Refine
Has Fulltext
- yes (17)
Is part of the Bibliography
- yes (17)
Year of publication
Document Type
- Journal article (16)
- Doctoral Thesis (1)
Keywords
- multiple sclerosis (5)
- Myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) (3)
- Neuromyelitis optica spectrum disorders (NMOSD) (3)
- Optic neuritis (3)
- Autoantibodies (2)
- Cerebrospinal fluid (2)
- Longitudinally extensive transverse myelitis (LETM) (2)
- MS (2)
- Multiple sclerosis (2)
- Antibody index (1)
- Aquaporin-4 antibodies (AQP4-Ig, NMO-IgG)G (1)
- Aquaporin-4 antibodies (AQP4-IgG) (1)
- Aquaporin-4 antibodies (AQP4-IgG, NMO-IgG) (1)
- Ataxia (1)
- Azathioprine (1)
- Barkhof criteria (1)
- Biomarker (1)
- Brainstem encephalitis (1)
- CBP (1)
- CSF (1)
- CXCL5 (1)
- CXCL8 (1)
- CXCR2 (1)
- Cell-based assays (1)
- Cerebellitis (1)
- Devic syndrome (1)
- Devic’s syndrome (1)
- Diplopia Internuclear ophthalmoplegia (INO) (1)
- Electrophysiology (1)
- Evoked potentials (1)
- Facial nerve palsy (1)
- Gehirn (1)
- Glatiramer acetate (1)
- Hearing loss (1)
- IL-22 binding protein isoform (1)
- IL22RA2 (1)
- IPND criteria (1)
- Infections (1)
- Interferon beta (1)
- International consensus diagnostic criteria for neuromyelitis optica spectrum disorders (1)
- Intractable nausea and vomiting (1)
- Longitudinally extensive transverse myelitis (1)
- Lysosomal storage disease (1)
- MOG-IgG (1)
- MRI criteria (1)
- Magnetic resonance imaging (1)
- McDonald criteria (1)
- Medizin (1)
- Methotrexate (1)
- Myelin oligodendrocyte glycoprotein (MOG) antibodies (1)
- Myelitis (1)
- NF-AT (1)
- NF-\(\kappa\)B (1)
- NFAT (1)
- NMO-IgG (1)
- Natalizumab (1)
- Neurodegeneration (1)
- Neuromyelitis optica (NMO) (1)
- Neuromyelitis optica antibodies (NMO-IgG) (1)
- Neuronal ceroid lipofuscinosis (1)
- OCB (1)
- Ofatumumab (1)
- Oligoclonal bands (1)
- Optical coherence tomography (1)
- Outcome (1)
- Pregnancy (1)
- Rac (1)
- Raf (1)
- Respiratory insufficiency (1)
- Retinal degeneration (1)
- Rhombencephalitis (1)
- Rituximab (1)
- SB332235 (1)
- TAD-A (1)
- Therapy (1)
- Transverse Myelitis (1)
- Transverse myelitis (1)
- Treatment (1)
- Ureaplasma species (1)
- VCAM-1 (1)
- Vaccination (1)
- Wingerchuk criteria 2006 and 2015 (1)
- acid sphingomyelinase (1)
- antidepressants (1)
- aquaporin-4 antibodies (AQP4-IgG) (1)
- association (1)
- atypical chemokine receptor 3 (1)
- autoimmune (1)
- barrier integrity (1)
- biomarker (1)
- blood-brain barrier (1)
- blood–brain barrier (1)
- cell adhesion (1)
- cerebrospinal fluid (1)
- conversion (1)
- criteria (1)
- differential diagnosis (1)
- dimethyl fumarate (1)
- drug (1)
- endothelial cells (1)
- gene (1)
- genetics (1)
- human brain microvascular endothelial cells (1)
- human cerebral endothelial cells (1)
- interleukin-8 (1)
- linkage (1)
- major depression (1)
- meningitis (1)
- monomethyl fumarate (1)
- multiple sklerosis (1)
- mutation (1)
- nervous-system (1)
- neuroinflammation (1)
- neuromyelitis optica (1)
- neuromyelitis optica spectrum disorders (NMOSD) (1)
- optic neuritis (1)
- optical coherence tomography (1)
- p300 (1)
- p38 mitogen-activated protein kinase (1)
- plasminogen (1)
- potent inducer (1)
- proteins (1)
- regulatory T cells (1)
- retinal neuro-axonal damage (1)
- serum (1)
- signal peptide (1)
- sphingolipids (1)
- visual acuity (1)
- visual evoked potentials (1)
Institute
- Neurologische Klinik und Poliklinik (13)
- Pathologisches Institut (3)
- Institut für Virologie und Immunbiologie (2)
- Kinderklinik und Poliklinik (2)
- Augenklinik und Poliklinik (1)
- Deutsches Zentrum für Herzinsuffizienz (DZHI) (1)
- Institut für Hygiene und Mikrobiologie (1)
- Institut für Klinische Neurobiologie (1)
- Institut für Organische Chemie (1)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (1)
Intrathecal, Polyspecific Antiviral Immune Response in Oligoclonal Band Negative Multiple Sclerosis
(2012)
Background: Oligoclonal bands (OCB) are detected in the cerebrospinal fluid (CSF) in more than 95% of patients with multiple sclerosis (MS) in the Western hemisphere. Here we evaluated the intrathecal, polyspecific antiviral immune response as a potential diagnostic CSF marker for OCB-negative MS patients.
Methodology/Principal Findings: We tested 46 OCB-negative German patients with paraclinically well defined, definite MS. Sixteen OCB-negative patients with a clear diagnosis of other autoimmune CNS disorders and 37 neurological patients without evidence for autoimmune CNS inflammation served as control groups. Antibodies against measles, rubella, varicella zoster and herpes simplex virus in paired serum and CSF samples were determined by ELISA, and virus-specific immunoglobulin G antibody indices were calculated. An intrathecal antibody synthesis against at least one neurotropic virus was detected in 8 of 26 (31%) patients with relapsing-remitting MS, 8 of 12 (67%) with secondary progressive MS and 5 of 8 (63%) with primary progressive MS, in 3 of 16 (19%) CNS autoimmune and 3 of 37 (8%) non-autoimmune control patients. Antibody synthesis against two or more viruses was found in 11 of 46 (24%) MS patients but in neither of the two control groups. On average, MS patients with a positive antiviral immune response were older and had a longer disease duration than those without.
Conclusion: Determination of the intrathecal, polyspecific antiviral immune response may allow to establish a CSF-supported diagnosis of MS in OCB-negative patients when two or more of the four virus antibody indices are elevated.