Refine
Has Fulltext
- yes (506)
Is part of the Bibliography
- yes (506)
Year of publication
- 2012 (506) (remove)
Document Type
- Journal article (364)
- Doctoral Thesis (133)
- Preprint (3)
- Review (3)
- Book (1)
- Conference Proceeding (1)
- Report (1)
Language
- English (506) (remove)
Keywords
- Medizin (42)
- hadron-hadron scattering (15)
- Biologie (13)
- Psychologie (12)
- systematic uncertainty (9)
- cancer (8)
- gene expression (8)
- melanoma (8)
- expression (7)
- jet energy scale (7)
- protein (7)
- brain (6)
- differentiation (6)
- in vitro (6)
- ATLAS (5)
- Apoptosis (5)
- Chemie (5)
- Maus (5)
- apoptosis (5)
- binding (5)
- genome-wide association (5)
- mice (5)
- therapy (5)
- transverse momentum (5)
- Atlas detector (4)
- Drosophila (4)
- HIV (4)
- Melanom (4)
- Taufliege (4)
- Vaccinia-Virus (4)
- cells (4)
- disease (4)
- emotion (4)
- gene (4)
- genetics (4)
- identification (4)
- inhibitor (4)
- jet energy resolution (4)
- lung cancer (4)
- messenger RNA (4)
- metaanalysis (4)
- model (4)
- neuroprotection (4)
- oncolytic virotherapy (4)
- receptor (4)
- resistance (4)
- signal transduction (4)
- single-crystal X-ray study (4)
- survival (4)
- tumors (4)
- vaccinia virus (4)
- validation (4)
- Dendritische Zelle (3)
- Evolution (3)
- Fuchsbandwurm (3)
- Genexpression (3)
- Knockout <Molekulargenetik> (3)
- Lungenkrebs (3)
- MC simulation (3)
- MRI (3)
- Modellierung (3)
- Myc (3)
- Perylenderivate (3)
- Pneumolysin (3)
- SM background (3)
- T cells (3)
- Zelldifferenzierung (3)
- association (3)
- breast-tumors (3)
- central-nervous-system (3)
- children (3)
- classification (3)
- colony-stimulating factor (3)
- combination therapy (3)
- epithelial cells (3)
- escherichia coli (3)
- genes (3)
- jet energy scale uncertainty (3)
- light quark jet (3)
- lung (3)
- magnetic resonance imaging (3)
- malaria (3)
- multijet background (3)
- multiple sclerosis (3)
- non-prompt lepton (3)
- onkolytische Virotherapie (3)
- oxidative stress (3)
- progression (3)
- quality of life (3)
- serum (3)
- stem cells (3)
- stroke (3)
- top quark mass (3)
- top quark pair (3)
- trial (3)
- ubiquitin (3)
- 5-HT1A (2)
- 5-HT2C (2)
- ADHD (2)
- Alzheimers disease (2)
- Anti-k Jet (2)
- Apoptose (2)
- Arzneimitteldesign (2)
- Ausbreitung (2)
- BDNF (2)
- Bakteriengift (2)
- Biochemie (2)
- Cl Lowe limit (2)
- DNA repair (2)
- Datenbank (2)
- Dendritic cell (2)
- Deutschland (2)
- Diabetes mellitus (2)
- Drugs (2)
- EF-1A (2)
- Echinococcus (2)
- Embryonale Stammzelle (2)
- Extrazelluläre Matrix (2)
- Extremwertstatistik (2)
- FAAH (2)
- Geruchssinn (2)
- Graphen (2)
- Heterostruktur (2)
- Hey (2)
- Higgs (2)
- Hirnhautentzündung (2)
- Image-guidance (2)
- Integrated network analysis (2)
- JES uncertainty (2)
- Keldysh formalism (2)
- Klimaänderung (2)
- LHC (2)
- Landnutzung (2)
- Learning (2)
- Leishmania major (2)
- Lernen (2)
- MAP-Kinase (2)
- MC event generator (2)
- MODIS (2)
- MYC (2)
- Makrophage (2)
- Malaria (2)
- Meningitis (2)
- Metastase (2)
- Modell (2)
- Molekulargenetik (2)
- Monte Carlo (2)
- NPY (2)
- Netzwerkanalyse (2)
- Neurogenese (2)
- New Zealand (2)
- Newton-Verfahren (2)
- Numerisches Verfahren (2)
- Onkolyse (2)
- Optimale Kontrolle (2)
- Optische Spektroskopie (2)
- P300 (2)
- Photoelektronenspektroskopie (2)
- Pore (2)
- Porenbildung (2)
- Pp Collision (2)
- Proliferation (2)
- RNA-seq (2)
- Radiosurgery (2)
- Raf kinases (2)
- Rastertunnelmikroskop (2)
- Renormierungsgruppe (2)
- SMN (2)
- Serotonin (2)
- Simulation (2)
- Sinnesphysiologie (2)
- Spektroskopie (2)
- Strahlentherapie (2)
- Strahlungstransport (2)
- Supraleiter (2)
- Supraleitung (2)
- Systembiologie (2)
- T = 100 K (2)
- T cell (2)
- Thrombozyt (2)
- Toxin (2)
- Transkriptionsfaktor (2)
- West Africa (2)
- Zeitreihenanalyse (2)
- Zeitrichtung (2)
- ablation (2)
- acceptance time efficiency (2)
- acute kidney injury (2)
- adalimumab (2)
- african trypanosomes (2)
- angiogenesis (2)
- anti-k jet (2)
- antirheumatic agents (2)
- architecture (2)
- astrocytes (2)
- basal ganglia (2)
- biomarkers (2)
- blood pressure (2)
- blood-brain barrier (2)
- breast cancer (2)
- c-myc (2)
- calorimeter (2)
- cancer cells (2)
- carcinoma (2)
- cerebral ischemia (2)
- chemotherapy (2)
- ciliary neurotrophic factor (2)
- climate change (2)
- closed head injury (2)
- coagulation (2)
- comparative genomic hybridization (2)
- decision making (2)
- deficient mice (2)
- degeneration (2)
- dementia (2)
- dendritic cells (2)
- dependent protein-kinase (2)
- depression (2)
- disease progression (2)
- dispersal (2)
- diversity (2)
- domain (2)
- dopamine (2)
- down regulation (2)
- drug (2)
- endocannabinoid (2)
- endophenotype (2)
- endothelial cells (2)
- enterica serovar typhimurium (2)
- environment (2)
- evolution (2)
- experimental autoimmune encephalomyelitis (2)
- fake lepton (2)
- films (2)
- focal cerebral-ischemia (2)
- follow up (2)
- follow-up (2)
- functional characterization (2)
- giant ventral hernia (2)
- graphene (2)
- growth (2)
- ideomotor theory (2)
- immunoreactive neurons (2)
- in vivo (2)
- in-vitro (2)
- inflammation (2)
- injury (2)
- insect immunity (2)
- jet channel (2)
- jet reconstruction efficiency (2)
- jet transverse momentum (2)
- kinase (2)
- laparostomy (2)
- lines (2)
- linkage (2)
- living cells (2)
- localization (2)
- magnetic resonance (2)
- malignant melanoma (2)
- mass spectrometry (2)
- mechanisms (2)
- melanogaster (2)
- metastasis (2)
- microenvironment (2)
- microglia (2)
- migration (2)
- multi-jet background (2)
- muon channel (2)
- mutation (2)
- mutations (2)
- myelin (2)
- myocardial infarction (2)
- myocardial-infarction (2)
- neurons (2)
- nude-mice (2)
- olfactory memory (2)
- oncolysis (2)
- open abdomen (2)
- ovarian cancer (2)
- partial decay width (2)
- pathway (2)
- peptide vaccination (2)
- perception (2)
- perspectives (2)
- phosphorylation (2)
- prevalence (2)
- primary vertex (2)
- proteasome (2)
- randomized controlled trial (2)
- recognition (2)
- regression analysis (2)
- resolution (2)
- responses (2)
- rheumatoid arthritis (2)
- ribosomal RNA (2)
- sample (2)
- schizophrenia (2)
- senescence (2)
- signal cross section (2)
- simulated signal event (2)
- single top event (2)
- single top production (2)
- single top quark (2)
- single top quark production (2)
- sleep (2)
- sleep disorders (2)
- smooth muscle cells (2)
- speech perception (2)
- stability (2)
- staphylococcus aureus (2)
- startle reflex (2)
- surface (2)
- susceptibility gene (2)
- synthetic mesh (2)
- tissue (2)
- tissue engineering (2)
- tolerance (2)
- top quark decay (2)
- trabeculectomy (2)
- transcription (2)
- transmission (2)
- traumatic brain injury (2)
- treatment outcome (2)
- triple in situ hybridization (2)
- tumor (2)
- vaccine (2)
- vacuum conditioning (2)
- variability (2)
- variants (2)
- virulence (2)
- visible cross section (2)
- wR factor = 0.068 (2)
- . (1)
- 1/N expansion (1)
- 14.7K (1)
- 19F-MR (1)
- 1ES 1011+496 (1)
- 1ES 2344+514 (1)
- 1p13.3 (1)
- 1q21 (1)
- 2',7'-dichlorofluorescin (1)
- 2,5-diketopiperazines (1)
- 5-HT transporter (1)
- 68Ga-DOTATATE (1)
- 7000 GeV-cms (1)
- 7q11.2 (1)
- A-type lamins (1)
- ACC deaminase (1)
- AGT (1)
- ALK-1 (1)
- ALMT (1)
- ALS (1)
- AMD (1)
- AMP (1)
- AMPK (1)
- ARF (1)
- ATLAS <Teilchendetektor> (1)
- ATLAS detector (1)
- Abl (1)
- Acetylneuraminsäure <N-> (1)
- Actin (1)
- Actin nucleation (1)
- Actin-bindende Proteine (1)
- Activation induced cell death/AICD (1)
- AdS-CFT-Korrespondenz (1)
- AdS/CFT (1)
- Adiabatic Theorem of quantum mechanics (1)
- Advanced snowmelt (1)
- Ag(111) (1)
- Aharonov-Bohm effect (1)
- Aharonov-Bohm-Effekt (1)
- Ako na Uche (1)
- Aktinnukleation (1)
- Alcohol (1)
- Aldehyde (1)
- Alkohol (1)
- Allergie (1)
- Allergy (1)
- Alliances (1)
- Alps (1)
- Altern (1)
- Alternative Conflict Resolutions (1)
- Alveolar Echinococcosis (1)
- Alveoläre Echinokokkose (1)
- Alzheimer Dementia (1)
- Alzheimer's disease (1)
- Alzheimer-Krankheit (1)
- Alzheimer’s disease (1)
- Amazonia (1)
- Ambulantes Assessment (1)
- Ambulatory Assessment (1)
- Ameisen (1)
- Amyloid <beta-> (1)
- Ancistrocladus (1)
- Anergy (1)
- Aneuploidie (1)
- Angeregter Zustand (1)
- Animal Spirits (1)
- Animal models (1)
- Anoikis (1)
- Anthocyane (1)
- Anthrax toxin (1)
- Antibody (1)
- Anticipation (1)
- Antigen CD28 (1)
- Antikörper (1)
- Antimicrobial activity (1)
- Antizipation (1)
- Anämie (1)
- Arabidopsis (1)
- Araneae (1)
- Areal (1)
- Argumentation (1)
- Artverbreitungsmodellierung (1)
- Arzneimittel (1)
- Aspergillus fumigatus (1)
- Aspergillus niger (1)
- Astrozyt (1)
- Atherosclerotic plaque (1)
- Attentional performance (1)
- Aufmerksamkeits-Defizit-Syndrom (1)
- Ausfallsicheres System (1)
- Ausfallsicherheit (1)
- Autoaggressionskrankheit (1)
- AuxRE (1)
- Auxin-regulated transcription (1)
- B cell (1)
- B cells (1)
- B neisseria meningitidis (1)
- B-tagged jet (1)
- BBCH (1)
- BK virus (1)
- BL Lacertae (1)
- BL-Lacertae-Objekt (1)
- BRAF (1)
- BRCA1 (1)
- BRCA1 positive (1)
- BRCA1/2 negative (1)
- BRCA2 positive (1)
- Bacillus anthracis (1)
- Bacillus megaterium (1)
- Bacterial Toxins (1)
- Bacterial meningitis (1)
- Bakterielle Hirnhautentzündung (1)
- Bakterien (1)
- Basin-Hopping (1)
- Bayesian Estimation (1)
- Berry Phase (1)
- Betriebssystem (1)
- Beweistheorie (1)
- Bildgebendes Verfahren (1)
- Biochemistry (1)
- Biodiversität (1)
- Biogenese (1)
- Biokonjugate (1)
- Biolabelling (1)
- Biologische Aktivität (1)
- Biomarker (1)
- Bioorganometallchemie (1)
- Bioorthogonal (1)
- Biotechnologie (1)
- Biotechnologische Industrie (1)
- Biotechnology (1)
- Black lipid bilayer (1)
- Blazar (1)
- Bloch-Siegert (1)
- Blochmannia (1)
- Blumeria graminis (1)
- Blut-Hirn-Schranke (1)
- Blutbildendes Gewebe (1)
- Blutplättchen (1)
- Blutstammzelle (1)
- Bor (1)
- Boracumulen (1)
- Boracumulene (1)
- Boraheterocycles (1)
- Borheterocyclen (1)
- Boron (1)
- Borylene (1)
- Borylene complexes (1)
- Borylenkomplexe (1)
- Botanik (1)
- Bowen’s disease, periungual (1)
- Box-Jenkins-Verfahren (1)
- Box–Jenkins Program (1)
- Brain edema (1)
- Brain ischemia (1)
- Bre (1)
- Bre-knockout (1)
- Brugia Malayi (1)
- Bullous pemphigoid (1)
- Burkholderia (1)
- Burkholderia pseudomallei (1)
- C-13 NMR (1)
- C-MYC (1)
- C-reactive protein (1)
- C57BL/KALWRIJ mouse (1)
- C9orf72 (1)
- CC2 (1)
- CCL2 (MCP-1) (1)
- CD28 antigen (1)
- CD28-Superagonist (1)
- CD28-superagonist (1)
- CD30 (1)
- CD4(+) (1)
- CD4(+) T-cells (1)
