- late enhancement (1)
- late gadolinium-enhancement (1)
- leaf cuticle (1)
- leaf-cutting ants (1)
- learned helplessness (1)
- learning and behaviour (1)
- leishmaniasis (1)
- lightsheet microscopy (1)
- lipid remodeling (1)
- liver (1)
- local point-spread function (1)
- local translation (1)
- locomotor network (1)
- logging (1)
- lokale Proteinsynthese (1)
- long-term memory formation (1)
- luciferase assay (1)
- lysosome (1)
- lytic infection (1)
- lytic phage resistance (1)
- mRNA processing (1)
- mRNA translation (1)
- mRNA-Translation (1)
- mTOR (1)
- machine learning (1)
- macrocolony (1)
- macrophage (1)
- macrophages (1)
- malnourishment (1)
- mammalian cells (1)
- marine sponges (1)
- mastitis (1)
- mastitis-associated Escherichia coli (MAEC) (1)
- mean first passage time (1)
- measles virus infection (1)
- mechanistische Modellierung (1)
- mechanosensing (1)
- mechanosensitive channels (1)
- medaka (1)
- medical device (1)
- megachilid bees (1)
- megakaryocytes (1)
- melanocytic nevi (1)
- melanoma cancer (1)
- melanoma dedifferentiation (1)
- melt electrowriting (1)
- membrane dynamics (1)
- membrane trafficking (1)
- memory (1)
- memory B cells (1)
- meniscus implant (1)
- menschliches Darmepithel (1)
- mental health (1)
- metabolic modelling (1)
- metabolic theory of ecology (1)
- metabolite repair (1)
- metabolomics (1)
- metallo protease (1)
- metapopulation (1)
- metatranscriptome (1)
- methionine biosynthesis (1)
- methylphenidate (1)
- miR-17~92 (1)
- miR-21 (1)
- miR-223-5p (1)
- miR-23a cluster (1)
- miR-26 (1)
- miRNA Biogenesis (1)
- miRNA target (1)
- mice (1)
- micro processor complex (1)
- microRNA biogenesis (1)
- microbial transmission (1)
- microbiology (1)
- microbiota (1)
- microelectrode array (1)
- microglomeruli (1)
- microinjection (1)
- micronuclei (1)
- microprocessor complex (1)
- microrna (1)
- mild cognitive impairment (1)
- minimum leaf conductance (1)
- mitochondria (1)
- mitogen cascade (1)
- mobil phone radiation (1)
- molecular biology of cytokines (1)
- molecular mechanism (1)
- monarch butterfly (1)
- monoclonal antibodies (1)
- monoclonal antibody (1)
- monoclonal antibody 103.2 (1)
- monoclonal antibody 20.1 (1)
- monocyte-derived dendritic cells (1)
- monoklonale Antikörper (1)
- monozytenderivierte dendritische Zellen (1)
- mossy fiber synapse (1)
- mossy fiber terminal (1)
- motoneurons (1)
- motor neuron (1)
- mouse platelets (1)
- movement disorders (1)
- movement interaction (1)
- mucormycosis (1)
- mukosale Immunantwort (1)
- multi-drug-resistance (1)
- multi-modal stimuli (1)
- multi-photon microscopy (1)
- multi-pinhole collimation (1)
- multiphoton microscopy (1)
- multiple sclerosis (1)
- murine (1)
- murine leishmaniasis (1)
- murines Modell der aufsteigenden Harnwegsinfektion (1)
- muscarinic m ACh receptors (1)
- mushroom body (1)
- mushroom body calyx microglomeruli (1)
- muskarinische Rezeptoren (1)
- mutualism (1)
- mutually exclusive expression (1)
- myelin barrier (1)
- myeloablation (1)
- myeloid derived suppressor cells (1)
- myocardial deformation (1)
- myocarditis (1)
- myokardiale Arbeit (1)
- nanotubes (1)
- ncRNA (1)
- near-infrared spectroscopy (1)
- nest climate (1)
- nesting behaviour (1)
- networkanalysis (1)
- neuer anti-infektiver Substanzen (1)
- neural biomarkers (1)
- neurodevelopment (1)
- neurodevelopmental disorders (1)
- neuroepithelial progenitors (1)
- neuroepitheliale Vorläufer (1)
- neurogenesis (1)
- neuroinflammation (1)
- neurologin-2 (1)
- neuromodulation (1)
- neuron (1)
- neuronal activation (1)
- neuronal cell death (1)
- neuronal excitability (1)
- neuronal network (1)
- neuronal nitric oxide synthase (1)
- neuronal visual system (1)
- neuronale Stickstoffmonoxidsynthase (1)
- neuropathic pain (1)
- neuropaticher Schmerz (1)
- neuropeptide S receptor gene (1)
- neuropeptide Y (1)
- neuropeptides (1)
- neuroprotection (1)
- neuropsychiatric disorders (1)
- neuropsychiatrische Störungen (1)
- neuroscience (1)
- neutrophil (1)
- neutrophils (1)
- next generation sequencing (1)
- nicht-viraler Gentransfer (1)
- nicht-visuell (1)
- nichtinvasive Bildgebung (1)
- nitric oxide (1)
- nitrogen regulation (1)
- nociception (1)
- nociceptors (1)
- non-coding RNA (1)
- non-ionizing radiation (1)
- non-visual (1)
- nuclear architecture (1)
- nuclear export signal (1)
- nuclear localization signal (1)
- nuclesosome positioning (1)
- nucleus (1)
- nurse bee (1)
- nutrients (1)
- nutrition (1)
- object segmentation (1)
- oilpalm plantation (1)
- oligopeptide transport (1)
- oncogenes (1)
- oncogenic signalling network (1)
- onkogenes Signalnetzwerk (1)
- opening of chromatin (1)
- opioid peptide (1)
- opioid receptor (1)
- opioid receptors (1)
- optogenetics (1)
- orientation (1)
- oscillations (1)
- ovarian cancer (1)
- ovarian carcinoma (1)
- oxidative stress (1)
- oxidativer Stress (1)
- oxidierte Phospholipide (1)
- p34 (1)
- p38MAPK (1)
- p44 (1)
- p97 (1)
- pICln (1)
- pain (1)
- pain regulation (1)
- pancreatic cancer (1)
- pancreatic differentiation (1)
- panic disorder (1)
- parasitology (1)
- parathyroid hormone (1)
- parkinson's disease (1)
- pathophysiological mechanisms (1)
- pathotypes (1)
- pdxp (1)
- pea aphid (1)
- pediatric hematology oncology (1)
- peptide engineering (1)
- peptide-based interleukin-5 inhibitor (1)
