Refine
Has Fulltext
- yes (66)
Is part of the Bibliography
- yes (66)
Year of publication
Document Type
- Journal article (65)
- Conference Proceeding (1)
Language
- English (66)
Keywords
- adrenocortical carcinoma (9)
- obesity (5)
- metabolomics (4)
- 18F-FDG (3)
- CXCR4 (3)
- Cushing’s syndrome (3)
- FGFR (3)
- PET (3)
- adrenocortical cancer (3)
- biomarker (3)
- cortisol (3)
- hypercortisolism (3)
- liraglutide (3)
- paraganglioma (3)
- pheochromocytoma (3)
- positron emission tomography (3)
- therapy (3)
- vandetanib (3)
- ACTH (2)
- C-X-C motif chemokine receptor 4 (2)
- CYP2W1 (2)
- Cushing’s disease (2)
- FGF-pathway (2)
- PPGL (2)
- Positronen-Emissions-Tomografie (2)
- TKI (2)
- [68Ga]PentixaFor (2)
- adenomas (2)
- adrenal cancer (2)
- adrenal tumours (2)
- adrenocortical tumors (2)
- cancer (2)
- carcinomas (2)
- cardiovascular events (2)
- chemokine receptor (2)
- endoradiotherapy (2)
- gastric bypass (2)
- immune response (2)
- immunohistochemistry (2)
- immunotherapy (2)
- machine learning (2)
- medullary thyroid carcinoma (2)
- mitotane (2)
- mortality (2)
- pediatric adrenocortical cancer (2)
- pediatric adrenocortical tumor (2)
- peptide tyrosine tyrosine (PYY) (2)
- prognosis (2)
- recurrence (2)
- theranostics (2)
- treatment (2)
- tyrosine kinase inhibitor (2)
- 2- deoxy-2-(18F)fluoro-D-glucose (1)
- 2-deoxy-2-(18F)fluoro-D-glucose (1)
- ALT (1)
- ATRX (1)
- Adrenocortial carcinomas (1)
- Antigen 4 (1)
- Autoimmune-Diseases (1)
- BIRC7 (1)
- BRAF(V600E) mutation (1)
- Biochemical-Diagnosis (1)
- C-terminal HSP90 inhibitors (1)
- CCR7 (1)
- CRH stimulation test (1)
- CTNNB1 (1)
- CXCR7 (1)
- CYP2B6 (1)
- Cell lung canger (1)
- Contrast-enhanced CT (1)
- Copeptin (1)
- Cushing (1)
- Cushing's disease (1)
- Cushings syndrome (1)
- Dendritic Cells (1)
- Diagnosis (1)
- Disease prevalence (1)
- EMT (1)
- F-18-FDG PET/CT (1)
- FGF21 (1)
- FGFR-inhibitors (1)
- Fibroblast Growth Factor-21 (1)
- FoxP3 Expression (1)
- GLP-1 (1)
- Immune-System (1)
- Immunological Self-Tolerance (1)
- Klotho-related molecules (1)
- LND (1)
- LNE (1)
- MASS (1)
- MR (1)
- MTL30 (1)
- Medicine (1)
- Medizin (1)
- Medullärer Schilddrüsenkrebs (1)
- Men (1)
- Metanephrine (1)
- Methodological quality (1)
- Multiple-Sclerosis (1)
- N-terminal HSP90 inhibitors (1)
- NAFLD (1)
- NASH (1)
- NMR (1)
- NOP10 (1)
- NR3C1 (1)
- Normetanephrine (1)
- PD-L1 (1)
- PF-05231023 (1)
- PYY3-36 (1)
- Paraganglioma (1)
- Plasma (1)
- Positron-emission-tomography (1)
- RNA Expression (1)
- RNAScope (1)
- RYGB (1)
- Resistance (1)
- Roux-en-Y Gastric Bypass (1)
- Roux-en-Y gastric bypass (1)
- Roux-en-Y gastric bypass surgery (1)
- SNP (1)
- SOAT1 (1)
- Sex-Hormones (1)
- Society (1)
- Spin echo (1)
- Suppressive Function (1)
- Systemic-Lupus-Erythematosus (1)
- TERT (1)
- Test accuracy (1)
- USP8 (1)
- Utility (1)
- [11C]-Choline PET/CT (1)
- [11C]-Methionine (1)
- [177Lu]/[90Y]PentixaTher (1)
- [177Lu]PentixaTher (1)
- [18F]FDG-PET-CT (1)
- [90Y]PentixaTher (1)
- [99mTc]-Sestamibi scan (1)
- abdominal lymph node metastases (1)
- adjuvant platinum-based chemotherapy (1)
- adjuvant treatment (1)
- adrenal (1)
- adrenal cortex hormones (1)
- adrenal cortex neoplasms (1)