- CD95 (1)
- CENP-A (1)
- CERN LHC Coll (1)
- CIS+ (1)
- CMR (1)
- COMT VAL(158)MET polymorphism (1)
- COPD diagnosis (1)
- CORM (1)
- CPP Peptide (1)
- CPP-peptide (1)
- CSE4, CENP-A (1)
- CSF (1)
- CSF-1 Rezeptor (1)
- CSF-1 receptor (1)
- CT-INT (1)
- CXCL8 (IL-8) (1)
- Caco-2 (1)
- Calcineurin (1)
- Calciumtransport (1)
- Camponotus (1)
- Camponotus floridanus (1)
- Cancer (1)
- Carcinogenität (1)
- Cardiovascular risk factors (1)
- Caspase 12 (1)
- Cerebral blood flow (1)
- Cerebral vasospasm (1)
- Chaos (1)
- Chaostheorie (1)
- Chaotisches System (1)
- Charcot-Marie-Tooth (1)
- Charcot-Marie-Tooth disease (1)
- Charcot–Marie–Tooth disease (1)
- Chemotherapie (1)
- Chemotherapy (1)
- Chondrozyten (1)
- Circadian Rhythms (1)
- Circadiane Rhythmik (1)
- Cis-elements (1)
- Cisterna magna (1)
- City Planning in the USA (1)
- Click-Chemie (1)
- Climate change (1)
- Cluster-Entwicklung (1)
- Cobaltate (1)
- Cobaltates (1)
- Coexpression (1)
- Cognitive (1)
- Coherent 2D Spectroscopy (1)
- Colloids (1)
- Combination (1)
- Commercial preparations (1)
- Compressed Sensig (1)
- Computational chemistry (1)
- Computersimulation (1)
- Cone-beam CT (1)
- Conjugate gradient method (1)
- Contaminants (1)
- Coronary artery bypass graft (1)
- Cortison (1)
- Cryolesion (1)
- Crystalloids (1)
- Cuprates (1)
- Cushings syndrome (1)
- Cyclooctine (1)
- Cyclooctyne (1)
- Cymantren (1)
- Cystic fibrosis (1)
- Cytotoxizität (1)
- DCA (1)
- DNA Methylation (1)
- DNA Reparatur (1)
- DNA repeat expansion (1)
- DNA replication (1)
- DNA-binding vesicles (1)
- DNS-Reparatur (1)
- DOT1 (1)
- DRD2 (1)
- Danish hernia database (1)
- Darmkrebs (1)
- Database (1)
- Datenbanksystem (1)
- Decision-making (1)
- Defensine (1)
- Delay-Differential Equations (1)
- Delayed snowmelt (1)
- Demenz (1)
- Dendrimer (1)
- Depression (1)
- Design (1)
- Diabetes (1)
- Diabetes Typ 1 (1)
- Diarylethen (1)
- Diarylethene (1)
- Diarylethylene (1)
- Dickblattgewächse (1)
- Dielektrikum (1)
- Dimension 2 (1)
- Dimeric Naphthylisoquinoline Alkaloids (1)
- Dimermethode (1)
- Direkte numerische Simulation (1)
- Diskursanalyse (1)
- Dissipatives System (1)
- Disulfidbrücken (1)
- Domänenprotein (1)
- Dopamin (1)
- Double hemorrhage model (1)
- Drahtloses Sensorsystem (1)
- Dreiecksgitter (1)
- Driver Assistance System (1)
- Driving (1)
- Drogen (1)
- Duftintensität (1)
- Duftstoff (1)
- Dynamic Geometry Environment (1)
- Dynamic Memory Management (1)
- Dynamische Geometriesysteme (1)
- Dynamische Speicherverwaltung (1)
- Dynamisches System (1)
- E. coli Nissle 1917 (1)
- E3 14.7-kilodalton protein (1)
- E3 ubiquitin ligase (1)
- EBRT (1)
- ECG-recording (1)
- ECORN-CF Projekt (1)
- EHS classification (1)
- EMG (1)
- EORTC-BN20 (1)
- EORTC-QLQ-C15-PAL (1)
- EP Procedures (1)
- ERK signaling (1)
- ERP-BCI (1)
- ERPS (1)
- ETR (1)
- Echinococcus multilocularis (1)
- Echtzeitsystem (1)
- Ecological Momentary Assessment (1)
- Eierstockkrebs (1)
- Eindrucksbildung (1)
- Eingebettetes System (1)
- Einzelhandel (1)
- Eisen-basierte Supraleiter (1)
- Electromagnon (1)
- Electronic diary (1)
- Electrospinning (1)
- Elektrizitätserzeugung (1)
- Elektromagnon (1)
- Elektromigration (1)
- Elektronenflüssigkeit (1)
- Elektronengas (1)
- Elektronenstrahllithographie (1)
- Elektronentransfer (1)
- Elektronisches Tagebuch (1)
- Elektrostatisches Verspinnen (1)
- Elementarteilchenphysik (1)
- Embedded Systems (1)
- Embryo (1)
- Embryonalentwicklung (1)
- Emery-Dreifuss muscular dystrophy (1)
- Encephalomyelitis (1)
- Endogenous Glucocorticoids (1)
- Energie (1)
- Energielandschaft (1)
- Entscheidung (1)
- Entscheidungsprozess (1)
- Entzündung (1)
- Epigenese (1)
- Epigenetic (1)
- Epigenetik (1)
- Epitaxieschicht (1)
- Erysiphe graminis (1)
- Erythropoietin (1)
- Escherichia coli (1)
- European beech (1)
- European countries (1)
- European experience (1)
- Evakuierung (1)
- Excitotoxicity (1)
- Experimental brain trauma (1)
- Experimentellen Autoimmun-Enzephalomyelitis (1)
- Extended field irradiation (1)
- Extremwerttheorie (1)
- Extremwetterereignisse (1)
- Exziton (1)
- FAS (1)
- FAS-II (1)
- FGF (1)
- FGF Signaling (1)
- FIR-Spektroskopie (1)
- FMRI (1)
- FXII (1)
- FabI (1)
- FabV (1)
- Fabry disease (1)
- Factor XII (1)
- Fahren (1)
- Fahrerassistenz (1)
- Faktor XII (1)
- Fanconi Anemia (1)
- Fanconi Anämie (1)
- Fanconi-anemia subtype (1)
- Farbstoff (1)
- Fe3O4 (1)
- Femtosekundenspektroskopie (1)
- Fermionensystem (1)
- Fernerkundung (1)
- Fernwartung (1)
- Festkörperphysik (1)
- Festkörpertheorie (1)
- Fettsäurebiosynthese (1)
- Fettsäurestoffwechsel (1)
- Fibroblasten (1)
- Fibroblastenwachstumsfaktor (1)
- Flowering (1)
- Fluency (1)
- Fluidnetzwerk (1)
- Fluor-19 (1)
- Fluoreszenz (1)
- Fluoreszenzmikrosopie (1)
- Foamy virus (1)
- Follicular lymphoma (1)
- Fontan’s Operation (1)
- Forschung und Entwicklung (1)
- Fotovoltaik (1)
- Frabin/Fgd4 (1)
- Frame-based (1)
- Frame-less (1)
- Freies Molekül (1)
- Frequency Domain (1)
- Front Collision Warning (1)
- Frontkollisionswarnung (1)
- Fumonisin B1 (1)
- Fumonisine (1)
- Functional interaction (1)
- Functional module search (1)
- Functional modules (1)
- Funktionelle Bildgebung (1)
- Funktionelle Modulsuche (1)
- G protein coupled receptor (1)
- G-Protein gekoppelte Rezeptoren (1)
- GABA (1)
- GABA A Receptors (1)
- GABA A Rezeptoren (1)
- GABA(A) receptors (1)
- GABAA-Rezeptor (1)
- GABP (1)
- GATA4 (1)
- GMSB model (1)
- GO1 (1)
- GOLD (1)
- GRN (1)
- GagPol fusion protein (1)
- Gametozyt (1)
- Gammaastronomie (1)
- Garcinia biflavonoids (1)
- Gaudium et Spes (1)
- Gedächtnis (1)
- Geldpolitik (1)
- Gen (1)
- Gen Umweltinteraktion (1)
- Gen notch (1)
- Genomische Bildgebung (1)
- Genotoxizität (1)
- Genregulation (1)
- Geoinformationssystem (1)
- Gephyrin (1)
- Gerinnungsfaktor XII (1)
- Germanium (1)
- Gerste (1)
- Geschmack (1)
- Geschmackssinn (1)
- Gesundheitswesen (1)
- Gewebe (1)
- Geweberegeneration (1)
- Gliom (1)
- Glioma (1)
- Globale Optimierung (1)
- Glucosetransportproteine (1)
- GlyRs (1)
- Glycine Receptors (1)
- Glycoengineering (1)
- Glycosyltransferase (1)
- Glyzin Rezeptoren (1)
- Glyzinrezeptor (1)
- Gold (1)
- Graft-versus-host disease (1)
- Graphene (1)
- Grassmann Manifold (1)
- Grassmann-Mannigfaltigkeit (1)
- Guanin Nukleotid Austauschfaktor (1)
- Guaninnucleotid-Austauschfaktoren (1)
- Göttingen (1)
- H.264 SVC (1)
- H.264/SVC (1)
- HBD2 (1)
- HBL (1)
- HBO (1)
- HD5 (1)
- HES (1)
- HIV-1; subtype C; proviral plasmid; viral replication; resistance assays; Vpu; CD317; CD4 (1)
- HLA (1)
- HMI (1)
- HPLC-MS/MS method (1)
- HRAS (1)
- HaCaT cells (1)
- Hadron-Hadron Scattering (1)
- Halbleiterlaser (1)
- Halbleiteroberfläche (1)
- Handelsgeographie (1)
- Hautkrebs (1)
- Helicobacterpylori (1)
- Helminths (1)
- Heparin (1)
- Hepatitis C infection (1)
- Hepatotoxizität (1)
- Herbivor-Parasitoid Interaktion (1)
- Herz (1)
- Herzentwicklung (1)
- Herzhypertrophie (1)
- Heterostrukturen (1)
- Hfq (1)
- HgTe (1)
- Hidden Markov Model (1)
- Higgs boson signal (1)
- Hilfe-System (1)
- Hochauflösendes Verfahren (1)
- Hochtemperatursupraleitung (1)
- Holliday junction reolvass (1)
- Hormone Receptor Signaling (1)
- Hospitalization (1)
- Housing (1)
- Human papillomavirus (1)
- Humorale Immunität (1)
- II type-2 receptor (1)
- IL-12 production (1)
- IL-17 (1)
- IL-4 (1)
- IL-4 Rezeptor alpha (1)
- IL-4 receptor alpha chain (1)
- IL28B (1)
- IMpACT (1)
- IVF-methods (1)
- Image Registration (1)
- Imatinib (1)
- Imd pathway (1)
- Immobilienmarkt (1)
- Immunisierung (1)
- Immunmodulation (1)
- Immunoadsorption (1)
- Immunoapheresis (1)
- Immunologie (1)
- Immunomodulation (1)
- Immunsystem (1)
- Impfstoff (1)
- Impfung (1)
- Impulslaserbeschichten (1)
- Incommensurate spin structure (1)
- Infectious disease (1)
- Inferior vena cava (1)
- Inflammation (1)
- Influenza (1)
- Informationsverarbeitung (1)
- Inkommensurable Zykloide (1)
- Innovation (1)
- Insulin (1)
- Insulinrezeptor (1)
- Insulinsignalweg (1)
- Integrase (1)
- Integrated Knowledgebase (1)
- Integrierte Datenbank (1)
- Inter-observer variability (1)
- Interactive Help System (1)
- Interaktion (1)
- Interferon <gamma-> (1)
- Interleukin 12 (1)
- Interleukin 6 (1)
- Internationaler Konflikt (1)
- Intrazelluläre Symbiose (1)
- Invasion (1)
- Inverse Probleme (1)
- JES (1)
- Japanese population (1)
- Japankärpfling (1)
- KATP channel (1)
- Kapazität (1)
- Kardial Hypertrophy (1)
- Katholische Kirche (1)
- Keldysh Formalismus (1)
- Keramischer Supraleiter (1)
- Kernspintomografie (1)
- Kerntransport (1)
- Kirche (1)
- Kleinkern (1)
- Klima (1)
- Klimamodellierung (1)
- Klimaschutz (1)
- Klimaschutzkonzept (1)
- Klimaschwankung (1)
- Knochendichte (1)
- Knochenstoffwechsel (1)
- Knockout-Maus (1)
- Knorpelzelle (1)
- Knowledge Management System (1)
- Knowledge-based System (1)
- Kognitive Kontrolle (1)
- Kohärente 2D Spektroskopie (1)
- Kohärente Optik (1)
- Kombinationstherapie (1)
- Konfliktlösung (1)
- Konforme Feldtheorie (1)
- Konjugate (1)
- Konjugierte-Gradienten-Methode (1)
- Koran (1)
- Korruption (1)
- Kraftfeld-Rechnung (1)
- Krebs <Medizin> (1)
- Kreditmarkt (1)
- Kristallwachstum (1)
- Kulturelle Identität <Motiv> (1)
- Kuprate (1)
- Kutikularwachs (1)
- Körper <Motiv> (1)
- L cells (1)
- LIFR (1)
- LMNA mutations (1)
- LPHN3 (1)
- LTD (1)
- LaAlO3 (1)
- LaVO3 (1)
- Ladungstransfer (1)
- Lamto Reserve (1)
- Land use (1)
- Landkreis (1)
- Landschaft (1)
- Large Hadron Collider (1)
- Leber (1)
- Lebertoxizität (1)
- Leishmania (1)
- Leukaemia-inhibitory factor (1)
- Levothyroxine (1)
- Lin9 (1)
- Lipidmembran (1)
- Ljapunov-Funktion (1)
- Ljapunov-Stabilitätstheorie (1)
- Localization (1)
- Lokalisation (1)
- Lung Cancer metastasis (1)
- Lung cancer (1)
- Luttinger liquide (1)
- Luttinger-Flüssigkeit (1)
- Lyapunov Funktion (1)
- Lyapunov functions (1)
- MAGIC-Teleskop (1)
- MAP3K4 (1)
- MBE (1)
- MC expectation (1)
- MC program (1)
- MCPH1 (1)
- MK801 (1)
- MR guidance (1)
- MRSA (1)
- MS (1)
- MYB (1)
- Macrophage (1)
- Magnetfeld (1)
- Magnetischer Sensor (1)
- Magnetoelectric effect (1)
- Magnetoelektrischer Effekt (1)
- Magnon (1)
- Majorana Zustände (1)
- Makrophagen (1)
- Management System (1)
- Management-Systeme (1)
- Manganate (1)
- Manganverbindungen (1)
- Marker (1)
- Martensit (1)
- Mass Isotopomers Distribution Analysis (1)
- Massen-Isotopomer Verteilungs-Analyse (1)
- Mast cells (1)
- Mastzelle (1)
- Mathematikunterricht (1)
- Mausmodell (1)
- Maximum Entropy Algorithmus (1)