- performance evaluation (1)
- perfused hydrogel (1)
- peripheral analgesia (1)
- peripheral nerve trauma (1)
- peripheral nervous system (1)
- permeability (1)
- permeance (1)
- permeation (1)
- personality traits (1)
- pflegende Angehörige (1)
- phage resistance (1)
- pharmacology (1)
- pheromone (1)
- phosphoantigen (1)
- phosphoglycolate phosphatase (1)
- phospholipase D (1)
- phosphorylation (1)
- phosphorylation sites (1)
- photoinduced electron transfer (1)
- photoinduzierter Elektronentransfer (1)
- phylogeny (1)
- plant defense (1)
- plant-bee visitation networks (1)
- platelet aggregation (1)
- platelet biogenesis (1)
- pluripotency (1)
- podosome formation (1)
- point-of-care (1)
- polarization (1)
- polarized epithelium (1)
- pollen (1)
- pollen analysis (1)
- pollen foraging (1)
- pollen metabarcoding (1)
- pollinator friendly plants (1)
- polyethism (1)
- polymer (1)
- polymorphism (1)
- polyradiculoneuropathy (1)
- population attributable fraction (1)
- post-transcriptional regulation (1)
- postradiogene Xerostomie (1)
- posttranscriptional regulation (1)
- potenzielles therapeutisches Target (1)
- precision medicine (1)
- preclinical PET (1)
- predictors and correlates (1)
- prefrontal cortex (1)
- prenatal stress (1)
- presynaptic (1)
- primary ciliary dyskinesia (1)
- primary-cell-derived immortalized cell line (1)
- primate (1)
- probiotica (1)
- proboscis extension response (1)
- profiles (1)
- progenitors (1)
- programmed ribosomal frameshifting (1)
- promoter invasion (1)
- proplatelets (1)
- protease activity (1)
- protease inhibitor (1)
- proteasome (1)
- protein disulfide isomerase (1)
- protein folding (1)
- protein immobilization (1)
- protein kinase D1 (1)
- protein kinase a (1)
- protein regulation and expression (1)
- protein-DNA interactions (1)
- protein-lipid interactions (1)
- protein-protein-interaction (1)
- pränataler Stress (1)
- psychophysiology (1)
- psychosocial resilience (1)
- psychosocial stress (1)
- psychotherapeutic intervention (1)
- psychotherapeutische Intervention (1)
- pyrrolidine carboxamides (1)
- quiescence (1)
- rIFG (1)
- rRNA processing (1)
- rac1 inhibitors (1)
- radial MR imaging (1)
- radionuclide (1)
- radionuclide therapy (1)
- ranskranielle magnetische Stimulation (1)
- rapid evolution (1)
- rat (1)
- reactive oxygen species (1)
- real-time imaging (1)
- reception (1)
- receptor signaling (1)
- reciprocity (1)
- reconstruction (1)
- reduction of ERK1/2 phosphorylation (1)
- reduction of cells proliferation (1)
- regenerative medicine (1)
- regional analgesia (1)
- regulatorische T Zellen (1)
- regulatory RNA (1)
- reinforcement sensitivity theory (1)
- replication (1)
- reporter screen (1)
- research software (1)
- resilience (1)
- resin (1)
- resolution (1)
- responsiveness (1)
- resting tremor (1)
- restriction factors (1)
- resveratrol (1)
- retinal development (1)
- reverse Transkription (1)
- reverse genetics (1)
- reverse transcription (1)
- reversible oxidation (1)
- rheumatoide Arthritis (1)
- rho gtpases (1)
- ribosomal RNA (1)
- ribosomale RNS (1)
- ribosome biogenesis (1)
- ribosome profiling (1)
- riboswitch (1)
- risk factors (1)
- rodent model (1)
- rtPA (1)
- salinen Wachstumsbedingungen (1)
- salt stress (1)
- sand mine (1)
- saure Sphingomyelinase (1)
- scale-up (1)
- schnelle Evolution (1)
- screening (1)
- second messenger (1)
- secondary metabolites (1)
- secondary prevention (1)
- secreted aspartic protease (1)
- secreted factors (1)
- secretion (1)
- secretory properties (1)
- seed coat (1)
- seed treatment (1)
- self-activation (1)
- self-regulation (1)
- self-targeting CRISPR-Cas (1)
- senecionine (1)
- seneciphylline (1)
- senescence (1)
- sensitivity (1)
- sensorische Neurone (1)
- sequence-structure (1)
- serine protease (1)
- serotonerges System (1)
- serotonin (1)
- serotonin deficiency (1)
- serotonin transporter (1)
- sexual stage surface proteins (1)
- short neuropeptide F (1)
- sifA (1)
- sigma factor (1)
- signaling pathway (1)
- signaltransduction (1)
- similarity (1)
- single cell anatomy (1)
- single molecule microscopy (1)
- single-cell RNA sequencing (1)
- single-cell genomics (1)
- single-molecule imaging (1)
- single-molecule localization microscopy (1)
- single-molecule microscopy (1)
- site directed immobilization (1)
- site-specific immobilization (1)
- skin (1)
- skin biopsy (1)
- skin cancer (1)
- skin model (1)
- small RNA expression (1)
- small fiber pathology (1)
- small intestinal submucosa (1)
- small proteins (1)
- small-animal SPECT (1)
- smell (1)
- smells (1)
- snoRNA (1)
- social cognition (1)
- social interaction (1)
- social stimuli (1)
- social understanding (1)
- solitary bee nests (1)
- somatic resilience (1)
- somatostatin receptor antagonists (1)
- soziale Insekten (1)
- spatial organization (1)
- specific phobia (1)
- speckle tracking (1)
- spezifische Phobie (1)
- sphingolipid (1)
- spider phobia (1)
- spiral trajectory (1)
- splicing (1)
- sponge microbiome (1)
- spontaneous neuronal activity (1)
- ssVEP (1)
- stachellose Biene (1)
- stachellose Bienen (1)
- steady-state visually evoked potentials (1)
- stem (1)
- stem cells (1)
- stiff person syndrome (1)
- stingless bees (1)
- store-operated calcium entry (1)
- strain (1)
- strain rate (1)
- stream (1)
