Refine
Is part of the Bibliography
- yes (982)
Year of publication
Document Type
- Doctoral Thesis (974)
- Journal article (7)
- Book (1)
Language
- English (761)
- German (220)
- Multiple languages (1)
Keywords
- Maus (37)
- Thrombozyt (32)
- T-Lymphozyt (29)
- Tissue Engineering (29)
- Taufliege (20)
- Dendritische Zelle (19)
- Genexpression (18)
- Angst (16)
- Entzündung (16)
- Myc (15)
- Signaltransduktion (15)
- Angststörung (14)
- Aufmerksamkeit (13)
- Drosophila (13)
- Staphylococcus aureus (13)
- Arteriosklerose (12)
- Biene (12)
- Candida albicans (12)
- G-Protein gekoppelte Rezeptoren (12)
- Immunologie (12)
- Kernspintomografie (12)
- Melanom (12)
- Schlaganfall (12)
- Serotonin (12)
- Fluoreszenzmikroskopie (11)
- Krebs <Medizin> (11)
- Mikroskopie (11)
- Stress (11)
- Epigenetik (10)
- GPCR (10)
- Microscopy (10)
- Regulation (10)
- Therapie (10)
- Thrombose (10)
- Transkriptionsfaktor (10)
- miRNS (10)
- ADHD (9)
- Apoptosis (9)
- DNS-Reparatur (9)
- Depression (9)
- Escherichia coli (9)
- Fluoreszenz-Resonanz-Energie-Transfer (9)
- Megakaryozyt (9)
- Motoneuron (9)
- Plasmozytom (9)
- Stammzelle (9)
- Tagesrhythmus (9)
- Zellskelett (9)
- Zellzyklus (9)
- platelets (9)
- Aspergillus fumigatus (8)
- Elektrophysiologie (8)
- Fuchsbandwurm (8)
- Furcht (8)
- Induzierte pluripotente Stammzelle (8)
- Konditionierung (8)
- Multiples Myelom (8)
- Neisseria meningitidis (8)
- Rezeptor (8)
- Spinale Muskelatrophie (8)
- Synapse (8)
- Alzheimerkrankheit (7)
- Arzneimitteldesign (7)
- Biomarker (7)
- DNS-Schädigung (7)
- EEG (7)
- Genetik (7)
- Herzinfarkt (7)
- Herzinsuffizienz (7)
- Inhibitor (7)
- Kutikula (7)
- Lernen (7)
- Makrophage (7)
- Regulatorischer T-Lymphozyt (7)
- Small RNA (7)
- Transcription (7)
- Transkription <Genetik> (7)
- Transplantat-Wirt-Reaktion (7)
- Verhalten (7)
- Zellkultur (7)
- dendritic cells (7)
- fMRI (7)
- Antigen CD28 (6)
- Bacteria (6)
- Bildgebendes Verfahren (6)
- Calcium (6)
- DNA damage (6)
- Diabetes mellitus (6)
- Drosophila melanogaster (6)
- Entwicklung (6)
- Funktionelle Kernspintomografie (6)
- Hippocampus (6)
- Immuntherapie (6)
- Inflammation (6)
- Kognition (6)
- Lungenkrebs (6)
- MRI (6)
- MYC (6)
- Masernvirus (6)
- Molekularbiologie (6)
- Monoklonaler Antikörper (6)
- Multiple Sklerose (6)
- Oxidativer Stress (6)
- Platelet (6)
- Platelets (6)
- Ratte (6)
- Thrombosis (6)
- Tiermodell (6)
- Transkriptomanalyse (6)
- Trypanosoma brucei (6)
- Ubiquitin (6)
- Virtuelle Realität (6)
- Zellmigration (6)
- Atherosclerosis (5)
- Aufmerksamkeits-Defizit-Syndrom (5)
- Autoantikörper (5)
- Bakterien (5)
- Biologie (5)
- Brain-derived neurotrophic factor (5)
- Cataglyphis (5)
- Chronobiologie (5)
- Cytoskeleton (5)
- Dendritic cells (5)
- Dünndarm (5)
- Evolution (5)
- Gefühl (5)
- Genetics (5)
- Gephyrin (5)
- HIV (5)
- Immunsystem (5)
- In-vitro-Kultur (5)
- Inhibition (5)
- MAP-Kinase (5)
- Metabolismus (5)
- Mutagenität (5)
- NFATc1 (5)
- Neurodegeneration (5)
- Neuroethologie (5)
- Polymorphismus (5)
- Resistenz (5)
- Schmerz (5)
- Transkription (5)
- Zelldifferenzierung (5)
- cancer (5)
- platelet (5)
- virtual reality (5)
- 3D-Druck (4)
- Actin (4)
- Anxiety (4)
- Aufmerksamkeitsdefizit-Syndrom (4)
- Aurora-A (4)
- Autoimmunität (4)
- B-Lymphozyt (4)
- Biofabrication (4)
- Biofilm (4)
- Bioinformatics (4)
- Biomaterial (4)
- Blut-Hirn-Schranke (4)
- Brustkrebs (4)
- CRISPR/Cas-Methode (4)
- CRISPR/Cas9 (4)
- Cadherine (4)
- Cancer (4)
- Chlamydia trachomatis (4)
- Chromatin (4)
- Chronophin (4)
- Darm (4)
- Dendritic cell (4)
- Dendritische Zellen (4)
- Einzelmolekülmikroskopie (4)
- Elektroencephalographie (4)
- Emotion (4)
- FRET (4)
- Fettsäurestoffwechsel (4)
- Fibroblastenwachstumsfaktor (4)
- Furchtgeneralisierung (4)
- Furchtkonditionierung (4)
- G-Protein gekoppelter Rezeptor (4)
- GPVI (4)
- Genotoxizität (4)
- Genregulation (4)
- Glucosetransportproteine (4)
- Graft-versus-host-disease (4)
- Herzmuskelzelle (4)
- Hämostase (4)
- Immunmodulation (4)
- Immunology (4)
- Immunreaktion (4)
- Immunsuppression (4)
- Infektion (4)
- Insulin (4)
- Interleukin 6 (4)
- Ionenkanal (4)
- Jugend (4)
- Kind (4)
- Knockout <Molekulargenetik> (4)
- MMB (4)
- MYCN (4)
- Malaria (4)
- Maschinelles Lernen (4)
- Mausmodell (4)
- Meeresschwämme (4)
- Mitochondrium (4)
- Mitose (4)
- Molekulargenetik (4)
- Myokardinfarkt (4)
- Natürliche Killerzelle (4)
- Neurobiologie (4)
- Neuroblastom (4)
- Neurowissenschaften (4)
- Opiatrezeptor (4)
- Panikstörung (4)
- Parkinson-Krankheit (4)
- Plasmodium falciparum (4)
- Posttranskriptionelle Regulation (4)
- Probiotikum (4)
- Proteasen (4)
- RNS-Bindungsproteine (4)
- Ribosom (4)
- SMN (4)
- Salmonella (4)
- Sepsis (4)
- Soziale Insekten (4)
- Stoffwechsel (4)
- TFIIH (4)
- Treg (4)
- TrkB (4)
- Tumor (4)
- Virulenz (4)
- Zelle (4)
- active zone (4)
- division of labor (4)
- genotoxicity (4)
- honeybee (4)
- inflammation (4)
- magnetic resonance imaging (4)
- measles virus (4)
- miRNA (4)
- microRNA (4)
- myocardial infarction (4)
- neuroblastoma (4)
- olfaction (4)
- regulation (4)
- 3D tissue model (3)
- ADHS (3)
- Adjuvans (3)
- Altern (3)
- Amygdala (3)
- Angiogenese (3)
- Angsterkrankungen (3)
- Animal model (3)
- Antibody (3)
- Antigen CD8 (3)
- Atherosklerose (3)
- B-MYB (3)
- B-Zell-Lymphom (3)
- Bacillus subtilis (3)
- Biochemie (3)
- Biodiversität (3)
- Bioinformatik (3)
- Biologische Uhr (3)
- Bioreaktor (3)
- Blutstammzelle (3)
- Blutstillung (3)
- CD1d (3)
- CD28 (3)
- CIDP (3)
- Campylobacter jejuni (3)
- Ceramid (3)
- Chemotherapie (3)
- Cyclo-AMP (3)
- Cytokine (3)
- Dimerisierung (3)
- E. coli Nissle 1917 (3)
- Echinococcus (3)
- Echinococcus multilocularis (3)
- Ecology (3)
- Electroencephalographie (3)
- Emotionsregulation (3)
- Endocytose (3)
- Endothel (3)
- Expansion Microscopy (3)
- Expositionstherapie (3)
- Extinktion (3)
- Fettzelle (3)
- Fibromyalgie (3)
- Fluorescence Microscopy (3)
- Gehirn (3)
- Gehirn-Computer-Schnittstelle (3)
- Genmutation (3)
- Genom (3)
- Geruch (3)
- Geruchssinn (3)
- Gewebekultur (3)
- Gewebemodell (3)
- Glioblastom (3)
- Glycinrezeptor (3)
- Graft-versus-host disease (3)
- GvHD (3)
- Helicasen (3)
- Helicobacter pylori (3)
- Herzhypertrophie (3)
- Heubacillus (3)
- Histone (3)
- Hyaliner Knorpel (3)
- Hyaluronsäure (3)
- Immuntoleranz (3)
- In vitro (3)
- Informationsverarbeitung (3)
- Knorpel (3)
- Komplement <Immunologie> (3)
- Koronare Herzkrankheit (3)
- Kristallstruktur (3)
- Kutikularwachs (3)
- Latrophilin (3)
- Lunge (3)
- MRSA (3)
- MRT (3)
- Magnetresonanztomographie (3)
- Massenspektrometrie (3)
- Megakaryocyte (3)
- Metagenom (3)
- Metalloproteinasen (3)
- Mitochondria (3)
- Miz1 (3)
- Molekulare Bildgebung (3)
- Multiproteinkomplex (3)
- Muscarinrezeptor (3)
- NIR-Spektroskopie (3)
- NMR-Tomographie (3)
- Nephroblastom (3)
- Nervennetz (3)
- Nervenzelle (3)
- Neuroanatomie (3)
- Neurogenese (3)
- Neuroinflammation (3)
- Neuronale Plastizität (3)
- Neuropathischer Schmerz (3)
- Neuropeptide (3)
- Neutrophiler Granulozyt (3)
- Non-coding RNA (3)
- Obesity (3)
- Opioide (3)
- Orientierung (3)
- PDXP (3)
- PET (3)
- Paniksyndrom (3)
- Parkinson's disease (3)
- Pathogenität (3)
- Pathophysiologie (3)
- Permeabilität (3)
- Phosphatase (3)
- Phosphoglykolatphosphatase (3)
- Phospholipide (3)
- Phosphorylierung (3)
- Physiologie (3)
- Pilzkörper (3)
- Plastizität (3)
- Pneumolysin (3)
- Proteine (3)
- Proteinkinase D (3)
- Präfrontaler Cortex (3)
- Prävention (3)
- Psychische Störung (3)
- RNS (3)
- Raf-Kinasen (3)
- Rho-Proteine (3)
- Rhodopsin (3)
- Salmonella enterica (3)
- Schmerzforschung (3)
- Secretion (3)
- Sphingolipide (3)
- Stressreaktion (3)
- Structural Biology (3)
- T cell activation (3)
- T-Zelle (3)
- T-Zellen (3)
- TNF (3)
- Thrombozytenaggregation (3)
- Transpiration <Pflanzen> (3)
- Transposon (3)
- Tumorzelle (3)
- Typ 1 (3)
- Ubiquitinierung (3)
- Visuelle Aufmerksamkeit (3)
- Wundheilung (3)
- Zellkern (3)
- Zentralnervensystem (3)
- adrenocortical carcinoma (3)
- apoptosis (3)
- atherosclerosis (3)
- attention (3)
- cAMP (3)
- cell wall (3)
- circadian rhythms (3)
- cytoskeleton (3)
- dopamine (3)
- expression (3)
- fear conditioning (3)
- gp130 (3)
- iPSC (3)
- ischemic stroke (3)
- learning (3)
- learning and memory (3)
- megakaryocyte (3)
- megakaryopoiesis (3)
- neurobiology (3)
- protease (3)
- regulatorische T-Zellen (3)
- regulatory T cells (3)
- signalling (3)
- super-resolution microscopy (3)
- translation (3)
- virulence (3)
- 3D cell culture (2)
- 3D-Zellkultur (2)
- 53BP1 (2)
- ALS (2)
- APOBEC3G (2)
- ASM (2)
- Acetylation (2)
- Ackerschmalwand (2)
- Actin-bindende Proteine (2)
- Actinomyceten (2)
- Actinomycetes (2)
- Adaptation (2)
- Adaptorproteine (2)
- Adenosinrezeptor (2)
- Adhesion GPCR (2)
- Adipogenesis (2)
- Adjuvant (2)
- Adrenalin (2)
- Adrenerger Rezeptor (2)
- Adventitia (2)
- Affekt (2)
- Analgesie (2)
- Angeborene Immunität (2)
- Angewandte Mikrobiologie (2)
- Antennallobus (2)
- Antiangiogenese (2)
- Antibiotikum (2)
- Antigen CD40 (2)
- Antigen CD95 (2)
- Antikörper (2)
- Aorta (2)
- Apis mellifera (2)
- Apoptose (2)
- Arabidopsis thaliana (2)
- Arbeitsgedächtnis (2)
- Arbeitsteilung (2)
- Arrestine (2)
- Aspergillus (2)
- Assoziation (2)
- Assoziatives Lernen (2)
- Astrozyt (2)
- Audiologie (2)
- Augenbewegung (2)
- Autoaggressionskrankheit (2)
- Autophagy (2)
- Aversive Konditionierung (2)
- Axon (2)
- B cells (2)
- B-Zellen (2)
- BAD (2)
- BCI (2)
- BOLD signal (2)
- BRET (2)
- Bacterial infection (2)
- Bakterielle Hirnhautentzündung (2)
- Bakterielle Infektion (2)
- Bakteriengift (2)
- Bauchspeicheldrüsenkrebs (2)
- Beta-1-Rezeptor (2)
- Beta-Rezeptor (2)
- Bildverarbeitung (2)
- Biogenese (2)
- Bioinks (2)
- Biomechanics (2)
- Biomedicine (2)
- Bioprinting (2)
- Bioreactor (2)
- Blickbewegung (2)
- Blut-Nerven-Barriere (2)
- Blutgerinnung (2)
- Bortezomib (2)
- Brain-computer interface (2)
- CD28 Superagonist (2)
- CD84 (2)
- CDH13 (2)
- COVID-19 (2)
- CRPS (2)
- CXCR4 (2)
- Calciumkanal (2)
- Calciumtransport (2)
- Camponotus floridanus (2)
- Cancer immunotherapy (2)
- Cardiomyocyte (2)
- Cartilage Tissue Engineering (2)
- Cell cycle (2)
- Cell migration (2)
- Cement (2)
- Ceramide (2)
- Cholesterinstoffwechsel (2)
- Chronische Niereninsuffizienz (2)
- Ciliary neurotrophic factor (2)
- Circadian Rhythms (2)
- Cochlear-Implantat (2)
- Colonkrebs (2)
- Compressed Sensing (2)
- Contactin-1 (2)
- Corpus amygdaloideum (2)
- Corti-Organ (2)
- Crosstalk (2)
- Cryptochrom (2)
- Cushing-Syndrom (2)
- Cuticle (2)
- Cuticular waxes (2)
- DNA Repair (2)
- DNA repair (2)
- DNA-Reparatur (2)
- DNS (2)
- DNS-Bindung (2)
- DNS-Doppelstrangbruch (2)
- DRG (2)
- DROSHA (2)
- Darmwandnervensystem (2)
- Deep sequencing (2)
- Diabetische Polyneuropathie (2)
- Diagnostik (2)
- Dichtegewichtung (2)
- Differentiation (2)
- Diffusionsgewichtete Magnetresonanztomografie (2)
- Dopamin (2)
- Dosimetrie (2)
- E. coli Nissle (2)
- EHEC (2)
- Echokardiographie (2)
- Einzelzellanalyse (2)
- Elektroencephalogramm (2)
- Elektrospinning (2)
- Emotionen (2)
- Emotionsverarbeitung (2)
- Encephalomyelitis (2)
- Endozytose (2)
- Enterobacteriaceae (2)
- Enzym (2)
- Epigenetic (2)
- Ereigniskorreliertes Potenzial (2)
- Erwachsener (2)
- Extrazelluläre Matrix (2)
- FKBP52 (2)
- Fabry-Krankheit (2)
- Farbensehen (2)
- Fettsucht (2)
- Fettsäurebiosynthese (2)
- Fitness (2)
- Fluconazol (2)
- Fluconazole (2)
- Fluorescence (2)
- Fluoreszenzkorrelationsspektroskopie (2)
- Fluoxetin (2)
- Frühdiagnostik (2)
- Förster Resonanz Energie Transfer (2)
- G-protein-coupled receptors (2)
- GABA-Rezeptor (2)
- Galectine (2)
- Gametogenese (2)
- Gastrointestinaltrakt (2)
- Gedächtnis (2)
- Gelenkknorpel (2)
- Generalisierung (2)
- Genomics (2)
- Gerinnungsfaktor XII (2)
- Glia (2)
- Glioblastoma (2)
- Gliom (2)
- Glukose (2)
- Glutamat-Decarboxylase (2)
- Glykosylierung (2)
- Golgi-Apparat (2)
- Growth (2)
- Guanylatcyclase (2)
- HUWE1 (2)
- Harnwegsinfektion (2)
- Hautleitfähigkeit (2)
- Hemostasis (2)
- Herz (2)
- Herzfrequenzvariabilität (2)
- Herzmuskel (2)
- Herzmuskelkrankheit (2)
- Herzschrittmacher (2)
- Hfq (2)
- High throughput screening (2)
- Hippo pathway (2)
- Hirnhautentzündung (2)
- Host-pathogen interaction (2)
- Hydrogel (2)
- Hypertrophie (2)
- Hypothalamus (2)
- Hypoxia (2)
- Hypoxie (2)
- Immunisierung (2)
- Immunological synapse (2)
- Immunotherapy (2)
- Impfung (2)
- Induced pluripotent stem cells (2)
- Infektionsmodell (2)
- Inhibitorische Synapse (2)
- Inhibitory synapse (2)
- Innate immunity (2)
- Innere Uhr (2)
- Insekten (2)
- Interaktion (2)
- Interferon (2)
- Interferon <gamma-> (2)
- Interleukin 2 (2)
- Intrazellulärraum (2)
- Invasion (2)
- Ischemic stroke (2)
- Japankärpfling (2)
- K-Ras (2)
- Kardiologie (2)
- Kardiomyozyt (2)
- Keratinozyt (2)
- Kernspintomographie (2)
- Klimaänderung (2)
- Knochen-Morphogenese-Proteine (2)
- Knochenmark (2)
- Knochenmarktransplantation (2)
- Knockout (2)
- Knockout-Maus (2)
- Komplement C5a (2)
- Konfokale Mikroskopie (2)
- Kontextkonditionierung (2)
- Kostimulation (2)
- Kraniosynostose (2)
- Krankheit (2)
- Krebsforschung (2)
- Krebsimmuntherapie (2)
- LC-MS (2)
- Lactatdehydrogenase (2)
- Larve (2)
- Learning (2)
- Leishmania (2)
- Leishmania major (2)
- Leishmaniose (2)
- Lidschlag (2)
- Lipide (2)
- Lung (2)
- Lysosom (2)
- Macrophages (2)
- Magnetische Resonanz (2)
- Malaria tropica (2)
- Manisch-depressive Krankheit (2)
- Marine sponges (2)
- Mechanosensation (2)
- Medizinphysik (2)
- Megakaryopoese (2)
- Melt Electrowriting (2)
- Meningitis (2)
- Mensch (2)
- Merkel cell carcinoma (2)
- Mesenchymzelle (2)
- Metabolomik (2)
- Metastase (2)
- Methylierung (2)
- Mikrotubuli (2)
- Monarchfalter (2)
- Motoneuron-Krankheit (2)
- Motorisches Lernen (2)
- Multidrug-Resistenz (2)
- Multiple Myeloma (2)
- Mutation (2)
- Myatrophische Lateralsklerose (2)
- N-MYC (2)
- N-Myc (2)
- NFAT (2)
- NNMT (2)
- Na+/K+-ATPase (2)
- NaV1.9 (2)
- Nahrungserwerb (2)
- Nanoparticles (2)
- Natriumkanal (2)
- Navigation (2)
- Neisseria gonorrhoeae (2)
- Nervendegeneration (2)
- Nervensystem (2)
- Nestbau (2)
- Neuralgie (2)
- Neurofascin (2)
- Neuromodulation (2)
- Neuropathie (2)
- Neuroscience (2)
- Neutrophils (2)
- Nicht-kleinzelliges Bronchialkarzinom (NSCLC) (2)
- Nociceptor (2)
- Nozizeptor (2)
- Nuklearmedizin (2)
- Nukleotid-Exzisions-Reparatur (2)
- Olfaction (2)
- Oligomerisation (2)
- Oncostatin M (2)
- Onkogen (2)
- Optogenetik (2)
- Organische Synthese (2)
- Organoid (2)
- Osteogenesis (2)
- Oxidative stress (2)
- P300 (2)
- PVM (2)
- Parathormon (2)
- Peptide (2)
- Peptidsynthese (2)
- Peyer's patch (2)
- Pflanzen (2)
- Pflanzenschutzmittel (2)
- Phosphatasen (2)
- Phospholipase D (2)
- Phylogenie (2)
- Phänologie (2)
- Plant Protection (2)
- Plant cuticle (2)
- Plasmamembran (2)
- Polyneuropathie (2)
- Positronen-Emissions-Tomographie (2)
- Post-transcriptional regulation (2)
- Probiotic (2)
- Progenitor (2)
- Prognose (2)
- Proliferation (2)
- Protein (2)
- Protein-Protein-Wechselwirkung (2)
- Proteinsynthese (2)
- Proteintyrosinphosphatase (2)
- Proteolyse (2)
- Proteom (2)
- Psychologie (2)
- RNA (2)
- RNA helicase (2)
- RNA modifications (2)
- RNA polymerase II (2)
- RNS-Interferenz (2)
- RNS-Viren (2)
- ROS (2)
- RS1 (2)
- Radionuklid (2)
- Ranvier-Schnürring (2)
- Regenerative Medizin (2)
- Resilienz (2)
- Rheumatoid arthritis (2)
- RhoA (2)
- Ribosome (2)
- Risikofaktoren (2)
- Röntgenkristallographie (2)
- SARS-CoV-2 (2)
- SGLT1 (2)
- SOCE (2)
- SPECT (2)
- Salmonella Typhimurium (2)
- Salmonella typhimurium (2)
- Schlaf (2)
- Schwertkärpfling (2)
- Schädel-Hirn-Trauma (2)
- Screening (2)
- Sekundärkrankheit (2)
- Sekundärmetabolit (2)
- Sequenzanalyse (2)
- Serotonerge Nervenzelle (2)
- Signalkette (2)
- Sinneszelle (2)
- Sozialangst (2)
- Soziale Wahrnehmung (2)
- Sphingomyelin (2)
- Spinal Muscular Atrophy (2)
- Spred-Proteine (2)
- Staphylococcus (2)
- Stickstoff (2)
- Streptococcus pneumoniae (2)
- Symbiose (2)
- Synthese (2)
- T cells (2)
- T-Lymphozyten-Rezeptor (2)
- TFIIIC (2)
- TLR3 (2)
- TWEAK (2)
- Therapieresistenz (2)
- Thrombo-inflammation (2)
- Thrombopoiesis (2)
- Tissue engineering (2)
- Toleranz (2)
- Toll-like-Rezeptoren (2)
- Transcriptome (2)
- Transforming Growth Factor beta (2)
- Transgener Organismus (2)
- Transkriptom (2)
- Tuberkelbakterium (2)
- Tumor-Nekrose-Faktor (2)
- Turbo Spin Echo (2)
- Ubiquitin-Protein-Ligase (2)
- VSG (2)
- Vaccine (2)
- Wahrnehmung (2)
- Wilms tumor (2)
- Wirkstoffdesign (2)
- X-ray crystallography (2)
- Xiphophorus (2)
- Zebrabärbling (2)
- Zebrafish (2)
- Zellteilung (2)
- Zellwand (2)
- Zement (2)
- Zink-Finger-Proteine (2)
- adipocytes (2)
- adult neurogenesis (2)
- amygdala (2)
- antennal lobe (2)
- anxiety (2)
- anxiety disorders (2)
- autophagy (2)
- bee (2)
- behavior (2)
- behaviour (2)
- biased agonism (2)
- bioinformatics (2)
- biology (2)
- biomedical applications (2)