- Maximum Entropy algorithm (1)
- Maße für Quantenverschränkung (1)
- Medienanalyse (1)
- Medienkommunikation (1)
- Mehrpfadübertragung (1)
- Mehrschichtnetze (1)
- Mehrschichtsystem (1)
- Mehrskalenmodell (1)
- Melanophor (1)
- Melatonin (1)
- Memory (1)
- Meningioma (1)
- Merocyanin (1)
- Merocyanine (1)
- Mesh Augmentation (1)
- Messenger-RNS (1)
- Metabolic Flux Analysis (1)
- Metabolic pathways (1)
- Metabolic profiles (1)
- Metabolische Flux-Analyse (1)
- Metall-Isolator-Phasenumwandlung (1)
- Metallorganische Verbindungen (1)
- Metastasierung (1)
- Methodenentwicklung (1)
- Methylierung (1)
- Methylphenidat (1)
- Mexico (1)
- Mexiko (1)
- Mice (1)
- Michael addition (1)
- Michael-Addition (1)
- Micro-Hall Magnetometry (1)
- Micro-SQUID (1)
- Microarray (1)
- Microcirculation (1)
- Micromonospora (1)
- Mikro-SQUID (1)
- Mikrohallmagnetometrie (1)
- Milnesium tardigradum (1)
- Minischwein (1)
- Mitose (1)
- Mittelmeer (1)
- Mittelmeerraum (1)
- Miz1 (1)
- Mobile technology (1)
- Mobiler Roboter (1)
- Molecular probes (1)
- Molekularelektronik (1)
- Molekularstrahlepitaxie (1)
- Molybdän (1)
- Molybdäncarbonyle (1)
- Monetary Policy (1)
- Monetary Union (1)
- Monoklonaler Antikoerper (1)
- Monte Carlo methods (1)
- Monte Carlo simulation (1)
- Motoneuron (1)
- Motor cortex (1)
- Motor plasticity (1)
- Mott-Schottky Analyse (1)
- Multi-Layer (1)
- Multiferroikum (1)
- Multipath Transmission (1)
- Multiple sclerosis (1)
- Multiwellenlängen (1)
- Muskelkraft (1)
- Mutagenität (1)
- Mycobacterium caprae (1)
- Mycobacterium tuberculosis complex (1)
- Mycoplasma (1)
- Myelin (1)
- Myeloblast (1)
- Myeloide Suppressorzellen (1)
- Mykotoxin (1)
- Myon (1)
- N-Myc down regulated gene 1 (1)
- N-RAS (1)
- N170 (1)
- NA/I symporter (1)
- NADPH oxidase (1)
- NADPH oxidases (NOX) (1)
- NCAM1 (1)
- NDVI (1)
- NF-kappa-B (1)
- NF-κB (1)
- NFATc (1)
- NFATc1/αA (1)
- NI(111) (1)
- NIH-3T3 (1)
- NMDA-Antagonist (1)
- NMDA-Rezeptor (1)
- NMDAR (1)
- NMO-IGG (1)
- NMR-Bildgebung (1)
- NMR-Tomographie (1)
- NP-hardness (1)
- NRPS (1)
- Nahfeldoptik (1)
- Nail unit (1)
- Nanodraht (1)
- Nanoelektromechanik (1)
- Nanoelektromechanische Systeme (1)
- Nanofaser (1)
- Nanooptic (1)
- Naphthochinonen (1)
- Naphthoquinones (1)
- Nephrotoxizität (1)
- Nervendegeneration (1)
- Nervennetz (1)
- Nervenzelle (1)
- Network Analysis (1)
- Networks (1)
- Netzwerk (1)
- Netzwerkalgorithmen (1)
- Neurobiologie (1)
- Neurodegeneration (1)
- Neuropathie (1)
- Neuropsychologie (1)
- Neurotransmitter Receptors (1)
- Neurotransmitter Rezeptoren (1)
- Neurotransmitter-Rezeptor (1)
- Neuseeland (1)
- New mexico (1)
- Newton Methods (1)
- Newton method (1)
- Newtonverfahren (1)
- Next generation sequencing (1)
- Nicht-Transparente Medien (1)
- Nicht-kleinzelliges Bronchialkarzinom (1)
- Nichtkonvexe Optimierung (1)
- Nichtlineare Kontrolltheorie (1)
- Nichtlineares System (1)
- Nichtlineares dynamisches System (1)
- Niederschlag (1)
- Nigeria (1)
- Niveaustufen des Beweises (1)
- Non-Small Cell Lung Cancer (1)
- Non-transparency (1)
- Nonlinear Dynamics (1)
- Notfall (1)
- Nothotaxa (1)
- Nukleäre Hormonrezeptoren (1)
- OIS (1)
- OPUS (1)
- OSMR (1)
- Oberflächenfunktionalisierung (1)
- Oberflächenphysik (1)
- Oberflächenplasmonresonanz (1)
- Oberflächenproteine der Sexualstadien (1)
- Odour Intensity (1)
- Olfaction (1)
- Olfactory (1)
- Oligofructoside (1)
- Oncostatin M (1)
- Onkogen (1)
- Optimierung (1)
- Optimization on Lie Groups (1)
- Organische Solarzelle (1)
- Organometall-Komplexe (1)
- Ovarialkarzinom (1)
- Ovarian Cancer (1)
- Oxid (1)
- Oxidativer Stress (1)
- Oxide (1)
- O–I 1 fluorescence rise (1)
- P15(INK4B) (1)
- P21 (1)
- P300-Speller (1)
- P67(PHOX) (1)
- PALM (1)
- PAR (1)
- PARM (1)
- PBPK/PBTK model (1)
- PDF set (1)
- PDI (1)
- PG neurons (1)
- PIK3CA mutations (1)
- PLD (1)
- POZ domain (1)
- PPAR-gamme (1)
- PRMT5 (1)
- PRRT (1)
- PTPN22 (1)
- Pain (1)
- Papier-Solarzelle (1)
- Parasit (1)
- Parathormon (1)
- Parkinsons disease (1)
- Parkinson’s disease (1)
- Path Computation Element (1)
- Patulin (1)
- Pediatric (1)
- Peptide receptor radionuclide therapy (1)
- Perception (1)
- Perforine (1)
- Performance Modeling (1)
- Persistenz (1)
- Person Perception (1)
- Perylenbisimid (1)
- Perylene bisimide (1)
- Pfadberechnungselement (1)
- Phage Display (1)
- Phase II trial (1)
- Phasenumwandlung (1)
- Phosphoproteomic analysis (1)
- Photochemie (1)
- Photochemistry (1)
- Photochromie (1)
- Photorezeption (1)
- Photostrom (1)
- Phylogenie (1)
- Physikalische Eigenschaft (1)
- Physikalische Zeit (1)
- Physiologie (1)
- Physiology (1)
- Planung (1)
- Plasmodium falciparum (1)
- Platelet activating Factor (1)
- Platelets (1)
- Plättchennetzwerk (1)
- Plättchenphosphoproteom (1)
- Pnictide (1)
- Polarisationspulsformung (1)
- Polarisiertes Licht (1)
- Polychromophores System (1)
- Polymere (1)
- Polyomaviren (1)
- Polyomavirus JC (1)
- Pontryagin Maximum Principle (1)
- Pontryagin Maximum Prinzip (1)
- Populorum Progressio (1)
- Pore formation (1)
- Pore-formation (1)
- Porifera (1)
- Postcolonial literature (1)
- Postkoloniale Literatur (1)
- Pragmatik (1)
- Predictors (1)
- Prednisolon (1)
- Preemptive-strike (1)
- Prefrontal cortex (1)
- Prevalence (1)
- Probiotic (1)
- Probiotikum (1)
- Proof (1)
- Prostatakrebs (1)
- Protein Disulfid Isomerase (1)
- Protein p53 (1)
- Proteinfaltung (1)
- Proteinkinasen (1)
- Proteinsynthese (1)
- Proteomanalyse (1)
- Proteome (1)
- Proving Level (1)
- Prozessierung (1)
- Prädiktor (1)
- Präfrontaler Kortex (1)
- Präparative organische Chemie (1)
- Prävalenz (1)
- Psychiatrie (1)
- Psychologische Diagnostik (1)
- Psychologische Sicherheitsforschung (1)
- Psychology (1)
- Ptpn22 (1)
- QCD (1)
- QCD background (1)
- QDTI (1)
- QMC (1)
- QUAC (1)
- QoE (1)
- Quality-of-Experience (1)
- Quanten Spin Hall Effekt (1)
- Quanten-Hall-Effekt (1)
- Quantenchemie (1)
- Quantenfeldtheorie (1)
- Quantenkontrolle (1)
- Quantenmechanisches System (1)
- Quantenspinsystem (1)
- Quantum dynamics (1)
- Quantum spin Hall (1)
- Quecksilbertellurid (1)
- Quran (1)
- R factor = 0.018 (1)
- R factor = 0.025 (1)
- R factor = 0.027 (1)
- R-715 (1)
- RAD51C (1)
- REST (1)
- RNA (1)
- RNA denaturation (1)
- RNA sequencing (1)
- RNA structure (1)
- RNA synthesis (1)
- RNA-polymerase-II (1)
- Radioastronomie (1)
- Radiotherapy (1)
- Rare earth manganites (1)
- Rashba effect (1)
- Rashba-Effekt (1)
- Rat (1)
- Ratte (1)
- Rauschgift (1)
- Real-Time Operating Systems (1)
- Receptor Anchoring (1)
- Receptor Preference (1)
- Recombinant defensins (1)
- Regeneration (1)
- Registrierung <Bildverarbeitung> (1)
- Regulation of protease activity (1)
- Regulatorischer T-Lymphozyt (1)
- Regulatory T-cell (1)
- Rekombinante DNS (1)
- Rekombination (1)
- Rekonstruktion (1)
- Remote sensing (1)
- Renal cell carcinoma (1)
- Repression <Genetik> (1)
- Resilience (1)
- Resonanzstreuung (1)
- Resource Management (1)
- Respiration correlated imaging (1)
- Ressourcenallokation (1)
- Ressourcenmanagement (1)
- Resveratrol (1)
- Rezeptor Verankerung (1)
- Rho (1)
- Rho-GTPase Cdc42 (1)
- Ribosomale RNA (1)
- Riemannian optimization (1)
- Riemannsche Geometrie (1)
- Riemannsche Optimierung (1)
- Ring closing metathesis (1)
- Ringschlussmetathese (1)
- Risikoindex (1)
- Ruthenate (1)
- Röntgen-Photoelektronenspektroskopie (1)
- Röntgenastronomie (1)
- Rüsselkäfer (1)
- SAS <Programm> (1)
- SCF (1)
- SER/THR kinase (1)
- SGLT1 (1)
- SIRP-alpha (1)
- SKP1 (1)
- SLAC/SLAH (1)
- SLX4 (1)
- SM Background (1)
- SM proteins (1)
- SOD1 mutations (1)
- SST (1)
- ST1797 (1)
- ST88 (1)
- STAIR (1)
- SUSY breaking scale (1)
- SVR (1)
- SWI/SNF (1)
- SacB (1)
- Sahel (1)
- Salmonella (1)
- Salmonella enterica (1)
- Salmonella typhimurium (1)
- Salmonella-containing vacuole (1)
- Sandwich-Verbindungen (1)
- Savanna (1)
- Savannas (1)
- Schilddrüse (1)
- Schilddrüsenhormontherapie (1)
- Schlaganfall (1)
- Schwann cells (1)
- Scleroderma (1)
- Secondary traumatic brain damage (1)
- Secretion (1)
- Sedum rupestre L. subsp. erectum ‘t Hart (1)
- Selbstorganisation (1)
- Selbstverteidigung (1)
- Selbstverteidigung <Völkerrecht> (1)
- Self-Trapping (1)
- Self-defense (1)
- Seltene Erden (1)
- Seltenerdverbindungen (1)
- Semiconductor Lasers (1)
- Seneszenz (1)
- Sensory (1)
- Sepsis (1)
- Sequenz (1)
- Serengeti (1)
- Serotonintransporter (1)
- Sexuelle Entwicklung (1)
- Short dsRNA oligonucleotides (1)
- Sialic acids (1)
- Sialinsäuren (1)
- Signalkette (1)
- Signaltransduktion (1)
- Silicium (1)
- Similarity (1)
- Simkania Negevensis (1)
- Single-Molecule Transistor (1)
- Small RNA (1)
- Small nuclear RNP (1)
- Smartphone (1)
- Social Influence (1)
- Software (1)
- Somatostatin receptor (1)
- South Africa (1)
- Sozialer Einfluss (1)
- Sozialethik (1)
- Soziallehre (1)
- Sozialpsychologie (1)
- Species distribution modeling (1)
- Spectrofluorimetry (1)
- Speicher <Informatik> (1)
- Spezialisierung (1)
- Spin-Bahn-Wechselwirkung (1)
- Spinal metastasis (1)
- Spir (1)
- Spitzwegerich (1)
- Stabilität (1)
- Stadtplanung (1)
- Stammzelle (1)
- Standardmodell (1)
- Standortpolitik (1)
- Stat5 (1)
- State-Space Models (1)
- Stereotactic (1)
- Stereotactic body radiotherapy (1)
- Stereotype (1)
- Stereotypes (1)
- Steuerbarkeit (1)
- Stim (1)
- Stochastic Algorithms (1)
- Stochastische Optimierung (1)
- Stoffwechsel (1)
- Strassentunnel (1)
- Streptococcus pneumoniae (1)
- Stressreaktion (1)
- Stringtheorie (1)
- Strong correlations (1)
- Struktur (1)
- Struktur-basiertes Wirkstoff Design (1)
- Subarachnoid (1)
- Subarachnoid hemorrhage (1)
- Suc1 (1)
- Sumo (1)
- Sumoylierung (1)
- Superconductivity (1)
- Suppressorzelle (1)
- Surface plasmons (1)
- Synapse (1)
- Synchronisierung (1)
- Synchronization (1)
- Synthesis (1)
- Systems Biology (1)
- T = 173 K (1)
- T = 199 K (1)
- T cell development (1)
- T cell homing (1)
- T cell receptor (1)
- T helper cell (1)
- T(H)17 cells (1)
- T-Lymphozyten-Rezeptor (1)
- T-PA (1)
- T-Zellhoming (1)
- T-antigen (1)
- T-cell reactivity (1)
- T1 (1)
- T3s (1)
- TGF-BETA (1)
- TGN1412 (1)
- TIC disorder (1)
- TMS (1)
- TNF-R1 (1)
- TNF-R2 (1)
- TNF-alpha (1)
- TNF-α (1)
- TO-target interval (1)
- TOJ (1)
- TRPC6 (1)
- Tabu-Search (1)
- Tanzania (1)
- Tapeworm (1)
- Taste (1)
- Temperatur (1)
- Terahertz (1)
- Terahertz spectroscopy (1)
- Terrylenbisimid (1)
- Terrylenderivate (1)
- Terrylene bisimide (1)
- Text Mining (1)
- Theoretische Chemie (1)
- Therapie (1)
- Thiostrepton (1)
- Thrombectomy (1)