- streptozotocin (1)
- stress response (1)
- striatum (1)
- stroop task (1)
- structural mechanism (1)
- structure analysis (1)
- structure based drug design (1)
- structure-based drug design (1)
- structure-function relationships (1)
- stx-Phagen (1)
- stx-phages (1)
- subcutaneous implanation (1)
- subthalamic nucleus (1)
- sugar perception (fructose, sucrose) (1)
- sugar receptor (1)
- sumo (1)
- sumoylation (1)
- superagonistische Funktion (1)
- superparamagnetische Eisenoxid Kontrastmittel (1)
- suspension culture (1)
- sustained fear (1)
- synaptic proteins (1)
- synaptische Plastizität (1)
- synaptische Proteine (1)
- synthetic lethal interaction (1)
- synthetisch lethale Interaktion (1)
- systemic inflammation (1)
- systems biology (1)
- t cell (1)
- tactil (1)
- tactile (1)
- tapeworm (1)
- tdcs (1)
- telomere-associated protein (1)
- temperate zones (1)
- temporal information transfer (1)
- temporal organization (1)
- temporo-parietal junction (1)
- terahertz radiation (1)
- terpenes (1)
- test system (1)
- th1/th2 polarization (1)
- therapeutic strategy (1)
- therapeutisches Target (1)
- therapy (1)
- therapy of glioblastoma (1)
- therapy outcome (1)
- therapy simulation (1)
- thermal orientation (1)
- thermotolerance (1)
- theta burst stimulation (1)
- think/no-think (1)
- thiostrepton (1)
- threat conditioning (1)
- thrombin (1)
- thrombo-inflammation (1)
- thrombosis (1)
- thyroid stimulating hormone receptor (1)
- time-correlated single photon counting (TCSPC) (1)
- time-resolved anisotropy (1)
- timing (1)
- tissue model (1)
- tolerance (1)
- tolerogen (1)
- tolerogenic (1)
- tool (1)
- tool-use (1)
- torque meter (1)
- tracheal cytotoxin (1)
- trachomatis (1)
- trade-offs (1)
- trans-Golgi network (1)
- transcranial Direct Current Stimulation (tDCS) (1)
- transcranial direct current stimulation (1)
- transcription factor (1)
- transcription regulator (1)
- transcription/replication conflicts (1)
- transcriptional termination site (1)
- transcriptome (1)
- transcriptome analysis (1)
- transcriptome data analysis (1)
- transcriptome profiling (1)
- transcriptomic analysis (1)
- transcutaneous vagus nerve stimulation (1)
- transfer (1)
- transgenes Modell (1)
- transient dynamics (1)
- transmission blocking vaccine (1)
- transpiration barrier (1)
- transport (1)
- transporter regulator (1)
- tuberculosis (1)
- tumor angiogenesis (1)
- tumor metabolism (1)
- tumor vascular morphologie (1)
- tumorspezifische Therapie (1)
- tumour (1)
- two-component (1)
- type 1 diabetes (1)
- tyrosine kinase (1)
- ubiquitin (1)
- ubiquitin chain formation (1)
- ubiquitin linkage specificity (1)
- ubiquitin recognition (1)
- ultimatum game (1)
- unconventional T cells (1)
- unklarer Signifikanz (1)
- vaccine (1)
- vacuole (1)
- validation study (1)
- variant surface glycoprotein (1)
- variational network (1)
- varroa (1)
- vascular cell adhesion molecules (1)
- vascular smooth muscle cells (1)
- vascular system (1)
- vaskuläre Adhäsionsmoleküle (1)
- vaskuläre glatte Muskelzelle (1)
- vaskuläre glatte Muskelzellen (1)
- vasp (1)
- vav2 (1)
- vdr (1)
- ve-cadherin (1)
- venus (1)
- viral genome packaging (1)
- viral miRNAs (1)
- virological synapse (1)
- virtual reality T-maze (1)
- virulence factors (1)
- virus transmission (1)
- vision (1)
- visual attention (1)
- visual cue (1)
- visual perception (1)
- visuelles Langzeitgedächtnis (1)
- vitamin d (1)
- vitamin d receptor (1)
- vmPFC (1)
- waggle dance (1)
- waggle dance decoding (1)
- water fat separation (1)
- water loss (1)
- wax (1)
- wild-living honey bees (1)
- workbench (1)
- x-ray micro computed tomography (1)
- xiphophorus (1)
- yeast (1)
- zeitgeber (1)
- zeitlich Informationsübertragung (1)
- zeitliche Organisation (1)
- zeitliche Trends (1)
- zentrale Spindel und Mittelkörper (1)
- zielgerichtete Therapien (1)
- zonal Hydrogels (1)
- zyklische Peptide (1)
- µ-Opioid Rezeptor (1)
- Ängstliche Depression (1)
- Ätiologie (1)
- Ölpalmenanbau (1)
- Überexpression (1)
- Übertragungsfunktion (1)
- Übung (1)
- ß-adrenerge Rezeptoren (1)
- ß-adrenergic Receptors (1)
- ΔNp63 (1)
- α-synuclein (1)
- β3 adrenergic receptor (1)
- γδ T cells (1)
Institute
- Graduate School of Life Sciences (974) (remove)
Sonstige beteiligte Institutionen
- Helmholtz Institute for RNA-based Infection Research (HIRI) (5)
- Universitätsklinikum Münster (3)
- Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg (2)
- Zentrum für Infektionsforschung (ZINF) Würzburg (2)
- Bio-Imaging Center Würzburg (1)
- Biomedical Center Munich, Department of Physiological Chemistry, Ludwig-Maximilians-Universität München (1)
- CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - the development agency of the Brazilian Federal Government (1)
- CBIO, University of Cape Town, South Africa (1)
- Carl-Ludwig-Institut für Physiologie, Universität Leipzig (1)
- Chair of Experimental Biomedicine I (1)
Electrochemical impedance spectroscopy (EIS) is a valuable technique analyzing electrochemical behavior of biological systems such as electrical characterization of cells and biomolecules, drug screening, and biomaterials in biomedical field. In EIS, an alternating current (AC) power signal is applied to the biological system, and the impedance of the system is measured over a range of frequencies.