- adrenal gland (1)
- adrenal glands (1)
- adrenal imaging (1)
- adrenal surgery (1)
- adrenal tumor (1)
- adrenal tumors (1)
- adrenalectomia (1)
- adrenocortical (1)
- adrenocortical adenocarcinoma (1)
- adrenocortical carcinoma (ACC) (1)
- adrenocortical development (1)
- adrenocortical tissues (1)
- aldosterone (1)
- association (1)
- autoantibodies (1)
- autonomous cortisol secretion (1)
- balance (1)
- bioinformatic clustering (1)
- biomarker prediction (1)
- biomarkers (1)
- blood pressure (1)
- branched-chain amino acids (1)
- cancer detection (1)
- cancer diagnosis (1)
- cancer treatment (1)
- cancer-testis antigens (1)
- carcinogenesis (1)
- carcinoma (1)
- carcinoma metastases to pancreas (1)
- cardiovascular risk factors (1)
- caspase-3 (1)
- catecholamines (1)
- catenin (1)
- cells (1)
- cholesterol metabolism (1)
- chromosomes (1)
- circulating microRNA (1)
- combination (1)
- comparability (1)
- comparative genomic hybridization (1)
- complication (1)
- confounders (1)
- copeptin (1)
- cortisol-producing adenoma (1)
- cytoplasmic staining (1)
- deubiquitinases (1)
- dexamethasone suppression test (1)
- diabetes insipidus (1)
- diagnosis (1)
- disease score (1)
- disease severity (1)
- dissection (1)
- distant metastases (1)
- dogs (1)
- drug therapy (1)
- early prognosis (1)
- ectopic (1)
- efficacy (1)
- endogenous hypercortisolism (1)
- epithelial markers (1)
- expression (1)
- feature selection (1)
- focused surgical approach (1)
- follow-up (1)
- genetic loci (1)
- glucocorticoid excess (1)
- guidelines (1)
- high dose dexamethasone suppression test (1)
- high-resolution analysis (1)
- hormones (1)
- hypothalamic gene expression (1)
- imaging (1)
- immune check inhibitor (1)
- immune checkpoint inhibitor (ICI) (1)
- immunity (1)
- immunohistochemistry techniques (1)
- in silico analysis (1)
- insulin resistance (1)
- intragastric balloon (1)
- isturisa (1)
- kidney disease (1)
- kinase (1)
- kinases (1)
- liquid chromatography–tandem mass spectrometry (LC–MS/MS) (1)
- livin (1)
- lymph node dissection (1)
- lymphadenectomy (1)
- lymphocytes (1)
- malignant tumors (1)
- management (1)
- mass spectrometry (1)
- mass spectronomy (1)
- medical therapy (1)
- mesenchymal markers (1)
- meta-analysis (1)
- metyrapone (1)
- miR-182-5p (1)
- miR-183 cluster (1)
- miR-483-5p (1)
- miRNA (1)
- molecular diagnostics (1)
- morbidity (1)
- multicenter (1)
- multiple myeloma (1)
- mutation (1)
- mutation triggers (1)
- neuroblastoma – diagnosis (1)
- neutral loss (1)
- normal adrenal glands (1)
- normal values (1)
- notch signaling (1)
- nuclear staining (1)
- operation (1)
- osilodrostat (1)
- osmotic stimulation (1)
- outcome (1)
- paired (1)
- papillary (1)
- papillary thyroid carcinoma (PTC) (1)
- parathyroid adenoma (1)
- parathyroid carcinoma (1)
- pathogenesis (1)
- patient survival (1)
- pediatric (1)
- pediatric adrenocortical adenoma (1)
- pediatric adrenocortical carcinoma (1)
- pembrolizumab (1)
- peptide tyrosine tyrosine 3-36 (PYY3-36) (1)
- peptide tyrosine tyrosine 3-36 (PYY\(_{3-36}\)) (1)
- personalized medicine (1)
- phosphatidylcholines (1)
- phosphorylation (1)
- pituitary adenomas (1)