- biomedicine (2)
- bioreactor (2)
- blood brain barrier (2)
- bone marrow (2)
- brain (2)
- calcium (2)
- cardiac hypertrophy (2)
- cell (2)
- ceramide (2)
- chlamydia (2)
- cytokines (2)
- cytokinesis (2)
- deep brain stimulation (2)
- dendritic cell (2)
- dendritische Zelle (2)
- depression (2)
- development (2)
- developmental differentiation (2)
- diet (2)
- dosimetry (2)
- drug development (2)
- ecology (2)
- electron microscopy (2)
- electrophysiology (2)
- emotion (2)
- emotion processing (2)
- emotion regulation (2)
- endosomal trafficking (2)
- endothelial cells (2)
- epigenetics (2)
- evolution (2)
- experimental autoimmune encephalomyelitis (2)
- extracellular matrix (2)
- fMRI time series (2)
- fear extinction (2)
- fear generalization (2)
- foxtapeworm (2)
- funktionelle Kernspintomographie (2)
- gamma-H2AX (2)
- genetics (2)
- genomics (2)
- gephyrin (2)
- glucose (2)
- hippocampus (2)
- host-pathogen interaction (2)
- immunologische Synapse (2)
- in vitro (2)
- infection (2)
- inflammatory pain (2)
- intestinal in vitro model (2)
- kinase (2)
- lipid rafts (2)
- lung cancer (2)
- malaria (2)
- mass spectrometry (2)
- medical physics (2)
- melanoma (2)
- mesenchymal stem cells (2)
- metabolism (2)
- metagenomics (2)
- mitosis (2)
- mitotic gene expression (2)
- monoclonal antibodies (2)
- monoklonale Antikörper (2)
- motoneuron (2)
- mouse model (2)
- multi-unit recording (2)
- multiple myeloma (2)
- neuroethology (2)
- neuropathy (2)
- nuclear medicine (2)
- oligomerization (2)
- p53 (2)
- pancreas (2)
- peptide (2)
- perception (2)
- phosphatase (2)
- receptor (2)
- regulatory t cells (2)
- resistance (2)
- serotonergic system (2)
- shRNA (2)
- signal transduction (2)
- single particle tracking (2)
- skin equivalent (2)
- small RNA (2)
- snRNP (2)
- social anxiety (2)
- social attention (2)
- social insects (2)
- sphingolipids (2)
- spontaneous blinks (2)
- stress (2)
- stroke (2)
- symbiosis (2)
- synaptic plasticity (2)
- synaptic proteins (2)
- synaptische Proteine (2)
- t cells (2)
- tDCS (2)
- targeted therapy (2)
- thrombopoiesis (2)
- tissue engineering (2)
- transcription (2)
- transkranielle Gleichstromstimulation (2)
- vascularization (2)
- virtuelle Realität (2)
- wild bees (2)
- working memory (2)
- wound healing (2)
- Ökologie (2)
- Übergewicht (2)
- "Lipid Rafts" (1)
- (hem)ITAM signaling (1)
- 13C-isotopologue profiling (1)
- 177Lu-OPS201 (1)
- 18S rRNA (1)
- 2-point Dixon (1)
- 3 D bioprinting (1)
- 3-D liver model (1)
- 3D Gewebemodelle (1)
- 3D Modell (1)
- 3D Printing (1)
- 3D Tumormodell (1)
- 3D model (1)
- 3D models (1)
- 3D muscle (1)
- 3D spheroid culture (1)
- 3D-Elektrode (1)
- 3D-Gewebemodell (1)
- 3D-Kultur (1)
- 3D-Modell (1)
- 4-HNE (1)
- 5-FU (1)
- 5`-UTR (1)
- 68Ga-OPS202 (1)
- 7 T (1)
- 7SK (1)
- 7T (1)
- A-RAF (1)
- A2B adenosine receptor (1)
- A2BAR (1)
- AAC (1)
- ABC-Transporter (1)
- ACC (1)
- ACL (1)
- ADGRL3 (1)
- ADORA2A (1)
- ADP (1)
- AI (1)
- AMPK (1)
- AMP‐activated protein kinase (1)
- ARF6 GTPase (1)
- ASM-Inhibition (1)
- ATF5 (1)
- ATGL (1)
- ATR-FTIR (1)
- ATRA (1)
- Absorbed Doses (1)
- Accelerated imaging (1)
- Acetylcholinrezeptor (1)
- Acetylierung (1)
- Acid adaptation (1)
- Actin Dynamics (1)
- Actin binding proteins (1)
- Actin cytoskeleton-related protein (1)
- Actinomyces (1)
- Acute myeloid leukemia (AML) (1)
- Acyrthosiphon pisum (1)
- Adapterprotein (1)
- Adenomatous-polyposis-coli-Protein (1)
- Adenosine receptors (1)
- Adhesion and Invasion (1)
- Adhesion and degranulation promoting adapter protein (1)
- Adhesion-GPCR (1)
- Adhesive Hydrogels (1)
- Adhärenz (1)
- Adhäsion (1)
- Adipose (1)
- Adipose Tissue Engineering (1)
- Adipose-Derived Stromal/Stem Cells (1)
- Adipositas (1)
- Administered Activities (1)
- Adrenergic receptor (1)
- Adrenocortical Carcinoma (1)
- Adrenokortikales Karzinom (1)
- Adulte Neurogenese (1)
- Adultschlupfes (1)
- Advanced Therapy Medicinal Products (ATMP) (1)
- Affinity probe (1)
- Agaphelin (1)
- Agarose (1)
- Aggregation (1)
- Agoraphobie (1)
- Agrobacterium vitis (1)
- Aiolos (1)
- Airway epithelia (1)
- Aktive Implantate (1)
- Aktivierung <Physiologie> (1)
- Aktivierungsenergie (1)
- Aktivitätstest (1)
- Akute lymphatische Leukämie (1)
- Akute myeloische Leukämie (1)
- Akzeptanz (1)
- Akzeptanz- und Commitment Therapie (1)
- Algorithmus (1)
- Aliphatics (1)
- Alkaloid (1)
- Allergie (1)
- Allergy (1)
- Allgemeine Zelle (1)
- Alloantigen (1)
- Alloantigen Expression (1)
- Allogene Zelle (1)
- Allogeneic stem cell transplantation (1)
- Allogenic hematopoietic stem cell transplantation (1)
- Allosterie (1)
- Alpaca (1)
- Alpha Neurofeedback (1)
- Alpha-Aktivität (1)
- Alternative polyadenylation (1)
- Alternative zum Tierversuch (1)
- Alveolar Echinococcosis (1)
- Alveoläre Echinokokkose (1)
- Alzheimer's Dementia (1)
- Alzheimer's disease (1)
- Alzheimer`s disease (1)
- AmGr1, AmGr2, AmGr3 (1)
- Ambrosia beetles (1)
- Ambrosiakäfer (1)
- Ameise (1)
- Ameisen (1)
- Ameisenstaat (1)
- Aminobisphosphonat (1)
- Aminobisphosphonate (1)
- Aminobuttersäure <gamma-> (1)
- Ammoniumpermease (1)
- Amphibien (1)
- Amyotrophe Lateralsklerose (1)
- Amyotrophic lateral sclerosis (1)
- Analyse (1)
- Anaphylatoxine (1)
- Anaphylatoxinrezeptoren (1)
- Anastomoseninsuffizienz (1)
- Ancistrocladaceae (1)
- Ancistrocladus (1)
- Androstadienon (1)
- Aneuploidy (1)
- Angewandte Toxikologie (1)
- Angiogenesis (1)
- Angiotensin II (1)
- Angst als Eigenschaft (1)
- Angst als Zustand (1)
- Angsterkrankung (1)
- Angstreaktionen (1)
- Angstsensitivität (1)
- Angstverhalten (1)
- Animal behavior IntelliCage system (1)
- Animales Nervensystem (1)
- Anisotropic structures (1)
- Annotation (1)
- Anoikis (1)
- Anpassung (1)
- Ant (1)
- Anthocyane (1)
- Anthropocene (1)
- Anti-CD52-Antikörper (1)
- Anti-infective (1)
- Antibiotic (1)
- Antibodies (1)
- Antifungal (1)
- Antigen CD3 (1)
- Antigen CD4 (1)
- Antigen CD44 (1)
- Antigen presentation (1)
- Antigen recognition (1)
- Antigenpräsentation (1)
- Antigenrezeptor (1)
- Antikörper-Antwort (1)
- Antimicrobial activities (1)
- Antimicrobial activity (1)
- Antimicrobial proteins (1)
- Antimikrobielle Aktivitäten (1)
- Antimikrobieller Wirkstoff (1)
- Antimykotika (1)
- Antimykotikum (1)
- Antioxidantien (1)
- Antivirale Substanzen (1)
- Antworthemmung (1)
- Antwortverhalten (1)
- Anxiety Disorders (1)
- Anxiety disorder (1)
- Anxiety disorders (1)
- Aortenaneurysma (1)
- Apallisches Syndrom (1)
- Aplysina aerophoba (1)
- Apolipoprotein E (1)
- Approved immunomodulators (1)
- Archaea (1)
- Archaebakterien (1)
- Arginine (1)
- Arid biomes (1)
- ArsZ (1)
- Artefakt (1)
- Artenreichtum (1)
- Arterielles Blut (1)
- Artery Models (1)
- Artesunate (1)
- Arthrose (1)
- Arthrosis deformans (1)
- Arzneimittel (1)
- Arzneimittelzulassung (1)
- Aspartatprotease (1)
- Aspergillose (1)
- Aspergillosis (1)
- Associative learning (1)
- Assoziatives Gedächtnis (1)
- AstA (1)
- Atemwege (1)
- Atemwegsschleimhaut (1)
- Atherogenese (1)
- Atmungsinsuffizienz (1)
- Atomic-force-microscopy (1)
- Atriales natriuretisches Hormon (1)
- Atta vollenweideri (1)
- Attention (1)
- Attention deficit / hyperactivity disorder (1)
- Attentional Avoidance (1)
- Attentional Bias (1)
- Attentional bias (1)
- Attraction (1)
- Attraktion (1)
- AuNPs (1)
- Auditorische Neuropathie (1)
- Auditorischer Kortex (1)
- Aufmerksamkeitsprozesse (1)
- Aurora B (1)
- Aurora-A-MYCN-Komplex (1)
- Ausbreitungsverhalten (1)
- Aussterbedynamik (1)
- Autoantigen (1)
- Autofocus (1)
- Autoimmunity (1)
- Autoinhibition (1)
- Automatische Klassifikation (1)
- Autophagie (1)
- Autophagie <Physiologie> (1)
- Autophagosom (1)
- Autophagozytose (1)
- Autoproteolysis (1)
- Autotransporter (1)
- Autotransporterprotein (1)
- Awareness (1)
- Axon Branching (1)
- B Lymphocytes (1)
- B-Lymphozyten (1)
- B0 (1)
- B0 correction (1)
- B0-Korrektur (1)
- B7-H1 (1)
- BCG (1)
- BCL-2 Familie (1)
- BCL-2 family (1)
- BCMA (1)
- BDNF (1)
- BDNF stimulation (1)
- BH3-only proteins (1)
- BIN2 (1)
- BMP (1)
- BMP signaling pathway (1)
- BMP-2 (1)
- BMP-Signaltransduktionsweg (1)
- BMP2 (1)
- BMS-5 (1)
- BRAF (1)
- BRCA1 (1)
- BTB domain (1)
- BTN3A1 and Phospho-antigen presentation (1)
- Bach (1)
- Bacteria-Host Cell Interaction (1)
- Bacterial Toxins (1)
- Bacterial community analysis (1)
- Bacterial meningitis (1)
- Bacteroides thetaiotaomicron (1)
- Baff (1)
- Baghdadite (1)
- Bahnung (1)
- Bakterielle Nanocellulose (1)
- Bakterienzellwand (1)
- Bakteriophagen (1)
- Bandwürmer (1)
- Bariatric surgery (1)
- Barth Syndrome (1)
- Barth syndrome (1)
- Basal Ganglia (1)
- Basalganglien (1)
- Basalmembran (1)
- Basement membrane (1)
- Batten disease (1)
- Bauchspeicheldrüse (1)
- Baumphysiologie (1)
- Bcl-2-Proteinfamilie (1)
- Bed nucleus of stria terminalis (1)
- Behavior (1)
- Behaviour (1)
- Benzimidazolderivate (1)
- Benzoate (1)
- Benzoate degradation (1)
- Beschleunigte Bildgebung (1)
- Bestimmung des Relaxations-Parameters in der Magnetresonanztomografie (1)
- Bestrahlung (1)
- Bestärkendes Lernen <Künstliche Intelligenz> (1)
- Bestäubung (1)
- Bestäubung Pollination Honigbiene Hummel (1)
- Beta-1-receptor (1)
- Beta-2-Rezeptor (1)
- Beta-Adrenergic Receptor (1)
- Beta-Adrenozeptor (1)
- Bevacizumab (1)
- Bewegungsstörung (1)
- Bienen <Familie> (1)
- Bienen Dressur Lernen (1)
- Bierhefe (1)
- Bildanalyse (1)
- Bildartefakte (1)
- Bildbearbeitung (1)
- Bilderzeugung (1)
- Bildgebung intakten Knochens (1)
- Bimolekulare Lipidschicht (1)
- Bindegewebe (1)
- BioVaSc (1)
- Biochemische Analyse (1)
- Biochemistry (1)
- Biodistribution (1)
- Biodiversity assessment (1)
- Biodiversity conservation (1)
- Biofabrikation (1)
- Biofilm formation (1)
- Biofilmarchitektur (1)
- Biofilms (1)
- Bioink (1)
- Biokinetics (1)
- Biolayerinterferometrie (1)
- Biologie / Zellbiologie (1)
- Biologischer Abbau (1)
- Biologisches Modell (1)
- Biology (1)
- Bioluminescence resonance energy transfer (1)
- Biolumineszenzmessung (1)
- Biomechanik (1)
- Bioprozessmethode (1)
- Bioreaktorplattform (1)
- Biosynthese der aromatischen Aminosäuren (1)
- Biosynthese-Genclustern (1)
- Bipolar (1)
- Bipolar Disorder (1)
- Bisphosphonate (1)
- Bitopic Ligands (1)
- Bitopische Liganden (1)
- Blick (1)
- Blickinteraktion (1)
- Blimp-1 (1)
- Blinatumomab (1)
- Blood nerve barrier (1)
- Blumeria graminis (1)
- Blut-Liquor-Schranke (1)
- Blut-Rückenmarkschranke (1)
- Blutgefäßsystem (1)
- Blutgerinnungsfaktor XII (1)
- Bluthirnschranke (1)
- Bone (1)
- Bone Marrow Dosimetry (1)
- Bone Quantification (1)
- Bone marrow stromal cell (1)
- Bone marrow stromal cell (BMSC) (1)
- Bone marrow transplantation (1)
- Bone morphogenetic protein 2 (1)
- Bone morphogenetic proteins (1)
- Bone regeneration (1)
- Bone-replacement (1)
- Bordetella (1)
- Borkenkäfer (1)
- Borneo (1)
- Borrelia (1)
- Bovine Mastitis (1)
- Brain (1)
- Brain derived neurotorphic factor (1)
- Brain endothelial cells (1)
- Brownsche Bewegung (1)
- Bruchpilot (1)
- Brustdrüsenentzündung (1)
- Burkholderia (1)
- Burkholderia pseudomallei (1)
- Burkitt Lymphom (1)
- Burkitt Lymphoma (1)
- Butyrophilin (1)
- Bäckerhefe (1)
- Bärtierchen (1)
- C. albicans (1)
- C. elegans (1)
- C/EBP (1)
- C1-inibitor (1)
- C5aR1-Antagonist (1)
- CA3 (1)
- CAMP production (1)
- CAR T Zellen (1)
- CAR T-Zelltherapie (1)
- CAR T-cells (1)
- CAR-T cell (1)
- CAR-T-Zell-Therapie (1)
- CCR4 (1)
- CD11b+ myeloid cells (1)
- CD150 (1)
- CD28 Molekül (1)
- CD28 Superagonisten (1)
- CD28 antigen (1)
- CD28-SA (1)
- CD28-Superagonist (1)
- CD28-superagonist (1)
- CD4 T-Zellen (1)
- CD4 positiv T cells (1)
- CD4+ (1)
- CD4+ T cell activation (1)
- CD40 gerichteter bifunktioneller scFv-TRAIL Fusionsproteine (1)
- CD40-targeted bifunctional scFv-TRAIL fusion proteins (1)
- CD44 (1)
- CD8 Effektorfunktionen (1)
- CD8 Gedächtnisreaktionen (1)
- CD8 T cell (1)
- CD8 T-Zelle (1)
- CD8 T-Zellen (1)
- CD8+ T cells (1)
- CD8+ T-Zellen (1)
- CD95 (1)
- CD95L (1)
- CDC42 (1)
- CDK4 Inhibitor (1)
- CDK4 inhibitor (1)
- CDR1-Effluxpumpe (1)
- CIP2A (1)
- CLEC-2 (1)
- CLEC16A (1)
- CMT1A (1)
- CMV (1)
- CNBP (1)
- COMT polymorphism (1)
- CRHR1 (1)
- CRISPR Cas9 (1)
- CRISPR Cas9 system (1)
- CTLA-4 (1)
- CVT (1)
- CX-5461 (1)
- CXCL13 (1)
- CXCR5 (1)
- CYP24A1 (1)
- CYP7A1 (1)
- CaCo-2 cell (1)
- Cadherin 13 (1)
- Cadherin-13 (1)
- Caenorhabditis elegans (1)
- Calcium Phosphate (1)
- Calcium phosphate-based biomaterials (1)
- Calcium signalling (1)
- Calcium-bindende Proteine (1)
- Calciumhomöostase (1)
- Calciumphosphat (1)
- Camponotus (1)
- Camponotus rufipes (1)
- Cancer Immune Therapy (1)
- Cancer Metabolism (1)
- Cancer biology (1)
- Cancer models (1)
- Cancer therapeutic resistance (1)
- Carabid beetles (1)
- Carcinogenese (1)
- Cardiac (1)
- Cardiac Efficiency (1)
- Cardiac MRI (1)
- Cardiac hypertrophy (1)
- Cardiac imaging (1)
- Cardiolipin (1)
- Cardiomyocytes (1)
- Cardiomyopathy (1)
- Carotis Intima Media Dicke (1)
- Cartiage Integration (1)
- Cartilage (1)
- Cartilage Regeneration (1)
- Cartilage defect (1)
- Cas9 (1)
- Caspr-1 (1)
- Catechol-0-Methyltransferase (1)
- Catechol-O-Methyltransferase (1)
- Catecholmethyltransferase <Catechol-0-Methyltransferase> (1)
- Cation Homeostasis (1)
- Caveolin-1 (1)
- Ccr4-Not (1)
- Cdh13 (1)
- Celecoxib (1)
- Cell (1)
- Cell Cycle (1)
- Cell Sheet Engineering (1)
- Cell adhesion (1)
- Cell culture (1)
- Cell differentiation (1)
- Cell line (1)
- Cell-Assisted Lipotransfer (1)
- Cells (1)
- Cellular invasion (1)
- Ceramides (1)
- Cerebrospinal fluid (CSF) (1)
- ChIP-Seq (1)
- ChIP-sequencing (1)
- Chaetomium thermophilum (1)
- Chain-length distribution (1)
- Characterization (1)
- Charcot-Marie-Tooth 1A (1)
- Chemische Synapsen (1)
- Chemokin CXCL10 (1)
- Chemokin CXCL12 (1)
- Chemokine (1)
- Chemokine receptors (1)
- Chemoresistenz (1)
- Chemotaxis (1)
- Chemotherapeutic resistance (1)
- Children (1)
- Chimeric Antigen Receptor (1)
- Chimeric antigen receptor (1)
- Chimeric antigen receptor (CAR) (1)
- Chimpanzee (1)
- Chimärer Antigenrezeptor (1)
- Chirurgie (1)
- Chlamydia (1)
- Chlamydienkrankheit (1)
- Cholesterintransporter (1)
- Chondrogenic Differentiation (1)
- Chordontonal organ (1)
- Chromatinremodeling (1)
- Chromatinremodelling (1)
- Chromosom 6 (1)
- Chromosome 6 (1)
- Chronic Mild Stres (1)
- Chronisch-myeloische Leukämie (1)
- Chronische Nierenerkrankung (1)
- Chronischer Schmerz (1)
- Chylomicron (1)
- Chylomicrons (1)
- Circadian (1)
- Circadian Clock (1)
- Circadian clock (1)
- Circadiane Uhr (1)
- Circadianer Rhythmus (1)
- Citalopram (1)
- Claudin (1)
- Click-Chemie (1)
- Climate change (1)
- Clonal competition assay (1)
- Clostridium difficile (1)
- Cluster (1)
- Co-Analgetika (1)
- Co-Kultur (1)
- Co-culture (1)
- Co-culture system (1)
- CoQ10 (1)
- Coactosin-like (1)
- Coffin-Lowry syndrome (1)
- Cofilin (1)
- Cognition (1)
- Cognitive Distortions (1)
- Collagen gels (1)
- Colliculus inferior (1)
- Collybistin (1)
- Colon cancer (1)
- Commensalism (1)
- Comorbidity (1)
- Comoé National Park (1)
- Complement system (1)
- Complex Regional Pain Syndrome (1)
- Complexes (1)
- Complexome (1)
- Compound eyes (1)
- Compressed sensing (1)
- Computational Fluid Dynamics (1)
- Computational drug design (1)
- Computersimulation (1)
- Computerunterstütztes Verfahren (1)
- Conditioning (1)
- Contact-Kinin System (1)
- Contrast Agent Bolus Based Perfusion Magnetic Resonance Imaging (1)
- Convolutional Neural Network (1)
- Coronary heart disease (1)
- Correlative microscopy (1)
- Cortico-striatal projection neurons (1)
- Corticoliberin (1)
- Counting (1)
- Coxiella burnetii (1)
- Craniosynostosis (1)
- Craving (1)
- CsrA (1)
- Cul4b (1)
- Cuticular transpiration (1)
- Cuticular water permeabilities (1)
- Cyanobacteria (1)
- Cyanobakterien (1)
- Cyclic peptides (1)
- Cyclics (1)
- Cystein (1)
- Cysteinproteasen (1)
- Cytologie (1)
- Cytomegalie-Virus (1)
- Cytoplasma (1)
- Cytotoxic T cell (1)
- D-4F (1)
- DC (1)
- DC/T-Zell-Konjugate (1)
- DEQCT (1)
- DExD/H box protein (1)
- DG diacyglycerol (1)
- DGCR8 (1)
- DHX30 (1)
- DNA Barcoding (1)
- DNA Damage (1)
- DNA Doppelstrangbrüche (1)
- DNA Schaden (1)
- DNA Sekundärstruktur (1)
- DNA double strand breaks (1)
- DNA lesion (1)
- DNA methylation (1)
- DNA secondary structure (1)
- DNA-Methylierung (1)
- DNA-Schaden (1)
- DNA-Schäden (1)
- DNS-Bindungsproteine (1)
- DNS-Schaden (1)
- DNS-Sequenz (1)
- DOT1 (1)
- DREAM (1)
- DREAM complex (1)
- DSIF (1)
- DTI (1)
- DUB Mutante (1)
- DYT-TOR1A (1)
- Danaus plexippus (1)
- Danio rerio (1)
- Darmepithel (1)
- Darmflora (1)
- Dasatinib (1)
- Datenbank (1)
- Decapping (1)
- Deep-sequencing (1)
- Deeplearning (1)
- Defensine (1)
- Defäkographie (1)
- Deletion (1)
- Denaturierende Gradienten-Gelelektrophorese (1)
- Denaturing Gradient Gel Electrophoresis (1)
- Density Weighting (1)
- Deoxyribozymes (1)
- Dephosphorylierung (1)
- Depletion (1)
- Dereplicaiton (1)
- Desmoglein 2 (1)