In vitro culture models of endothelial or epithelial barrier tissue can be achieved by culturing barrier tissue on scaffolds made with synthetic or biological materials that provide separate compartments (apical and basal sides), allowing for further studies on drug transport. EIS is a great candidate for non-invasive and real-time monitoring of the electrical properties that correlate with barrier integrity during the tissue modeling. Although commercially available transendothelial/transepithelial electrical resistance (TEER) measurement devices are widely used, their use is particularly common in static transwell culture. EIS is considered more suitable than TEER measurement devices in bioreactor cultures that involve dynamic fluid flow to obtain accurate and reliable measurements. Furthermore, while TEER measurement devices can only assess resistance at a single frequency, EIS measurements can capture both resistance and capacitance properties of cells, providing additional information about the cellular barrier's characteristics across various frequencies. Incorporating EIS into a bioreactor system requires the careful optimization of electrode integration within the bioreactor setup and measurement parameters to ensure accurate EIS measurements. Since bioreactors vary in size and design depending on the purpose of the study, most studies have reported using an electrode system specifically designed for a particular bioreactor. The aim of this work was to produce multi-applicable electrodes and established methods for automated non-invasive and real-time monitoring using the EIS technique in bioreactor cultures. Key to the electrode material, titanium nitride (TiN) coating was fabricated on different substrates (materials and shape) using physical vapor deposition (PVD) and housed in a polydimethylsiloxane (PDMS) structure to allow the electrodes to function as independent units. Various electrode designs were evaluated for double-layer capacitance and morphology using EIS and scanning electron microscopy (SEM), respectively. The TiN-coated tube electrode was identified as the optimal choice. Furthermore, EIS measurements were performed to examine the impact of influential parameters related to culture conditions on the TiN-coated electrode system. In order to demonstrate the versatility of the electrodes, these electrodes were then integrated into in different types of perfusion bioreactors for monitoring barrier cells. Blood-brain barrier (BBB) cells were cultured in the newly developed dynamic flow bioreactor, while human umblical vascular endothelial cells (HUVECs) and Caco-2 cells were cultured in the miniature hollow fiber bioreactor (HFBR). As a result, the TiN-coated tube electrode system enabled investigation of BBB barrier integrity in long-term bioreactor culture. While EIS measurement could not detect HUVECs electrical properties in miniature HFBR culture, there was the possibility of measuring the barrier integrity of Caco-2 cells, indicating potential usefulness for evaluating their barrier function. Following the bioreactor cultures, the application of the TiN-coated tube electrode was expanded to hemofiltration, based on the hypothesis that the EIS system may be used to monitor clotting or clogging phenomena in hemofiltration. The findings suggest that the EIS monitoring system can track changes in ion concentration of blood before and after hemofiltration in real-time, which may serve as an indicator of clogging of filter membranes. Overall, our research demonstrates the potential of TiN-coated tube electrodes for sensitive and versatile non-invasive monitoring in bioreactor cultures and medical devices.
Barth Syndrome (BTHS) is an inherited X-chromosomal linked disorder, characterized by early development of cardiomyopathy, immune system defects, skeletal muscle myopathy and growth retardation. The disease displays a wide variety of symptoms including heart failure, exercise intolerance and fatigue due to the muscle weakness. The cause of the disease are mutations in the gene encoding for the mitochondrial transacylase Tafazzin (TAZ), which is important for remodeling of the phospholipid cardiolipin (CL). All mutations result in a pronounced decrease of the functional enzyme leading to an increase of monolysocardiolipin (MLCL), the precursor of mature CL, and a decrease in mature CL itself. CL is a hallmark phospholipid of mitochondrial membranes, highly enriched in the inner mitochondrial membrane (IMM). It is not only important for the formation of the cristae structures, but also for the function of different protein complexes associated with the mitochondrial membrane. Reduced levels of mature CL cause remodeling of the respiratory chain supercomplexes, impaired respiration, defects in the Krebs cycle and a loss of mitochondrial calcium uniporter (MCU) protein. The defective Ca2+ handling causes impaired redox homeostasis and energy metabolism resulting in cellular arrhythmias and defective electrical conduction. In an uncompensated situation, blunting mitochondrial Ca2+ uptake provokes increased mitochondrial emission of H2O2 during workload transitions, related to oxidation of NADPH, which is required to regenerate anti-oxidative enzymes. However, in the hearts and cardiac myocytes of mice with a global knock-down of the Taz gene (Taz-KD), no increase in mitochondrial ROS was observed, suggesting that other metabolic pathways may have compensated for reduced Krebs cycle activation.