- Thrombozytenaggregation (1)
- Tiergesellschaft (1)
- Time Series Analysis (1)
- Time hole (1)
- Topolgical Phase (1)
- Topological Insulator (1)
- Topologische Isolatoren (1)
- Topologischer Isolator (1)
- Topology (1)
- Total nodal irradiation (1)
- Toulmin Modell (1)
- Toxikologie (1)
- Translokation (1)
- Transmissionsblockierende Impfstoffe (1)
- Transplantat-Wirt-Reaktion (1)
- Trend test (1)
- Triclosan (1)
- Trigger System (1)
- Tuberkulose (1)
- Tumor thrombus (1)
- Tumor-Nekrose-Faktor <alpha> (1)
- Tunnel emergencies (1)
- Tunneling spectroscopy (1)
- Typ 1 (1)
- Type 1 diabetes (1)
- USA (1)
- UV-VIS-Spektroskopie (1)
- Ultrafast spectroscopy (1)
- Ultrakurzzeit Spektroskopie (1)
- Ultrakurzzeitspektroskopie (1)
- Ultraschall (1)
- Ultraschalldiagnostik (1)
- Umweltgefährdung (1)
- United States (1)
- Univted-States (1)
- Unternehmenskooperation (1)
- Unwetter (1)
- Uzbekistan (1)
- VAL66MET polymorphism (1)
- Vaccine (1)
- Vaccinia Virus Replikation (1)
- Vaccinia virus (1)
- Variationsrechnung (1)
- Variovorax paradoxus (1)
- Vektorboson (1)
- Verarbeitungsflüssigkeit (1)
- Verbrauch (1)
- Verbreitungsgrenzen (1)
- Verfahren der konjugierten Gradienten (1)
- Verhalten (1)
- Verkehrspsychologie (1)
- Verkehrsunfall (1)
- Verschränkung (1)
- Verteiltes System (1)
- Vertretbarkeit (1)
- Video Streaming (1)
- Videoübertragung (1)
- Virtuelle Realitaet (1)
- Visualisierung (1)
- Visualization (1)
- Vorurteil (1)
- WISP1/CCN4 (1)
- WNT signaling pathway (1)
- WW (1)
- WZ production (1)
- Wachstum (1)
- Wahrnehmung (1)
- Warnung (1)
- Warteschlangennetz (1)
- Weisheit (1)
- West-Africa (1)
- Wetter (1)
- Wireless Sensor/Actuator Systems (1)
- Wirkstofffreisetzung (1)
- Wirkungsquerschnitt (1)
- Wisdom and Justifiability (1)
- Wissensbanksystem (1)
- Wissensmanagement (1)
- Wohnbau (1)
- Währungsunion (1)
- Wärmekraftwerk (1)
- Würmer (1)
- XA (1)
- Xmrk (1)
- Yersinia (1)
- Yersinia pestis (1)
- Yolk protein (1)
- Z Boson (1)
- Z boson (1)
- Zebrabärbling (1)
- Zeitdifferenzierung (1)
- Zeitoptimale Regelung (1)
- Zelladhäsion (1)
- Zelltransport (1)
- Zellzyklus (1)
- Zusammenstoss (1)
- Zustandsraummodelle (1)
- a-posteriori error estimates (1)
- abdominal (1)
- abdominal wall hernia (1)
- abdominal wall surgery (1)
- abiotic formation (1)
- abscisic acid (1)
- absolute configuration (1)
- accelerated atherosclerosis (1)
- acetivorans C2A (1)
- acoustic communication (1)
- acoustic startle (1)
- actin cortex (1)
- actin cytoskeleton (1)
- actinomycetes (1)
- action planning (1)
- action-effects (1)
- activated-receptor gamma (1)
- activation (1)
- activation mechanism (1)
- acute ischemic stroke (1)
- acute myeloid leukemia (1)
- acute renal failure (1)
- adaptation (1)
- adaption (1)
- adaptive refinement (1)
- addiction (1)
- addicts (1)
- additional jet (1)
- adenovirus (1)
- adhesion (1)
- adipose tissue (1)
- adjuvant hormonal treatment (1)
- adolescence (1)
- adsorption (1)
- adult bee (1)
- adult drosophila (1)
- age (1)
- age-related osteoporosis (1)
- agency (1)
- aging (1)
- aging brain (1)
- agnoists (1)
- agonist (1)
- airway (1)
- akt (1)
- alagille syndrome (1)
- alias pilot trial (1)
- alignment (1)
- alkaline-phosphatase (1)
- alleles (1)
- alpha galactosidase (1)
- alpha-synuclein (1)
- alternative Konfliktlösung (1)
- alveoar echinococcosis (1)
- alveolar epithelium in vitro model, claudin-1, claudin-3, claudin-4, claudin-5 (1)
- aminoacyl-transfer-RNA (1)
- amplitude (1)
- amygdala (1)
- amyloid beta (1)
- amyotrophic lateral sclerosis (1)
- anal atresia (1)
- anaplastic large cell lymphoma (1)
- anemia (1)
- anesthetics (1)
- aneuploidy (1)
- aneurysm repair (1)
- angiography (1)
- angioplasty (1)
- angiotensin II (1)
- animal communication (1)
- animal ecology (1)
- animal model (1)
- animal models (1)
- animal-model (1)
- anion channel (1)
- annihilation (1)
- anoikis (1)
- anomaly mediation (1)
- anorectal malformation (1)
- ant communities (1)
- anterior insula (1)
- anthocyanins (1)
- anthropogenic noise (1)
- anti inflammation (1)
- anti-aquaporin-4 antibody (1)
- anti-proliferative effects (1)
- anti-protease (1)
- anti-tumor agents (1)
- antibacterial activity (1)
- antibiotic resistance (1)
- antibodies (1)
- antibody (1)
- anticipation (1)
- anticipatory mechanisms (1)
- antidepressant (1)
- antigen (1)
- antigen expression (1)
- antigen presentation (1)
- antigen-B (1)
- antimicrobial (1)
- antimicrobial activity (1)
- antioxidant (1)
- antisense RNA (1)
- antisense RNAs (1)
- ants (1)
- anxiety like (1)
- aortic-valve (1)
- apolipoprotein E (1)
- appliances (1)
- approximation algorithm (1)
- aquaporin 3 protein (1)
- aquaporin-4 autoantibodies (1)
- aquired resistance (1)
- arabidopsi (1)
- arabidopsis (1)
- arabidopsis thaliana (1)
- arabidpsis thaliana (1)
- aral sea basin (1)
- archwires (1)
- area (1)
- arf (1)
- arginine methylation (1)
- arm (1)
- artery occlusion (1)
- arthritis (1)
- aryl hydrocarbon receptor (AhR) (1)
- asbestos (1)
- asparaginase (1)
- asparagine (1)
- asparagine synthetase (1)
- aspergillosis (1)
- assessment (1)
- assisitvetechnology (1)
- assisted reproductive techniques (1)
- associative learning (1)
- astrocyte (1)
- astrocytic tumor (1)
- astroglia (1)
- astrogliosis (1)
- atherothrombosis (1)
- atomic-force microscopy (1)
- atrial fibrillation (1)
- atrial natriuretic peptide (1)
- attention (1)
- auditory discrimination (1)
- auditory masking (1)
- aureus infections (1)
- auto-calibration (1)
- autologous chondrocyte implantation (1)
- autophagy (1)
- avaliação de risco (1)
- axial skeletal defects (1)
- axonal degeneration (1)
- axonopathic changes (1)
- bZIP (1)
- bacillus calmette guerin (1)
- back pain (1)
- background (1)
- background cross section (1)
- background expectation (1)
- bacterial meningitis (1)
- bacterial persistence (1)
- bacterial signal molecule (1)
- bactericidal activity (1)
- balance (1)
- balloon distension (1)
- barley (1)
- baroreflex mechanism (1)
- basal cell (1)
- basin hopping (1)
- beaver-dam eye (1)
- bee larva (1)
- behavior (1)
- behavioral addiction (1)
- benzo[a]pyrene (1)
- beta actin (1)
- bi-steerable robot (1)
- biflavanoids (1)
- big brown bats (1)
- bilayers (1)
- binary tanglegram (1)
- biocompatibility (1)
- bioconjugate (1)
- bioengineering (1)
- biogenic amines (1)
- biolabelling (1)
- biomarker (1)
- bioorganometallic chemistry (1)
- bipolar disorder (1)
- birth defects (1)
- bitter taste (1)
- blastocysts (1)
- bleomicina (1)
- bleomycin (1)
- blood biomarker (1)
- blood brain barrier (1)
- blood sampling (1)
- blood-brain-barrier (1)
- blood-stream forms (1)
- blowfly calliphora-vomitoria (1)
- body <motif> (1)
- bone disease (1)
- bone marrow (1)
- bone metabolism (1)
- bone mineral density (1)
- bone-mineral density (1)
- brain barrier (1)
- brain cancer (1)
- brain computer interface (1)
- brain development (1)
- brain edema (1)
- brain tumours (1)
- brain-computer-interface (1)
- brain–computerinterface (1)
- brucei (1)
- burned savanna (1)
- cEND (1)
- caenorhabditis elegans (1)
- caffeine-induced anxiety (1)
- call (1)
- calorimeter response (1)
- camp signaling pathway (1)
- cancer patients (1)
- cancer-cells (1)
- candidate gene (1)
- canine cancer therapy (1)
- canopy fogging (1)
- capacity (1)
- capsid protein (1)
- carcinogenicity (1)
- cardiac aging (1)
- cardiac arrhythmia (1)
- cardiac fibrosis (1)
- cardiac hyperthrophy (1)
- cardiac protection (1)
- cardiovascular arousal (1)
- cardiovascular disease (1)
- cardiovascular events (1)
- cardiovascular magnetic resonance (1)
- cardiovascular risk factors (1)
- care (1)
- carotid artery (1)
- case-control study (1)
- cased-control studies (1)
- catalytic (1)
- catenin (1)
- catheter tip (1)
- causal belief (1)
- causality (1)
- caveolin-1 (1)
- cavity (1)
- cavity polaritons (1)
- cell adhesion (1)
- cell carcinoma (1)
- cell death (1)
- cell surface (1)
- cell-cycle arrest (1)
- cell-cycle regulation (1)
- cell-line (1)
- cell-penetrating peptides (1)
- cellular-trafficking (1)
- centomeres (1)
- central corneal thickness (1)
- central nervous system (1)
- centromere (1)
- cephalic-vagal influences (1)
- cerebrospina (1)
- cerebrospinal fluid (1)
- cerebrospinal fluid culture (1)
- cerebrospinal-fluid (1)
- chain (1)
- chalinolobus-tuberculatus (1)
- charge misidentification (1)
- chargino --> neutralino pi (1)
- chargino decay (1)
- chargino lifetime (1)
- chargino mass (1)
- charingo mass (1)
- chemistry (1)
- chemosensory protein (1)
- chemosensory system (1)
- childhood cancer (1)
- children born (1)
- chiral boson (1)
- chlorella (1)
- chlorophyll fluorescence (1)
- cholinergic neurons (1)
- choroid-plexus (1)
- chromatin (1)
- chronic kidney disease (1)
- church (1)
- cigarette smoking (1)
- ciliary neurotrophic factor (CNTF) (1)
- ciliolenticular block glaucoma (1)
- circadian photoreception (1)
- circular dichroism (1)
- cis-element modules (1)
- clara cell (1)
- classifiaction (1)
- climate action plan (1)
- climate modelling (1)
- clinical diagnosis (1)
- clinical practice (1)
- clinical trial (1)
- clinical trials (1)
- clock (1)
- cluster (1)
- co-infection (1)
- coa reductase inhibitors (1)
- cochlear implant (1)
- coding strategy (1)
- coexpression (1)
- cognitive control (1)
- coloteral cancer (1)
- commercial preparations (1)
- communication (1)
- community sample (1)
- compartmentalization (1)
- complement factor-H (1)
- complex stability (1)
- computational model (1)
- conditional promoter replacement (1)
- confinement (1)
- conformal field theory (1)
- congenital malformations (1)
- conjugate (1)
- connector (1)
- conservation (1)
- consolidation (1)
- consortium (1)
- contact force (1)
- containing GABA(A) receptors (1)
- containing neurons (1)
- contaminants (1)
- context (1)
- contingent negative-variation (1)
- continuous performance-test (1)
- contralateral breast cancer (1)
- contrast (1)
- contrast-enhanced MRI (1)
- contrast-enhanced ultrasound. (1)
- conversion (1)
- cooperative-oncology-group (1)
- coordination (1)
- copy number variants (1)
- core depression (1)
- coronary artery bypass (1)
- coronary disease (1)
- coronary-heart-disease (1)
- coronene (1)
- cortex (1)
- corticotropin-releasing hormone (1)
- coupling strength (1)
- courtship displays (1)
- crantiectomy (1)
- criteria (1)
- critically ill (1)
- cropland abandonment (1)
- cross section measurement (1)
- cross section time (1)
- cross-sectional studies (1)
- crossing minimization (1)