- Desmoglein 3 (1)
- Desmogleine (1)
- Desmosom (1)
- Deubiquitination (1)
- Development (1)
- Dexamethason (1)
- Diabetes (1)
- Diabetes Typ 1 (1)
- Diabetes mellitus Typ 1 (1)
- Diabetic painful neuropathy (1)
- Diabetic polyneuropathy (1)
- Diagnostic Imaging Exams (1)
- Dickdarmkrebs (1)
- Differential scanning calorimetry (1)
- Differentielle Genexpression (1)
- Differentielle Ressourcenallokation (1)
- Differenzierung (1)
- Differenzierungszustand (1)
- Diffusion (1)
- Diffusion Tensor Imaging (1)
- Diffusion coefficient (1)
- Dihydrooxazole (1)
- Dilated cardiomyopathy (1)
- Dimension 3 (1)
- Dimere (1)
- Dimeric Naphthylisoquinoline Alkaloids (1)
- Diphenylether (1)
- Dispersal (1)
- Disulfidbrücken (1)
- Diversifikation <Biologie> (1)
- Diversity (1)
- Dolutegravir (1)
- Domäne <Biochemie> (1)
- Domänenprotein (1)
- Dopamin-Transporter (1)
- Dopamine transporter (1)
- Dopaminstoffwechsel (1)
- Dopamintransporter (1)
- Dorsal Root Ganglion (1)
- Dorsal root ganglion (1)
- Dosimetry (1)
- Double Negative B cells (1)
- Droseraceae (1)
- Drosophila Larva (1)
- Drosophila Larve (1)
- Drosophila Myc transcription growth PAF1 (1)
- Drug delivery system (DDS) (1)
- Drug resistance (1)
- Drug targets (1)
- Drug testing (1)
- Dual RNA-seq (1)
- Dual RNA-seq data analysis (1)
- Dual-setting (1)
- Dualstere Liganden (1)
- Dualsteric Ligands (1)
- Duodenal Jejunal Bypass (1)
- Duplikation (1)
- Durchflusscytometrie (1)
- Dynabeads (1)
- Dynamic MR imaging (1)
- Dynamics of ribosome assembly (1)
- Dynamik (1)
- Dynamik von Membranrezeptoren (1)
- Dynamische MR-Bildgebung (1)
- Dynein Light Chain (1)
- Dystonie (1)
- Dürrestress (1)
- E.coli Nissle 1917 (1)
- E1 inhibitoren (1)
- E1 inhibitors (1)
- E2 (1)
- EAE (1)
- ECAP (1)
- ECG-gated PET (1)
- ELISA (1)
- EMT (1)
- ER dynamics in axon terminals (1)
- ERK (1)
- Eap (1)
- Early-Life Stress (1)
- Echo Planar Imaging (1)
- Echo planar imaging (1)
- Echocardiography (1)
- Echoplanar-Bildgebung (1)
- Echtzeit (1)
- Echtzeitbildgebung (1)
- Ecological Momentary Assessment (1)
- Ecological Momentary Assessments (1)
- Ecosystem services (1)
- Effect anticipation (1)
- Effektantizipation (1)
- Efflux pump (1)
- Effluxpumpen (1)
- Eierstockkrebs (1)
- Eierstocktumor (1)
- Einfühlung (1)
- Einfühlung <Motiv> (1)
- Eingeweidewürmer (1)
- Einsamkeit (1)
- Einzel-Molekül (1)
- Einzelpartikelverfolgung (1)
- Einzelzellgelelektrophorese (1)
- Electrochemical Impedance Spectroscopy (1)
- Electrode (1)
- Electroencephalography (1)
- Electromyography (1)
- Electrophysiology (1)
- Elektroakupunktur (1)
- Elektrode (1)
- Elektromyographie (1)
- Elektronencephalographie (1)
- Elektrospinnen (1)
- Elektrostimulation (1)
- Elektrotherapie (1)
- Elevated Plus-Maze (1)
- Elongation (Transkription) (1)
- Embryo (1)
- Embryonale Stammzelle (1)
- Emotionale Informationsverarbeitung (1)
- Emotionales Verhalten (1)
- Empfindlichkeit (1)
- Endobrachyösophagus (1)
- Endocytosis (1)
- Endogenous clock (1)
- Endokrinologie (1)
- Endophenotype (1)
- Endophänotyp (1)
- Endophänotypen (1)
- Endoplasmatisches Retikulum (1)
- Endorganschaden (1)
- Endosomes (1)
- Endothelium (1)
- Endothelzelle (1)
- Enoyl-Reduktase (1)
- Enoyl-acyl-carrier-protein-Reductase (1)
- Enoyl-acyl-carrier-protein-Reductase <Enoyl-[acyl-carrier-protein]-Reductase> (1)
- Enterische Glia (1)
- Enterisches Nervensystem (1)
- Enterohemorrhagic Escherichia coli (1)
- Entscheidungsverhalten (1)
- Entwicklung chimärer Antigenrezeptor T-Zellen (1)
- Entzündungschmerz (1)
- Entzündungsreaktion (1)
- Entzündungsschmerz (1)
- Enzymaktivierung (1)
- Enzyminhibitor (1)
- Eosinophiler Granulozyt (1)
- EphA2 (1)
- Ephrin ligand (1)
- Ephrine (1)
- Epidemiologie (1)
- Epigenetische Mechanismen (1)
- Epithel (1)
- Epithelial layer (1)
- Epithelial lineage (1)
- Epithelial-mesenchymale Transition (1)
- Epithelzelle (1)
- Erk1/2 (1)
- Erkennung (1)
- Erregbarkeit (1)
- Esophageal adenocarcinoma (1)
- Esophageal disease (1)
- Essgewohnheit (1)
- Essstörung (1)
- Essverhalten (1)
- Estrogens (1)
- Excitatory/inhibitory imbalance (1)
- Excitotoxicity (1)
- Exon Array (1)
- Expansion microscopy (1)
- Expansionsmikroskopie (1)
- Experimental Autoimmune Encephalomyelitis (EAE) (1)
- Experimentelle Autoimmune Enzephalomyelitis (1)
- Experimentelle Autoimmune Enzephalomyelitis (EAE) (1)
- Experimentelle autoimmune Enzephalomyelitis (1)
- Experimentellen Autoimmun-Enzephalomyelitis (1)
- Experimenteller Schlaganfall (1)
- Explainable AI (1)
- Explainable Artificial Intelligence (1)
- Explorationsverhalten (1)
- Exposition (1)
- Expositionslernen (1)
- Exposure treatment (1)
- Expression (1)
- Extracellular Matrix (1)
- Extracellular Vesicles (1)
- Extracellular matrix proteins (1)
- Extrazellulärmatrix (1)
- Exzitatorische Synapse (1)
- Eye irritation (1)
- FAS (1)
- FAS-II (1)
- FAT10ylation (1)
- FBXO6 (1)
- FCS (1)
- FGF (1)
- FGF Signaling (1)
- FLT3 inhibitor (1)
- FMMs (1)
- FMS-like tyrosine kinase 3 (FLT3) (1)
- FOXM1 (1)
- FOXP2 (1)
- FP635 (1)
- FRAP (1)
- FRET sensors (1)
- FT-IR-Spektroskopie (1)
- FabI (1)
- FabV (1)
- Fabry disease (1)
- Factor XII (1)
- Faktor XII (1)
- Fanconi Anemia (1)
- Fanconi-Anämie (1)
- Farnesyl Pyrophosphate Synthase (1)
- Farnesylpyrophosphatsynthase (FPPS) (1)
- Fas-Ligand (1)
- Fat Quantification (1)
- FcgR (1)
- FeS cluster (1)
- Fear (1)
- Fear Conditioning (1)
- Fear Extinction (1)
- Fear Generalization (1)
- Fear Learning (1)
- Fear conditioning (1)
- Fear generalization (1)
- Feedforward loop (1)
- FemX (1)
- Ferroptosis (1)
- Fertilization in angiosperm (1)
- Fettgewebe (1)
- Fettleber (1)
- Fettsäure-Synthase (1)
- Fibroblast (1)
- Fibroblasts (1)
- Fibromyalgia (1)
- Fibromyalgia syndrome (1)
- Fibromyalgiesyndrom (1)
- Fibrose (1)
- Filter (1)
- Flagelle (1)
- Flavonoide (1)
- Flavonoids (1)
- Flippase (1)
- Flotillin (1)
- Flow (1)
- Flugzeitmassenspektrometrie (1)
- FluidFM (1)
- Fluorescence Correlation Spectroscopy (1)
- Fluorescence Resonance Energy Transfer (1)
- Fluorescence correlation spectroscopy (1)
- Fluorescence microscopy (1)
- Fluorescence-resonance-energy-transfer (1)
- Fluorescent probes (1)
- Fluoreszenz (1)
- Fluoreszenzproteine (1)
- Fluoreszenzsonde (1)
- Fluoreszenzspektroskopie (1)
- Fluoxetine (1)
- Fluss (1)
- Foamyviren (1)
- Folliculin (1)
- Forkhead Transcription Factors (1)
- Forkhead-Box-Proteine (1)
- Fox tapeworm (1)
- FoxO transcription factors (1)
- Foxo1 (1)
- Foxp3+CD4+ regulatorische T-Zelle (1)
- Foxp3+CD4+ regulatory T cell (1)
- Fragebogen (1)
- Fragmentscreening (1)
- Französische Feldwespe (1)
- Freezing (1)
- Freies Molekül (1)
- Fremdkörpermodell (1)
- Frizzled 5 (1)
- Frontal asymmetry (1)
- Froschlurche (1)
- Fructosebisphosphat-Aldolase (1)
- Fruit (1)
- Frühe Gene (1)
- Function (1)
- Functional analyses (1)
- Functioning Assessment Short Test (1)
- Funktionelle Annotation (1)
- Funktionelle Bildgebung (1)
- Funktionelle Kernspintomographie (1)
- Funktionsausfälle (1)
- Furagieraktivität (1)
- Furchkonditionierung (1)
- Furchtentwicklung (1)
- Furchtextinktion (1)
- Fusarium (1)
- Fusobacterium nucleatum (1)
- Förster Resonance Energy Transfer (1)
- G Protein-Coupled Receptor (1)
- G Protein-Coupled Receptors (1)
- G Protein-coupled receptor (1)
- G glycoprotein (1)
- G protein coupled receptor (1)
- G protein-coupled receptor kinase (1)
- G protein-coupled receptor kinase 2 (GRK2) (1)
- G protein-coupled receptors (1)
- G protein-gekoppelte Rezeptor Kinase 2 (GRK2) (1)
- G-Protein (1)
- G-Protein gekoppelte Rezeptor (1)
- G-Protein-gekoppelte Rezeptoren (1)
- G-protein (1)
- G-quadruplex (1)
- G2/M genes (1)
- GABA (1)
- GABA A Receptors (1)
- GABA A Rezeptoren (1)
- GABA receptor (1)
- GABA(A) receptor (1)
- GABAA-Rezeptor (1)
- GABAerge Nervenzelle (1)
- GAD1 (1)
- GAD65 (1)
- GAS2L3 (1)
- GC1 cells (1)
- GDF-15 (1)
- GLA KO mouse model (1)
- GLP-1 (1)
- GMP (1)
- GPCR dimerisation (1)
- GPCR nanodomains (1)
- GPCR signaling (1)
- GRM8 (1)
- GWAS (1)
- Ga-68-labelled Peptides (1)
- Galactosidase <alpha-> (1)
- Galectin 1 (1)
- Gambler's Fallacy (1)
- Gametocyt (1)
- Gametozyt (1)
- Ganzkörperbestrahlung (1)
- Gap Junction (1)
- Gas chromatography (1)
- Gaschromatographie (1)
- Gastroesophageal reflux (1)
- Gastrointestinal tract (1)
- Gauss Prozess Klassifikation (1)
- Gaussian Process Classification (1)
- Gaze interaction (1)
- Gb3 accumulation (1)
- Gefrierstrukturierung (1)
- Gefäßalter (1)
- Gefäßwand (1)
- Gefäßwand-residente Stamm- und Vorläuferzellen (1)
- Gehirn-Computer Schnittstelle (1)
- Geißel <Biologie> (1)
- Gelernte Hilflosigkeit (1)
- Gemcitabin (1)
- Gen BRCA 1 (1)
- Gen Umweltinteraktion (1)
- Gen notch (1)
- Gen-Umwelt Interaktion (1)
- Gene by Environment (1)
- Gene expression regulation (1)
- Gene regulation (1)
- Gene therapy (1)
- General Transcription Factor II H (1)
- General amplifier model (1)
- Generalization (1)
- Genetic etiology (1)
- Genome Annotation (1)
- Genome Instability (1)
- Genome editing (1)
- Genomeditierung (1)
- Genomic Selection (1)
- Genomik (1)
- Genotoxicity (1)
- Genotyping (1)
- Gentoxizität (1)
- Geomagnetic Field (1)
- Gerinnungsfaktor (1)
- Germination and differentiation (1)
- Germinative Zellen (1)
- Geruchswahrnehmung (1)
- Geschlechtsunterschiede (1)
- Geschmack (1)
- Gestational diabetes (1)
- Gestationsdiabetes (1)
- Gewebe (1)
- Gewebemodelle (1)
- Glatte Muskulatur (1)
- Glatter Krallenfrosch (1)
- Glioblastomtherapie (1)
- Glioma (1)
- Global change (1)
- Glottoplastik (1)
- Glucocorticoids (1)
- Glucose Starvation (1)
- Glucose metabolism (1)
- Glucosetransport (1)
- Glucosetransporter (1)
- Glukosemetabolismus (1)
- Glukosetransporter -1 (1)
- Glutamin (1)
- Glutathion (1)
- Glycerin-3-phosphat (1)
- Glycerinphosphate (1)
- Glycin (1)
- Glycine Receptors (1)
- Glycocalyx (1)
- Glycolipid (1)
- Glycophyten (1)
- Glycoprotein GPV (1)
- Glycoprotein hormone (1)
- Glykane (1)
- Glykobiologie (1)
- Glykokalyx (1)
- Glykomodifizierung (1)
- Glykosyltransferase (1)
- Glyzin Rezeptoren (1)
- Glyzinrezeptor (1)
- Glücksspiel (1)
- Gold Nanoparticles (1)
- Golgi apparatus (1)
- Gonococcal invasion (1)
- Grad-seq (1)
- Gradient System Transfer Function (1)
- Graft versus Host Disease (1)
- Graft versus Host disease (1)
- Graft versus host disease (1)
- Graft-versus-host disease (GvHD) (1)
- Graft-versus-leukemia (1)
- Gram-positive (1)
- Gram-positive bacteria (1)
- Granulozyten (1)
- Growth-differentiation Factor 15 (1)
- Guanin Nukleotid Austauschfaktor (1)
- Guanine nucleotide exchange factor (GEF) (1)
- Guaninnucleotid-Austauschfaktoren (1)
- Guanylyl cyclase A (1)
- Guillain-Barré-Syndrom (1)
- GvL (1)
- Gvhd (1)
- H2A.Z (1)
- HAD phosphatase (1)
- HASH (1)
- HBD2 (1)
- HCMV (1)
- HD5 (1)
- HDAC (1)
- HECTD1 (1)
- HERV (1)
- HFpEF (1)
- HIF1alpha (1)
- HIV Drug resistance (1)
- HIV South Africa (1)
- HIV-1 (1)
- HIV-1 Vif (1)
- HIV-associated neurocognitive disorder (HAND) (1)
- HIV-assoziierte neurokognitive Störung (HAND) (1)
- HLA-G (1)
- HMBPP (1)
- HNE (1)
- HP1432, Hpn2 (1)
- HPLC-MS (1)
- HRV (1)
- HSF1 (1)
- HST1 (1)
- HSV-1 (1)
- Haarzelle (1)
- Habituationstraining (1)
- Haemostasis (1)
- Haloacid dehalogenase (1)
- Halophyten (1)
- Halophytes (1)
- Harze (1)
- Hautkrebs (1)
- Hautmodell (1)
- Hautverbrennung (1)
- Heart (1)
- Heart Failure (1)
- Heart Period (1)
- Heart development (1)
- Heart failure (1)
- Heat shock protein 90 (1)
- Heat stress (1)
- Heilmittel (1)
- Heilung (1)
- Heißhunger (1)
- Helferzelle (1)
- Helicase (1)
- Helikasen (1)
- Helminths (1)
- Hematopoietic Cell Transplantation (1)
- Hematopoietic Stem Cell (1)
- Hematopoietic cell transplantation (1)
- Hemmung der Proliferation schnell wachsender Krebszellen (1)
- Hemodynamics (1)
- Hemofiltration (1)
- Heparin (1)
- Hereditary spastic paraplegia (1)
- Hereditäre spastsiche Paraplegie (1)
- Herpes (1)
- Herpes simplex Virus DUB C65A (1)
- Herpes simplex virus C65A (1)
- Herpesviren (1)
- Herpesviruses (1)
- Herz-Kreislauf-Erkrankung (1)
- Herzbildgebung (1)
- Herzfrequenz (1)
- Herzfunktion (1)
- Herzruptur (1)
- Heterogenität von Mikroorganismen (1)
- Hey Proteine (1)
- Hey proteins (1)
- Hi-C (1)
- Hic-5 (1)
- Hidden Markov Model (1)
- Hidden-Markov-Modell (1)
- High-thropughput screening (1)
- Himmelskompass (1)
- Hippokampus (1)
- Hirnendothelzellen (1)
- Hirnhaut (1)
- Hirnstimulation (1)
- Histatin 5 (1)
- Histon-Deacetylase (1)
- Histon-Methyltransferase (1)
- Histonacetyltransferase (1)
- Histone Acetylation (1)
- Histone modification (1)
- Histone variant (1)
- Histones (1)
- Hitzeschock Proteine (1)
- Hitzeschock-Proteine (1)
- Hitzeschockprotein 90 (1)
- Hitzeschocktranskriptionsfaktor (1)
- Hitzestress (1)
- Hochauflösende Mikroskopie (1)
- Hochauflösungsmikroskopie (1)
- Hochdurchsatz-Screening (1)
- Hochdurchsatzsequenzierung (1)
- Holobiont (1)
- Homing (1)
- Homöostase (1)
- Honeybee (1)
- Honigbiene (1)
- Honigbienen (1)
- Hormone Receptor Signaling (1)
- Hornhaut (1)
- Hornhautinfektionen (1)
- Hospitalismus <Hygiene> (1)
- Host Colonization (1)
- Host Genome Integrity (1)
- Host defense (1)
- Hot Hand Fallacy (1)
- Huh6 (1)
- Human Herpesvirus 6 (1)
- Human Transcriptome (1)
- Human-pathogenic (1)
- Humanes Herpesvirus 6 (1)
- Humanparasitologie (1)
- Huwe1 (1)
- Hyaluronic Acid (1)
- Hyaluronic acid (1)
- Hybrid-Molecules (1)
- Hydrocortison (1)
- Hydrogels (1)
- Hyperactivity (1)
- Hyperekplexie (1)
- Hypertension (1)
- Hypertrophy (1)
- Hyrogels (1)
- Hämatopoetische Stammzellen (1)
- Hämatopoetische Stammzelltransplantation (1)
- Hämodynamik (1)
- Hämophilie A (1)
- Hämsotase (1)
- Höhenangst (1)
- Hörbahn (1)
- Hörrinde (1)
- ICP22 (1)
- IE3 (1)
- IEG (1)
- IFN-g (1)
- IFNAR (1)
- IKZF1 (1)
- IKZF3 (1)
- IL-12p70 (1)
- IL-2 (1)
- IL-23 (1)
- IL-4 (1)
- IL-4 Rezeptor alpha (1)
- IL-4 receptor alpha chain (1)
- IL-6 Inhibition (1)
- IMP1/ZBP1 (1)
- IP6 (1)
- IPP (1)
- IRAK2 (1)
- ITAM (1)
- ITAM-signalling (1)
- IVIG (1)
- Ibrutinib (1)
- Ideomotor gaze control (1)
- Ideomotorik (1)
- Ideomotorische Blickkontrolle (1)
- IgG-Subklasse (1)
- Ighmbp2 (1)
- Ikaros (1)
- Ileal Trasposition (1)
- Illumina HiSeq (1)
- Image Processing (1)
- Image Quality (1)
- Immunaktivierung (1)
- Immunantwort (1)
- Immune Checkpoint Therapy (1)
- Immune System (1)
- Immune Thrombocytopenia (1)
- Immune activation (1)
- Immune cell assays (1)
- Immune cells (1)
- Immunglobulin G (1)
- Immunität <Medizin> (1)
- Immunkardiologie (1)
- Immunocardiology (1)
- Immunologe (1)
- Immunomodulation (1)
- Immunophilin (1)
- Immunosuppressant (1)
- Immunozyt (1)
- Immunsuppressiva (1)
- Immunthrombozytopenie (1)
- Immunzellassays (1)
- Immunzellrekrutierung (1)
- Impfstoff (1)
- Implantatentwicklung (1)
- Impulsivität (1)
- In vitro models (1)
- In vivo Imaging (1)
- Individual based model (IBM) (1)
- Individualisierte Medizin (1)
- Infection imaging (1)
- Infection models (1)
- Infectious diseases (1)
- Infektiologie (1)
- Infektionsbildgebung (1)
- Infektionsbiologie (1)
- Infektionsprozess (1)
- Infektionsstudien (1)
- Inferior colliculus (1)
- Inflamamtion (1)
- Inflammatory Pain (1)
- Inflammatory pain (1)
- Informationsnutzung (1)
- Infrared radiation (1)
- Inhibitory-postsynapse (1)
- Injectability (1)
- Insect (1)
- Insekt (1)
- Insektenstaaten (1)
- Instrumental Activities of Daily Living (1)
- Insulin-like Growth (1)
- Insulin-like-Growth-Factor-Binding-Protein-5 (1)
- Insulinresistenz (1)
- Integrase inhibitor (1)
- Integrated Defensive States (1)
- Integrin (1)
- Integrine (1)
- Interaction analysis (1)
- Interaction of 7SK with the Smn complex modulates snRNP production (1)
- Interaktionsrezeptor (1)
- Interferon <Gamma-> (1)
- Interferonrezeptor (1)
- Interleukin (1)
- Interleukin 12 (1)
- Interleukin 17 (1)
- Interleukin 5 (1)
- Interleukin-4 Antagonist (1)
- Interleukine (1)
- Internal Dosimetry (1)
- Internalisierende Störung (1)
- Intestinal metaplasia (1)
- Intestinal stem cell (1)
- Intracellular bacteria (1)
- Intracellular virulence (1)
- Intratumorale Heterogenität (1)
- Intravoxel Incoherent Motion (1)
- Intrazelluläre Bakterien (1)
- Intrinsische Gerinnungskaskade (1)
- Ion channel function (1)
- Ionisierende Strahlung (1)
- Irradiation (1)
- Ischemia (1)
- Ischämischer Schlaganfall (1)
- Isolation (1)
- Isolation and Characterization (1)
- Isomer (1)
- Isopentenyl pyrophosphate (IPP) (1)
- Isopentenyl-pyrophosphat (IPP) (1)
- Isoprenoid Synthesis (1)
- Isoprenoide (1)
- Isoprenoidsynthese (1)
- Ixolaris (1)
- JNCL (1)
- JNK (1)
- JURKAT-Zelle (1)
- Judgment (1)
- Jugendliche (1)
- Jun (1)
- K-RAS (1)
- K5 capsule (1)
- KDELR2 (1)
- Kaliumkanal (1)
- Kallikrein-Kinin-System (1)
- Kardiale MR-Bildgebung (1)
- Kardiovaskuläre Krankheit (1)
- Karotis-Intima-Media-Dicke (1)
- Kation (1)
- Kationen-Homöostase (1)
- Kehlkopfchirurgie (1)
- Keimzentrumsreaktion (1)
- Kern (1)
- Kidney (1)
- Kilimandscharo (1)
- Kinase (1)