The healthy heart produces most of its energy by consuming fatty acids. In this study, the fatty acid uptake into mitochondria and their further degradation was investigated, which showed a switch of the metabolism in general in the Taz-KD mouse model. In vivo studies revealed an increase of glucose uptake into the heart and decreased fatty acid uptake and oxidation. Disturbed energy conversion resulted in activation of retrograde signaling pathways, implicating overall changes in the cell metabolism. Upregulated integrated stress response (ISR) was confirmed by increased levels of the downstream target, i.e., the activating transcription factor 4 (ATF4). A Tafazzin knockout mouse embryonal fibroblast cell model (TazKO) was used to inhibit the ISR using siRNA transfection or pharmaceutical inhibition. This verified the central role of
II
the ISR in regulating the metabolism in BTHS. Moreover, an increased metabolic flux into glutathione biosynthesis was observed, which supports redox homeostasis. In vivo PET-CT scans depicted elevated activity of the xCT system in the BTHS mouse heart, which transports essential amino acids for the biosynthesis of glutathione precursors. Furthermore, the stress induced signaling pathway also affected the glutamate metabolism, which fuels into the Krebs cycle via -ketoglutarate and therefore supports energy converting pathways. In summary, this thesis provides novel insights into the energy metabolism and redox homeostasis in Barth syndrome cardiomyopathy and its regulation by the integrated stress response, which plays a central role in the metabolic alterations. The aim of the thesis was to improve the understanding of these metabolic changes and to identify novel targets, which can provide new possibilities for therapeutic intervention in Barth syndrome.
Sepsis ist ein häufiges und akut lebensbedrohliches Syndrom, das eine Organfunktionsstörung in Folge einer dysregulierten Immunantwort auf eine Infektion beschreibt. Eine frühzeitige Diagnosestellung und Therapieeinleitung sind von zentraler Bedeutung für das Überleben der Patient:innen. In einer Pilotstudie konnte unsere Forschungsgruppe mittels Durchflusszytometrie eine ausgeprägte Hyporeaktivität der Thrombozyten bei Sepsis nachweisen, die einen potenziell neuen Biomarker zur Sepsis-Früherkennung darstellt. Zur Evaluation des Ausmaßes und Entstehungszeitpunktes der detektierten Thrombozytenfunktionsstörung wurden im Rahmen der vorliegenden Arbeit zusätzlich zu Patient:innen mit Sepsis (SOFA-Score ≥ 2; n=13) auch hospitalisierte Patient:innen mit einer Infektion ohne Sepsis (SOFA-Score < 2; n=12) rekrutiert. Beide Kohorten wurden zu zwei Zeitpunkten (t1: <24h; t2: Tag 5-7) im Krankheitsverlauf mittels Durchflusszytometrie und PFA-200 untersucht und mit einer gesunden Kontrollgruppe (n=28) verglichen.
Phänotypische Auffälligkeiten der Thrombozyten bei Sepsis umfassten: (i) eine veränderte Expression verschiedener Untereinheiten des GPIb-IX-V-Rezeptorkomplexes, die auf ein verstärktes Rezeptor-Shedding hindeutet; (ii) ein ausgeprägtes Mepacrin-Beladungsdefizit, das auf eine zunehmend reduzierte Anzahl von δ-Granula entlang des Infektion-Sepsis Kontinuums hinweist; (iii) eine Reduktion endständig gebundener Sialinsäure im Sinne einer verstärkten Desialylierung. Die funktionelle Analyse der Thrombozyten bei Sepsis ergab bei durchflusszytometrischer Messung der Integrin αIIbβ3-Aktivierung (PAC-1-Bindung) eine ausgeprägte generalisierte Hyporeaktivität gegenüber multiplen Agonisten, die abgeschwächt bereits bei Infektion nachweisbar war und gemäß ROC-Analysen gut zwischen Infektion und Sepsis diskriminierte (AUC >0.80 für alle Agonisten). Im Gegensatz dazu zeigten Thrombozyten bei Sepsis und Analyse mittels PFA-200 unter Einfluss physiologischer Scherkräfte eine normale bis gar beschleunigte Aggregation.
Die Reaktivitätsmessung von Thrombozyten mittels Durchflusszytometrie stellt weiterhin einen vielversprechenden Biomarker für die Sepsis-Früherkennung dar. Für weitere Schlussfolgerungen ist jedoch eine größere Kohorte erforderlich. In nachfolgenden Untersuchungen sollten zudem mechanistische Ursachen der beschriebenen phänotypischen und funktionellen Auffälligkeiten von Thrombozyten bei Infektion und Sepsis z.B. mittels Koinkubationsexperimenten untersucht werden.
Platelets play an important role in haemostasis by mediating blood clotting at sites of blood vessel damage. Platelets, also participate in pathological conditions including thrombosis and inflammation. Upon vessel damage, two glycoprotein receptors, the GPIb-IX-V complex and GPVI, play important roles in platelet capture and activation.
GPIb-IX-V binds to von Willebrand factor and GPVI to collagen. This initiates a signalling cascade resulting in platelet shape change and spreading, which is dependent on the actin cytoskeleton. This thesis aimed to develop and implement different super-resolution microscopy techniques to gain a deeper understanding of the conformation and location of these receptors in the platelet plasma membrane, and to provide insights into their signalling pathways. We suggest direct stochastic optical reconstruction microscopy (dSTORM) and structured illumination microscopy (SIM) as the best candidates for imaging single platelets, whereas expansion microscopy (ExM) is ideal for imaging platelets aggregates.
