• Deutsch
  • Home
  • Search
  • Browse
  • Publish
  • Help
Schließen

Refine

Has Fulltext

  • yes (16)

Is part of the Bibliography

  • yes (16)

Year of publication

  • 2020 (3)
  • 2019 (1)
  • 2017 (3)
  • 2016 (4)
  • 2015 (1)
  • 2014 (3)
  • 2013 (1)

Document Type

  • Book article / Book chapter (8)
  • Journal article (5)
  • Book (2)
  • Preprint (1)

Language

  • German (13)
  • English (3)

Keywords

  • Geschlechterforschung (4)
  • Schulbuch (4)
  • Bibliografie (2)
  • Deutschunterricht (2)
  • Forschungsparadigma (2)
  • Schulbuchforschung (2)
  • Bestimmt wird alles gut (1)
  • Bildungsmedien (1)
  • Deutsch (1)
  • Educational media (1)
  • Erlebnisgesellschaft (1)
  • Flüchtlingsgeschichte (1)
  • Frauenbild (1)
  • Hartmann von Aue (1)
  • Jan Birck (1)
  • Kinderbuchwelt (1)
  • Kirsten Boie (1)
  • Kompetenzbereich (1)
  • Lehr-Lernmittel (1)
  • Lehrmittel (1)
  • Linguistische Methodik (1)
  • Literatur (1)
  • Mathematikbücher (1)
  • Methodik (1)
  • Männerbild (1)
  • Nils Mohl (1)
  • Omp85 (1)
  • POTRA domain (1)
  • PorB (1)
  • Ratgeber (1)
  • Schulbuchanalyse (1)
  • Schulbucharbeit (1)
  • Schulbuchzulassung (1)
  • Sprechen (1)
  • Stadtrandritter (1)
  • Stereotype (1)
  • Typologie (1)
  • Vermittlung (1)
  • amyotrophic-lateral-sclerosis (1)
  • biogenesis (1)
  • co-immunoprecipitation (1)
  • data-bank (1)
  • dominant optic atrophy (1)
  • gender (1)
  • gender representation (1)
  • kommunikative Ressource (1)
  • linguistische Pragmatik (1)
  • membrane organization (1)
  • membrane potential (1)
  • membrane proteins (1)
  • mitochondria (1)
  • mitochondrial membrane (1)
  • mitochondrion (1)
  • mitofilin (1)
  • model (1)
  • morphology (1)
  • motor proteins (1)
  • nervous system (1)
  • outer membrane proteins (1)
  • protein complexes (1)
  • reveals (1)
  • stilistische Analyse (1)
  • textbook research (1)
  • β-barrel (1)
- less

Author

  • Ott, Christine (16) (remove)

Institute

  • Institut für deutsche Philologie (13)
  • Theodor-Boveri-Institut für Biowissenschaften (3)