- Kinase signaling (1)
- Kinasen (1)
- Kinder (1)
- Kinderpsychiatrie (1)
- Kinderschlaf (1)
- Kindesalter (1)
- Kindheit und Jugend (1)
- Kinetik (1)
- Klassifikations- und Regressionsbaum (1)
- Klassische Konditionierung (1)
- Kleine Proteine (1)
- Kleinkern (1)
- Kleinkind (1)
- Klima (1)
- Klimawandel (1)
- Klinischer Behandlungspfad (1)
- Kniegelenkarthrose (1)
- Knochenbildung (1)
- Knochenersatz (1)
- Knochenmarkzelle (1)
- Knochenmetastase (1)
- Knochenmetastasen (1)
- Kofaktorbindung (1)
- Koffein (1)
- Kognitive Beeinträchtigung (1)
- Kognitive Inhibition (1)
- Kognitive Störung (1)
- Kognitiver Prozess (1)
- Kognitives Lernen (1)
- Kohlendioxid (1)
- Kohlenhydrate (1)
- Kohlenstoff (1)
- Kohlenstofffaser (1)
- Kohlenstoffstoffwechsel (1)
- Kohlenwasserstoffe (1)
- Kollektive Invasion (1)
- Kolloid (1)
- Kolonieerkennung (1)
- Kolonkarzinom (1)
- Kommunikation (1)
- Kommunikationshilfe (1)
- Komorbidität (1)
- Kompass (1)
- Komplement (1)
- Komplement C3a (1)
- Komplement C5a Rezeptor 1 (1)
- Komplementsystem (1)
- Komplexauge (1)
- Komplexes regionales Schmerzsyndrom (1)
- Komprimierte Abtastung (1)
- Kongestive Herzmuskelkrankheit (1)
- Kongo (1)
- Konnektivitätsschätzung (1)
- Konsolidierung (1)
- Kontingenz (1)
- Kontrastmittel (1)
- Kontrastmittel-gestützte MRT-Perfusionsmessung (1)
- Kontrolle (1)
- Kopfschmerz (1)
- Kopienzahlvariation (1)
- Korrelative Mikroskopie (1)
- Krebs (1)
- Kristallographie (1)
- Kryokonservierung (1)
- Kuh (1)
- Körperachsen (1)
- Körperliche Leistungsfähigkeit (1)
- Künstliche Ingelligenz (1)
- Künstliche Intelligenz (1)
- L-typ Calciumkanal Antagonist (1)
- LAD (1)
- LASP1 (1)
- LASP1 (LIM and SH3 Protein 1) (1)
- LASP1 (LIM und SH3 Protein 1) (1)
- LAT2 (1)
- LIMK (1)
- LIS (1)
- LPS (1)
- LPS Biosynthese (1)
- LV Function (1)
- Labeling (1)
- Lactobacillus reuteri (1)
- Lambdoide Prophagen (1)
- Langerhans cells (1)
- Langzeitgedächtnis (1)
- Lasermikrodissektion (1)
- Lasiocarpin (1)
- Lateral root development (1)
- Latrophilin receptor (1)
- Latrophilin-3 (1)
- Ldlr-Knockout (1)
- Leaf (1)
- Learning & Memory (1)
- Learning Walk (1)
- Learning walk (1)
- Lebendzellmikroskopie (1)
- Lebensmittelchemie (1)
- Lebensqualität (1)
- Leber-Metabolismus (1)
- Leberepithelzelle (1)
- Leichte kognitive Beeinträchtigung (1)
- Leitlinien (1)
- Lenalidomid (1)
- Lentiviral transgenesis (1)
- Leptomeningeal cells (1)
- Leptomeningealzellen (1)
- Lernverhalten (1)
- Letalität (1)
- Leukaemia-inhibitory factor (1)
- Lgr5 (1)
- Library Screening (1)
- Library of Phytochemicals (1)
- Library of plant species (1)
- Licht (1)
- Lichtblattmikroskopie (1)
- Lichtscheibenmikroskopie (1)
- Licl (1)
- Ligand <Biochemie> (1)
- Ligand uncaging (1)
- Light Sheet Fluorescence Microscopy (1)
- Light sheet microscopy (1)
- Lipid Raft (1)
- Lipid Rafts (1)
- Lipid Transfer Protein (1)
- Lipidom (1)
- Lipidomics (1)
- Lipidomik (1)
- Lipidumbau (1)
- Lipolysis (1)
- Liquor (1)
- Locomotor activity (1)
- Lokalanästhesie (1)
- Luftfeuchtigkeit (1)
- Lung Cancer metastasis (1)
- Lung cancer (1)
- Lung squamous cancer cells (1)
- Lungenentzündung (1)
- Lungentumor (1)
- Lurche (1)
- Lysin-Oxidase (1)
- Lysosome (1)
- Lysyl oxidases (1)
- Lysyloxidasen (1)
- Ländlicher Raum (1)
- M1 Muscarinic Receptor (1)
- MAP kinase (1)
- MAX (1)
- MCMV (1)
- MDR1 (1)
- MDSC (1)
- MDSCs (1)
- MEK5/ERK5 (1)
- MEK5/ERK5 cascade (1)
- MET-T-box riboswitch (1)
- MGMT (1)
- MIPs (1)
- MIZ1 (1)
- MLN7243 (1)
- MM (1)
- MMB complex (1)
- MMN (1)
- MMP (Matrix-Metalloproteasen) (1)
- MMP (Matrix-Metalloproteases) (1)
- MND (1)
- MRR1 (1)
- MS2-affinity purification and RNA-seq (1)
- MT02 (1)
- MYCN-amplified (1)
- Machine Learning (1)
- Macromolecular machine (1)
- Macrophage (1)
- Macrophage extracellular traps (1)
- Macrophytes (1)
- Magen (1)
- Magenchirurgie (1)
- Magenkrankheit (1)
- Magenkrebs (1)
- Magnetic Resonance Imaging (1)
- Magnetic Resonance Relaxometry (1)
- Magnetic resonance imaging (1)
- Magnetresonanz-Relaxometrie (1)
- Major depression (1)
- Makrokolonie (1)
- Makrophagen (1)
- Makrophyten (1)
- Malignant melanoma (1)
- Mamma carcinoma (1)
- Mammakarzinom (1)
- Mantle cell lymphoma (1)
- Marine natural products (1)
- Marine sponge (1)
- Marine sponge-derived actinomycetes (1)
- Marker (1)
- Marketing authorisation of pharmaceuticals (1)
- Marrow (1)
- Masern (1)
- Masern-Virus (1)
- Masernvirus-Infektion (1)
- Mass Spectrometry (1)
- Mass spectrometry (1)
- Massenspektrometrie/Proteomics (1)
- Masspectrometry (1)
- Mast cells (1)
- Mastzelle (1)
- Mathematical modeling (1)
- Mathematische Modellierung (1)
- Matrix-Metalloprotease (1)
- Matrix-Metalloproteasen (1)
- Matrix-Metalloproteinase (1)
- Mauerbiene (1)
- Mc4r (1)
- Measles virus (1)
- Mechanical deformation (1)
- Mechanisms of Social Attention (1)
- Mechanismus (1)
- Mechanistic model (1)
- Mechanorezeptor (1)
- Medaka (1)
- Mediator Komplex (1)
- Medium spiny neurons (1)
- Medizinprodukt (1)
- Medizintechnik (1)
- Medulloblastom (1)
- Megakaryocytes (1)
- Megakaryozytopoese (1)
- Mek5/Erk5-Signalweg (1)
- Melanin (1)
- Melanin release (1)
- Melanoma (1)
- Melanophor (1)
- Melt electrowriting (1)
- Membrane Receptor Dynamics (1)
- Membrane transporters (1)
- Membranlipide (1)
- Membranrezeptor (1)
- Membrantransporter (1)
- Memory (1)
- Memory B cells (1)
- Menaquinon-BIosynthese (1)
- Menaquinone Biosynthesis (1)
- Meninges (1)
- Meningokokken-Sepsis (1)
- Meniskus (1)
- Meniskusimplantat (1)
- Meniskustransplantation (1)
- Merkel cell polyomavirus (1)
- Merkelzellkarzinom (1)
- Mesenchymal Stem Cell (1)
- Mesenchymal Stromal Cell (1)
- Mesenchymal Stromal Cells (1)
- Mesenchymal stem cell (1)
- Mesenchymal stromal cells (1)
- Mesenchymale Stammzelle (1)
- Mesenchymale Stromazelle (1)
- Messenger-RNS (1)
- Meta-barcoding (1)
- Metabolic Glycoengineering (1)
- Metabolic Labeling (1)
- Metabolism (1)
- Metabolite von Morphin (1)
- Metabolites of morphine (1)
- Metabolomics (1)
- Metagenomics (1)
- Metalloprotease (1)
- Metalloproteasen (1)
- Metalloproteases (1)
- Metalloproteinase (1)
- Metapopulation (1)
- Metastasierung (1)
- Metatranscriptomics (1)
- Methioninbiosynthese (1)
- Method development (1)
- Methodenentwicklung (1)
- Methylphenidat (1)
- Methyltransferase (1)
- Mevalonate Pathway (1)
- MgrB (1)
- MicF (1)
- MicroRNA (1)
- MicroRNAs (1)
- Microarray (1)
- Microbial community (1)
- Microbiota (1)
- Microglia (1)
- Micronucleus (1)
- Microvesicle (1)
- Microwave Assisted Extraction (1)
- Migraine (1)
- Migration (1)
- Migräne (1)
- Mikroarray basierte vergleichende Genomhybridisierung (Array-CGH) (1)
- Mikrobiota (1)
- Mikroglia (1)
- Mikroglomeruli (1)
- Mikrokerne (1)
- Mikroorganismus (1)
- Mikrotubuli-assoziiertes Protein (MAP) (1)
- Mikrotubulus (1)
- Mimik (1)
- Minor histocompatibility antigen mismatch transplantation (1)
- Mitochondrien (1)
- Mittelohrimplantat (1)
- Mobile Crowdsensing (1)
- Mobile Health (1)
- Mobiles Endgerät (1)
- Mobilfunkstrahlung (1)
- Moco biosynthesis (1)
- Model (1)
- Model Based Reconstruction Algorithms in Magnetic Resonance Imaging (1)
- Model Organism (1)
- Model simulation (1)
- Modell (1)
- Modellbasierte-Rekonstruktionsalgorithmen in der Magnetresonanztomografie (1)
- Modellierung (1)
- Modellorganismus (1)
- Modellsystem (1)
- Moderator (1)
- Modification (1)
- Modifizierung (1)
- ModulationTregs (1)
- Molecular Pharmacology (1)
- Molecular Radiotherapy (1)
- Molekulare Zielstrukturen (1)
- Mongolische Rennmaus (1)
- Monitoring (1)
- Monoklonale Gammopathie (1)
- Monoklonaler Antikoerper (1)
- Monoklonaler bispezifischer Antikörper (1)
- Monozyt (1)
- Moonlight (1)
- Moosfaserterminalen (1)
- Morbus Alzheimer (1)
- Morbus Fabry (1)
- Morphin (1)
- Morphology (1)
- Morris Water Maze (1)
- Motivation (1)
- Motoneuron diseases (1)
- Motoneuronenerkrankung (1)
- Motoneurons (1)
- Motor Memory (1)
- Motor learning (1)
- Motor neuron disease (1)
- Motorische Endplatte (1)
- Motorisches Gedächtnis (1)
- Mouse Model (1)
- Mrap2 (1)
- Mrr1 (1)
- MscS (1)
- Mucorales (1)
- Mucormycosis (1)
- Mucormykose (1)
- Multi-Unit Aufnahmen (1)
- Multicellular aggregates (1)
- Multidrug-Resistance-Related Proteine (1)
- Multidrugresistant (1)
- Multilayered skin tissue model (1)
- Multiphotonenmikroskopie (1)
- Multiple Sclerosis (1)
- Multiple myeloma (1)
- Multizellulären Bakteriengemeinschaften (1)
- Mundschleimhautzellen (1)
- Murine models of thrombosis and haemostasis (1)
- Muskelin (1)
- Muskelzelle (1)
- Mustererkennungsrezeptoren (1)
- Myb-MuvB complex (1)
- Mycobacterium tuberculosis (1)
- Mycobacterium tuberculosis InhA (1)
- Myeloblast (1)
- Myeloid (1)
- Myeloid-derived suppressor cells (1)
- Myeloide Suppressorzellen (1)
- Myelom (1)
- Myeloma (1)
- Myocardial Work (1)
- Myocardial infarction (1)
- Myokardiale Deformation (1)
- Myokarditis (1)
- Myosin IIA (1)
- Myrmecology (1)
- N-RAS (1)
- N2pc (1)
- N400 (1)
- NA (1)
- NAFLD (1)
- NEDMIAL (1)
- NES (1)
- NF-kB (1)
- NF-kappaB (1)
- NFATc3 (1)
- NHERF (1)
- NK (1)
- NK cell (1)
- NK-DC cross-talk (1)
- NKT (1)
- NLS (1)
- NMJ (neuromuscular junction) (1)
- NMR (1)
- NNMT activity assay (1)
- NO-GC (1)
- NOS-I (1)
- NOS1AP (1)
- NOTES <Chirurgie> (1)
- NRF2 (1)
- NSM2 (1)
- NTRK fusions (1)
- NaV1.9. oxidized phospholipids (1)
- Nachtschattengewächse (1)
- Nahrung (1)
- Nahrungsaufnahme (1)
- Nanofabrication (1)
- Nanofabrikation (1)
- Nanofaser (1)
- Nanomedicine (1)
- Nanomedizin (1)
- Nanopartikel (1)
- Nanotubes (1)
- Naphthalinderivate (1)
- Naphthochinonen (1)
- Naphthoquinones (1)
- Naphthylisochinolinalkaloide (1)
- Naphthylisoquinoline (1)
- Narrow escape problem (1)
- Nasenschleimhaut (1)
- Natrium-Kalium-Pumpe (1)
- Natrium-abhängigen Glukosetransporter-1 (1)
- Natriumoxamat (1)
- Natural pest control (1)
- Natural products (1)
- Nature-Insipired Synthesis (1)
- Naturschutz (1)
- Naturstoff (1)
- Near Miss (1)
- Nebenniere (1)
- Nebennierenrindenkarzinom (1)
- Nebennierenrindenkrebs (1)
- Nebennierentumor (1)
- Nectin4 (1)
- Neogenin-1 (1)
- Nephrogenese (1)
- Nerven (1)
- Nervenstimulation (1)
- Netrin-1 (1)
- Netzhaut (1)
- Netzwerkanalyse (1)
- Neuartige Arzneimittel (1)
- Neural Stem cells (1)
- Neurobiology (1)
- Neuroblastoma (1)
- Neurodegenerative Erkrankung (1)
- Neurodevelopment (1)
- Neurodevelopmental Disorder (1)
- Neurodevelopmental diseases (1)
- Neuroepigenomics (1)
- Neuroethology (1)
- Neurofeedback (1)
- Neurofilament (1)
- Neurogenesis (1)
- Neurogenetik (1)
- Neuroligin 2 (1)
- Neuromuskuläre Endplatte (1)
- Neuronale Stammzellen (1)
- Neuronales visuelles System (1)
- Neuropathic Pain (1)
- Neuropathic pain (1)
- Neuropathologie (1)
- Neuropathy (1)
- Neuropeptid S Rezeptor Gen (1)
- Neuropeptid Y (1)
- Neuropeptidom (1)
- Neurophysiologie (1)
- Neuroplasticity (1)
- Neuroprotection (1)
- Neuroprotektivum (1)
- Neurotransmitter Receptors (1)
- Neurotransmitter Rezeptoren (1)
- Neurotransmitter-Rezeptor (1)
- Neurotrophic factors (1)
- Neutrophil (1)
- Neutrophil granulocyte (1)
- Neutrophil granulocytes interaction (1)
- Newman strain sae (1)
- Next Generation Sequencing (NGS) (1)
- Nicht-kartesische Bildgebung (1)
- Nicht-kleinzelliges Bronchialkarzinom (1)
- Nichtionisierende Strahlung (1)
- Nichtstrukturproteine (1)
- Nicotiana tabacum (1)
- Niere (1)
- Nierenversagen (1)
- Nimodipin (1)
- Nitrogen (1)
- Nodo-Paranodopathie (1)
- Non-Hodgkin-Lymphom (1)
- Non-conventional T cell (1)
- Non-invasive imaging (1)
- Non-ribosomal peptide synthetase (1)
- Non-viral genome engineering (1)
- Noonan-Syndrom (1)
- Noradrenalin (1)
- Noradrenalinstoffwechsel (1)
- Nosocomial Infections (1)
- Nosokomiale Infektionen (1)
- Notch Signalweg (1)
- Notch signalling (1)
- Nozizeption (1)
- Nuclar Medicine (1)
- Nuclear Factor of Activated T cells (NFAT) (1)
- Nuclear Medicine (1)
- Nuclear imaging (1)
- Nuclease (1)
- Nucleasen (1)
- Nucleotide excision repair (1)
- Nucleotide-Excision-Repair (1)
- Nucleus subthalamicus (1)
- Nuklearfaktor Kappa B (1)
- Nukleäre Hormonrezeptoren (1)
- Numerische Fluidmechanik (1)
- O(6)-Methylguanine-DNA Methyltransferase (1)
- OCT1 (1)
- OIS (1)
- OSM (1)
- OSMR (1)
- Oberflächenproteine der Sexualstadien (1)
- Olfaktion (1)
- Olfaktorik (1)
- Oligomerization (1)
- OmoMYC (1)
- Onchocerca volvulus (1)
- Onchozerkose (1)
- Oncogenes (1)
- Oncolytic Virotherapy (1)
- Onkologie (1)
- Onkolyse (1)
- Oozyte (1)
- Open chromatin (1)
- Opioidpeptide (1)
- Optimal foraging (1)
- Optogenetics (1)
- Orai1 (1)
- Organ of Corti (1)
- Organoids (1)
- Orientia tsutsugamushi (1)
- Osmr-Knockout (1)
- Osteoporose (1)
- OxPL (1)
- Oxidative Stress (1)
- Oxidized Phospholipids (1)
- Oxidized phospholipids (1)
- Oxygen partial pressure (1)
- Oxytocin (1)
- Oxytosis (1)
- P4-ATPase (1)
- PAF1c (1)
- PAR-CLIP (1)
- PCDHGC3 (1)
- PD-L1 (1)
- PDE (1)
- PDI (1)
- PE Phosphoethanolamine (1)
- PEG (1)
- PER (1)
- PG neurons (1)
- PGE2 (1)
- PHMB (1)
- PI3K (1)
- PKA signaling (1)
- PLEKHG5 (1)
- PLP phosphatase (1)
- PP2A (1)
- PRKACA (1)
- PROTAC (1)
- PRR (1)
- PTH1R (1)
- PTMs (1)
- PTPN22 (1)
- PacBio sequencing (1)
- Palbociclib (1)
- Panic Disorder (1)
- Panik (1)
- Pankreas (1)
- Paranodopathie (1)
- Parasitology (1)
- Parc National de la Comoé (1)
- Parkinson Krankheit (1)
- Partial Agonists (1)
- Partialagonismus (1)
- Paternal age and BMI effects (1)
- Pathogene Bakterien (1)
- Pathogenese (1)
- Pathogenesis (1)
- Pathogenicity (1)
- Pathogens (1)
- Pathologie (1)
- Pathology (1)
- Pathophysiologische Mechanismen (1)
- Patienten-orientierte Versorgung (1)
- Patientenklassifikation (1)
- Patientenorientierte Medizin (1)
- Pattern recognition receptors (1)
- Pattern-Recognition-Receptors (1)
- Patulin (1)
- Pediatric Nuclear Medicine (1)
- Pediatric Patients (1)
- Pemphigus (1)
- Peptides (1)
- Perforation <Medizin> (1)
- Perforine (1)
- Perfusion Bioreactor (1)
- Perianova, Irina (1)
- Periaqueductal gray (1)
- Period2 (1)
- Peripheral eosinophils (1)
- Periphere Analgesie (1)
- Peripheres Nervensystem (1)
- Permeability (1)
- Permeation (1)
- Peroxisomen-Proliferator-aktivierter Rezeptor (1)
- Persistence (1)
- Pertussis (1)
- Pesticide (1)
- Peyersche Plaques (1)
- Pflanzen-Bienen-Netzwerke (1)
- Pflanzenaussterben (1)
- Pflanzenhydraulik (1)
- Pflanzenzelle (1)
- Pflanzenzellkulturen (1)
- Pflanzenökologie (1)
- PhD thesis pharmacology (1)
- Pharmaceutische Biologie (1)
- Pharmacology (1)
- Pharmakodynamik (1)
- Phasenvariation (1)
- Phenotypic switch (1)
- Pheromon (1)
- Phonochirurgie (1)
- Phosphatidylinositolkinase <Phosphatidylinositol-3-Kinase> (1)
- Phosphoantigen (1)
- Phosphodiesterase (1)
- Phosphoglykolat (1)
- Phosphoglykolat-Phosphatase (1)
- Phospholamban (1)
- Phosphorylation (1)
- Photoreceptor (1)
- Photoswitch (1)
- Phyllosphere (1)
- Phyllosphäre (1)
- Phylogeny (1)
- Pilze (1)
- PinT (1)
- Plant Biology (1)
- Plant Ecology (1)
- Plant cell cultures (1)
- Plant extracts (1)
- Plant hydraulic (1)
- Plants (1)
- Plasmonic (1)
- Plastin 3 (1)
- Platelet activating Factor (1)
- Platelet count (1)
- Platelet granules (1)
- Platelet-Membranglykoprotein p62 (1)
- Platy (1)
- Pluripotenz (1)
- Pmn mutant mouse (1)
- Pneumoviruses (1)
- Point Spread Function (1)
- Polistes (1)
- Pollen (1)
- Polo-like kinase 1 (1)
- Poly(2-oxazoline) (1)
- Poly(2-oxazoline)s (1)
- Poly(glycidol) (1)
- Polyadenylierung (1)
- Polyethism (1)
- Polymer Science (1)
- Polymere (1)
- Polymers (1)
- Polyphosphate (1)
- Polysaccharide (1)
- Polysaccharide intercellular adhesin (PIA) (1)
- Pore (1)
- Pore formation (1)
- Pore-formation (1)
- Porenbildung (1)
- Porifera (1)
- Porins (1)
- Positron emission tomography (1)
- Positronen-Emissions-Tomografie (1)
- Posttranslationale Änderung (1)
- Powdery mildew fungus (1)
- Pra1 (1)
- Preclinical studies (1)
- Prefrontal cortex (1)
- Prefrontalt Cortex (1)
- Primaten (1)
- Primär-basierte immortalisierte Zelllinie (1)
- Primäre Ziliendyskinesie (1)
- Primärelement (1)
- Primärprevention (1)
- Primärtumor (1)
- Primärzellen (1)
- ProQ (1)
- Problem Gambling (1)
- Processing fluency (1)
- Profilin (1)
- Programmed Cell Death 1 (1)
- Programmed Cell Death Ligand 1 (1)
- Promotor (1)
- Prosoziales Verhalten (1)
- Prostaglandin E2 (1)
- Protease (1)
- Proteaseaktivität (1)
- Proteaseinhibitor (1)
- Proteases (1)
- Proteasom (1)
- Proteasomaler Abbau (1)
- Proteasome (1)
- Protein Disulfid Isomerase (1)
- Protein Kinase D2 (1)
- Protein TRPC6 (1)
- Protein chemistry (1)
- Protein crosslinking (1)
- Protein folding (1)
- Protein interactions (1)
- Protein interactor (1)
- Protein purification (1)
- Protein-Protein Interaktion (1)
- Protein-Protein-Interaktion (1)
- Protein-Tyrosin-Kinasen (1)
- Proteinen mit antimikrobieller Wirkung (1)
- Proteinfaltung (1)
- Proteininteraktion (1)
- Proteininteraktionen (1)
- Proteinkinase A (1)
- Proteinkinase C (1)
- Proteinmodifizierung (1)
- Proteinquervernetzungen (1)
- Proteolysis (1)
