Refine
Has Fulltext
- yes (70)
Is part of the Bibliography
- yes (70)
Year of publication
Document Type
- Journal article (70) (remove)
Language
- English (70)
Keywords
- multiple myeloma (5)
- apoptosis (4)
- gene expression (4)
- Hodgkin lymphoma (3)
- Medizin (3)
- Activation (2)
- CD30 (2)
- CXCR4 (2)
- NFATc1 (2)
- T cells (2)
Author
- Rosenwald, Andreas (70) (remove)
Institute
- Pathologisches Institut (67)
- Medizinische Klinik und Poliklinik II (20)
- Comprehensive Cancer Center Mainfranken (10)
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (7)
- Theodor-Boveri-Institut für Biowissenschaften (7)
- Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie (6)
- Urologische Klinik und Poliklinik (5)
- Medizinische Klinik und Poliklinik I (4)
- Kinderklinik und Poliklinik (3)
- Klinik und Poliklinik für Nuklearmedizin (3)
Sonstige beteiligte Institutionen
Murti, Krisna ; Fender, Hendrik ; Glatzle, Carolin ; Wismer, Rhoda ; Sampere-Birlanga, Salvador ; Wild, Vanessa ; Muhammad, Khalid ; Rosenwald, Andreas ; Serfling, Edgar ; Avots, Andris
In Burkitt lymphoma (BL), a tumor of germinal center B cells, the pro-apoptotic properties of MYC are controlled by tonic B cell receptor (BCR) signals. Since BL cells do not exhibit constitutive NF-κB activity, we hypothesized that anti-apoptotic NFATc1 proteins provide a major transcriptional survival signal in BL. Here we show that post-transcriptional mechanisms are responsible for the calcineurin (CN) independent constitutive nuclear over-expression of NFATc1 in BL and Eµ-MYC – induced B cell lymphomas (BCL). Conditional inactivation of the Nfatc1 gene in B cells of Eµ-MYC mice leads to apoptosis of BCL cells in vivo and ex vivo. Inhibition of BCR/SYK/BTK/PI3K signals in BL cells results in cytosolic re-location of NFATc1 and apoptosis. Therefore, NFATc1 activity is an integrated part of tonic BCR signaling and an alternative target for therapeutic intervention in BL.