- pituitary gland (1)
- plasma (1)
- plasma NMR (1)
- polarization (1)
- preanalytical conditions (1)
- precision medicine (1)
- predictive marker (1)
- primary hyperparathyroidism (1)
- primary polydipsia (1)
- prognostic biomarker (1)
- prognostic factors (1)
- prognostic marker (1)
- prospective (1)
- prostate cancer (1)
- protein expression (1)
- radical resection (1)
- radioiodine (1)
- radioiodine therapy (1)
- radiotherapy (1)
- radiotherapy (RT) (1)
- recurrence free survival (1)
- recurrence-free survival (1)
- reference data (1)
- repeated surgery (1)
- review (1)
- rodent model (1)
- rygb (1)
- selpercatinib (1)
- serum (1)
- signs and symptoms (1)
- sleeve gastrectomy (1)
- somatic mutations (1)
- sphingolipids (1)
- steroid measurement (1)
- sudden cardiac death (1)
- super-obesity (1)
- surgery (1)
- surgical oncology (1)
- surgical treatment (1)
- t-lymphocytes (1)
- targeted metabolomics (1)
- targeted treatment (1)
- telomeres (1)
- thyroid carcinoma (TC) (1)
- timing (1)
- transgenic rats (1)
- tumor microenvironment (1)
- tumor-infiltrating (1)
- tumors (1)
- tyrosine kinase inhibitor (TKI) (1)
- unsupervised clustering (1)
- urine (1)
- volume (1)
Institute
- Medizinische Klinik und Poliklinik I (66) (remove)
Sonstige beteiligte Institutionen
Context:
Adrenal tumors have a prevalence of around 2% in the general population. Adrenocortical carcinoma (ACC) is rare but accounts for 2–11% of incidentally discovered adrenal masses. Differentiating ACC from adrenocortical adenoma (ACA) represents a diagnostic challenge in patients with adrenal incidentalomas, with tumor size, imaging, and even histology all providing unsatisfactory predictive values.
Objective:
Here we developed a novel steroid metabolomic approach, mass spectrometry-based steroid profiling followed by machine learning analysis, and examined its diagnostic value for the detection of adrenal malignancy.
Design:
Quantification of 32 distinct adrenal derived steroids was carried out by gas chromatography/mass spectrometry in 24-h urine samples from 102 ACA patients (age range 19–84 yr) and 45 ACC patients (20–80 yr). Underlying diagnosis was ascertained by histology and metastasis in ACC and by clinical follow-up [median duration 52 (range 26–201) months] without evidence of metastasis in ACA. Steroid excretion data were subjected to generalized matrix learning vector quantization (GMLVQ) to identify the most discriminative steroids.
Results:
Steroid profiling revealed a pattern of predominantly immature, early-stage steroidogenesis in ACC. GMLVQ analysis identified a subset of nine steroids that performed best in differentiating ACA from ACC. Receiver-operating characteristics analysis of GMLVQ results demonstrated sensitivity = specificity = 90% (area under the curve = 0.97) employing all 32 steroids and sensitivity = specificity = 88% (area under the curve = 0.96) when using only the nine most differentiating markers.
Conclusions:
Urine steroid metabolomics is a novel, highly sensitive, and specific biomarker tool for discriminating benign from malignant adrenal tumors, with obvious promise for the diagnostic work-up of patients with adrenal incidentalomas.