- Proteolysis-Targeting-Chimera (1)
- Proteomics (1)
- Prozessierung (1)
- Prädiktoren und Korrelate (1)
- Präklinische Bildgebung (1)
- Präklinische Studien (1)
- Pränatale Entwicklung (1)
- Präzisionsmedizin (1)
- Pseudouridin (1)
- Psoriasis (1)
- Psychische Belastung (1)
- Psychische Gesundheit (1)
- Psychobiologie (1)
- Psychotherapie (1)
- Ptpn22 (1)
- Puberty (1)
- Pubertät (1)
- Pulswelle (1)
- Punktmutation (1)
- Purinozeptor (1)
- Pyridoxal 5'-phosphate phosphatase (1)
- Pyridoxalphosphat (1)
- Pyrrolidinderivate (1)
- Pyrrolidine carboxamides (1)
- Pyrrolizidinalkaloide (1)
- QPCR (1)
- QTOF (1)
- Quadruplex-DNS (1)
- Qualität (1)
- Qualitätsindikator (1)
- Qualitätssicherung (1)
- Quantifizierung (1)
- Quantitation (1)
- Quantitative Genetics (1)
- Quartäre Bisnaphthalimide (1)
- Quaternary Bisnaphthalimide (1)
- RAF (1)
- RAF Kinasen (1)
- RAMP (1)
- REDD1 (1)
- REST-Complex (1)
- RESTORE protocol (1)
- RIL-seq (1)
- RIM1α (1)
- RNA Abbau (1)
- RNA G-quadruplex (1)
- RNA Sequencing (1)
- RNA binding potein CNBP (1)
- RNA binding proteins (1)
- RNA decay (1)
- RNA metabolism (1)
- RNA protein interactions (1)
- RNA secondary structures (1)
- RNA sequencing (1)
- RNA structures (1)
- RNA virus (1)
- RNA-Protein Interaktom (1)
- RNA-RNA interactions (1)
- RNA-Seq (1)
- RNA-Sequenzierung (1)
- RNA-bindendes Protein (1)
- RNA-binding protein (1)
- RNA-binding proteins (1)
- RNA-protein interactome (1)
- RNAi (1)
- RNS Polymerase I (1)
- RNS-Polymerase II (1)
- RNS-Spleißen (1)
- ROR2 (1)
- RS-Virus (1)
- RS1 Peptides (1)
- RS1 derived peptides (1)
- RSK2 (1)
- RSV (1)
- RYGB (1)
- Rac1 (1)
- Radiale MR-Bildgebung (1)
- Radiation Protection (1)
- Radiation-associated Cancer Risk (1)
- Radiologische Diagnostik (1)
- Radionuklidtherapie (1)
- Raf <Biochemie> (1)
- Raf Kinase Inhibitor Protein (RKIP) (1)
- Raf kinase inhibitor protein (1)
- Raf1 (1)
- Random Forest (1)
- Random-walk simulations (1)
- Raphe (1)
- Raphe Kerne (1)
- Rasterionenmikroskop (1)
- Rasterkraft-Mikroskopie (1)
- Rauch (1)
- Rbm8a (1)
- Read-through transcription (1)
- Reaktive Sauerstoffspezies (1)
- Real-time imaging (1)
- RecQ helicase (1)
- Receptor (1)
- Receptor Anchoring (1)
- Receptor dynamics (1)
- Receptor internalization (1)
- Receptor signaling (1)
- Recombinant defensins (1)
- Recycling- Endosomen (1)
- Red Sea (1)
- Regenerative Medicine (1)
- Regulation of Gene Expression (1)
- Regulator of G protein signaling 2 (1)
- Regulatorische T-Zellen (1)
- Regulatory T Cells (1)
- Regulatory T-cell (1)
- Rekombinante DNS (1)
- Rekonsolidierung (1)
- Rekonstruktion (1)
- Relaxation Parameter Mapping in Magnetic Resonance Imaging (1)
- Remission (1)
- Remodeling (1)
- Renaturierung <Ökologie> (1)
- Repeats (1)
- Reperfusion (1)
- Reporter Cells (1)
- Reporterzellen (1)
- Repression (1)
- Repression <Genetik> (1)
- Reproducibility challenges (1)
- Reprogrammming (1)
- Rescue behaviour (1)
- Resistance (1)
- Resistenzmechanismen (1)
- Respiratorisches System (1)
- Response Inhibition (1)
- Ressourcenallokation (1)
- Restriktionsenzym (1)
- Resveratrol (1)
- Retinales S-Antigen (1)
- Retinoesäure (1)
- Retinoic acid (1)
- Reverse Transkriptase (1)
- Rezeptor Verankerung (1)
- Rezeptor-Tyrosinkinasen (1)
- Rezeptorblocker (1)
- Rezeptorpharmakologie (1)
- Rezidiv (1)
- Rgs2 (1)
- Rheologie (1)
- Rheology (1)
- Rheumatoider arthritis (1)
- Rhizopus arrhizus (1)
- Rho GTPase (1)
- Rho GTPasen (1)
- Rho GTPasw (1)
- Rho-GTPasen (1)
- Rho-Kinasen (1)
- RhoGTPase (1)
- Rhodopseudomonas palustris (1)
- Rhodopsin 7 (1)
- Ribonuclease H2 (1)
- Riboregulation (1)
- Ribosomale RNA (1)
- Ribosome biogenesis (1)
- Ribosome profiling (1)
- Ribozymes (1)
- Riesensynapsen (1)
- Risk Assessment (1)
- Rituximab (1)
- Rodents (1)
- Rodung (1)
- Roscovitine (1)
- Rossameise (1)
- Rotes Meer (1)
- Rothmund-Thomson-Syndrome (1)
- Rupturen (1)
- Räumliches Gedächtnis (1)
- SAP2 (1)
- SCV maturation (1)
- SEPHCHC Synthase (1)
- SERCA2a (1)
- SET7 (1)
- SGLT (1)
- SIS-muc (1)
- SIX1 (1)
- SLC2A3 (1)
- SLFN5 (1)
- SMARD1 (1)
- SMN complex (1)
- SNAP-Rezeptor (1)
- SNPs (1)
- SOC (1)
- SOD1 (1)
- SPECT/CT (1)
- SR proteins (1)
- SREBP (1)
- STAAB Cohort Study (1)
- STAAB study (1)
- STAAB-Studie (1)
- STD patients (1)
- STEC (1)
- STED (1)
- STIM2 (1)
- STP1 (1)
- SUMOylation (1)
- SWI/SNF (1)
- Saatgutbeizung (1)
- Saccharomyces cerevisiae (1)
- Salmonellose (1)
- Samenschale (1)
- Sandminen (1)
- Sap47 (1)
- Satellite glial cell (1)
- Sauerstoffkonzentration (1)
- Saure Sphingomyelinase (1)
- Scaffold bone implant (1)
- Scherstress (1)
- Schilddrüse (1)
- Schimmelpilze (1)
- Schimpanse (1)
- Schizosaccharomyces pombe (1)
- Schlafstörung (1)
- Schlaganfallversorgung (1)
- Schließzellfunktion (1)
- Schmerztherapie (1)
- Schmetterlinge (1)
- Schnelle MR-Bildgebung (1)
- Schreckreaktion (1)
- Schuppenflechte (1)
- Schwamm (1)
- Schwämme (1)
- Sehen (1)
- Sekretion (1)
- Sekretion von Aspartatproteasen (1)
- Sekundäre Inflammation (1)
- Sekundärprävention (1)
- Sekundärstruktur (1)
- Selbstregulation (1)
- Selective extraction (1)
- Selektiver Serotonin Wiederaufnahmehemmer / SSRI (1)
- Senecionin (1)
- Seneciphyllin (1)
- Seneszenz (1)
- Sensory Gating (1)
- Sequence Analysis (1)
- Sequence-Structure (1)
- Sequenz (1)
- Sequenzanalyse <Chemie> (1)
- Sequenzdaten (1)
- Sequenzwiederholung (1)
- Serinprotease (1)
- Serotonin Transporter (1)
- Serotonin transporter (1)
- Serotonin-Reuptake-Hemmer (1)
- Serotonin-Wiederaufnahmehemmer (1)
- Serotonindefizienz (1)
- Serotonintransporter (1)
- Sertralin (1)
- Setting Control (1)
- Sexuelle Entwicklung (1)
- Sezernierte Faktoren (1)
- Sglt1 (1)
- Shear Stress (1)
- Shigella (1)
- Shigella flexneri (1)
- Shimming (1)
- Sialoadhesin (1)
- Signal-Übertragung (1)
- Signaling (1)
- Signalregenerierung (1)
- Silica precursor (1)
- Simulation (1)
- Single Particle Tracking (1)
- Single-cell RNA Sequencing (1)
- Single-cell RNA-sequencing (1)
- Single-molecule (1)
- Sinusthrombose (1)
- Skin (1)
- Skin Tissue Engineering (1)
- Skin conductance (1)
- Sleep (1)
- Sleep in children (1)
- Sleeping Beauty Transposon System (1)
- Sleeping Beauty transposon (1)
- Smad (1)
- Small angle X-ray scattering (1)
- Small intestine (1)
- Small non-messenger RNS (1)
- Small nuclear RNP (1)
- Small-angle X-ray Scattering (1)
- Smoke (1)
- SnRK1-bZIP complex (1)
- Snap25 (1)
- Social Buffering (1)
- Social Distancing (1)
- Social action effects (1)
- Social buffering (1)
- Sociomotor gaze control (1)
- Sodium dependent glucose transporter-1 (1)
- Sol-gel (1)
- Solanaceae (1)
- Solanum species (1)
- Solid-phase peptide synthesis (1)
- South Africa (1)
- Soziale Handlungseffekte (1)
- Soziale Phobie (1)
- Sozialer Kontakt (1)
- Soziobiologie (1)
- Soziomotorische Blickkontrolle (1)
- Spatial heterogeneity (1)
- Spatiotemporal analysis (1)
- Specialized pro resolving mediators (1)
- Species richness (1)
- Speckle Tracking (1)
- Speicheldrüse (1)
- Sphingolipidstoffwechsel (1)
- Sphingomyelinase (1)
- Sphingomyelinphosphodiesterase (1)
- Sphingosine-1-phosphate (1)
- Sphingosine-1-phosphats (1)
- Spielsucht (1)
- Spinal muscular Atrophy (1)
- Spinal muscular atrophy (1)
- Spinal muscular atrophy (DLC) (1)
- Spinalganglion (1)
- Spirale (1)
- Spleen tyrosine kinase (1)
- Spliceosome (1)
- Splicing (1)
- Spo0A (1)
- Sponge diseases (1)
- Sponges (1)
- Sporenbildung (1)
- Sporulation (1)
- Spumaviren (1)
- Squamous cell carcinoma (1)
- Ssl1 (1)
- Stack-of-Stars Sequenz (1)
- Stack-of-Stars sequence (1)
- Stammzellen (1)
- Stammzelltransplantation (1)
- Staphylococci (1)
- Staphylococcus epidermidis (1)
- Stat3 (1)
- Stat5 (1)
- Stathmin (1)
- Staupevirus (1)
- SteC (1)
- Stechameisen (1)
- Stem Cells (1)
- Stem cells (1)
- Sterblichkeit (1)
- Steroide (1)
- Steroidhormon (1)
- Stickstoffkontrolle (1)
- Stickstoffmetabolismus (1)
- Stickstoffmonoxid-Synthase (1)
- Stickstoffwechsel (1)
- Stiff person syndrome (1)
- Stiff-Person Syndrom (1)
- Stiff-person syndrome (1)
- Stimmbandchirurgie (1)
- Stimmerhöhung (1)
- Stimulation (1)
- Stimulationsversuche (1)
- Stk (1)
- Stofftransport <Biologie> (1)
- Stoffwechselinhibitoren (1)
- Store-Operated (1)
- Stp (1)
- Strahlenpilze (1)
- Streptomyces (1)
- Stressresistenz (1)
- Striatum (1)
- Stroke (1)
- Stroke Unit (1)
- Stroop-Verfahren (1)
- Structural elucidation (1)
- Structural organisation (1)
- Structure-based (1)
- Structured Illumination Microscopy (1)
- Struktur (1)
- Struktur-basiertes Wirkstoff Design (1)
- Strukturanalyse (1)
- Strukturbiologie (1)
- Strumpellin (1)
- Störabstand (1)
- Störung des Sozialverhaltens (1)
- Subitizing (1)
- Subtyp C (1)
- Sumo (1)
- Sumoylierung (1)
- Super-Resolution Microscopy (1)
- Super-resolution microscopy (1)
- Super-resolution microsopy (1)
- Superhochauflösende Mikroskopie (1)
- Superparamagnetische Eisenoxid Kontrastmittel (1)
- Superresolution microscopy (1)
- Suppressorzelle (1)
- Survival Motor Neuron (1)
- Suspensionskultur (1)
- Syap1 (1)
- Symbionts (1)
- Symbiosis (1)
- Synapse-associated protein (1)
- Synapsen assoziiert (1)
- Synapses (1)
- Synapsine (1)
- Synaptic plasticity (1)
- Synaptische Plastizität (1)
- Synaptische Transmission (1)
- Synaptische Vesikel (1)
- Synchronitätsmessung (1)
- Syncytin (1)
- Synthesis (1)
- Systematik (1)
- Systembiologie (1)
- Säugerzellen (1)
- Säugetiere (1)
- Südafrika (1)
- Südostasien (1)
- T Helper Cell (1)
- T Lymphocyte (1)
- T Zell Selektion (1)
- T Zellen (1)
- T cell (1)
- T cell cytotoxicity (1)
- T cell engaging Antibody (1)
- T cell homing (1)
- T cell receptor (1)
- T cell selection (1)
- T cell specificity (1)
- T zellen (1)
- T-Zell-Aktivierung (1)
- T-Zellaktivierung (1)
- T-Zellhoming (1)
- T-Zellmigration (1)
- T-cell (1)
- T-cell engineering (1)
- T-cell therapy (1)
- TAC (1)
- TCTP (1)
- TGF-ß (1)
- TGF-β (1)
- TGN1412 (1)
- TH2 Immunantwort (1)
- TLR signaling (1)
- TMEM16F (1)
- TNFR2 (1)
- TP53 (1)
- TP53 lesions (1)
- TRAIL mutants (1)
- TRPA1 (1)
- TRPA1 channel (1)
- TRPC (1)
- TRPC-Ionenkanäle (1)
- TRPC3 (1)
- TRPC6 (1)
- TRPM7 kinase (1)
- TRPV1 (1)
- TRRAP (1)
- TT-Fields (1)
- TTF (1)
- Tabakkonsum (1)
- Tageslänge (1)
- Tagesrhythmik (1)
- Tamoxifen (1)
- Tansania (1)
- Tanzania (1)
- Tapeworm (1)
- Targeted therapies (1)
- Targeted therapy (1)
- Tc-99m-MAG3 Scans (1)
- Telomer <Molekulargenetik> (1)
- Telomerase (1)
- Temperatur (1)
- Temperaturabhängigkeit (1)
- Temporal heterogeneity (1)
- Temporal predictability (1)
- Terahertzbereich (1)
- Terahertzstrahlung (1)
- Terpene (1)
- Test system (1)
- Tfb4 (1)
- Thebain (1)
- Theoretical Ecology (1)
- Theory of Mind (1)
- Therapeutical application (1)
- Therapieoutcome (1)
- Therapiesimulation (1)
- Therapy (1)
- Thermoregulation (1)
- Thermoresponsive Polymere (1)
- Thermotoleranz (1)
- Theta Burst Stimulation (1)
- Thigmotaxis (1)
- Think/No-Think (1)
- Thiolase (1)
- Thiostrepton (1)
- Thrombin (1)
- Thromboinflammation (1)
- Thrombopoese (1)
- Thrombozyten (1)
- Thrombozytenfunktion (1)
- Thrombozytenfunktionsanalyse (1)
- Thrombozytopathie (1)
- Thrombozytopenie (1)
- Thrombozytopoese (1)
- Thrombus (1)
- Thymocytes (1)
- Thymosin b4 (1)
- Thymus (1)
- Tierphysiologie (1)
- Tight Junction Proteins (1)
- Tight junction (1)
- Tight-Junction-Protein (1)
- Time-of-flight (1)
- Timing (1)
- Tissue staining (1)
- Tobacco smoking (1)
- Tolerance (1)
- Toleranz <Biologie> (1)
- Toxin (1)
- TraDIS (1)
- Tracer (1)
- Trailmaking Test (1)
- Transcranial Magnetic Stimulation (1)
- Transcription Factor (1)
- Transcription factor (1)
- Transgenic mice (1)
- Transkriptomik anlyze (1)
- Translation <Genetik> (1)
- Transmission (1)
- Transmissionsblockierende Impfstoffe (1)
- Transpiration barrier (1)
- Transplantatabstoßung (1)
- Transportbarriere (1)
- Transporters (1)
- Transsexualismus (1)
- Transthorakale Echokardiographie (1)
- Trauma (1)
- Traumatic neuropathy (1)
- Tree physiology (1)
- Trem2 (1)
- Trend (1)
- Trennungsangst (1)
- Triclosan (1)
- Triglyceride (1)
- Tripartite Model (1)
- Trockenstress (1)
- Trophic Factors (1)
- Tropomyosin receptor kinase B (1)
- TruD (1)
- Trypanosoma (1)
- Trypanosoma Brucei (1)
- Trypanosoma brucei brucei (1)
- Trypanosomiasis (1)
- Tryptophan hydroxylase (1)
- Tryptophan hydroxylase 2 (1)
- Tuberkulose (1)
- Tumor Treating Fields (1)
- Tumor microenvironment (1)
- Tumor-Nekrose-Faktor <alpha> (1)
- Tumorangiogenese (1)
- Tumorgefäßmorphologie (1)
- Tumorhypoxie (1)
- Tumorimmunologie (1)
- Tumormetabolismus (1)
- Tumortherapiefeld (1)
- Tumorwachstum (1)
- Tumorzellen (1)
- Tumour (1)
- Tumour angiogenesis (1)
- Twilight (1)
- Typ 2 (1)
- Type 1 Diabetes (1)
- Type 1 diabetes (1)
- Type II-C CRISPR/Cas (1)
- Type VIIb secretion system (1)
- Tyrosinkinaseinhibitor (1)
- U snRNPs (1)
- U1 snRNA (1)
- UBA6 (1)
- UBE2S (1)
- UBE2Z (1)
- UNC5B (1)
- UPEC (1)
- USA300 (1)
- USP (1)
- USP28 (1)
- Ubiquitin activating eznyme 1 (1)
- Ubiquitin system (1)
- Ubiquitin-PA (1)
- Ubiquitin-aktivierende Enzym 1 (1)
- Ubiquitin-conjugating enzyme (1)
- Ubiquitylation (1)
- Ultrahigh field (1)
- Ultraschall (1)
- Ultrashort echo time - UTE (1)
- Unidirectional Freezing (1)
- Untertyp (1)
- Uremic cardiomyopathy (1)
- Urinary tract infection (1)
- Urteilen (1)
- Urämie (1)
- Urämische Kardiomyopathie (1)
- VCAM (1)
- VE-Cadherin (1)
- VE-PTP (1)
- VLA-1 (1)
- VSMC (1)
- VW-SCs (1)
- Vaccinia-Virus (1)
- Vagus (1)
- Vagusnervstimulation (1)
- Vakuole (1)
- Vakzinen (1)
- Validierung (1)
- Validierungsstudie (1)
- Validität (1)
- Valscularization (1)
- Variant Surface Glycoprotein (1)
- Variants (1)
- Vascular system (1)
- Vaskularisation (1)
- Vaskularisierung (1)
- Vaskuläre Integrität (1)
- Vasopressin (1)
- Venusfliegenfalle (1)
- Verbreitungsökologie (1)
- Verhaltenplastizität (1)
- Verhaltenskontrolle (1)
- Verhaltensplastizität (1)
- Verhaltensstörung (1)
- Vermehrung (1)
- Vermeidungsreaktion (1)
- Vermeidungsverhalten (1)
- Vernetzung <Chemie> (1)
- Versorgungsqualität (1)
- Verweildauer (1)
- Verwundbarkeit (1)
- Very-long-chain aliphatic (1)
- Vesikel (1)
- Vesikelbildung (1)
- Vessel wall (1)
- Vg9Vd2 T Zellaktivierung (1)
- Vg9Vd2 T cell (1)
- Vgamma9Vdelta2 T cell (1)
- Vgamma9Vdelta2 T cells (1)
- Vibrationstraining (1)
- Vielfalt (1)
- Virologische Synapse (1)
- Virology (1)
- Virulenzfaktor (1)
- Virus infection (1)
- Virus-Transmission (1)
- Virusreplikation (1)
- Visual attention (1)
- Visuelle Orientierung (1)
- Visuelle Wahrnehmung (1)
- Visuelles Gedächtnis (1)
- Visuelles System (1)
- Vitamin D (1)
- Vitamin D-Rezeptor (1)
- Vitamin D3 (1)
- Voltage-Clamp-Methode (1)
- Vorhersage (1)
- Vorläufer (1)
- Vulnerable plaque (1)
- Vγ9Vδ2 T cells (1)
- WASH complex (1)
- WNT (1)
- WNT signaling (1)
- Wachstum (1)
- Wachstumsfaktor (1)
- Waiting Impulsivity (1)
- Warburg, Otto (1)
- Warburg-Effekt (1)
- Wasser Fett Trennung (1)
- Wasted Work (1)
- Water stress (1)
- Web services (1)
- Wechselwirkungen (1)
- Weinrebe (1)
- Wildbienen (1)
- Wilms Tumor (1)
- Wilms tumor protein 1 (1)
- Wilms-Tumor (1)
- Wirbelströme (1)
- Wirkstoff (1)
- Wirkstofftestung (1)
- Wirt-Erreger Interaktion (1)
- Wirtszelle (1)
- Wnt-Proteine (1)
- Wnt-Signalweg (1)
- Wnt-pathway (1)
- Wurzelhalsgalle (1)
- Würmer (1)
- Wüstenpflanze (1)
- X-ray Crystallography (1)
- X-ray diffraction (1)
- XPD (1)
- Xenograft (1)
- Xeroderma pigmentosum (1)
- Xerostomie (1)
- Xiphophorus Melanom (1)
- Xmrk (1)
- YAP (1)
- YB-1 (1)
- Yb1 (1)
- Yeast (1)
- Yersinia (1)
- Yersinia pestis (1)
- YnaI (1)
- ZFAND1 (1)
- Zebrafisch (1)
- Zeitgeber (1)
- Zell Migration (1)
- Zell-Migration (1)
- Zelladhäsion (1)
- Zellfilamente (1)
- Zellkernarchitektur (1)
- Zellkontakt (1)
- Zelllinie (1)
- Zellteilung (Zytokinese) (1)
- Zelltod (1)
- Zelltransport (1)
- Zielstruktur (1)
- Zink-Cluster-Transkriptionsfaktoren (1)
- Zytokin (1)
- Zytokingenpolymorphismus (1)
- Zytoskelett (1)
- Zytoskelettreorganisation (1)
- Zählen (1)
- aGPCR (1)
- acceptance-based strategies (1)
- acid sphingomyelinase (1)
- actin cytoskeleton (1)
- actin-binding proteins (1)
- actinomycetes (1)
- acute brain slices (1)
- acute graft-versus host disease (1)
- acute lymphoblastic leukaemia (1)
- adhesion (1)
- adhesion-GPCR (1)
- adipogenic differentiation (1)
- adipose (1)
- adipose-derived (1)
- adolescents (1)
- adrenal gland (1)
- adrenal incidentaloma (1)
- adrenerge Rezeptoren (1)
- adrenergic receptor (1)
- adrenergic receptors (1)
- adrenocortical adenoma (1)
- adult ADHD (1)
- adult attention deficit hyperactivity disorder (aADHD) (1)
- adulte Neurogenese (1)
- aggressive behavior (1)
- aging (1)
- agonist (1)
- airflow (1)
- airways (1)
- akute lymphatische Leukämie bei Kindern (1)
- alfa-cyano-4-hydroxycinnamat (1)
- alkaloids (1)
- allogen (1)
- allogeneic stem cell transplantation (1)
- allogenic (1)
- allogenic stem cell transplantation (1)
- allografts (1)
- alloreactive T cells (1)
- alltägliche Funktionsfähigkeit (1)