- crosstalk (1)
- crystal structure (1)
- ctdsp2 (1)
- cubic-monoclinic martensites (1)
- cultivation (1)
- cultural identity (1)
- cultured hippocampal-neurons (1)
- cyanelle (1)
- cymantrene (1)
- cystic fibrosis (1)
- cytogenetic effects (1)
- cytokine (1)
- cytokines (1)
- cytotoxicity (1)
- dSTORM (1)
- damage (1)
- damage cool aid (1)
- dart-poison frog (1)
- data-to-parameter ratio = 14.0. (1)
- data-to-parameter ratio = 14.6 (1)
- data-to-parameter ratio = 20.8 (1)
- data-to-parameter ratio = 22.3 (1)
- database (1)
- dead region (1)
- death (1)
- decay (1)
- decompressive surgery (1)
- deep sequencing (1)
- deep-vein thrombosis (1)
- defective Mitosis (1)
- deficit hyperactivity disorder (1)
- deficit-hyperactivity disorder (1)
- dehydrogenases (1)
- delays progression (1)
- demyelination (1)
- dendrimer (1)
- dental casting alloys (1)
- dentate gyrus (1)
- dependent magnetosensitvity (1)
- depth (1)
- derivates (1)
- derivation (1)
- dermatite flagelada (1)
- dermatitis (1)
- descriptive epidemiology (1)
- deseases (1)
- detector track (1)
- detoxified lipooligosaccharide (1)
- developmental dyslexia (1)
- diabetes (1)
- diagnostic (1)
- diazepinomicin (1)
- differential diagnosis (1)
- diffractive dissociation (1)
- diketopiperazines (1)
- dilepton channel (1)
- dilepton invariant mass (1)
- dilepton invariant mass, (1)
- dilepton mass (1)
- dimer (1)
- dimer method (1)
- dimerer Naphthylisochinolin-Alkaloide (1)
- diphoton invariant mass (1)
- direct pair production (1)
- discourse analysis (1)
- discrete (1)
- disease-modifying therapies (1)
- disorder (1)
- disrupting chemicals (1)
- disruptor endócrino (1)
- dissipative Umgebung (1)
- dissipative environments (1)
- dissociation process, (1)
- district (1)
- disturbance (1)
- disulfide bonds (1)
- dogs (1)
- dosage (1)
- double knockout mice (1)
- double-blind (1)
- doublecortine-like (1)
- drosophila embryo (1)
- drosophila melanogaster (1)
- drosophila mushroom body (1)
- drug addiction (1)
- drug delivery (1)
- drug development (1)
- drug release (1)
- drug research and development (1)
- drug therapies (1)
- drug therapy (1)
- duchenne muscular dystrophy (1)
- dwelling bat (1)
- dyes (1)
- dynamics (1)
- dysfunction (1)
- dyspeptic symptoms (1)
- early diagnosis (1)
- eating disorders (1)
- ecosystem (1)
- electromagnetic calorimeter (1)
- electromigration (1)
- electron energy deposition (1)
- electron probe microanalysis (1)
- electronic states (1)
- electroweak background (1)
- elementary mode analysis (1)
- elements (1)
- elongation (1)
- embolic stroke (1)
- embryonale Maus (1)
- embryonic stem cells (1)
- emission-computed-tomography (1)
- emotional experience (1)
- enatnglement measure (1)
- encephalitis (1)
- endocrine disruptor (1)
- endogenous psychoses (1)
- endogenous shifts of attention (1)
- endothelial cell interactions (1)
- endothelial growth-factor (1)
- endotheliopathy (1)
- energy (1)
- energy conservation (1)
- energy dissipation (1)
- energy expenditure (1)
- energy landscapes (1)
- energy scale (1)
- energy scale uncertainty (1)
- engineered measles-virus (1)
- engineering (1)
- enoxaparin (1)
- entanglement (1)
- environmental phenols (1)
- environmental regulation (1)
- enzyme (1)
- enzyme replacement therapy (1)
- epicutaneous (1)
- epidemic (1)
- epidemiology (1)
- epigastric hernia (1)
- epimutation (1)
- epithelial-mesenchymal transition (1)
- epithelium (1)
- eptesicus-fuscus (1)
- erythropoietin (1)
- escherichia coli K-12 (1)
- estrogen receptor (1)
- estrogens (1)
- eucera berlandi (1)
- eukaryotes (1)
- evacuation behavior (1)
- event rates (1)
- event selcetion cut (1)
- event shape observable (1)
- event shape variable (1)
- event-related potential (1)
- event-related potentials (1)
- event-relatedpotentials (1)
- exchange factor collybistin (1)
- excited state (1)
- exciton (1)
- excitons (1)
- exercise (1)
- experimental (1)
- experimental results (1)
- experimental stroke (1)
- experimental systematic uncertainty (1)
- exposição humana (1)
- expressed sequence tag (1)
- expression pattern (1)
- expression signature (1)
- extensiv transverse myelitis (1)
- extracellular matrix (1)
- extractives (1)
- extrapolation factor (1)
- extreme value theory (1)
- extreme weather event (1)
- eyes (1)
- fMRI (1)
- face perception (1)
- facial expression (1)
- factor 1-alpha (1)
- factor EEF1A2 (1)
- factor H (1)
- factor prevents (1)
- failure (1)
- families (1)
- family (1)
- fear-potentiated startle (1)
- features (1)
- feeding behavior (1)
- fehlerhafte Mitose (1)
- femoral hernia (1)
- femtosecond spectroscopy (1)
- fetal liver (1)
- fibrosis progression (1)
- fiducial cross section (1)
- field gel-electrophoreresis (1)
- fine structure processing (1)
- fission yeast (1)
- fixed-parameter tractability (1)
- flagellar (1)
- flagellate dermatitis (1)
- flagellum (1)
- flavenoids (1)
- flavour changing (1)
- fluid (1)
- fluid networks (1)
- fluorescence detection (1)
- fluorescent protein (1)
- fluoride (1)
- forced-choice (1)
- forest (1)
- forest disturbance (1)
- forest soils (1)
- formaldehyde (1)
- fosfomycin (1)
- fracture (1)
- fragmin (1)
- free radical scavenger (1)
- free-choice (1)
- frontotemporal dementia (1)
- frontotemporal lobar degeneration (1)
- fruit fly (1)
- fumonisin B1 (1)
- functional D-norm (1)
- functional Renormalization Group (1)
- functional absorption cross section of PS II (1)
- functional imaging (1)
- functional neuroanatomy (1)
- functional neuroimaging (1)
- functional renormalization group (1)
- fungos shiitake (1)
- gadofluorine (1)
- gadolinium-DTPA (1)
- gait (1)
- galvanic corrosion (1)
- gametocyte (1)
- gamma (1)
- gamma-aminobutyric-acid (1)
- gamma-interferon (1)
- gene conversion (1)
- gene delivery (1)
- gene environment interaction (1)
- gene family targeting (1)
- geneexpression (1)
- general stress response (1)
- generalized anxiety disorder (1)
- genetic interaction (1)
- genetic loci (1)
- genetic modifiers (1)
- genetic renal disease (1)
- genetics of disease (1)
- genome-wide scan (1)
- genotoxicity (1)
- genotyping (1)
- geometrically linear elasticity (1)
- geometrisch lineare Elastizitätstheorie (1)
- gephyrin (1)
- glaucoma surgery (1)
- glia (1)
- glioblastoma cell-lines (1)
- glioblastoma multiforme (1)
- glomerulonephritis (1)
- glossy11 (1)
- glucagon-like peptide-1 (GLP-1) (1)
- glucokinase (1)
- glut1 (1)
- glv-1h68 (1)
- glycine (1)
- glycoprotein Ib (1)
- go/no-go task (1)
- goldmann applanation tonometer (1)
- good agreement (1)
- gp130 (1)
- gradient (1)
- grading system (1)
- graft surgery (1)
- granulosus (1)
- granzyme B (1)
- gravidez (1)
- growing escherichia coli (1)
- growth factor (1)
- growth rate control (1)
- growth regulator (1)
- growth-factor receptor (1)
- guanine nucleotide exchange factor (1)
- guttiferae (1)
- hadron hadron scattering (1)
- hadronic final state (1)
- hadronisation model (1)
- haemolymph (1)
- hardwood dust (1)
- harmonia axyridis (1)
- harmonine (1)
- head involution (1)
- health-related quality of life (1)
- hearing loss (1)
- heart (1)
- heart development (1)
- heart-rate-variability (1)
- heartbeat perception (1)
- heat shock protein Hsc-70 (1)
- heavy flavour (1)
- heavy flavour quark (1)
- heavy neutrino (1)
- helicase BRIP1 (1)
- helicity fraction (1)
- helper T cells (1)
- hemagglutinin (1)
- hemicraniectomy (1)
- hemodialysis (1)
- hemophilus influenzae (1)
- hepatotoxicity (1)
- herbivore-parasitoid interaction (1)
- hereditary motor and sensory neuropathy (1)
- heritability (1)
- hernia defect (1)
- hernia repair material (1)
- heterostructures (1)
- hexanucleotide repeat (1)
- hierarchy (1)
- high jet multiplicity (1)
- high-dose atorvastatin (1)
- high-resolution analysis (1)
- high-temperature NMR (1)
- higher pitch (1)
- highland malaria (1)
- highlands (1)
- hindbrain boundary (1)
- hippocampal neurogenesis (1)
- histidine kinase (1)
- homeostasis (1)
- homology modeling (1)
- honey bee (1)
- honey bees (1)
- honeybees (1)
- hormone flow modelling (1)
- hormone-related protein (1)
- host cell death (1)
- host genetics (1)
- human (1)
- human cancer diseases (1)
- human diseases (1)
- human endothelial cells (1)
- human exposure (1)
- human factor H (1)
- human genetics (1)
- human jagged1 (1)
- human keratinocytes (1)
- human monocytes (1)
- human parthenogenetic neural stem cells (1)
- human parthenogenetic stem cells (1)
- human pathogens (1)
- humaner Faktor H (1)
- humans (1)
- hybrid (1)
- hydatid disease (1)
- hydrodynamics (1)
- hymenoptera (1)
- hyper-IL-6 (1)
- hyperekplexia (1)
- hypertension (1)
- idiotype (1)
- imaging genetics (1)
- immortalization (1)
- immune response (1)
- immune suppression (1)
- immune-response (1)
- immunity (1)
- immunization (1)
- immunoglobulin-G (1)
- immunohistochemistry (1)
- immunology (1)
- immunosenescence (1)
- immunostaining (1)
- imperforate anus (1)
- imprinting. (1)
- in situ guided tissue regeneration (1)
- in vitro cell culture models (1)
- in vitro neural differentiation (1)
- in vivo imaging (1)
- in-vitro fertilization (1)
- in-vitro propagation (1)
- in-vivo (1)
- inactivation (1)
- incisional abdominal wall hernia (1)
- incisional hernia (1)
- inclusive cross section (1)
- inclusive jet sample (1)
- individual systematic uncertainty (1)
- individual-based simulation (1)
- induction (1)
- infants born (1)
- infected bee (1)
- infection (1)
- infiltrate (1)
- inflammatory cytokines (1)
- inflammatory mechanisms (1)
- influenza (1)
- information (1)
- ingle-molecule microscopy (1)
- inguinal hernia (1)
- inhibitory synapse (1)
- inos (1)
- insecticides (1)
- instrument (1)
- insulin pathway (1)
- insulin receptor (1)
- integration (1)
- intensity-modulated radiotherapy (1)
- intent (1)
- intentional binding (1)
- interacting species (1)
- interaction (1)
- interaktive Arten (1)
- interferon gamma (1)
- interferon-gamma (1)
- interleukin 6 (1)
- interleukin-1 receptor antagonist (1)
- interleukin-6-type cytokines (1)
- internal fixation (1)
- internal transcribed spacer 2 (1)
- internalization studies (1)
- intervention (1)
- intraarticular fractures (1)
- intracellular pathogen (1)
- intractable hiccup (1)
- intramolecular Michael addition (1)
- intravenous glucose tolerance test (1)
- invadopodia (1)
- invariant mass (1)
- invariant mass distribution (1)
- invariant mass resolution (1)
- investigators (1)
- iodine contrast (1)
- ionizing radiation (1)
- iron oxide nanoparticles (1)
- iron-pnictides (1)