Furthermore, we highlighted the role of the actin cytoskeleton, through Rac in GPVI signalling pathway. Inhibition of Rac, with EHT1864 in human platelets induced GPVI and GPV, but not GPIbα shedding. Furthermore, EHT1864 treatment did not change GPVI dimerisation or clustering, however, it decreased phospholipase Cγ2 phosphorylation levels, in human, but not murine platelets, highlighting interspecies differences. In summary, this PhD thesis demonstrates that; 1) Rac alters GPVI signalling pathway in human but not mouse platelets; 2) our newly developed ExM protocol can be used to image platelet aggregates labelled with F(ab’) fragments
Early-onset torsion dystonia (DYT-TOR1A, DYT1) is an inherited hyperkinetic movement disorder caused by a mutation of the TOR1A gene encoding the torsinA protein. DYT-TOR1A is characterized as a network disorder of the central nervous system (CNS), including predominantly the cortico-basal ganglia-thalamo-cortical loop resulting in a severe generalized dystonic phenotype. The pathophysiology of DYTTOR1A is not fully understood. Molecular levels up to large-scale network levels of the CNS are suggested to be affected in the pathophysiology of DYT-TOR1A. The reduced penetrance of 30% - 40% indicates a gene-environmental interaction, hypothesized as “second hit”. The lack of appropriate and phenotypic DYT-TOR1A animal models encouraged us to verify the “second hit” hypothesis through a unilateral peripheral nerve trauma of the sciatic nerve in a transgenic asymptomatic DYT-TOR1A rat model (∆ETorA), overexpressing the human mutated torsinA protein. In a multiscale approach, this animal model was characterized phenotypically and pathophysiologically.
Nerve-injured ∆ETorA rats revealed dystonia-like movements (DLM) with a partially generalized phenotype. A physiomarker of human dystonia, describing increased theta oscillation in the globus pallidus internus (GPi), was found in the entopeduncular nucleus (EP), the rodent equivalent to the human GPi, of nerve-injured ∆ETorA rats. Altered oscillation patterns were also observed in the primary motor cortex. Highfrequency stimulation (HFS) of the EP reduced DLM and modulated altered oscillatory activity in the EP and primary motor cortex in nerve-injured ∆ETorA rats. Moreover, the dopaminergic system in ∆ETorA rats demonstrated a significant increased striatal dopamine release and dopamine turnover. Whole transcriptome analysis revealed differentially expressed genes of the circadian clock and the energy metabolism, thereby pointing towards novel, putative pathways in the pathophysiology of DYTTOR1A dystonia.
In summary, peripheral nerve trauma can trigger DLM in genetically predisposed asymptomatic ΔETorA rats leading to neurobiological alteration in the central motor network on multiple levels and thereby supporting the “second hit” hypothesis. This novel symptomatic DYT-TOR1A rat model, based on a DYT-TOR1A genetic background, may prove as a valuable chance for DYT-TOR1A dystonia, to further investigate the pathomechanism in more detail and to establish new treatment strategies.
Das Masernvirus (MV) kann in Erkrankten eine schwere, langanhaltende Immunsuppression verursachen, wodurch Infektionen mit opportunistischen Pathogenen begünstigt werden. Diese basiert auf einer Paralyse der hämatopoetischen Zellen, welche das Virus durch Kontakt eines viralen Glykoproteinkomplexes zu einem unbekannten RezeptorX auf der Zell- Oberfläche induzieren kann. Kerncharakterisitika hiervon sind unter anderem die Herabregulation der Akt-Kinase-Phosphorylierung, die Inhibition der zellulären Proliferation und die Aktivierung der neutralen Sphingomyelinase 2 (NSM2).
In einem kinetischen Phosphoproteom konnten zwei potentielle Interaktionsrezeptoren des MV identifiziert werden: CD43 und P2X3. Das hochglykosylierte Oberflächenmolekül CD43 ist auf hämatopoetischen Zellen ubiquitär exprimiert und reguliert in T-Zellen deren Überleben, Proliferation, Aktivierung, Migration und Adhäsion. P2X3 wird in hämatopoetischen Zellen nur in geringem Maße exprimiert. Seine funktionelle Bedeutung ist in diesem Kompartiment nicht bekannt. Beide Kandidaten wurden mittels CRISPR/Cas9 Verfahren einzeln oder kombiniert aus Jurkat-T-Zellen ablatiert, welche nachfolgend nach MV-Kontakt hinsichtlich der oben erwähnten MV-modulierten Parameter getestet wurden. Zusätzlich wurden iso- und allosterische P2X3-Inhibitoren an primären und Jurkat-T-Zellen verwendet, um dessen Rolle in Ca2+-Mobilisierung und Proliferation nach T-Zell-Rezeptor Co-Stimulation zu analysieren.
Die genetische Depletion beider Rezeptor-Kandidaten verringerte die Effekte des MV auf alle getesteten Parameter signifikant, was darauf hindeutet, dass beide Proteine entscheidend an der T-Zell-Suppression beteiligt sind. Während die isosterische Inhibition von P2X3 keinen Effekt hatte, wurde die Proliferation primärer T-Zellen durch dessen allosterische Inhibition vor Co-Stimulation fast verdoppelt und die Effizienz der Ca2+-Mobilisierung in Jurkat- und primären T-Zellen signifikant erhöht. In P2X3-depletierten Jurkat-Zellen hingegen war die Ca2+-Mobilisierung nach Stimulation signifikant geringer als in WT-Zellen.
In dieser Arbeit konnten zwei wichtige Mediatoren der MV induzierten T-Zell-Suppression identifiziert werden. Vor allem P2X3, dessen Expression, Regulation und funktionelle Bedeutung im hämatopoetischen Kompartiment noch nicht erforscht wurde, könnte ein vielversprechender Kandidat für eine antivirale Therapie darstellen, da ein klinisch getesteter P2X3-Inhibitor bereits verfügbar ist.
After priming in Peyer's patches (PPs) and mesenteric lymph nodes (mLN) T- cells infiltrate the intestine through lymphatic draining and homing through the bloodstream. However, we found that in mouse models of acute graft-versus-host disease (GvHD), a subset of alloreactive T-cells directly migrates from PPs to the adjacent intestinal lamina propria (LP), bypassing the normal lymphatic drainage and vascular trafficking routes. Notably, this direct migration occurred in irradiated and unirradiated GvHD models, indicating that irradiation is not a prerequisite for this observed behavior.