- alpha-IIb beta-3 (1)
- alternative intronic polyadenylation (1)
- ammonium (1)
- ammonium permease (1)
- amphibia (1)
- amphiphysin (1)
- amyotrophic lateral sclerosis (1)
- anaerobe (1)
- analysis (1)
- anaphylatoxin receptors (1)
- androstadienone (1)
- anoikis (1)
- anterior insula (1)
- anthocyanins (1)
- anti-hDEC205-WT1 antibody fusion protein (1)
- anti-infective (1)
- antigen (1)
- antigenic variation (1)
- antileukemia vaccine (1)
- antimicrobial (1)
- antithrombotic (1)
- antivirale Gene (1)
- anxiety conditioning (1)
- arf (1)
- aromatic amino acid biosynthesis (1)
- articular cartilage progenitor cells (1)
- artificial diet (1)
- artificial human skin (1)
- artifizielle Aktivierung (1)
- artifizielle Hautmodelle (1)
- asialoGM1 (1)
- aspartic protease (1)
- aspergillus fumigatus (1)
- assembly (1)
- association studies (1)
- astrocytoma (1)
- asymptomatic bacteriuria (1)
- atomic force microscopy (1)
- atopic diseases (1)
- atrial natriuretic peptide (1)
- attributable fraction (1)
- attributable risk (1)
- auditorisch (1)
- auditory (1)
- auditory cortex (1)
- auditory pathway (1)
- autoantibodies (1)
- autoantibody (1)
- autoimmunity (1)
- autophagocytose (1)
- autophagocytosis (1)
- autophagosome (1)
- autotransporter (1)
- bSSFP (1)
- bac-genomics-scripts (1)
- bacterial cancer therapy (1)
- bacterial fatty-acid biosynthesis (1)
- bacterial lipid rafts (1)
- bacterial nanocellulose (1)
- bacterial tumor targeting (1)
- bakterielle Flora (1)
- balanced steady state free precession (1)
- bark beetles (1)
- bee microbiota (1)
- bee-associated bacteria (1)
- bee-lining (1)
- bees (1)
- behavioral maturation (1)
- behavioral rhythms (1)
- beige adipocytes (1)
- benzimidazole (1)
- bestäuberfreundliche Pflanzen (1)
- beta actin (1)
- beta cell (1)
- beta-Arrestin2 (1)
- beta-Catenin (1)
- beta-adrenerge Signalwege (1)
- bicuculline (1)
- bilateral BAS model (1)
- binding mode (1)
- biochemistry (1)
- biodistribution (1)
- biodiversity (1)
- biofabrication (1)
- biofilm architecture (1)
- bioimage analysis (1)
- bioink (1)
- biokinetics (1)
- biolayerinterferometry (1)
- biological scaffolds (1)
- bioluminescence imaging (1)
- biomaterials (1)
- bioprocessing (1)
- bioreactor plattform (1)
- biosynthetic gene clusters (1)
- bipolar disorder (1)
- bipolare Störung (1)
- bispecific (1)
- bispezifisch (1)
- bitter taste (1)
- blood (1)
- blood cerebrospinal fluid barrier (1)
- blood glucose regulation (1)
- blood nerve barrier (1)
- blood-brain barrier (1)
- body axis (1)
- bone marrow niche (1)
- bone marrow transplantation (1)
- bone metastases (1)
- bone regeneration (1)
- brood rearing (1)
- building behavior (1)
- bumblebee*s (1)
- burn wound (1)
- butyrophilin 3A (1)
- c-Jun Phosphorylierung (1)
- c-myc (1)
- cAMP signaling (1)
- cadherin-13 (1)
- caffeine (1)
- calcium activity (1)
- calcium homeostasis (1)
- calcium imaging (1)
- cancer therapy (1)
- candida (1)
- candida albicans (1)
- canine (1)
- carbon dioxide (1)
- cardiac imaging (1)
- cardiac magnetic resonance imaging (1)
- cardiac tissue (1)
- cardiac tissue engineering (1)
- cardiovascular (1)
- carnivorous plants (1)
- cartilage (1)
- cartilage regeneration (1)
- cd28 superagonists (1)
- cell adhesion (1)
- cell cycle (1)
- cell filaments (1)
- cell migration (1)
- cell therapy (1)
- cellular model (1)
- cellular-trafficking (1)
- central complex (1)
- chaperone (1)
- chemotherapy (1)
- children (1)
- chimeric antigen receptor (1)
- chlamydia trachomatis (1)
- chondrogene Differenzierung (1)
- chromatin accessibility (1)
- chromosome conformation capture (1)
- chronic kidney disease (1)
- chronic pain (1)
- chronophin (1)
- cine loop (1)
- circadian clock (1)
- circadian clocks (1)
- circuitopathies (1)
- claudin-12 (1)
- climate change (1)
- climate control (1)
- clock genes (1)
- closing of chromatin (1)
- co-culture (1)
- co-dependent expression (1)
- co-infection (1)
- coagulation factor XII (1)
- cochlea implant (1)
- cofactorbinding (1)
- cognitive decline (1)
- cognitive deficits (1)
- cognitive inhibition (1)
- cognitive remediation (1)
- cohesin (1)
- collective invasion (1)
- collybistin (1)
- colony recognition (1)
- color vision (1)
- comet assay (1)
- compartments (1)
- compound eyes (1)
- compressed sensing (1)
- conditional Knockout (1)
- confocal microscopy (1)
- conformational activation (1)
- context conditioning (1)
- contextual conditioning (1)
- contingency awareness (1)
- continuous wavelet analysis (1)
- control (1)
- convolutional neural network (1)
- corneal confocal microscopy (1)
- coronary heart disease (1)
- correlation (1)
- corticosteroids and cyclophosphamide (1)
- cryokonservation (1)
- crystal structure (1)
- ctr (1)
- current source density (1)
- cushing's syndrome (1)
- cuticular hydrocarbons (1)
- cuticular leaf wax (1)
- cuticular transpiration barrier (1)
- cuticular water permeability (1)
- cuticular waxes (1)
- cyclase-associated protein (1)
- cyclase-associated protein 2 (1)
- cyclo-AMP (1)
- cytokine release syndrome (1)
- cytoskeletal reorganisation (1)
- dCIRL (1)
- dSTORM (1)
- decellularization (1)
- decision-making (1)
- defense (1)
- degeneratives Nervengewebe (1)
- delipidation (1)
- dendritic cells (1)
- dendritic cell-targeting (1)
- density weighting (1)
- desert plant (1)
- deubiquitinase (1)
- dexamethasone suppression test (1)
- diabetic cardiomyopathy (1)
- diagnostic Microarray (1)
- diagnostic accuracy (1)
- diagnostics (1)
- diagnostischer Microarray (1)
- diastolic dysfunction (1)
- differential RNA-seq (1)
- differential coverage binning (1)
- differential geneexpression (1)
- differentiation status (1)
- differenzielle Genexpression (1)
- dilated cardiomyopathy with ataxia (DCMA) (1)
- dimerer Naphthylisochinolin-Alkaloide (1)
- disease model (1)
- dispersal (1)
- distance (1)
- distribution (1)
- disulfide bonds (1)
- diversity (1)
- double-strand break repair (1)
- drift-diffusion model (1)
- drug (1)
- drug repurposing (1)
- dual RNA-seq (1)
- early detection (1)
- early neural precursors (1)
- early-life stress (1)
- early-onset isolated dystonia (1)
- eating behavior (1)
- eating disorders (1)
- echocardiography (1)
- ecoli_VF_collection (1)
- ecological validity (1)
- ectopic bone formation (1)
- ectopic release (1)
- effector protein (1)
- efflux pump (1)
- electroacupuncture (1)
- electrode scaffold (1)
- electroencephalogram (1)
- electron cryomicroscopy (1)
- electron tomography (1)
- electrospinning (1)
- embryonale Maus (1)
- emojis (1)
- emotional (1)
- emotional feedback (1)
- emotional information processing (1)
- emotional interference (1)
- emotional processing (1)
- emotionale Anspannung (1)
- emotionale Interferenz (1)
- emotions (1)
- endocytic recycling (1)
- endocytosis (1)
- endophyte (1)
- enhancers (1)
- enoyl ACP reductase (1)
- enoyl reductase (1)
- enoyl-ACP reductase (1)
- entero-aggregative-haemorrhagic Escherichia coli (EAHEC) (1)
- enteroinvasive (1)
- eosinophil (1)
- epidemiology (1)
- epigenetic (1)
- epithelial to mesenchymal transition (1)
- epithelial-mesenchymal transition (1)
- ereigniskorreliertes Potential (1)
- etiology (1)
- evozierte Potentiale (1)
- exotische Pflanzen (1)
- experimentelle autoimmune Enzephalomyelitis (1)
- exposition training (1)
- exposure therapy (1)
- extinction (1)
- extinction dynamics (1)
- extracellular signal–regulated kinases 1/2 (1)
- extrazelluläre Matrix (1)
- eye contact (1)
- eye tracking (1)
- eye-tracking (1)
- eyetracking (1)
- fabry disease (1)
- facial expressions (1)
- fast MR imaging (1)
- fatty acid biosynthesis (1)
- fatty acid synthesis (1)
- fear potentiated startle response (1)
- feasibility (1)
- feral bees (1)
- fgf (1)
- fibroblast growth factors (1)
- fibromyalgia sydrome (1)
- filtering (1)
- fitness (1)
- flagellum (1)
- fluorescence imaging (1)
- fluorescence microscopy (1)
- fluorescence resonance energy transfer (1)
- fluorescence resonance energy transfer (FRET) (1)
- flytrap (1)
- fmri activity (1)
- foamy viruses (1)
- follicular regulatory T cell (1)
- follikuläre regulatorische T-Zelle (1)
- food craving (1)
- forager (1)
- foraging (1)
- foraging activity (1)
- forest landscape (1)
- fragment screening (1)
- frameshifting (1)
- freezing of gait (1)
- frequency modulation (1)
- frogs (1)
- fruit cuticle (1)
- frühe neurale Vorläufer (1)
- functional connectivity (1)
- functional imaging (1)
- functional membrane microdomains (1)
- functional modules (1)
- functional neuroimaging (1)
- functional resting-state connectivity (1)
- functional selectivity (1)
- functional studies (1)
- fungal endophytes of grasses (1)
- fungi (1)
- fungus (1)
- funktionale Bildgebung (1)
- funktionelle Magnetresonanztomographie (1)
- funktionelle Module (1)
- funktionelle Resting-State Konnektivität (1)
- g-factor (1)
- gait analysis (1)
- gait initiation (1)
- gametocyt (1)
- gametocyte (1)
- gametogenesis (1)
- gamma delta T cells (1)
- gastrointestinal infection (1)
- gastronintestinal microbiota (1)
- gene environment interaction (1)
- gene-environmental interaction (1)
- genetic cytokine polymorphism (1)
- genetic modification (1)
- genetic screen (1)
- genome stability (1)
- genomic damage (1)
- genomic imaging (1)
- genomische Schäden (1)
- genotoxic agents (1)
- genotoxische Agenzien (1)
- gepaarte Vagusnerv-Stimulation (1)
- germinal center (1)
- germinative cell (1)
- gezielte Therapie (1)
- glioblastoma multiforme (1)
- glioma (1)
- glutamate decarboxylase 65 (1)
- glycine receptor (1)
- glycine receptor autoantibodies (1)
- glycophytes (1)
- glycoprotein GPV (1)
- gonococcal (1)
- gonococcal infection (1)
- grass (1)
- guanine nucleotide exchange factor (1)
- guanylyl cyclase (GC) (1)
- guard cells (1)
- gustation (1)
- habitat (1)
- haloacid dehalogenase phosphatase (1)
- hearing (1)
- heart failure (1)
- heat shock proteins (1)
- hematopoiesis (1)
- hereditary spastic paraplegia (1)
- hiPSC aggregation (1)
- hibernation (1)
- high-pressure freezing/freeze substitution (1)
- high-throughput sequencing (1)
- histone variants (1)
- hnRNP (1)
- hnRNP R (1)
- homeostasis (1)
- homoFRET (1)
- honey bee density (1)
- honey bees (1)
- honeybee*s (1)
- honeybees (1)
- host colonization (1)
- huh6 (1)
- human (1)
- human adipose tissue (1)
- human chromosome 6 (1)
- human factor H (1)
- human induced pluripotent stem cells (1)
- human intestinal epithelium (1)
- human parthenogenetic neural stem cells (1)
- human parthenogenetic stem cells (1)
- human plasma (1)
- human primary cells (1)
- humanen induzierte pluripotente Stammzellen (1)
- humaner Faktor H (1)
- humans (1)
- hyaline cartilage (1)
- hyaluronic acid (1)
- hybrid (1)
- hybrid assembly (1)
- hydrogel (1)
- hyperekplexia (1)
- iNKT cell (1)
- iPSC-derived CMs (iPSC-CMs) (1)
- iPSCs (1)
- icaADBC (1)
- imaging (1)
- immediate early genes (1)
- immune cell recruitment (1)
- immune escape (1)
- immune evasion (1)
- immune response (1)
- immune system (1)
- immunologic tolerance (1)
- immunological synapse (1)
- imprinting. (1)
- imunology (1)
- in situ microscopy (1)
- in vitro Kulturmodelle (1)
- in vitro Modelle (1)
- in vitro Testmodell (1)
- in vitro Testsystem (1)
- in vitro model (1)
- in vitro model system of inherited cardiomyopathies (1)
- in vitro neural differentiation (1)
- in vitro-Testsystem (1)
- in vivo study (1)
- induced pluripotent stem cells (1)
- induced pluripotent stem cells (iPSCs) (1)
- induzierte Phosphatasen MKP-1 und MKP-2 (1)
- infection biology (1)
- infectionmodel (1)
- infectionprocess (1)
- inferior frontal gyrus (1)
- inferiore frontale Gyrus (1)
- inflammatorische Gewebeschäden (1)
- influenza A virus (1)
- information processing (1)
- information use (1)
- inherited macrothrombocytopenia (1)
- inhibitor residence time (1)
- inhibitory postsynapse (1)
- innate immunity (1)
- insect visual learning (1)
- insects (1)
- insertion-site deep sequencing (1)
- instrumentelle Aktivitäten des täglichen Lebens (1)
- insulin (1)
- insulin resistance (1)
- intact bone imaging (1)
- integrins (1)
- interaction stress and circadian system (1)
- interactions (1)
- interferon (1)
- interleukin-5 signaling (1)
- internal dosimetry (1)
- interphase gap (1)
- interpulse interval (1)
- intestinal mucus (1)
- intestine (1)
- intracellular calcium release (1)
- intracellular domain (1)
- intraoperative Ankopplungseffizienz (1)
- intravenöse Immunglobuline (1)
- intrazelluläre Domäne (1)
- invariant NKT cells (1)
- invariante NKT Zellen (1)
- invasive meningococcal diseases (1)
- invasive pulmonary aspergillosis (1)
- ion channel (1)
- iron oxide contrast agent (1)
- ischemia reperfusion injury (1)
- ischämischer Schlaganfall (1)
- islets of Langerhans (1)
- jasmonate (1)
- juvenile hormone (1)
- kardiales Gewebe (1)
- kardiales Tissue Engineering (1)
- kardiovaskuläre Risikofaktoren (1)
- ketamine anaesthesia (1)
- kidney development (1)
- kinesin (1)
- knockout (1)
- knockout-mice (1)
- kognitive Defizite (1)
- kognitive Remediation (1)
- kolorektale Karzinomzelllinien (1)
- konventionelle CD4 T Zellen (1)
- koronare Herzerkrankung (1)
- kutikuläre Kohlenwasserstoffe (1)
- kutikuläre Wasserpermeabilität (1)
- kutikuläres Blattwachs (1)
- l-type calcium channel antagonist (1)
- labeling techniques (1)
- lambdoid phage resistance (1)
- lambdoid prophage (1)
- laminar recording (1)
- lasiocarpine (1)
- late enhancement (1)
- late gadolinium-enhancement (1)
- leaf cuticle (1)
- leaf-cutting ants (1)
- learned helplessness (1)
- learning and behaviour (1)
- leishmaniasis (1)
- lightsheet microscopy (1)
- lipid remodeling (1)
- liver (1)
- local point-spread function (1)
- local translation (1)
- locomotor network (1)
- logging (1)
- lokale Proteinsynthese (1)
- long-term memory formation (1)
- luciferase assay (1)
- lymph node stromal cells (1)
- lymph node transplantation (1)
- lysosome (1)
- lytic infection (1)
- lytic phage resistance (1)
- mRNA (1)
- mRNA processing (1)
- mRNA translation (1)
- mRNA-Translation (1)
- mTOR (1)
- machine learning (1)
- macrocolony (1)
- macrophage (1)
- macrophages (1)
- malnourishment (1)
- mammalian cells (1)
- marine sponges (1)
- mastitis (1)
- mastitis-associated Escherichia coli (MAEC) (1)
- mean first passage time (1)
- measles virus infection (1)
- mechanistische Modellierung (1)
- mechanosensing (1)
- mechanosensitive channels (1)
- medaka (1)
- medical device (1)
- megachilid bees (1)
- megakaryocytes (1)
- melanocytic nevi (1)
- melanoma cancer (1)
- melanoma dedifferentiation (1)
- melt electrowriting (1)
- membrane dynamics (1)
- membrane trafficking (1)
- memory (1)
- memory B cells (1)
- meniscus implant (1)
- menschliches Darmepithel (1)
- mental health (1)
- mesenteric lymph node (1)
- mesoscopic (1)
- metabolic modelling (1)
- metabolic theory of ecology (1)
- metabolite repair (1)
- metabolomics (1)
- metallo protease (1)
- metapopulation (1)
- metatranscriptome (1)
- methionine biosynthesis (1)
- methylphenidate (1)
- miR-17~92 (1)
- miR-21 (1)
- miR-223-5p (1)
- miR-23a cluster (1)
- miR-26 (1)
- miRNA Biogenesis (1)
- miRNA target (1)
- mice (1)
- micro processor complex (1)
- microRNA biogenesis (1)
- microbial transmission (1)
- microbiology (1)
- microbiota (1)
- microcircuitry (1)
- microelectrode array (1)
- microglomeruli (1)
- microinjection (1)
- micronuclei (1)
- microprocessor complex (1)
- microrna (1)
- mild cognitive impairment (1)
- minimum leaf conductance (1)
- mitochondria (1)
- mitogen cascade (1)
- mobil phone radiation (1)
- molecular biology of cytokines (1)
- molecular mechanism (1)
- monarch butterfly (1)
- monoclonal antibody (1)
- monoclonal antibody 103.2 (1)
- monoclonal antibody 20.1 (1)
- monocyte-derived dendritic cells (1)
- monozytenderivierte dendritische Zellen (1)
- mossy fiber synapse (1)
- mossy fiber terminal (1)
- motoneurons (1)
- motor neuron (1)
- mouse models (1)
- mouse platelets (1)
- movement disorders (1)
- movement interaction (1)
- mucormycosis (1)
- mukosale Immunantwort (1)
- multi-drug-resistance (1)
- multi-modal stimuli (1)
- multi-photon microscopy (1)
- multi-pinhole collimation (1)
- multiphoton microscopy (1)
- multiple sclerosis (1)
- murine (1)
- murine leishmaniasis (1)
- murines Modell der aufsteigenden Harnwegsinfektion (1)
- muscarinic m ACh receptors (1)
- mushroom body (1)
- mushroom body calyx microglomeruli (1)
- muskarinische Rezeptoren (1)
- mutualism (1)
- mutually exclusive expression (1)
- myelin barrier (1)
- myeloablation (1)
- myeloid derived suppressor cells (1)
- myocardial deformation (1)
- myocarditis (1)
- myokardiale Arbeit (1)
- nanotubes (1)
- ncRNA (1)
- near-infrared spectroscopy (1)
- nest climate (1)
- nesting behaviour (1)
- networkanalysis (1)
- neuer anti-infektiver Substanzen (1)
- neural biomarkers (1)
- neurodevelopment (1)
- neurodevelopmental disorders (1)
- neuroepithelial progenitors (1)