- ischaemic stroke (1)
- ischemia (1)
- ischemia-reperfusion injury (1)
- ischemic cascade (1)
- ischemic stroke (1)
- isolation requirement (1)
- isthmic oragnizer (1)
- italian population (1)
- jet axis (1)
- jet background (1)
- jet calibration (1)
- jet cross section (1)
- jet energy (1)
- jet energy measurement (1)
- jet multiplicity (1)
- jet response (1)
- jet sample (1)
- jet scale energy (1)
- judgements (1)
- kidney (1)
- kingdom (1)
- kinin receptors (1)
- knock-out mice (1)
- knock-out mouse (1)
- knockout mice (1)
- knockout-mice (1)
- kubisch-monokliner Phasenübergang (1)
- label-free analysis (1)
- lacking (1)
- laminopathies (1)
- land (1)
- land use (1)
- landscape (1)
- large rapidity gap (1)
- larva (1)
- laser suture lysis (1)
- learning performances (1)
- legionella pneumophila (1)
- lepton flavour (1)
- leptonic final state (1)
- lesion formation (1)
- lesion size (1)
- leukemia-inhibitory factor (1)
- leukocyte adhesion (1)
- life events (1)
- life style (1)
- life-span regulation (1)
- light avoidance (1)
- lineage (1)
- linear trend analysis (1)
- lipid-lowering therapy (1)
- liver (1)
- livingstonei (1)
- local translation (1)
- locomotor activity (1)
- locus coeruleus (1)
- logistic regression modeling (1)
- lokale Proteinsynthese (1)
- long-term reuse (1)
- long-term-memory (1)
- low molecular weight (1)
- lower limit of normal (1)
- lower reaches of Amu Darya River (1)
- mRNA processing (1)
- macrophage (1)
- macrophages (1)
- macular degeneration (1)
- maculopathy (1)
- magnetic resonsance imaging (1)
- magnetic-resonance-spectroscopy (1)
- major depression (1)
- majorana bound states (1)
- malaria model (1)
- malaria projection (1)
- male bees (1)
- malignant MCA infarct (1)
- malignant glaucoma (1)
- malignant pleural mesothelioma (1)
- mammalian CRY1 (1)
- mammalian cells (1)
- mammographic density (1)
- mapping function (1)
- marathon running (1)
- marine sponge (1)
- markers (1)
- masked priming (1)
- mass spectometry (1)
- mast cells (1)
- matrix metalloproteinase (1)
- matrix metalloproteinases (1)
- maxillary sinus (1)
- mean σ(C–C) = 0.003 Å (1)
- mean σ(C–C) = 0.004 Å (1)
- measles virus (1)
- mechanism (1)
- mechanismofaction (1)
- medaka (1)
- media communication (1)
- mediated apoptosis (1)
- medicine (1)
- megavoltage computed-tomography (1)
- melatonin (1)
- memory (1)
- memory suppression (1)
- meningococcal disease (1)
- mesenchymal cells (1)
- mesenchymal stem cells (1)
- mesenchymal tissues (1)
- mesenchymale Stammzellen (1)
- mesh augmentation (1)
- mesh repair (1)
- metabolic flux (1)
- metabolism (1)
- metacestode vesicles (1)
- metagenomics (1)
- metal-to-insulator transition (1)
- metallurgical characterization (1)
- methane emissions (1)
- methanol methyltransferase isozymes (1)
- methanosarcina mazei GO1 (1)
- methicillin (1)
- method development (1)
- methyl-bromide (1)
- methylation (1)
- methylene blue (1)
- methylphenidate (1)
- miR-22 (1)
- miR-26b (1)
- miRNA (1)
- miRNS (1)
- mices (1)
- microRNA (1)
- microRNAs (1)
- microangiopathy (1)
- microarray (1)
- microarrays (1)
- microdeletion (1)
- microdomains (1)
- micronucleus assay (1)
- microscopy (1)
- microvascular density (1)
- microvascular endothelial cells (1)
- microvascular endothelial-cells (1)
- microvessel permeability (1)
- mimecan (1)
- mimicry (1)
- minimal inhibitory concentration (1)
- mirrorneuronsystem (1)
- mismatch negativity mmn (1)
- mitochondria (1)
- mitochondrial dysfunction (1)
- modelo PBPK/PBTK (1)
- models (1)
- modules (1)
- molecular epidemiology (1)
- molecular genetics (1)
- molecular systematics (1)
- molecular transport (1)
- molybdenum (1)
- molybdenum cofactor biosynthesis (1)
- momentum scale (1)
- monoamine transporters (1)
- monoclonal antibody (1)
- monocycline (1)
- monolayer graphite (1)
- mononuclear phagocytes (1)
- monozygotic twins (1)
- morphogenetic protein (1)
- moth manduca sexta (1)
- motility (1)
- motoneurons (1)
- motor function (1)
- motor neuron (1)
- motor preparation (1)
- motor-neuron protein (1)
- mouse (1)
- mouse model (1)
- movement ecology (1)
- movements (1)
- mulitple-sclerosis patients (1)
- multi-band superconductivity (1)
- multi-wavelength (1)
- multicenter (1)
- multicomponent Ugi-type reaction (1)
- multifactorial (1)
- multiflora (1)
- multijet event (1)
- multilocularis (1)
- multiparticle collision dynamics (1)
- multiple myeloma (1)
- multiple system atrophy (1)
- multiple-sclerosis (1)
- muon (1)
- muon decay channel (1)
- muon reconstruction efficiency (1)
- muon spectrometer (1)
- murine leishmaniasis (1)
- muscle force (1)
- mushroom bodies (1)
- music (1)
- mutagenicity (1)
- mutant mice (1)
- myasthenia gravis (1)
- mycobacterium-tuberculosis (1)
- mycotoxin (1)
- myelination (1)
- myeloid derived suppressor cells (1)
- myoelectric activity (1)
- myosin-VI (1)
- nano (1)
- nanoelectromechanical systems (1)
- nanographenes (1)
- nanowires (1)
- nasal cancer (1)
- nasal lavage (1)
- nasal snuff (1)
- nasal spray (1)
- nasopharyngeal carcinoma (1)
- nasopharyngeal colonization (1)
- natural history (1)
- necrosis-factor-alpha (1)
- neisseria gonorrhoeae (1)
- neisseria meningitidis (1)
- neobellieria bullata (1)
- neonates (1)
- nephrotoxicity (1)
- nervour system (1)
- nervous system (1)
- nervous-system (1)
- netcar-feeding bats (1)
- neural apoptosis (1)
- neural crest (1)
- neurite outgrowth (1)
- neurobehavioural deficits (1)
- neuroinflammation (1)
- neuronal differentiation (1)
- neuronale Differenzierung (1)
- neurons form (1)
- neuropathy (1)
- neuropsychology (1)
- neurorepair (1)
- neuroscience (1)
- neurothrophic factor (1)
- neurovirulence (1)
- neutral Higgs boson (1)
- neutral currents (1)
- neutral loss (1)
- neutrophils (1)
- nichtholonomes System (1)
- nickel (1)
- nickel release (1)
- nicotine addiction (1)
- nicotinic acetylcholine-receptors (1)
- nitric oxide synthase (1)
- nitricoxidesynthase (1)
- non-convex optimal control problems (1)
- nonalcoholic steatohepatitis (1)
- noncooperative binding (1)
- nonholonomic system (1)
- noninvasive detection (1)
- nonribosomal peptide synthetase (1)
- noradrenalin (1)
- norepinephrine (1)
- novelty detection (1)
- nuclear envelope (1)
- nuclear lamina (1)
- nuclear organization (1)
- nuclear transport (1)
- nucleosome (1)
- nucleotide exchange (1)
- nucleotide excision-repair (1)
- nucleus (1)
- nude mice (1)
- numerical approximations (1)
- nutrient uptake (1)
- nutrients (1)
- nyctalus noctula (1)
- obstructive pulmonary disease (1)
- occupational exposures (1)
- odourants (1)
- oncogenes (1)
- oncolytic therapy (1)
- oncolytic virus (1)
- one-dimensional (1)
- onset (1)
- open reduction (1)
- ophrys heldreichii (1)
- optical coherence tomography (1)
- organic bulk heterojunction solar cell (1)
- organic chemistry (1)
- organic photovoltaics (1)
- organic solvents (1)
- organische Photovoltaik (1)
- organische Solarzelle (1)
- organization (1)
- organogenesis (1)
- organometal complexes (1)
- organometallic complexes (1)
- organosilicon (1)
- orthodontic brackets (1)
- oscillator (1)
- osteoblast differentiation (1)
- osteochondral allografts (1)
- osteogenesis imperfecta (1)
- osteoglycin (1)
- osteoporosis (1)
- otitis media (1)
- outer membrane protein (1)
- outer-membrane proteins (1)
- oxide (1)
- p53 (1)
- pair invariant mass (1)
- pancreatic cancer (1)
- panic disorder (1)
- panton-valentine leukocidin (1)
- paradigm (1)
- paranasal sinuses (1)
- parastomal hernia (1)
- parathyroid hormone (1)
- parathyroid-hormone (1)
- parent-child agreement (1)
- parkinson disease (1)
- pars plana vitrectomy (1)
- partial purification (1)
- particle level jet (1)
- partitioning analysis RPA (1)
- parton shower (1)
- pathogenicity island 2 (1)
- pathophysiology (1)
- pathways (1)
- pea (1)
- pediatric lymphoma (1)
- people (1)
- peptide (1)
- peptides (1)
- percutaneous fixation (1)
- performance liquid-chromatography (1)
- perfusion (1)
- period variability (1)
- persistent ADHD (1)
- persistierende Infektion (1)
- perylene bisimide (1)
- pesticides (1)
- pet (1)
- pet dogs (1)
- phagocytosis (1)
- phagosomalescape (1)
- phase variation (1)
- photocurrent (1)
- photoelectron spectroscopy (1)
- photoemission (1)
- photoinhibition (1)
- photon energy scale (1)
- photoprotection (1)
- photosystem II (1)
- phylogenetic tree (1)
- phylogeny (1)
- physical activity (1)
- physical time (1)
- pig or swine (1)
- pioglitazone (1)
- pitch (1)
- placebo-controlled (1)
- placebo-controlled trial (1)
- planning (1)
- plant-microbe interaction (1)
- plant–microbe interaction (1)
- plasma cells (1)
- plasmodium falciparum (1)
- platelet adhesion (1)
- platelets (1)
- plexus epithelial-cells (1)
- pluripotent (1)
- polarisation pulse shaping (1)
- political discourse (1)
- politischer Diskurs (1)
- pollination (1)
- polyarcylamide gels (1)
- polymavirus (1)
- polymorphism (1)
- polymorphisms (1)
- polyomavirus (1)
- population (1)
- population biology (1)
- pore formation and translocation (1)
- positron-emission-tomography (1)
- post-transcriptionalregulation (1)
- posttraumatic-stress-disorder (1)
- pp collision (1)
- pragmatics (1)
- pre-messenger RNA (1)
- predation risk (1)
- prediction (1)
- predictivetextentry (1)
- predictors (1)
- pregnancy (1)
- prenatal stress (1)
- prepulse inhibition (1)
- preterm (1)
- preterm infants (1)
- primary prevention (1)
- primary ventral hernia (1)
- primary-care physicians (1)
- printed paper photovoltaics (1)
- probes (1)
- processing deficits (1)
- producation cross section (1)
- production cross section (1)
- progenitor cells (1)
- prognostic index (1)
- prognostic relevance (1)
- prognostic value (1)
- proliferation (1)
- promoter (1)
- promoter methylation (1)
- propagation (1)
- prophylaxis (1)
- propulsion (1)
- prostate (1)
- prostate cancer (1)
- protein argentine methyltranserase (1)
- protein disulfide isomerase (1)
- protein docking (1)
- protein familiy (1)
- protein folding (1)
- protein subunit (1)
- protein synthesis (1)
- protein-interaction networks (1)
- proteins (1)
- proteinuria (1)
- proteolipid protein gene (1)
- proton (1)
- präemptiver Schlag (1)
- pränataler Stress (1)
- pseudomas-syringae (1)
- psoas muscle (1)
- psychopathology (1)
- psychosis (1)
- pulmonary embolism (1)
- pulmonary gas-exchange (1)
- pyrococcus furiosus (1)
- pythia parton shower (1)
- quali-chick chimeras (1)
- quality-of-life (1)
- quantitative trait locus (1)
- quantized vortices (1)