16 search hits

  • 1 to 16
  • BibTeX
  • CSV
  • RIS
  • XML
  • 10
  • 20
  • 50
  • 100

Sort by

  • Year
  • Year
  • Title
  • Title
  • Author
  • Author
Ratgeber und RAT GEBEN. Textlinguistische Reflexionen zur Identifizierung, Typologisierung und pragmatisch-stilistischen Analyse von Ratgebern. (2019)
Ott, Christine ; Kiesendahl, Jana
Kein Abstract verfügbar.
Sprechen als kommunikative Ressource. Was die linguistische Pragmatik für den Kompetenzbereich ‚Sprechen‘ zu bieten hat (2014)
Staffeldt, Sven ; Ott, Christine
Kein Abstract verfügbar
Kirsten Boie/Jan Birck: Bestimmt wird alles gut. Deutsch – Arabisch (2016). Eine syrisch-deutsche Flüchtlingsgeschichte (2017)
Ott, Christine
Kein Abstract verfügbar.
40 Jahre Geschlechterforschung zu Rechen- und Mathematikbüchern. Forschungsparadigmen und Methodik im Wandel (2016)
Ott, Christine
Kein Abstract verfügbar.
Literarisches Dorfleben in Maienfeld oder Wie Heidi lebte. (2017)
Ott, Christine
Kein Abstract verfügbar.
Literatur und Vermittlung – Anmerkungen zu deren Verhältnis (2020)
Ott, Christine
Kein Abstract verfügbar.
Nils Mohl und Hartmann von Aue. Zur intertextuellen Verweisstruktur in Stadtrandritter und ihrem didaktischen Potential für den Deutschunterricht. (2016)
Tomasek, Stefan ; Ott, Christine
Kein Abstract verfügbar.
Geschlechterforschung zu Schulbüchern gestern und heute. Forschungsparadigmen und Methodik. (2017)
Ott, Christine
Kein Abstract verfügbar.
Zur Ver- und Entschränkung von Schulbucharbeit und Schulbuchzulassung. Theoretische Grundlegung und historische Skizze. (2016)
Ott, Christine
Kein Abstract verfügbar.
Das Schulbuch beim Wort nehmen – Linguistische Methodik in der Schulbuchforschung (2014)
Ott, Christine
Kein Abstract verfügbar.
Geschlechterstereotypen auf der Spur. Ein Plädoyer für mehr Linguistik in der Bildungsforschung (2016)
Ott, Christine
Kein Abstract verfügbar.
Bildungsmedien/Lehr-Lernmittel und Deutschunterricht. Eine Auswahlbibliographie (2020)
Ott, Christine
Die Bibliographie führt Forschungsaktivitäten zu Bildungsmedien/Lehr-Lernmitteln für das Fach Deutsch und/oder mit Relevanz für sprachlich-literarische Lehr-Lern-Settings zusammen.
Bibliographie Schulbuchforschung zum Aspekt Geschlecht (2020)
Ott, Christine
Die Bibliographie dokumentiert die Entwicklung des deutschsprachigen Forschungsfelds Schulbuchanalysen zum Aspekt Geschlecht von seinen Anfängen in den späten 1960er Jahren bis in die Gegenwart.
Detailed Analysis of the Human Mitochondrial Contact Site Complex Indicate a Hierarchy of Subunits (2015)
Ott, Christine ; Dorsch, Eva ; Fraunholz, Martin ; Straub, Sebastian ; Kozjak-Pavlovic, Vera
Mitochondrial inner membrane folds into cristae, which significantly increase its surface and are important for mitochondrial function. The stability of cristae depends on the mitochondrial contact site (MICOS) complex. In human mitochondria, the inner membrane MICOS complex interacts with the outer membrane sorting and assembly machinery (SAM) complex, to form the mitochondrial intermembrane space bridging complex (MIB). We have created knockdown cell lines of most of the MICOS and MIB components and have used them to study the importance of the individual subunits for the cristae formation and complex stability. We show that the most important subunits of the MIB complex in human mitochondria are Mic60/Mitofilin, Mic19/CHCHD3 and an outer membrane component Sam50. We provide additional proof that ApoO indeed is a subunit of the MICOS and MIB complexes and propose the name Mic23 for this protein. According to our results, Mic25/CHCHD6, Mic27/ApoOL and Mic23/ApoO appear to be periphery subunits of the MICOS complex, because their depletion does not affect cristae morphology or stability of other components.
A Splicing Mutation in the Novel Mitochondrial Protein DNAJC11 Causes Motor Neuron Pathology Associated with Cristae Disorganization, and Lymphoid Abnormalities in Mice (2014)
Ioakeimidis, Fotis ; Ott, Christine ; Kozjak-Pavlovic, Vera ; Violitzi, Foteini ; Rinotas, Vagelis ; Makrinou, Eleni ; Eliopoulos, Elias ; Fasseas, Costas ; Kollias, George ; Douni, Eleni
Mitochondrial structure and function is emerging as a major contributor to neuromuscular disease, highlighting the need for the complete elucidation of the underlying molecular and pathophysiological mechanisms. Following a forward genetics approach with N-ethyl-N-nitrosourea (ENU)-mediated random mutagenesis, we identified a novel mouse model of autosomal recessive neuromuscular disease caused by a splice-site hypomorphic mutation in a novel gene of unknown function, DnaJC11. Recent findings have demonstrated that DNAJC11 protein co-immunoprecipitates with proteins of the mitochondrial contact site (MICOS) complex involved in the formation of mitochondrial cristae and cristae junctions. Homozygous mutant mice developed locomotion defects, muscle weakness, spasticity, limb tremor, leucopenia, thymic and splenic hypoplasia, general wasting and early lethality. Neuropathological analysis showed severe vacuolation of the motor neurons in the spinal cord, originating from dilatations of the endoplasmic reticulum and notably from mitochondria that had lost their proper inner membrane organization. The causal role of the identified mutation in DnaJC11 was verified in rescue experiments by overexpressing the human ortholog. The full length 63 kDa isoform of human DNAJC11 was shown to localize in the periphery of the mitochondrial outer membrane whereas putative additional isoforms displayed differential submitochondrial localization. Moreover, we showed that DNAJC11 is assembled in a high molecular weight complex, similarly to mitofilin and that downregulation of mitofilin or SAM50 affected the levels of DNAJC11 in HeLa cells. Our findings provide the first mouse mutant for a putative MICOS protein and establish a link between DNAJC11 and neuromuscular diseases.
Requirements for the import of neisserial Omp85 into the outer membrane of human mitochondria (2013)
Kozjak‑Pavlovic, Vera ; Ott, Christine ; Utech, Mandy ; Goetz, Monika ; Rudel, Thomas
β-Barrel proteins are present only in the outer membranes of Gram-negative bacteria, chloroplasts and mitochondria. Fungal mitochondria were shown to readily import and assemble bacterial β-barrel proteins, but human mitochondria exhibit certain selectivity. Whereas enterobacterial β-barrel proteins are not imported, neisserial ones are. Of those, solely neisserial Omp85 is integrated into the outer membrane of mitochondria. In this study, we wanted to identify the signal that targets neisserial β-barrel proteins to mitochondria. We exchanged parts of neisserial Omp85 and PorB with their Escherichia coli homologues BamA and OmpC. For PorB, we could show that its C-terminal quarter can direct OmpC to mitochondria. In the case of Omp85, we could identify several amino acids of the C-terminal β-sorting signal as crucial for mitochondrial targeting. Additionally, we found that at least two POTRA (polypeptide-transport associated) domains and not only the β-sorting signal of Omp85 are needed for its membrane integration and function in human mitochondria. We conclude that the signal that directs neisserial β-barrel proteins to mitochondria is not conserved between these proteins. Furthermore, a linear mitochondrial targeting signal probably does not exist. It is possible that the secondary structure of β-barrel proteins plays a role in directing these proteins to mitochondria.
  • 1 to 16

DINI-Zertifikat     OPUS4 Logo

  • Contact
  • |
  • Imprint
  • |
  • Sitemap