- neuroepitheliale Vorläufer (1)
- neurogenesis (1)
- neuroinflammation (1)
- neurologin-2 (1)
- neuromodulation (1)
- neuron (1)
- neuronal activation (1)
- neuronal cell death (1)
- neuronal excitability (1)
- neuronal network (1)
- neuronal nitric oxide synthase (1)
- neuronal visual system (1)
- neuronale Stickstoffmonoxidsynthase (1)
- neuropathic pain (1)
- neuropaticher Schmerz (1)
- neuropeptide S receptor gene (1)
- neuropeptide Y (1)
- neuropeptides (1)
- neuroprotection (1)
- neuropsychiatric disorders (1)
- neuropsychiatrische Störungen (1)
- neuroscience (1)
- neutrophil (1)
- neutrophils (1)
- next generation sequencing (1)
- nicht-viraler Gentransfer (1)
- nicht-visuell (1)
- nichtinvasive Bildgebung (1)
- nitric oxide (1)
- nitrogen regulation (1)
- nociception (1)
- nociceptors (1)
- non-coding RNA (1)
- non-ionizing radiation (1)
- non-visual (1)
- nuclear architecture (1)
- nuclear export signal (1)
- nuclear localization signal (1)
- nuclesosome positioning (1)
- nucleus (1)
- nurse bee (1)
- nutrients (1)
- nutrition (1)
- object segmentation (1)
- oilpalm plantation (1)
- oligopeptide transport (1)
- oncogenes (1)
- oncogenic signalling network (1)
- onkogenes Signalnetzwerk (1)
- opening of chromatin (1)
- opioid peptide (1)
- opioid receptor (1)
- opioid receptors (1)
- optogenetics (1)
- orientation (1)
- oscillations (1)
- ovarian cancer (1)
- ovarian carcinoma (1)
- oxidative stress (1)
- oxidativer Stress (1)
- oxidierte Phospholipide (1)
- p34 (1)
- p38MAPK (1)
- p44 (1)
- p97 (1)
- pICln (1)
- pain (1)
- pain regulation (1)
- pancreatic cancer (1)
- pancreatic differentiation (1)
- panic disorder (1)
- parasitology (1)
- parathyroid hormone (1)
- parkinson's disease (1)
- pathophysiological mechanisms (1)
- pathotypes (1)
- pdxp (1)
- pea aphid (1)
- pediatric hematology oncology (1)
- peptide engineering (1)
- peptide-based interleukin-5 inhibitor (1)
- performance evaluation (1)
- perfused hydrogel (1)
- peripheral analgesia (1)
- peripheral nerve trauma (1)
- peripheral nervous system (1)
- permeability (1)
- permeance (1)
- permeation (1)
- personality traits (1)
- pflegende Angehörige (1)
- phage resistance (1)
- pharmacology (1)
- pheromone (1)
- phosphoantigen (1)
- phosphoglycolate phosphatase (1)
- phospholipase D (1)
- phosphorylation (1)
- phosphorylation sites (1)
- photoinduced electron transfer (1)
- photoinduzierter Elektronentransfer (1)
- phylogeny (1)
- plant defense (1)
- plant-bee visitation networks (1)
- platelet aggregation (1)
- platelet biogenesis (1)
- pluripotency (1)
- podosome formation (1)
- point-of-care (1)
- polarization (1)
- polarized epithelium (1)
- pollen (1)
- pollen analysis (1)
- pollen foraging (1)
- pollen metabarcoding (1)
- pollinator friendly plants (1)
- polyethism (1)
- polymer (1)
- polymorphism (1)
- polyradiculoneuropathy (1)
- population attributable fraction (1)
- population dynamics (1)
- post-transcriptional regulation (1)
- postradiogene Xerostomie (1)
- posttranscriptional regulation (1)
- potenzielles therapeutisches Target (1)
- precision medicine (1)
- preclinical PET (1)
- predictors and correlates (1)
- prefrontal cortex (1)
- prenatal stress (1)
- presynaptic (1)
- primary ciliary dyskinesia (1)
- primary-cell-derived immortalized cell line (1)
- primate (1)
- probiotica (1)
- proboscis extension response (1)
- profiles (1)
- progenitors (1)
- programmed ribosomal frameshifting (1)
- promoter invasion (1)
- proplatelets (1)
- protease activity (1)
- protease inhibitor (1)
- proteasome (1)
- protein (1)
- protein disulfide isomerase (1)
- protein folding (1)
- protein immobilization (1)
- protein kinase D1 (1)
- protein kinase a (1)
- protein regulation and expression (1)
- protein-DNA interactions (1)
- protein-lipid interactions (1)
- protein-protein-interaction (1)
- pränataler Stress (1)
- psychophysiology (1)
- psychosocial resilience (1)
- psychosocial stress (1)
- psychotherapeutic intervention (1)
- psychotherapeutische Intervention (1)
- pyrrolidine carboxamides (1)
- quiescence (1)
- rIFG (1)
- rRNA processing (1)
- rac1 inhibitors (1)
- radial MR imaging (1)
- radionuclide (1)
- radionuclide therapy (1)
- ranskranielle magnetische Stimulation (1)
- rapid evolution (1)
- rat (1)
- reactive oxygen species (1)
- real-time imaging (1)
- reception (1)
- receptor signaling (1)
- reciprocity (1)
- reconstruction (1)
- recurrence (1)
- reduction of ERK1/2 phosphorylation (1)
- reduction of cells proliferation (1)
- regenerative medicine (1)
- regional analgesia (1)
- regulatorische T Zellen (1)
- regulatory RNA (1)
- reinforcement sensitivity theory (1)
- relapse (1)
- replication (1)
- reporter screen (1)
- research software (1)
- resilience (1)
- resin (1)
- resolution (1)
- responsiveness (1)
- resting tremor (1)
- restriction factors (1)
- resveratrol (1)
- retinal development (1)
- reverse Transkription (1)
- reverse genetics (1)
- reverse transcription (1)
- reversible oxidation (1)
- rheumatoide Arthritis (1)
- rho gtpases (1)
- ribosomal RNA (1)
- ribosomale RNS (1)
- ribosome biogenesis (1)
- ribosome profiling (1)
- riboswitch (1)
- risk factors (1)
- rodent model (1)
- rtPA (1)
- salinen Wachstumsbedingungen (1)
- salt stress (1)
- sand mine (1)
- saure Sphingomyelinase (1)
- scale-up (1)
- schnelle Evolution (1)
- screening (1)
- second messenger (1)
- secondary metabolites (1)
- secondary prevention (1)
- secreted aspartic protease (1)
- secreted factors (1)
- secretion (1)
- secretory properties (1)
- seed coat (1)
- seed treatment (1)
- self-activation (1)
- self-regulation (1)
- self-targeting CRISPR-Cas (1)
- senecionine (1)
- seneciphylline (1)
- senescence (1)
- sensitivity (1)
- sensorische Neurone (1)
- sequence-structure (1)
- serine protease (1)
- serotonerges System (1)
- serotonin (1)
- serotonin deficiency (1)
- serotonin transporter (1)
- serum retention (1)
- sexual stage surface proteins (1)
- short neuropeptide F (1)
- sifA (1)
- sigma factor (1)
- signaling pathway (1)
- signaltransduction (1)
- similarity (1)
- single cell anatomy (1)
- single molecule microscopy (1)
- single-cell RNA sequencing (1)
- single-cell genomics (1)
- single-molecule imaging (1)
- single-molecule localization microscopy (1)
- single-molecule microscopy (1)
- site directed immobilization (1)
- site-specific immobilization (1)
- skin (1)
- skin biopsy (1)
- skin cancer (1)
- skin model (1)
- small RNA expression (1)
- small fiber pathology (1)
- small intestinal submucosa (1)
- small proteins (1)
- small-animal SPECT (1)
- smell (1)
- smells (1)
- snoRNA (1)
- social cognition (1)
- social interaction (1)
- social stimuli (1)
- social understanding (1)
- solitary bee nests (1)
- somatic resilience (1)
- somatostatin receptor antagonists (1)
- soziale Insekten (1)
- spatial organization (1)
- specific phobia (1)
- speckle tracking (1)
- spezifische Phobie (1)
- sphingolipid (1)
- spider phobia (1)
- spiral trajectory (1)
- splicing (1)
- sponge microbiome (1)
- spontaneous neuronal activity (1)
- ssVEP (1)
- stachellose Biene (1)
- stachellose Bienen (1)
- steady-state visually evoked potentials (1)
- stem (1)
- stem cells (1)
- stiff person syndrome (1)
- stingless bees (1)
- store-operated calcium entry (1)
- strain (1)
- strain rate (1)
- stream (1)
- streptozotocin (1)
- stress response (1)
- striatum (1)
- stroop task (1)
- structural mechanism (1)
- structure analysis (1)
- structure based drug design (1)
- structure-based drug design (1)
- structure-function relationships (1)
- stx-Phagen (1)
- stx-phages (1)
- subcutaneous implanation (1)
- subthalamic nucleus (1)
- sugar perception (fructose, sucrose) (1)
- sugar receptor (1)
- sumo (1)
- sumoylation (1)
- superagonistische Funktion (1)
- superparamagnetische Eisenoxid Kontrastmittel (1)
- suspension culture (1)
- sustained fear (1)
- synaptische Plastizität (1)
- synthetic lethal interaction (1)
- synthetisch lethale Interaktion (1)
- systemic inflammation (1)
- systems biology (1)
- t cell (1)
- tactil (1)
- tactile (1)
- tapeworm (1)
- tdcs (1)
- telomere-associated protein (1)
- temperate zones (1)
- temporal information transfer (1)
- temporal organization (1)
- temporo-parietal junction (1)
- terahertz radiation (1)
- terpenes (1)
- test system (1)
- th1/th2 polarization (1)
- therapeutic strategy (1)
- therapeutisches Target (1)
- therapy (1)
- therapy of glioblastoma (1)
- therapy outcome (1)
- therapy simulation (1)
- thermal orientation (1)
- thermotolerance (1)
- theta burst stimulation (1)
- think/no-think (1)
- thiostrepton (1)
- threat conditioning (1)
- thrombin (1)
- thrombo-inflammation (1)
- thrombosis (1)
- thyroid stimulating hormone receptor (1)
- time-correlated single photon counting (TCSPC) (1)
- time-resolved anisotropy (1)
- timing (1)
- tissue model (1)
- tolerance (1)
- tolerogen (1)
- tolerogenic (1)
- tool (1)
- tool-use (1)
- torque meter (1)
- tracheal cytotoxin (1)
- trachomatis (1)
- trade-offs (1)
- trans-Golgi network (1)
- transcranial Direct Current Stimulation (tDCS) (1)
- transcranial direct current stimulation (1)
- transcription factor (1)
- transcription regulator (1)
- transcription/replication conflicts (1)
- transcriptional termination site (1)
- transcriptome (1)
- transcriptome analysis (1)
- transcriptome data analysis (1)
- transcriptome profiling (1)
- transcriptomic analysis (1)
- transcutaneous vagus nerve stimulation (1)
- transfer (1)
- transgenes Modell (1)
- transient dynamics (1)
- transmission blocking vaccine (1)
- transpiration barrier (1)
- transport (1)
- transporter regulator (1)
- tuberculosis (1)
- tumor angiogenesis (1)
- tumor metabolism (1)
- tumor vascular morphologie (1)
- tumorspezifische Therapie (1)
- tumour (1)
- two-component (1)
- type 1 diabetes (1)
- tyrosine kinase (1)
- ubiquitin (1)
- ubiquitin chain formation (1)
- ubiquitin linkage specificity (1)
- ubiquitin recognition (1)
- ultimatum game (1)
- unconventional T cells (1)
- unklarer Signifikanz (1)
- vaccine (1)
- vacuole (1)
- validation study (1)
- variant surface glycoprotein (1)
- variational network (1)
- varroa (1)
- vascular cell adhesion molecules (1)
- vascular smooth muscle cells (1)
- vascular system (1)
- vaskuläre Adhäsionsmoleküle (1)
- vaskuläre glatte Muskelzelle (1)
- vaskuläre glatte Muskelzellen (1)
- vasp (1)
- vav2 (1)
- vdr (1)
- ve-cadherin (1)
- venus (1)
- viral genome packaging (1)
- viral miRNAs (1)
- virological synapse (1)
- virtual reality T-maze (1)
- virulence factors (1)
- virus transmission (1)
- vision (1)
- visual attention (1)
- visual cue (1)
- visual perception (1)
- visuelles Langzeitgedächtnis (1)
- vitamin d (1)
- vitamin d receptor (1)
- vmPFC (1)
- waggle dance (1)
- waggle dance decoding (1)
- water fat separation (1)
- water loss (1)
- wax (1)
- wild-living honey bees (1)
- workbench (1)
- x-ray micro computed tomography (1)
- xiphophorus (1)
- yeast (1)
- zeitgeber (1)
- zeitlich Informationsübertragung (1)
- zeitliche Organisation (1)
- zeitliche Trends (1)
- zentrale Spindel und Mittelkörper (1)
- zielgerichtete Therapien (1)
- zonal Hydrogels (1)
- zyklische Peptide (1)
- µ-Opioid Rezeptor (1)
- Ängstliche Depression (1)
- Ätiologie (1)
- Ölpalmenanbau (1)
- Überexpression (1)
- Übertragungsfunktion (1)
- Übung (1)
- ß-adrenerge Rezeptoren (1)
- ß-adrenergic Receptors (1)
- ΔNp63 (1)
- α-synuclein (1)
- β3 adrenergic receptor (1)
- γδ T cells (1)
Institute
- Graduate School of Life Sciences (982) (remove)
Sonstige beteiligte Institutionen
- Helmholtz Institute for RNA-based Infection Research (HIRI) (5)
- Universitätsklinikum Münster (3)
- Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg (2)
- Zentrum für Infektionsforschung (ZINF) Würzburg (2)
- Bio-Imaging Center Würzburg (1)
- Biomedical Center Munich, Department of Physiological Chemistry, Ludwig-Maximilians-Universität München (1)
- CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - the development agency of the Brazilian Federal Government (1)
- CBIO, University of Cape Town, South Africa (1)
- Carl-Ludwig-Institut für Physiologie, Universität Leipzig (1)
- Chair of Experimental Biomedicine I (1)
In addition to bradykinesia and tremor, patients with Parkinson’s disease (PD) are known to exhibit non-motor symptoms such as apathy and hypomimia but also impulsivity in response to dopaminergic replacement therapy. Moreover, a plethora of studies observe differences in electrocortical and autonomic responses to both visual and acoustic affective stimuli in PD subjects compared to healthy controls. This suggests that the basal ganglia (BG), as well as the hyperdirect pathway and BG thalamocortical circuits, are involved in affective processing. Recent studies have shown valence and dopamine-dependent changes in synchronization in the subthalamic nucleus (STN) in PD patients during affective tasks. This thesis investigates the role of dopamine, valence, and laterality in STN electrophysiology by analyzing event-related potentials (ERP), synchronization, and inter-hemispheric STN connectivity. STN recordings were obtained from PD patients with chronically implanted electrodes for deep brain stimulation during a passive affective picture presentation task. The STN exhibited valence-dependent ERP latencies and lateralized ‘high beta’ (28–40 Hz) event-related desynchronization. This thesis also examines the role of dopamine, valence, and laterality on STN functional connectivity with the anterior cingulate cortex (ACC) and the amygdala. The activity of these limbic structures was reconstructed using simultaneously recorded electroencephalographic signals. While the STN was found to establish early coupling with both structures, STN-ACC coupling in the ‘alpha’ range (7–11 Hz) and uncoupling in the ‘low beta’ range (14–21 Hz) were lateralized. Lateralization was also observed at the level of synchrony in both reconstructed sources and for ACC ERP amplitude, whereas dopamine modulated ERP latency in the amygdala. These results may deepen our current understanding of the STN as a limbic node within larger emotional-motor networks in the brain.
Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity
(2019)
Adaptation to alterations in nutrient availability ensures the survival of organisms. In vertebrates, adipocytes play a decisive role in this process due to their ability to store large amounts of excess nutrients and release them in times of food deprivation. In todays western world, a rather unlimited excess of nutrients leads to high-caloric food consumption in humans. Nutrient overload together with a decreased energy dissipation result in obesity as well as associated diseases such as insulin resistance, diabetes, and liver steatosis. Obesity causes a hormonal imbalance, which in combination with altered nutrient levels can aberrantly activate G-protein coupled receptors utilizing diacylglycerol (DAG) as secondary messenger. Protein kinase D (PKD) 1 is a DAG effector integrating multiple hormonal and nutritional inputs. Nevertheless, its physiological role in adipocytes has not been investigated so far. In this thesis, evidence is provided that the deletion of PKD1 in adipocytes suppresses lipogenesis as well as the accumulation of triglycerides. Furthermore, PKD1 depletion results in increased mitochondrial biogenesis as well as decoupling activity. Moreover, PKD1 deletion promotes the expression of the β3-adrenergic receptor (ADRB3) in a CCAAT/enhancer-binding protein (C/EBP)-α and δ-dependent manner. This results in elevated expression levels of beige markers in adipocytes in the presence of a β-agonist. Contrarily, adipocytes expressing a constitutive active form of PKD1 present a reversed phenotype. Additionally, PKD1 regulates adipocyte metabolism in an AMP-activated protein kinase (AMPK)-dependent manner by suppressing its activity through phosphorylation of AMPK α1/α2 subunits. Thus, PKD1 deletion results in an enhanced activity of the AMPK complex. Consistent with the in vitro findings, mice lacking PKD1 in adipocytes demonstrate a resistance to high-fat diet-induced obesity due to an elevated energy expenditure caused by trans-differentiation of white into beige adipocytes. Moreover, deletion of PKD1 in murine adipocytes improves systemic insulin sensitivity and ameliorates liver steatosis. Finally, PKD1 levels positively correlate with HOMA-IR as well as insulin levels in human subjects. Furthermore, inhibition of PKD1 in human adipocytes leads to metabolic alterations, which are comparable to the alterations seen in their murine counterparts. Taken together, these data demonstrate that PKD1 suppresses energy dissipation, drives lipogenesis, and adiposity. Therefore, increased energy dissipation induced by several complementary mechanisms upon PKD1 deletion might represent an attractive strategy to treat obesity and its related complications.
