Refine
Has Fulltext
- yes (24)
Is part of the Bibliography
- yes (24)
Document Type
- Journal article (23)
- Doctoral Thesis (1)
Keywords
- HNSCC (5)
- artificial intelligence (5)
- head and neck cancer (5)
- caloric restriction (3)
- deep learning (3)
- machine learning (3)
- prediction (3)
- ARONJ (2)
- HGF (2)
- Met (2)
- amino acid restriction (2)
- cancer metabolism (2)
- classification (2)
- mass spectrometry (2)
- methionine (2)
- osteonecrosis of the jaw (2)
- osteoradionecrosis (2)
- 2-DG (1)
- 2-deoxy-D-glucose (1)
- AMPK (1)
- Adult (1)
- CBCT (1)
- CD44 (1)
- COPD (1)
- Cephalometry (1)
- Compound 3k (1)
- DASA-58 (1)
- Dysgnathie (1)
- FasL (1)
- Fernröntgenseitenbild (1)
- Head (1)
- Kephalometrie (1)
- Kraniometrie (1)
- L929 (1)
- LC/MS (1)
- MRONJ (1)
- NFκB (1)
- OHIP-49 (1)
- ONJ (1)
- PD-L1 (1)
- PET (1)
- PKM2 (1)
- Rhabdomyosarcoma (1)
- SCCHN (1)
- SLC-family (1)
- SWLS (1)
- Spindle cell (1)
- Surgery (1)
- TNFα (1)
- TPCA1 (1)
- TXNIP (1)
- Volumentomographie (1)
- Warburg effect (1)
- X-ray (1)
- agar diffusion test (1)
- alveolar bone loss (1)
- amino acid (1)
- amino acid transporter (1)
- ampicillin (1)
- antibiotic bone concentration (1)
- antiresorptive drug-related osteonecrosis of the jaw (1)
- apoptosis (1)
- beta-lactam (1)
- bone loss (1)
- cancer (1)
- case report (1)
- cell vitality (1)
- cisplatin (1)
- complications (1)
- computer-aided (1)
- contact inhibition (1)
- craniofacial orthodontics (1)
- design (1)
- donor-site morbidity (1)
- energy restriction (1)
- fibroblast activation protein (1)
- fibula (1)
- frailty (1)
- free skin grafts (1)
- geriatric cancer patient (1)
- gingivitis (1)
- glucose restriction (1)
- glycolysis (1)
- graft (1)
- immune therapy (1)
- inflammation (1)
- inhibitor (1)
- intraosseous (1)
- ischemia (1)
- jaw bone (1)
- lateral radiograph (1)
- length of stay (1)
- liquid chromatography/mass spectrometry (1)
- low carb (1)
- low energy metabolism (1)
- lymph node (1)
- malocclusion (1)
- mandible (1)
- mandibular (1)
- manufacturing (CAD/CAM) (1)
- maxillofacial surgery (1)
- medication-related osteonecrosis of the jaw (1)
- metabolomics (1)
- methionine restriction (1)
- model (1)
- molecular imaging (1)
- multicentric (1)
- object detection (1)
- operative planning (1)
- oral functional capacity (1)
- oral health (1)
- oral health-related quality of life (1)
- oral microbiome (1)
- oral squamous cell carcinoma (1)
- oral-health-related quality of life (1)
- oro-antral communication (1)
- oro-antral fistula (1)
- oroantral fistula (1)
- oropharyngeal carcinoma (1)
- osteocutaneous (1)
- pN1 (1)
- perfusion culture (1)
- periodontitis (1)
- physical examination (1)
- planning (1)
- platelet-rich fibrin (1)
- preoperative (1)
- progression-free survival (1)
- proliferation (1)
- prospective (1)
- prosthetic rehabilitation (1)
- pseudocarcinomatous hyperplasia (1)
- quality of life (1)
- radial forearm flap (1)
- radiographic bone loss (1)
- radiotherapy (1)
- reconstruction (1)
- recurrent/metastatic head and neck squamous cell carcinoma (1)
- resection (1)
- satisfaction with life (1)
- surgery (1)
- survival (1)
- teeth extraction (1)
- three-dimensional imaging (1)
- tooth extraction (1)
- treatment benefit (1)
Institute
- Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie (24)
- Comprehensive Cancer Center Mainfranken (4)
- Pathologisches Institut (3)
- Poliklinik für Zahnärztliche Prothetik (3)
- Theodor-Boveri-Institut für Biowissenschaften (3)
- Institut für Hygiene und Mikrobiologie (2)
- Institut für Pharmazie und Lebensmittelchemie (2)
- Medizinische Klinik und Poliklinik II (2)
- Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik) (1)
- Klinik und Poliklinik für Hals-, Nasen- und Ohrenkrankheiten, plastische und ästhetische Operationen (1)
Sonstige beteiligte Institutionen
To define frailty in older cancer patients, the aim of this study was to assess the geriatric status and quality of life (QoL) aspects in patients suffering from recurrent/metastatic head and neck squamous cell carcinoma (r/m HNSCC) under palliative treatment. A comprehensive geriatric assessment (CGA) was performed on 21 r/m HNSCC patients at two defined assessments, and the QoL aspects and the impact of descriptive data were evaluated. The Kolmogorov–Smirnov test, Spearman’s rho correlation, and two-way mixed ANOVA were used for statistical analysis. All patients were found to be “frail”. Pain, fatigue, and the burden of illness were the highest-rated symptoms. Oral function and orofacial appearance were highly impaired. A significant impact of descriptive data on the CGA and QoL results was found (all p ≤ 0.05). Thus, the CGA results revealed high frailty, severe comorbidities, and high impairments in QoL aspects. The CGA and QoL results were negatively affected by the primary HNSCC treatment approach, the need for prosthetic treatment, and worse oral functional capacity. Therefore, frailty in r/m HNSCC patients seems to be multidimensional. The evaluation of the CGA and QoL aspects in r/m HNSCC patients can be recommended to detect special needs, organize aftercare, and improve the support for frail and vulnerable cancer patients to create a multidisciplinary treatment approach.