- quantum chemistry (1)
- quantum field theory (1)
- queueing networks (1)
- radiation oncology (1)
- radiofrequency ablation (1)
- radiotherapy (1)
- rain forest (1)
- raman spectroscopy (1)
- randomized-trial (1)
- range formation (1)
- rapidity interval (1)
- rare (1)
- rare decays (1)
- rat (1)
- rat calyx (1)
- rat heart (1)
- rat spinal-cord (1)
- reaction centre (1)
- reactivity (1)
- reading disability (1)
- real-time glucose monitoring (1)
- receptor clustering (1)
- receptor-beta subunits (1)
- receptors (1)
- recolonization (1)
- recombination (1)
- recombination hotspot (1)
- reconstructed mass spectrum (1)
- reconstruction (1)
- recurrence (1)
- recurrent abdominal wall hernia (1)
- recursive Green's functions (1)
- regenerative medicine (1)
- region (1)
- regional climate model (1)
- regionales Klimamodell (1)
- registries (1)
- registry (1)
- regulation (1)
- regulatory RNA (1)
- regulatory T cell (1)
- regulatory T cells (1)
- relative abundance (1)
- releasable suture (1)
- relevance (1)
- renal disease (1)
- renal perfusion (1)
- renewable energies (1)
- renewal (1)
- replicating adenovirus (1)
- replicative senescence (1)
- reporter gene (1)
- reproductive medicine (1)
- rescue (1)
- resonant scattering (1)
- respiratory-distress-syndrome (1)
- response inhibition (1)
- response regulator (1)
- resting tremor (1)
- restricition enzymes (1)
- resummation (1)
- resurgence (1)
- resveratrol (1)
- retinal ganglion cells (1)
- retinocochleocerebral (1)
- retroviral infection (1)
- reward (1)
- rheumatoid (1)
- rhizobacteria (1)
- rhythm (1)
- ribonuclease-P (1)
- ribonucleases (1)
- ribwort plantain (1)
- richtersius coronifer (1)
- risk (1)
- risk assessment (1)
- risk factor (1)
- risk genes (1)
- room temperature (1)
- root (1)
- rotational diffusion (1)
- rs112587690 (1)
- rs12628 (1)
- rules (1)
- rural domain (1)
- ruthenates (1)
- sDMA (1)
- sRNA (1)
- safety (1)
- safety research (1)
- salmonella enterica (1)
- salt lakes (1)
- satellite rainfall products (1)
- sationary phase (1)
- satisfiability problems (1)
- savanna woodland (1)
- scaffolding protein gephyryrin (1)
- scaffolds (1)
- scanning tunneling microscopy (1)
- scattering (1)
- scattering amplitudes (1)
- scenarios (1)
- schizosaccaromyces-pombe (1)
- scid mice (1)
- scintigraphy (1)
- screening (1)
- secondary cancer (1)
- secondary prevention (1)
- secondary structure (1)
- seed protein concentration (1)
- segmental collapse (1)
- selective attention (1)
- self-assembly (1)
- self-rating (1)
- self-trapping (1)
- semi-convex hulls (1)
- semi-konvexe Hüllen (1)
- semiconductor microavity (1)
- semiconductors (1)
- sensitization (1)
- sensor (1)
- sepsis (1)
- sequence (1)
- sequence alignment (1)
- sequence imaging protocol (1)
- sequence-structure (1)
- sequential standard model (1)
- sequestration (1)
- serogroup B (1)
- serotonin (1)
- serotonin deficiency (1)
- serotonin transporter (1)
- serotonin transporter gene (1)
- set (1)
- severe renal insufficiency (1)
- sexual deception (1)
- sexual stage surface proteins (1)
- sglt1 (1)
- sheep model (1)
- shiitake dermatitis (1)
- shiitake mushrooms (1)
- shiitake-dermatite (1)
- shock (1)
- shock sigma factor (1)
- signal peptides (1)
- signal template (1)
- signals (1)
- simulaed event sample (1)
- simulated event sample (1)
- simulation (1)
- sinonasal cancer (1)
- size (1)
- skeletal overexpression (1)
- skin (1)
- skin cancer (1)
- slow cortical potentials (1)
- small RNA (1)
- small noncoding RNAs (1)
- small nucleolar RNAs (1)
- small vessel disease (1)
- smoking (1)
- smoking habits (1)
- smoking-cessation (1)
- snRNP (1)
- social calls (1)
- social teachings (1)
- sodium (1)
- soil macrofauna (1)
- soils/sediments (1)
- solid-phase extraction (1)
- solvent (1)
- somatic mosaicism (1)
- sonic hedghog (1)
- sorbents (1)
- soybean (1)
- sparticle cascade decay (1)
- sparticle pair production (1)
- spatial attention (1)
- spatial cueing (1)
- specialization (1)
- species composition (1)
- species richness (1)
- species richness estimation (1)
- specification (1)
- spectrofluorimetry (1)
- spectroscopy (1)
- spectrum disorders (1)
- spin-orbit coupling (1)
- spinal-cord (1)
- spiroplasma (1)
- splicing factor (1)
- spontaneous mouse mutants (1)
- sporadic Parkinson's disease (1)
- sptPALM (1)
- squamous cell (1)
- stage pT1 (1)
- standard heparin (1)
- standard model (1)
- states (1)
- stationary phase (1)
- steady state (1)
- stent (1)
- still-face (1)
- stochastic processes (1)
- stochastischer Prozess (1)
- stocks (1)
- strain (1)
- strain MC58 (1)
- stranded DNAs (1)
- strategies (1)
- strategy (1)
- streptozotocin (1)
- stress perfusion (1)
- string theory (1)
- stroke therapy (1)
- stromal cells (1)
- subacute sclerosing-panencephalitis (1)
- subpopulation (1)
- subspace clustering (1)
- substantia nigra (1)
- subunit (1)
- sufficient optimality conditions (1)
- summer rainfall (1)
- sumo (1)
- sumoylation (1)
- superoxide-dismutase (1)
- superresolution (1)
- supersymmetric standard model (1)
- supersymmetry (1)
- supersymmetry phenomenology (1)
- surface analysis (1)
- surface functionalisation (1)
- surfactant (1)
- surfactant protein-A (1)
- surrogate endpoints (1)
- survivin (1)
- survivin T-cell reactivity (1)
- survivors (1)
- susceptibility (1)
- susceptibility loci (1)
- swiss model (1)
- symbiosis (1)
- symmetry breaking (1)
- symptoms (1)
- synapse formation (1)
- synaptic inhibition (1)
- synechocystis (1)
- synthesis (1)
- synthesis silicon (1)
- synthetic biology (1)
- synthetic surfactant (1)
- systematic effect (1)
- systems (1)
- tPA (1)
- tandem mass-spectrometry (1)
- tardigrada (1)
- target molecule (1)
- task force (1)
- technology (1)
- teleconnection (1)
- temperature (1)
- temperatures (1)
- temporal order judgments (1)
- temporal-lobe epilepsy (1)
- tensor rank (1)
- tergite (1)
- teriparatide (1)
- term memory (1)
- territory infaction (1)
- think/no-think paradigm (1)
- thiostrepton (1)
- thrombosis (1)
- thymus (1)
- tight junctions (1)
- time (1)
- time hole (1)
- time series (1)
- time-optimal control (1)
- tissue microarray (1)
- tissue-plasminogen activator (1)
- titanium (1)
- to-disc ratio (1)
- top event dilepton invariant mass (1)
- top physics (1)
- top quark (1)
- top quark contribution (1)
- top quark masse (1)
- topology (1)
- total pancreatectomy (1)
- total systematic uncertainty (1)
- toxicity (1)
- toxicocinética (1)
- toxicokinetics (1)
- track data analysis (1)
- track momentum (1)
- track multipilicty (1)
- tracking (1)
- traffic noise (1)
- transcription activation (1)
- transcription factor (1)
- transcription factor MIZ-1 (1)
- transcription factors (1)
- transcription-3 (STAT3) (1)
- transcriptional regulator (1)
- transcriptome (1)
- transcriptomeanalysis (1)
- transcutaneous (1)
- transduction (1)
- transgenic mouse model (1)
- transient absorption spectroscopy (1)
- transient ischemic attack (1)
- transiente Absorptionsspektroskopie (1)
- transistors (1)
- transitional cell carcinoma (1)
- translation (1)
- translational initiation (1)
- translational research (1)
- translocation (1)
- transmission blocking vaccine (1)
- transverse momentum momentum spectrum (1)
- transverse momentum vector (1)
- transverse plane (1)
- tremor (1)
- triangular lattice (1)
- trinervitermes (1)
- tropical North-Africa (1)
- true diversity (1)
- trypanosome lytic factor (1)
- tryptophan (1)
- tube formation (1)
- tuberculous meningitis (1)
- tumor microenvironment (1)
- tumor necrosis factor (1)
- tumor specific antigen (1)
- tumor subtypes (1)
- tumor suppressor (1)
- tumor-draining lymph node (1)
- tumor-necrosis-factor (1)
- type 2 diabetes mellitus (1)
- typification (1)
- tyrosine kinase (1)
- tyrosine phosphorylation (1)
- ultrasoft pseudopotentials (1)
- ultrasound (1)
- ultrastructure (1)
- umbilical hernia (1)
- unconscious processing (1)
- unconverted photon (1)
- underlying event tune (1)
- unfractionated heparin (1)
- univentricular heart (1)
- unpaired median neurons (1)
- up regulation (1)
- upside-down faces (1)
- urothelial bladder carcinoma (1)
- user-centered (1)
- utilization distributions (1)
- vaccination (1)
- vaccines (1)
- vaccinia virus replication (1)
- validation region (1)
- validity (1)
- variant genotypes (1)
- vascular dementia (1)
- vasculopathy (1)
- vav2 (1)
- ventilation (1)
- ventral hernia (1)
- ventral hernia model (1)
- ventricular tachycardia (1)
- very-long-chain aldehydes (1)
- vibrio cholerae (1)
- vicinal surfaces (1)
- viral therapy (1)
- virotherapy (1)
- virtual reality (1)
- virus-induced encephalitis (1)
- visceral leishmaniasis (1)
- viscosity (1)
- visual-evoked potentials (1)
- vitamin C (1)
- vitamin-D-receptor (1)
- vitellogenin (1)
- vivo (1)
- voltage dependent (1)
- volume determination (1)
- von Willebrand factor (1)
- voxel-based morphometry (1)
- wR factor = 0.038 (1)
- wR factor = 0.052 (1)
- waking states (1)
- walking (1)
- water channels (1)
- water load test (1)
- water stress (1)
- wax (1)
- well (1)
- whole-brain radiotherapy (1)
- wires (1)
- women (1)
- wood dust (1)
- work bee (1)
- workbench (1)
- worker bee larva (1)
- young work bee (1)
- zeitoptimale Steuerung (1)
- zweiachsgelenkter Roboter (1)
- Ähnlichkeit (1)
- Übergangsmetallkomplexe (1)
- Übergangszustand (1)
- β-APP (1)
- “basic emotion” (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (83)
- Fakultät für Physik und Astronomie (38)
- Graduate School of Life Sciences (32)
- Institut für Psychologie (25)
- Neurologische Klinik und Poliklinik (24)
- Institut für Molekulare Infektionsbiologie (23)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (21)
- Physikalisches Institut (19)
- Rudolf-Virchow-Zentrum (16)
- Lehrstuhl für Biochemie (15)
Sonstige beteiligte Institutionen
A search for the Standard Model Higgs boson in the H→WW(⋆)→ℓνℓνH→WW(⋆)→ℓνℓν (ℓ=e,μℓ=e,μ) decay mode is presented. The search is performed using proton–proton collision data corresponding to an integrated luminosity of 4.7 fb\(^{−1}\) at a centre-of-mass energy of 7 TeV collected during 2011 with the ATLAS detector at the Large Hadron Collider. No significant excess of events over the expected background is observed. An upper bound is placed on the Higgs boson production cross section as a function of its mass. A Standard Model Higgs boson with mass in the range between 133 GeV and 261 GeV is excluded at 95% confidence level, while the expected exclusion range is from 127 GeV to 233 GeV.