Bacterial meningitis occurs when blood-borne bacteria are able to penetrate highly specialized brain endothelial cells (BECs) and gain access to the meninges. Neisseria meningitidis (Nm) is a human-exclusive pathogen for which suitable in vitro models are severely lacking. Until recently, modeling BEC-Nm interactions has been almost exclusively limited to immortalized human cells that lack proper BEC phenotypes. Specifically, these in vitro models lack barrier properties, and continuous tight junctions. Alternatively, humanized mice have been used, but these must rely on known interactions and have limited translatability. This motivates the need to establish novel human-based in vitro BEC models that have barrier phenotypes to research Nm-BEC interactions. Recently, a human induced pluripotent stem cell (iPSC) model of BECs has been developed that possesses superior BEC phenotypes and closely mimics the in vivo blood vessels present at the blood-meningeal barrier.
Here, iPSC-BECs were tested as a novel cellular model to study Nm-host pathogen interactions, with focus on host responses to Nm infection. Two wild type strains and three mutant strains of Nm were used to confirm that these followed similar phenotypes to previously described models. Importantly, the recruitment of the recently published pilus adhesin receptor CD147 underneath meningococcal microcolonies could be verified in iPSC-BECs. Nm was also observed to significantly increase the expression of pro-inflammatory and neutrophil-specific chemokines IL6, CXCL1, CXCL2, CXCL8, and CCL20, at distinct time points of infection, and the secretion of IFN γ and RANTES by iPSC-BECs. Nm was directly observed to disrupt tight junction proteins ZO-1, Occludin, and Claudin-5 at late time points of infection, which became frayed and/or discontinuous upon infection. This destruction is preceded by, and might be dependent on, SNAI1 activation (a transcriptional repressor of tight junction proteins). In accordance with tight junction loss, a sharp loss in trans-endothelial electrical resistance, and an increase in sodium fluorescein permeability was observed at late infection time points. Notably, bacterial transmigration correlated with junctional disruption, indicating that the paracellular route contributes for bacterial crossing of BECs. Finally, RNA-Sequencing (RNA-Seq) of sorted, infected iPSC-BECs was established through the use of fluorescence-activated cell sorting (FACS) techniques following infection. This allowed the detection of expression data of Nm-responsive host genes not previously described thus far to play a role during meningitidis.
In conclusion, here the utility of iPSC-BECs in vitro to study Nm infection could be demonstrated. This is the first BEC in vitro model to express all major BEC tight junctions and to display high barrier potential. Altogether, here this model provides novel insights into Nm pathogenesis, including an impact of Nm on barrier properties and tight junction complexes and suggests that the paracellular route contributes to Nm traversal of BECs.
Chlamydia trachomatis (Ct) is an obligate intracellular human pathogen. It causes blinding trachoma and sexually transmitted disease such as chlamydia, pelvic inflammatory disease and lymphogranuloma venereum. Ct has a unique biphasic development cycle and replicates in an intracellular vacuole called inclusion. Normally it has two forms: the infectious form, elementary body (EB); and the non-infectious form, reticulate body (RB). Ct is not easily amenable to genetic manipulation. Hence, to understand the infection process, it is crucial to study how the metabolic activity of Ct exactly evolves in the host cell and what roles of EB and RB play differentially in Ct metabolism during infection. In addition, Ct was found regularly coinfected with other pathogens in patients who got sexually transmitted diseases (STDs). A lack of powerful methods to culture Ct outside of the host cell makes the detailed molecular mechanisms of coinfection difficult to study.
In this work, a genome-scale metabolic model with 321 metabolites and 277 reactions was first reconstructed by me to study Ct metabolic adaptation in the host cell during infection. This model was calculated to yield 84 extreme pathways, and metabolic flux strength was then modelled regarding 20hpi, 40hpi and later based on a published proteomics dataset. Activities of key enzymes involved in target pathways were further validated by RT-qPCR in both HeLa229 and HUVEC cell lines. This study suggests that Ct's major active pathways involve glycolysis, gluconeogenesis, glycerolphospholipid biosynthesis and pentose phosphate pathway, while Ct's incomplete tricarboxylic acid cycle and fatty acid biosynthesis are less active. EB is more activated in almost all these carbohydrate pathways than RB. Result suggests the survival of Ct generally requires a lot of acetyl-CoA from the host. Besides, both EB and RB can utilize folate biosynthesis to generate NAD(P)H but may use different pathways depending on the demands of ATP. When more ATP is available from both host cell and Ct itself, RB is more activated by utilizing energy providing chemicals generated by enzymes associated in the nucleic acid metabolism. The forming of folate also suggests large glutamate consumption, which is supposed to be converted from glutamine by the glutamine-fructose-6-phosphate transaminase (glmS) and CTP synthase (pyrG).
Then, RNA sequencing (RNA-seq) data analysis was performed by me in a coinfection study. Metatranscriptome from patient RNA-seq data provides a realistic overview. Thirteen patient samples were collected and sequenced by our collaborators. Six male samples were obtained by urethral swab, and seven female samples were collected by cervicovaginal lavage. All the samples were Neisseria gonorrhoeae (GC) positive, and half of them had coinfection with Ct. HISAT2 and Stringtie were used for transcriptomic mapping and assembly respectively, and differential expression analysis by DESeq2, Ballgown and Cuffdiff2 are parallelly processed for comparison. Although the measured transcripts were not sufficient to assemble Ct's transcriptome, the differential expression of genes in both the host and GC were analyzed by comparing Ct positive group (Ct+) against Ct-uninfected group. The results show that in the Ct+ group, the host MHC class II immune response was highly induced. Ct infection is associated with the regulation of DNA methylation, DNA double-strand damage and ubiquitination. The analysis also shows Ct infection enhances host fatty acid beta oxidation, thereby inducing mROS, and the host responds to reduce ceramide production and glycolysis. The coinfection upregulates GC's own ion transporters and amino acid uptake, while it downregulates GC's restriction and modification systems. Meanwhile, GC has the nitrosative and oxidative stress response and also increases the ability for ferric uptake especially in the Ct+ group compared to Ct-uninfected group.
In conclusion, methods in bioinformatics were used here in analyzing the metabolism of Ct itself, and the responses of the host and GC respectively in a coinfection study with and without Ct. These methods provide metabolic and metatranscriptomic details to study Ct metabolism during infection and Ct associated coinfection in the human microbiota.
Die Implantation eines Medizinprodukts in den menschlichen Körper ruft eine Immunreaktion hervor, die zur fibrösen Einkapselung führen kann. Makrophagen in direktem Kontakt mit der Oberfläche des Implantats erfassen sensorisch den Fremdkörper und übersetzten das Signal in die Freisetzung zahlreicher löslicher Mediatoren. Das generierte Entzündungsmilieu moduliert die Heilungsreaktion und kann zur Anreicherung von Fibroblasten sowie zur Erhöhung der Matrixsyntheserate in der Wundumgebung führen. Eine dichte fibröse Kapsel um ein Medizinprodukt beeinträchtigt den Ersatz von Körperstrukturen, das Unterstützen physiologischer Körperfunktionen sowie die Effizienz einer medizinischen Therapie. Zur Identifizierung potenzieller Biomaterialkandidaten mit optimalen Eigenschaften ist jedoch eine evidenzbasierte Entscheidungsfindung notwendig und diese wiederum muss durch geeignete Testmethoden unterstützt werden.
Zur Erfassung lokaler Effekte nach Implantation eines Biomaterials begründet die Komplexi-tät der ablaufenden Fremdkörperreaktion die Anwendung von Tiermodellen als Goldstandard. Die Eingliederung von in vitro Modellsystemen in standardisierte Testverfahren scheitert oft an der Verfügbarkeit validierter, verlässlicher und reproduzierbarer Methoden. Demnach ist kein standardisiertes in vitro Testverfahren beschrieben, das die komplexen dreidimensionalen Gewebsstrukturen während einer Fremdkörperreaktion abbildet und sich zur Testung über längere Kontaktphasen zwischen Blutkomponenten und Biomaterialien eignet. Jedoch können in vitro Testungen kosten- und zeiteffizienter sein und durch die Anwendung humaner Zellen eine höhere Übertragbarkeit auf den Menschen aufweisen. Zusätzlich adressiert die Präferenz zu in vitro Testmethoden den Aspekt „Reduzierung“ der 3R-Prinzipien „Replacement, Reduction, Refinement“ (Ersatz, Reduzierung, Verbesserung) von Russel und Burch (1959) zu einer bewussten und begründeten Anwendung von Tiermodellen in der Wissenschaft. Ziel von diesem Forschungsvorhaben war die Entwicklung von humanen in vitro Modellsystemen, die den Kontakt zu Blutkomponenten sowie die Reaktion des umliegenden Bindegewebes bei lokaler Implantation eines Biomaterials abbilden. Referenzmaterialien, deren Gewebsantwort nach Implantation in Tiere oder den Menschen bekannt ist, dienten als Validierungskriterium für die entwickelten Modellsysteme. Die Anreicherung von Zellen sowie die Bildung extrazellulärer Matrix in der Wundumgebung stellen wichtige Teilprozesse während einer Fremdkörperreaktion dar. Für beide Teilprozesse konnte in einem indirekten zellbasierten Modellsystem der Einfluss einer zellvermittelten Konditionierung wie die Freisetzung von löslichen Mediatoren durch materialadhärente Makrophagen auf die gerichtete Wanderung von Fibroblasten sowie den Umbau eines dreidimensionalen Bindegewebsmodells aufgezeigt werden.
Des Weiteren ließ sich das Freisetzungsprofil von Zytokinen durch materialständige Makrophagen unter verschiedenen Testbedingungen wie der Kontamination mit LPS, der Oberflächenbehandlung mit humanem Blutplasma und der Gegenwart von IL-4 bestimmen. Die anschließende vergleichende statistische Modellierung der generierten komplexen multifaktoriellen Datenmatrix ermöglichte die Übersetzung in eine Biomaterialbewertung. Dieses entwickelte Testverfahren eignete sich einerseits zur Validierung von in vitro Testbedingungen sowie andererseits zur Bewertung von Biomaterialien. Darüber hinaus konnte in einem dreidimensionalen Fremdkörpermodell die komplexe dreidimensionale Struktur der extrazellulären Matrix in einer Wunde durch die Kombination unterschiedlicher Zell- und Matrixkomponenten biomimetisch nachgebaut werden. Diese neuartigen dreidimensionalen Fremdkörpermodelle ermöglichten die Testung von Biomaterialien über längere Testphasen und können in anschließenden Studien angewandt werden, um dynamische Prozesse zu untersuchen. Zusammenfassend konnten in dieser Arbeit drei unterschiedliche Teststrategien entwickelt werden, die (I) die Bewertung von Teilprozessen ermöglichen, (II) die Identifizierung verlässlicher Testbedingungen unterstützen und (III) biomimetisch ein Wundgewebe abbilden. Wesentlich ist, dass biomimetisch ein dreidimensionales Gewebemodell entwickelt werden konnte, das eine verlässliche Unterscheidungskapazität zwischen Biomaterialien aufweist.
Functional analysis of polarization and podosome formation of murine and human megakaryocytes
(2019)
In mammals, blood platelets are produced by large bone marrow (BM) precursor cells, megakaryocytes (MK) that extend polarized cell protrusions (proplateles) into BM sinusoids. Proplatelet formation (PPF) requires substantial cytoskeletal rearrangements that have been shown to involve the formation of podosomes, filamentous actin (F-actin) and integrin-rich structures. However, the exact molecular mechanisms regulating MK podosome formation, polarization and migration within the BM are poorly defined. According to current knowledge obtained from studies with other cell types, these processes are regulated by Rho GTPase proteins like RhoA and Cdc42.
In this thesis, polarization and podosome formation were investigated in MKs from genetically modified mice, as well as the cell lines K562 and Meg01 by pharmacological modulation of signaling pathways.
The first part of this thesis describes establishment of the basic assays for investigation of MK polarization. Initial data on polarization of the MK-like erythroleukemia cell line K562 revealed first insights into actin and tubulin dynamics of wild type (WT) and RhoA knock-out (RhoA-/-) K562 cells. Phorbol 12-myristate 13-acetate (PMA)-induction of K562 cells led to the expected MK-receptor upregulation but also RhoA depletion and altered polarization patterns.
The second part of this thesis focuses on podosome formation of MKs. RhoA is shown to be dispensable for podosome formation. Cdc42 is revealed as an important, but not essential regulator of MK spreading and podosome formation. Studies of signaling pathways of podosome formation reveal the importance of the tyrosine kinases Src, Syk, as well as glycoprotein (GP)VI in MK spreading and podosome formation.
This thesis provides novel insights into the mechanisms underlying polarization and podosome formation of MKs and reveals new, important information about cytoskeletal dynamics of MKs and potentially also platelets.
Das Multiple Myelom muss trotz stetiger Fortschritte im Hinblick auf die verfügbaren Therapieoptionen und die Krankheitsprognose weiterhin im Wesentlichen als eine unheilbare Erkrankung angesehen werden. Dies kann vor allem auf die große inter- und intraindividuelle Heterogenität des MM zurückgeführt werden, welche die Entwicklung gezielter molekularer Therapiestrategien erheblich erschwert. Hierbei stellen loss-of-function- Experimente, welche die Identifikation einzelner oder mehrerer potenziell therapeutisch relevanter Zielstrukturen durch die (kombinierte) Depletion von Proteinen ermöglichen, eine wichtige Säule dar, für deren Durchführung verschiedene Systeme mit jeweils eigenen Vor- und Nachteilen zur Verfügung stehen. Im Rahmen dieser Arbeit konnte die Etablierung eines auf RNA-Interferenz basierenden stabilen und induzierbaren Knockdownsystems durch Elektroporation von MM Zelllinien mit Einzel- und Mehrfach-shRNA-Vektoren abgeschlossen werden. Die Transfektion von tet-Repressor-exprimierenden Zellinien mit einer oder mehreren shRNAExpressionskassetten innerhalb eines Plasmidvektors ermöglicht durch die vollständige Repression der shRNA-Transkription im nicht-induzierten Zustand die Selektion erfolgreich transponierter Zellen ohne Effekt-vermittelte Bias und die Generierung großer Zellmengen für Versuchsreihen in vergleichsweise kurzer Zeit. Die Induktion der verschiedenen in dieser Arbeit evaluierten Einzel- und Mehrfach-shRNA-Konstrukte gegen (Kombinationen von) Zielstrukturen im Ras/MAPK- sowie im NFκB-Signalsystem mittels Doxyzyklin als Induktionsagens zeigte durchweg deutliche und den Erwartungen aus transienten Experimenten entsprechende Knockdownergebnisse. Auch die Resultate hinsichtlich funktioneller Readouts und zellphysiologischer Effekte der induzierten Knockouts stehen im Einklang mit vorangegangenen Experimenten und bestätigen somit die Äquivalenz des stabilen induzierbaren Systems zu transienten Ansätzen auf RNAi-Basis oder zu pharmakologischen Inhibitoren. Der hierbei erzielte hypomorphe Phänotyp innerhalb einer polyklonalen Zellpopulation bildet die Realität einer medikamentösen Blockade einer oder weniger Zielstrukturen einer heterogenen MM Tumorpopulation näherungsweise ab, weshalb das vorgestellte System ein hilfreiches, kosteneffizientes und leicht zu handhabendes Werkzeug für die Identifikation potenziell relevanter Zielstrukturen für molekulare Therapieansätze im Multiplen Myelom darstellt
Protein kinase A (PKA) is the main effector of cyclic-adenosine monophosphate (cAMP) and plays an important role in steroidogenesis and proliferation of adrenal cells. In a previous study we found two mutations (L206R, 199_200insW) in the main catalytic subunit of protein kinase A (PKA C) to be responsible for cortisol-producing adrenocortical adenomas (CPAs). These mutations interfere with the formation of a stable holoenzyme, thus causing constitutive PKA activation. More recently, we identified additional mutations affecting PKA C in CPAs associated with overt Cushing syndrome: S213R+insIILR, 200_201insV, W197R, d244 248+E249Q, E32V.
This study reports a functional characterization of those PKA Cmutations linked to CPAs of Cushing’s patients. All analyzed mutations except for E32V showed a reduced interaction with at least one tested regulatory (R) subunit. Interestingly the results of the activity differed among the mutants and between the assays employed. For three mutants (L206R, 199_200insW, S213R+insIILR), the results showed enhanced translocation to the nucleus. This was also observed in CRISPR/Cas9 generated PRKACA L206R mutated HEK293T cells. The enhanced nuclear translocation of this mutants could be due to the lack of R subunit binding, but also other mechanisms could be at play. Additionally, I used an algorithm, which predicted an effect of the mutation on substrate specificity for four mutants (L206R, 199_200insW, 200_201insV, d244 248+E249Q). This was proven using phosphoproteomics for three mutants (L206R, 200_201insV, d244 248+E249Q). In PRKACA L206R mutated CPAs this change in substrate specificity also caused hyperphosphorylation of H1.4 on serine 36, which has been reported to be implicated in mitosis. Due to these observations, I hypothesized, that there are several mechanisms of action of PRKACA mutations leading to increased cortisol secretion and cell proliferation in adrenal cells: interference with the formation of a stable holoenzyme, altered subcellular localization and a change in substrate specificity. My data indicate that some PKA C mutants might act via just one, others by a combination of these mechanisms. Altogether, these findings indicate that several mechanisms contribute to the development of CPAs caused by PRKACA mutations. Moreover, these findings provide a highly illustrative example of how alterations in a protein kinase can cause a human disease.
The Myb-MuvB (MMB) multiprotein complex is a master regulator of cell cycle-dependent gene expression. Target genes of MMB are expressed at elevated levels in several different cancer types and are included in the chromosomal instability (CIN) signature of lung, brain, and breast tumors.
This doctoral thesis showed that the complete loss of the MMB core subunit LIN9 leads to strong proliferation defects and nuclear abnormalities in primary lung adenocarcinoma cells. Transcriptome profiling and genome-wide DNA-binding analyses of MMB in lung adenocarcinoma cells revealed that MMB drives the expression of genes linked to cell cycle progression, mitosis, and chromosome segregation by direct binding to promoters of these genes. Unexpectedly, a previously unknown overlap between MMB-dependent genes and several signatures of YAP-regulated genes was identified. YAP is a transcriptional co-activator acting downstream of the Hippo signaling pathway, which is deregulated in many tumor types. Here, MMB and YAP were found to physically interact and co-regulate a set of mitotic and cytokinetic target genes, which are important in cancer. Furthermore, the activation of mitotic genes and the induction of entry into mitosis by YAP were strongly dependent on MMB. By ChIP-seq and 4C-seq, the genome-wide binding of MMB upon YAP overexpression was analyzed and long-range chromatin interaction sites of selected MMB target gene promoters were identified. Strikingly, YAP strongly promoted chromatin-association of B-MYB through binding to distal enhancer elements that interact with MMB-regulated promoters through chromatin looping.
Together, the findings of this thesis provide a so far unknown molecular mechanism by which YAP and MMB cooperate to regulate mitotic gene expression and suggest a link between two cancer-relevant signaling pathways.
Regulation of gene expression by the control of transcription is essential for any cell to adapt to the environment and survive. Transcription regulators, i.e. sequence-specific DNA binding proteins that regulate gene expression, are central elements within the gene networks of most organisms. Transcription regulators are grouped into distinct families based on structural features that determine, to a large extent, the DNA sequence(s) that they can recognise and bind. Less is known, however, about how the DNA binding preferences can diversify within transcription regulator families during evolutionary timescales, and how such diversification can affect the biology of the organism.
In this dissertation I study the SREBP (sterol regulatory element binding protein) family of transcriptional regulators in yeasts, and in Candida albicans in particular, as an experimental system to address these questions. The SREBPs are conserved from fungi to humans and represent a subgroup of basic helix-loop-helix DNA binding proteins. Early chromatin immunoprecipitation experiments with SREBPs from humans and yeasts showed that these proteins bound in vivo to the canonical DNA sequence, termed E-box, most basic helix-loop-helix proteins bind to. By contrast, most recent analysis carried out with less-studied fungal SREBPs revealed a non-canonical DNA motif to be the most overrepresented sequence in the bound regions.
This study aims to establish the intrinsic DNA binding preferences of key branches of this family and to determine how the divergence in DNA binding affinities originated. To this end, I combined phylogenetic and ancestral reconstruction with extensive biochemical characterisation of key SREBP proteins. The results indicated that while the most-studied SREBPs (in mammals) indeed show preference for the E-box, a second branch of the family preferentially binds the non-E-box, and a third one is able to bind both sequences with similar affinity. The preference for one or the other DNA sequence is an intrinsic property of each protein because their purified DNA binding domain was sufficient to recapitulate their in vivo binding preference. The ancestor that gave rise to these two different types of SREBPs (the branch that binds E-box and the one that binds non-E-box DNA) appears to be a protein with a broader DNA binding capability that had a slight preference for the non-canonical motif. Thus, the results imply these two branches originated by either enhancing the original ancestral preference for non-E-box or tilting it towards the E-box DNA and flipping the preference for this sequence.
The main function associated with members of the SREBP family in most eukaryotes is the control of lipid biosynthesis. I have further studied the function of these proteins in the lineage that encompasses the human associated yeast C. albicans. Strikingly, the three SREBPs present in the fungus’ genome contribute to the colonisation of the mammalian gut by regulating cellular processes unrelated to lipid metabolism. Here I describe that two of the three C. albicans SREBPs form a regulatory cascade that regulates morphology and cell wall modifications under anaerobic conditions, whereas the third SREBP has been shown to be involved in the regulation of glycolysis genes.
Therefore, I posit that the described diversification in DNA binding specificity in these proteins and the concomitant expansion of targets of regulation were key in enabling this fungal lineage to associate with animals.