Refine
Has Fulltext
- yes (70)
Is part of the Bibliography
- yes (70)
Year of publication
Document Type
- Journal article (68)
- Report (2)
Language
- English (70) (remove)
Keywords
- ischemic stroke (11)
- B cells (5)
- multiple sclerosis (5)
- Medizin (4)
- acute ischemic stroke (4)
- factor XII (4)
- inflammation (4)
- traumatic brain injury (4)
- MS (3)
- Mice (3)
- closed head injury (3)
- expression (3)
- neurology (3)
- relapse (3)
- trial (3)
- EAE (2)
- ELISPOT (2)
- Inflammation (2)
- NEUROWIND (2)
- SHRSP (2)
- Schlaganfall (2)
- Stroke (2)
- astrocytoma (2)
- biomarker (2)
- biomarkers (2)
- blood pressure (2)
- blood-brain barrier (2)
- cerebral autoregulation (2)
- chronic cerebrovascular disease (2)
- colony-stimulating factor (2)
- contact-kinin system (2)
- generalized cerebral edema (2)
- immune cells (2)
- in vivo imaging (2)
- infarction (2)
- lymphocytes (2)
- mouse (2)
- neuroinflammation (2)
- neuroprotection (2)
- oxidative stress (2)
- platelets (2)
- predictive value (2)
- reversible posterior leukoencephalopathy syndrome (2)
- stroke (2)
- therapy (2)
- von Willebrand factor (2)
- 2 PM (1)
- Alemtuzumab (1)
- Alzheimer’s disease (1)
- Arterial water (1)
- Brain (1)
- C1-inhibitor (1)
- CD52 (1)
- CNS (1)
- COU254 (1)
- CSVD (1)
- Cardiac dysfunction| Brain natriuretic peptide (1)
- Cerebral small vessel disease (1)
- Cerebral-ischemia (1)
- Coefficient (1)
- Crespi effect (1)
- Cryolesion (1)
- ERK1/2 (1)
- Experimental brain trauma (1)
- Experimental stroke (1)
- FTY720 (1)
- FTY720-P (1)
- FXII (1)
- FXIIa inhibitor rHA-Infestin (1)
- Glatiramer acetate (1)
- Head-injury (1)
- Heart failure (1)
- Hemodynamic depression (1)
- IBA-1 (1)
- IDH (1)
- IL-15 (1)
- IntelliCage (1)
- Intravascular coagulation (1)
- Intravital imaging (1)
- Ischemia (1)
- Kaliumkanal (1)
- MGMT (1)
- MIC ligands (1)
- MRI (1)
- Magnetic-resonance (1)
- Maus (1)
- Model (1)
- Molecular-weight heparin (1)
- NADPH oxidase inhibitors (1)
- NADPH oxidases (NOX) (1)
- NKG2D (1)
- NKG2D ligands (1)
- NMO-IGG (1)
- NMR-Tomographie (1)
- Neurodegeneration (1)
- Neurologie (1)
- PCDHGC3 (1)
- PET (1)
- Perfusion (1)
- R-715 (1)
- RKIP (1)
- Rats (1)
- STAIR (1)
- Secondary traumatic brain damage (1)
- Sphingosine 1-Phosphate (1)
- Stim (1)
- T cell activation (1)
- TBI (1)
- TLO (1)
- TNF-α (1)
- TSPO (1)
- Thrombus (1)
- Thrombus formation (1)
- Troponin (1)
- Vasodilatator-stimuliertes Phosphoprotein (1)
- Vasodilator-Stimulated Phosphoprotein (1)
- Von-Willebrand-factor (1)
- WNT signaling (1)
- Wissenschaftlicher Nachwuchs (1)
- Zonula Occludens-1 (1)
- accuracy (1)
- acute management of stroke (1)
- acute neurology (1)
- acute stroke imaging (1)
- acute stroke management (1)
- acute stroke outcome (1)
- adherence (1)
- alias pilot trial (1)
- animal model (1)
- anti-aquaporin-4 antibody (1)
- antibodies (1)
- anticoagulants (1)
- aquaporin-4 autoantibodies (1)
- astrocyte (1)
- astrocytes (1)
- astrogliosis (1)
- atherosclerosis (1)
- atrial fibrillation (1)
- autoimmunity (1)
- autoradiography (1)
- blood (1)
- blood coagulability (1)
- blood coagulation (1)
- bradykinin (1)
- brain (1)
- brain edema (1)
- cancer stem cells (1)
- cardiovascular disease (1)
- celiac disease (1)
- cerebral inflammation (1)