Next, we established a method termed serial intravascular staining (SIVS) in mouse models to systematically investigate the trafficking and migration of donor T- cells in the early stages of acute GvHD initiation. We found that the direct migration of T-cells from PPs to LP resulted in faster recruitment of cells after allogeneic hematopoietic cell transplantation (allo-HCT). These directly migrating T-cells were found to be in an activated and proliferative state, exhibiting a TH1/TH17-like phenotype and producing cytokines such as IFN-γ and TNF-α. Furthermore, we observed that the directly migrating alloreactive T-cells expressed specific integrins (α4+, αE+) and chemokine receptors (CxCR3+, CCR5+, and CCR9+). Surprisingly, blocking these integrins and chemokine-coupled receptors did not hinder the direct migration of T- cells from PPs to LP, suggesting the involvement of alternative mechanisms. Previous experiments ruled out the involvement of S1PR1 and topographical features of macrophages, leading us to hypothesize that mediators of cytoskeleton reorganization, such as Coro1a, Dock2, or Cdc42, may play a role in this unique migration process.
Additionally, we observed that directly migrating T-cells created a local inflammatory microenvironment, which attracts circulating T-cells. Histological analysis confirmed that alloreactive PPs-derived T-cells and bloodborne T-cells colocalized. We employed two experimental approaches, including either photoconversion of T-cells in PPs or direct transfer of activated T-cells into the vasculature, to demonstrate this colocalization. We hypothesize that cytokines released by migrating T-cells, such as IFN-γ and TNF-α, may play a role in recruiting T-cells from the vasculature, as inhibiting chemokine-coupled receptors did not impair recruitment.
Gastroesophageal junction (GEJ), demarcating the region where the distal esophagus meets with the proximal stomach region, is known for developing pathological conditions, including metaplasia and esophageal adenocarcinoma (EAC). It is essential to understand the mechanisms of developmental stages which lead to EAC since the incidence rate of EAC increased over 7-fold during the past four decades, and the overall five years survival rate is 18.4%. In most cases, patients are diagnosed in the advanced stage without prior symptoms. The main precursor for the development of EAC is a pre-malignant condition called Barrett's esophagus (BE). BE is the metaplastic condition where the multilayered squamous epithelium of the native esophagus is replaced by specialized single-layered columnar epithelium, which shows the molecular characteristics of the gastric as well as intestinal epithelium. The main risk factors for BE development include chronic gastro-esophageal acid reflux disease (GERD), altered microbiota, and altered retinoic acid signaling (RA). The cell of origin of BE is under debate due to a lack of clear evidence demonstrating the process of BE initiation. Here, I investigated how GEJ homeostasis is maintained in healthy tissue by stem cell regulatory morphogens, the role of vitamin A (RA signaling), and how its alteration contributes to BE development.
In the first part of my thesis, I showed the presence of two types of epithelial cells, the squamous type in the esophagus and the columnar type in the stomach region in the GEJ, using single-molecule RNA in situ hybridization (smRNA-ISH) and immunohistochemistry. Employing lineage tracing in the mouse model, I have demonstrated that the esophageal epithelial and stomach epithelial cells derived from two distinct epithelial stem cell lineages in the GEJ. The border between squamous and columnar epithelial cells in the Squamo-columnar junction (SCJ) of GEJ is regulated by opposing Wnt microenvironments. The regeneration of stomach columnar epithelial stem cells is maintained by Wnt activating signal from the stromal compartment while squamous epithelial stem cells of the esophagus are maintained by the Wnt inhibitory signals. I recapitulated the in vivo GEJ epithelial stem cell maintenance by using in vitro epithelial 3D organoid culture model. The growth and propagation of stomach columnar epithelial organoids depend on Wnt growth factors, while squamous epithelial organoids' development needs Wnt-deficient culture conditions.
Further, single-cell RNA sequence (scRNA-seq) analysis of organoid-derived epithelial cells revealed the non-canonical Wnt/ planar cell polarity (PCP) pathway involvement in regulating the squamous epithelial cells. In contrast, columnar stomach epithelial cells are regulated by the canonical Wnt/ beta-catenin and non-canonical Wnt/Ca2+ pathways. My data indicate that the SCJ epithelial cells that merge at the GEJ are regulated by opposing stromal Wnt factors and distinct Wnt pathway signaling in the epithelial cells.
In the second part of the thesis, I investigated the role of Vitamin A-derived bioactive compound RA on esophageal and stomach epithelial stem cells. In vitro treatment of esophageal and stomach, epithelial organoids with RA or its pharmacological inhibitor BMS 493 revealed that each cell type was regulated distinctly. I observed that enhanced RA promoted esophageal stem cell differentiation and loss of stratification, while RA inhibition led to enhanced stemness and regeneration of the esophagus stratified epithelium. As opposed to the esophagus, RA signaling is active in the stomach organoids, and inhibition of RA reduces the growth of stomach organoids. Global transcriptomic data and scRNA-seq data revealed that RA signaling induces dormancy phenotype in the esophageal cells. In contrast, the absence of RA in stomach epithelial cells induces the expression of genes associated with BE. Thus, spatially defined regulation of Wnt and RA signaling at GEJ is critical for healthy homeostasis, and its perturbation leads to disease development.