Detailed measurements of the electron performance of the ATLAS detector at the LHC are reported, using decays of the Z, W and J/ψ particles. Data collected in 2010 at s√=7 TeV are used, corresponding to an integrated luminosity of almost 40 pb\(^{−1}\). The inter-alignment of the inner detector and the electromagnetic calorimeter, the determination of the electron energy scale and resolution, and the performance in terms of response uniformity and linearity are discussed. The electron identification, reconstruction and trigger efficiencies, as well as the charge misidentification probability, are also presented.
Proton–proton collisions at √s=7 TeV and heavy ion collisions at \(\sqrt{sNN}\)=2.76 TeV were produced by the LHC and recorded using the ATLAS experiment’s trigger system in 2010. The LHC is designed with a maximum bunch crossing rate of 40 MHz and the ATLAS trigger system is designed to record approximately 200 of these per second. The trigger system selects events by rapidly identifying signatures of muon, electron, photon, tau lepton, jet, and B meson candidates, as well as using global event signatures, such as missing transverse energy. An overview of the ATLAS trigger system, the evolution of the system during 2010 and the performance of the trigger system components and selections based on the 2010 collision data are shown. A brief outline of plans for the trigger system in 2011 is presented.
Using inelastic proton-proton interactions at s√=900 GeV and 7 TeV, recorded by the ATLAS detector at the LHC, measurements have been made of the correlations between forward and backward charged-particle multiplicities and, for the first time, between forward and backward charged-particle summed transverse momentum. In addition, jet-like structure in the events is studied by means of azimuthal distributions of charged particles relative to the charged particle with highest transverse momentum in a selected kinematic region of the event. The results are compared with predictions from tunes of the pythia and herwig++ Monte Carlo generators, which in most cases are found to provide a reasonable description of the data.
Diazepinomicin is a dibenzodiazepine alkaloid with an unusual structure among the known microbial metabolites discovered so far. Diazepinomicin was isolated from the marine sponge-associated strain Micromonospora sp. RV115 and was identified by spectroscopic analysis and by comparison to literature data. In addition to its interesting preclinical broad-spectrum antitumor potential, we report here new antioxidant and anti-protease activities for this compound. Using the ferric reducing antioxidant power (FRAP) assay, a strong antioxidant potential of diazepinomicin was demonstrated. Moreover, diazepinomicin showed a significant antioxidant and protective capacity from genomic damage induced by the reactive oxygen species hydrogen peroxide in human kidney (HK-2) and human promyelocytic (HL-60) cell lines. Additionally, diazepinomicin inhibited the proteases rhodesain and cathepsin L at an IC50 of 70–90 μM. It also showed antiparasitic activity against trypomastigote forms of Trypanosoma brucei with an IC50 of 13.5 μM. These results showed unprecedented antioxidant and anti-protease activities of diazepinomicin, thus further highlighting its potential as a future drug candidate.
The high failure rate of new drug candidates in preclinical or clinical studies due to hepatotoxicity represents a considerable problem in the drug development. Hence, there is an urgent need to develop new approaches for early and reliable prediction of drug-induced hepatotoxicity that enables a better identification of drug candidates with high potential for toxicity at early stages of drug development. Therefore, the aim of this work was to improve the prediction of drug-induced liver injury in preclinical studies through evaluation of more reliable and sensitive biomarkers of hepatotoxicity and a better understanding of the underlying mechanistic basis for drug-induced toxicity. First, the ability of a set of potential markers (NGAL, thiostatin, clusterin, PON1) to detect early signs of liver injury was assessed in rats treated with drug candidates that were dropped from further development, in part due to toxic adverse effects in the liver. In summary, PON1 and clusterin were not consistently altered in response to liver injury and thus provide no additive information to the traditional liver enzymes in detecting drug-induced hepatotoxicity. In contrast, thiostatin and NGAL were increased in serum and urine of treated animals in a time- and dose-dependent manner. These changes correlated well with mRNA expression in the target organ and generally reflected the onset and degree of drug-induced liver injury. Receiver-operating characteristics analyses supported serum thiostatin, but not NGAL, as a better indicator of drug-induced hepatobiliary injury than conventional clinical chemistry parameters, such as ALP, ALT and AST. Although thiostatin, an acute phase protein expressed in a range of tissues, may not be specific for liver injury, our results indicate that thiostatin may serve as a sensitive, minimally-invasive diagnostic marker of inflammation and tissue damage in preclinical safety assessment. In the second part of this work, combined application of genomics profiling technology and RNAi to inhibit the pharmacological target of a drug candidate BAY16, a glucagon receptor (GCGR) antagonist, was used to determine if interference with the pharmacological target plays a role in the toxic response to BAY16, and to narrow down those molecular changes that are associated with toxicity, and not the pharmacological action of BAY16. In contrast to Bay 16, which was found to be cytotoxic at concentrations of 75 µM, silencing of the glucagon receptor did not affect cell viability in primary rat hepatocytes. Thus, it can be concluded that hepatotoxicity of Bay 16 was not related to the drugs inhibitory effect on the glucagon receptor in vitro and in vivo. These findings were supported by the fact that most of BAY16-induced changes in gene expression occurred independently of the pharmacological modulation of GCGR. These off-target effects include altered xenobiotic metabolism, oxidative stress, increased fatty acid synthesis, and alterations in cholesterol and bile acid metabolic processes. Although it was not possible to draw a final conclusion about the mechanism of BAY16 hepatotoxicity, changes in these molecular mechanisms appear contribute to progression of hepatic injury. With regard to drug safety assessment in preclinical studies, the utilization of siRNA technology in vitro represents a new approach to improve mechanistic understanding of the nature of drug’s toxicity, being either chemically mediated or due to primary or secondary pharmacological mode of action.
Optimal open-loop control, i.e. the application of an analytically derived control rule, is demonstrated for nanooptical excitations using polarization-shaped laser pulses. Optimal spatial near-field localization in gold nanoprisms and excitation switching is realized by applying a shift to the relative phase of the two polarization components. The achieved near-field switching confirms theoretical predictions, proves the applicability of predefined control rules in nanooptical light–matter interaction and reveals local mode interference to be an important control mechanism.
Background: During early stages of brain development, secreted molecules, components of intracellular signaling pathways and transcriptional regulators act in positive and negative feed-back or feed-forward loops at the mid-hindbrain boundary. These genetic interactions are of central importance for the specification and subsequent development of the adjacent mid-and hindbrain. Much less, however, is known about the regulatory relationship and functional interaction of molecules that are expressed in the tectal anlage after tectal fate specification has taken place and tectal development has commenced.
Results: Here, we provide experimental evidence for reciprocal regulation and subsequent cooperation of the paired-type transcription factors Pax3, Pax7 and the TALE-homeodomain protein Meis2 in the tectal anlage. Using in ovo electroporation of the mesencephalic vesicle of chick embryos we show that (i) Pax3 and Pax7 mutually regulate each other's expression in the mesencephalic vesicle, (ii) Meis2 acts downstream of Pax3/7 and requires balanced expression levels of both proteins, and (iii) Meis2 physically interacts with Pax3 and Pax7. These results extend our previous observation that Meis2 cooperates with Otx2 in tectal development to include Pax3 and Pax7 as Meis2 interacting proteins in the tectal anlage.
Conclusion: The results described here suggest a model in which interdependent regulatory loops involving Pax3 and Pax7 in the dorsal mesencephalic vesicle modulate Meis2 expression. Physical interaction with Meis2 may then confer tectal specificity to a wide range of otherwise broadly expressed transcriptional regulators, including Otx2, Pax3 and Pax7.
Imprinted genes play important roles in brain development. As the neural developmental capabilities of human parthenogenetic embryonic stem cells (hpESCs) with only a maternal genome were not assessed in great detail, hence here the potential of hpESCs to differentiate into various neural subtypes was determined. In addition DNA methylation and expression of imprinted genes upon neural differentiation was also investigated. The results demonstrated that hpESC-derived neural stem cells (hpNSCs) showed expression of NSC markers Sox1, Nestin, Pax6, and Musashi1 (MS1), the silencing of pluripotency genes (Oct4, Nanog) and the absence of activation of neural crest (Snai2, FoxD3) and mesodermal (Acta1) markers. Moreover, confocal images of hpNSC cultures exhibited ubiquitous expression of NSC markers Nestin, Sox1, Sox2 and Vimentin. Differentiating hpNSCs for 28 days generated neural subtypes with neural cell type-specific morphology and expression of neuronal and glial markers, including Tuj1, NeuN, Map2, GFAP, O4, Tau, Synapsin1 and GABA. hpNSCs also responded to region-specific differentiation signals and differentiated into regional phenotypes such as midbrain dopaminergic- and motoneuron-type cells. hpESC-derived neurons showed typical neuronal Na+/K+ currents in voltage clamp mode, elicited multiple action potentials with a maximum frequency of 30 Hz. Cell depicted a typical neuron-like current pattern that responded to selective pharmacological blockers of sodium (tetrodotoxin) and potassium (tetraethylammonium) channels. Furthermore, in hpESCs and hpNSCs the majority of CpGs of the differentially methylated regions (DMRs) KvDMR1 were methylated whereas DMR1 (H19/Igf2 locus) showed partial or complete absence of CpG methylation, which is consistent with a parthenogenetic (PG) origin. Upon differentiation parent-of-origin-specific gene expression was maintained in hpESCs and hpNSCs as demonstrated by imprinted gene expression analyses. Together this shows that despite the lack of a paternal genome, hpNSCs are proficient in differentiating into glial- and neuron-type cells, which exhibit electrical activity similar to newly formed neurons. Moreover, maternal-specific gene expression and imprinting-specific DNA-methylation are largely maintained upon neural differentiation. hpESCs are a means to generate histocompatible and disease allele-free ESCs. Additionally, hpESCs are a unique model to study the influence of imprinting on neurogenesis.
Parent of origin imprints on the genome have been implicated in the regulation of neural cell type differentiation. The ability of human parthenogenetic (PG) embryonic stem cells (hpESCs) to undergo neural lineage and cell type-specific differentiation is undefined. We determined the potential of hpESCs to differentiate into various neural subtypes. Concurrently, we examined DNA methylation and expression status of imprinted genes. Under culture conditions promoting neural differentiation, hpESC-derived neural stem cells (hpNSCs) gave rise to glia and neuron-like cells that expressed subtype-specific markers and generated action potentials. Analysis of imprinting in hpESCs and in hpNSCs revealed that maternal-specific gene expression patterns and imprinting marks were generally maintained in PG cells upon differentiation. Our results demonstrate that despite the lack of a paternal genome, hpESCs generate proliferating NSCs that are capable of differentiation into physiologically functional neuron-like cells and maintain allele-specific expression of imprinted genes. Thus, hpESCs can serve as a model to study the role of maternal and paternal genomes in neural development and to better understand imprinting-associated brain diseases.