- cerebral ischemia (1)
- cerebral small vessel disease (1)
- cerebrospinal-fluid (1)
- cerebrovascular diseases (1)
- chronic kidney disease (1)
- coagulation (1)
- coagulation factor XIIa (1)
- contact activation system (1)
- cortical pathology (1)
- cutting edge (1)
- damage cool aid (1)
- darbepoetin alpha (1)
- demography (1)
- dendric cells (1)
- developmental signaling (1)
- diabetes mellitus (1)
- diffuse (1)
- dimethyl fumarate (1)
- disability (1)
- disease (1)
- disease-modifying therapy (1)
- echocardiography (1)
- edema (1)
- efficacy (1)
- ejection fraction (1)
- emulsions (1)
- endothelial cells (1)
- endothelin-1 (1)
- experimental autoimmune encephalomyelitis (1)
- experimental stroke (1)
- extensiv transverse myelitis (1)
- factor XI (1)
- feasibility (1)
- fingolimod (1)
- fluorine (1)
- focal (1)
- focal brain lesion (1)
- focal cerebral ischemia (1)
- focal cerebral-ischemia (1)
- free radical scavenger (1)
- glioblastoma (1)
- glioblastoma multiforme (1)
- glioma (1)
- glycoprotein Ib (1)
- glycoprotein receptor Ib (1)
- guidelines (1)
- heart failure (1)
- hematopoietic (1)
- histology (1)
- human muscle-cells (1)
- hypercholesterolemia (1)
- idiopathic inflammatory myopathies (1)
- immune-response (1)
- immunoglobulin-G (1)
- immunohistochemistry (1)
- in-vivo (1)
- increased risk (1)
- injection site reactions; (1)
- interleukin-1 receptor antagonist (1)
- intractable hiccup (1)
- intravenous thrombolysis (1)
- ischemia (1)
- ischemic cascade (1)
- kallikrein–kinin system (1)
- kinin receptor (1)
- kinin receptors (1)
- lesions (1)
- leukocytes (1)
- lymphokine-activated killer (1)
- mRNA (1)
- macrophages (1)
- magnetic resonance imaging (1)
- matrix metalloproteinases (1)
- mechanical thrombectomy (1)
- mechanisms (1)
- meninges (1)
- mice (1)
- mice impact (1)
- microglia (1)
- microsphere/macrosphere (1)
- middle cerebral artery occlusion (1)
- mitochondria (1)
- monocytes (1)
- mouse model (1)
- myasthenia gravis (1)
- myeloid (1)
- natural history (1)
- natural killer cells (1)
- neurobehavioural deficits (1)
- neuroimmunology (1)
- neurons (1)
- neurorepair (1)
- non-VKA oral anticoagulants (1)
- novo renal transplantation (1)
- object recognition memory (1)
- occlusion (1)
- pathology section (1)
- permanent and transient middle cerebral artery occlusion (1)
- pharmacology (1)
- photothrombosis (1)
- placebo-controlled (1)
- point-of-care echocardiography (1)
- polymorphisms inflammation (1)
- polymyositis (1)
- prefrontal cortex (1)
- prevention (1)
- progenitor (1)
- protein (1)
- quality of life (1)
- randomized controlled trial (1)
- rat (1)
- rat brain microvascular endothelial cell culture (1)
- receptor (1)
- recurrence (1)
- regulatory T cells (1)
- relapsing multiple sclerosis (1)
- relapsing-remitting multiple sclerosis (1)
- scale (1)
- search filter (1)
- sex addiction (1)
- small vessel disease (1)
- stress (1)
- stroke therapy (1)
- stroke unit (1)
- subcutaneous injection (1)
- systems biology (1)
- systolic dysfunction (1)
- tMCAO (1)
- temozolomide (1)
- thrombo-inflammation (1)
- thromboembolic clot model (1)
- thromboembolic stroke (1)
- thromboinflammation (1)
- thrombosis (1)
- thrombus formation (1)
- tight junctions (1)
- tissue-plasminogen activator (1)