The unicellular pathogen Trypanosoma brucei is the causative agent of African
trypanosomiasis, an endemic disease prevalent in sub-Saharan Africa. Trypanosoma brucei alternates between a mammalian host and the tsetse fly vector. The extracellular parasite survives in the mammalian bloodstream by periodically exchanging their ˈvariant surface glycoproteinˈ (VSG) coat to evade the host immune response. This antigenic variation is achieved through monoallelic expression of one VSG variant from subtelomeric ˈbloodstream
form expression sitesˈ (BES) at a given timepoint. During the differentiation from the bloodstream form (BSF) to the procyclic form (PCF) in the tsetse fly midgut, the stage specific surface protein is transcriptionally silenced and replaced by procyclins. Due to their subtelomeric localization on the chromosomes, VSG transcription and silencing is partly regulated by homologues of the mammalian telomere complex such as TbTRF, TbTIF2 and TbRAP1 as well as by ˈtelomere-associated proteinsˈ (TelAPs) like TelAP1. To gain more insights into transcription regulation of VSG genes, the identification and characterization of other TelAPs is critical and has not yet been achieved. In a previous study, two biochemical approaches were used to identify other novel TelAPs. By using ˈco-immunoprecipitationˈ (co-IP) to enrich possible interaction partners of TbTRF and by affinity chromatography using telomeric repeat oligonucleotides, a listing of TelAP candidates has been conducted. With this approach TelAP1 was identified as a novel component of the telomere complex, involved in the kinetics of transcriptional BES silencing during BSF to PCF differentiation. To gain further insights into the telomere complex composition, other previously enriched proteins were characterized through a screening process using RNA interference to deplete potential candidates. VSG expression profile changes and overall proteomic changes after depletion were analyzed by mass spectrometry. With this method, one can gain insights into the functions of the proteins and their involvement in VSG expression site regulation. To validate the interaction of proteins enriched by co-IP with TbTRF and TelAP1 and to identify novel interaction proteins, I performed reciprocal affinity purifications of the four most promising candidates (TelAP2, TelAP3, PPL2 and PolIE) and additionally confirmed colocalization of two candidates with TbTRF via immunofluorescence (TelAP2, TelAP3). TelAP3 colocalizes with TbTRF and potentially interacts with TbTRF, TbTIF2, TelAP1 and TelAP2, as well as with two translesion polymerases PPL2 and PolIE in BSF. PPL2 and PolIE seem to be in close contact to each other at the telomeric ends and fulfill different roles as only PolIE is involved in VSG regulation while PPL2 is not. TelAP2 was previously characterized to be associated with telomeres by partially colocalizing with TbTRF and cells show a VSG derepression phenotype when the protein was depleted. Here I show that TelAP2 interacts with the telomere-binding proteins TbTRF and TbTIF2 as well as with the telomere-associated protein TelAP1 in BSF and that TelAP2 depletion results in a loss of TelAP1 colocalization with TbTRF in BSF.
In conclusion, this study demonstrates that characterizing potential TelAPs is effective in gaining insights into the telomeric complex's composition and its role in VSG regulation in Trypanosoma brucei. Understanding these interactions could potentially lead to new therapeutic targets for combatting African trypanosomiasis.
The mold Aspergillus fumigatus (A. fumigatus) is known as human pathogen and can cause life-threatening infections in humans with a weakened immune system. This is a known complication in patients receiving glucocorticoids, e.g. after hematopoietic stem cell transplantation or solid organ transplantation. Although research in the field of immune cell/fungus interaction has discovered key strategies how immune cells fight against infectious fungi, our knowledge is still incomplete. In order to develop effective treatment options against fungal infections, a detailed understanding of their interactions is crucial. Thus, visualization of immune cell and fungus is an excellent approach to gain further knowledge. For a detailed view of such interaction processes, a high optical resolution on nanometer scale is required. There is a variety of super resolution microscopy techniques, enabling fluorescence imaging beyond the diffraction limit. This work combines the use of three complementary super resolution microscopy techniques, in order to study immune cell/fungus interaction from different points of view.
Aim of this work is the introduction of the recently invented imaging technique named expansion microscopy (ExM) for the study of immune cell/fungus interactions. The core aspect of this method is the physical magnification of the specimen, which increases the distance between protein structures that are close to each other and which can therefore be imaged separately.
The simultaneous magnification of primary human natural killer (NK) cells and A. fumigatus hyphae was established in this work using ExM. Reorganization of cytoskeletal components of interacting NK cells was demonstrated here, by expansion of the immunological synapse (IS), formed between NK cells and A. fumigatus. In addition, reorganization of the microtubule-organizing center (MTOC) towards fungal hyphae and an accumulation of actin at the IS has been observed. Furthermore, ExM has been used to visualize lytic granules of NK cells after degranulation. After magnification of the specimen, lysosome associated protein 1 (LAMP1) was shown to surround perforin. In absence of the plasma membrane-exposed degranulation marker LAMP1, a “ring-shaped” structure was often observed for fluorescently labeled perforin. Volume calculation of lytic granules demonstrated the benefit of ExM. Compared to pre-expansion images, analyses of post-expansion images showed two volume distributions for degranulated and non-degranulated NK cells. In addition, this work emphasizes the importance of determining the expansion factor for a structure in each species, as variations of expansion factors have been observed. This factor, as well as possible sample distortions should be considered, when ExM is used in order to analyze the interaction between two species.
A second focus of this work is the visualization of a chimeric antigen receptor (CAR), targeting an epitope on the cell wall of A. fumigatus. Structured illumination microscopy (SIM) revealed that the CAR is part of the immunological synapse of primary human CAR T cells and CAR-NK-92 cells. At the interaction site, an accumulation of the CAR was observed, as well as the presence of perforin. CAR accumulation at fungal hyphae was further demonstrated by automated live cell imaging of interacting CAR-NK-92 cells, expressing a fluorescent fusion protein.
Additionally, the use of direct stochastic optical reconstruction microscopy (dSTORM) gave first insights in CAR expression levels on the basal membrane of CAR-NK-92 cells, with single molecule sensitivity. CAR cluster analyses displayed a heterogeneous CAR density on the basal membrane of transfected NK 92 cells.
In summary, this work provides insights into the application of ExM for studying the interaction of primary human NK cells and A. fumigatus for the first time. Furthermore, this thesis presents first insights regarding the characterization of an A. fumigatus-targeting CAR, by applying super-resolution fluorescence microscopy, like SIM and dSTORM.