- transient ischemic attack (1)
- transient middle cerebral artery (1)
- transient middle cerebral artery occlusion (1)
- transient middle cerebral artery occlusion model (1)
- translation (1)
- translational research (1)
- translational stroke research (1)
- troponin (1)
- tumor immunity (1)
- vascular dementia (1)
- vascular permeability (1)
- vitamin K antagonists (1)
- warfarin (1)
- weight drop (1)
- β-APP (1)
Institute
- Neurologische Klinik und Poliklinik (61)
- Neurochirurgische Klinik und Poliklinik (12)
- Institut für Anatomie und Zellbiologie (9)
- Institut für Klinische Epidemiologie und Biometrie (6)
- Rudolf-Virchow-Zentrum (5)
- Medizinische Klinik und Poliklinik I (4)
- Deutsches Zentrum für Herzinsuffizienz (DZHI) (3)
- Abteilung für Molekulare Innere Medizin (in der Medizinischen Klinik und Poliklinik II) (2)
- Institut für Experimentelle Biomedizin (2)
- Pathologisches Institut (2)
Background: Animal models have implicated an integral role for coagulation factors XI (FXI) and XII (FXII) in thrombus formation and propagation of ischemic stroke (IS). However, it is unknown if these molecules contribute to IS pathophysiology in humans, and might be of use as biomarkers for IS risk and severity. This study aimed to identify predictors of altered FXI and FXII levels and to determine whether there are differences in the levels of these coagulation factors between acute cerebrovascular events and chronic cerebrovascular disease (CCD). Methods: In this case-control study, 116 patients with acute ischemic stroke (AIS) or transitory ischemic attack (TIA), 117 patients with CCD, and 104 healthy volunteers (HVs) were enrolled between 2010 and 2013 at our University hospital. Blood sampling was undertaken once in the CCD and HV groups and on days 0, 1, and 3 after stroke onset in patients with AIS or TIA. Correlations between serum FXI and FXII levels and demographic and clinical parameters were tested by linear regression and analysis of variance. Results: The mean age of AIS/TIA patients was 70 ± 12. Baseline clinical severity measured with NIHSS and Barthel Index was 4.8 ± 6.0 and 74 ± 30, respectively. More than half of the patients had an AIS (58%). FXI levels were significantly correlated with different leukocyte subsets (p < 0.05). In contrast, FXII serum levels showed no significant correlation (p > 0.1). Neither FXI nor FXII levels correlated with CRP (p > 0.2). FXII levels were significantly higher in patients with CCD compared with those with AIS/TIA (mean ± SD 106 ± 26% vs. 97 ± 24%; univariate analysis: p < 0.05); these differences did not reach significance in multivariate analysis adjusted for sex and age. FXI levels did not differ significantly between study groups. Sex and age were significantly associated with FXI and/or FXII levels in patients with AIS/TIA (p < 0.05). In contrast, no statistical significant influence was found for treatment modality (thrombolysis or not), pre-treatment with platelet inhibitors, and severity of stroke. Conclusions: In this study, there was no differential regulation of FXI and FXII levels between disease subtypes but biomarker levels were associated with patient and clinical characteristics. FXI and FXII levels might be no valid biomarker for predicting stroke risk.