Refine
Has Fulltext
- yes (37)
Is part of the Bibliography
- yes (37)
Year of publication
Document Type
- Journal article (37)
Language
- English (37)
Keywords
- melanoma (4)
- Biologie (3)
- gene expression (3)
- NRF2 (2)
- RCC (2)
- T cells (2)
- biomarker (2)
- evolutionary genetics (2)
- gene regulation (2)
- meiosis (2)
- microRNA (2)
- oncogenes (2)
- prostate cancer (2)
- retinoic acid (2)
- AP-1 (1)
- ATF4 (1)
- Apoptosis (1)
- Axonal degeneration (1)
- B cell receptors (1)
- B-MYB (1)
- Biomarker (1)
- Bone morphogenetic protein-2 (1)
- COX2 expression (1)
- CYR61 (1)
- Cancer (1)
- Cancer Cell (1)
- Central nervous system (1)
- Co-option (1)
- DNA methylation (1)
- DNA transcription (1)
- Diabetic polyneuropathy (1)
- Dopamine (1)
- Drosophila melanogaster (1)
- Fgf-signalling (1)
- Genome (1)
- Genomics (1)
- Hypothalamus (1)
- Jmjd6 (1)
- Kidney cancer (1)
- Krebs (1)
- LASP1 (1)
- Mechanisms (1)
- Medizin (1)
- MircoRNA (1)
- Motor nerve biopsy (1)
- Myb-MuvB (1)
- Myofibroblast differentiation (1)
- Neuropathy (1)
- Neurotrophic factors (1)
- PSMA (1)
- Profiling (1)
- Prognosis (1)
- Proliferation (1)
- RNA extraction (1)
- RNA-Seq (1)
- RNA-seq transcriptome (1)
- Receptor (1)
- Renal cell carcinoma (1)
- Serotonin (1)
- Smooth-muscle-cells (1)
- Sunitinib (1)
- T cell receptors (1)
- TCR signaling cascade (1)
- TGF-beta (1)
- Tumour markers (1)
- Tyrosine kinase inhibition (1)
- Wilms tumor (1)
- Xiphophorus (1)
- YAP (1)
- achiasmatic (1)
- agrobacterium tumefaciens (1)
- alternative splicing (1)
- angiogenesis (1)
- arabidopsis thaliana (1)
- aspergillus fumigatus (1)
- beetle horns (1)
- bioinformatics (1)
- biomarkers (1)
- breast cancer (1)
- c-Fos (1)
- cancer genomics (1)
- cancer models (1)
- cardiac aging (1)
- cardiac fibrosis (1)
- cell cycle and cell division (1)
- cell differentiation (1)
- cell proliferation (1)
- cholera (1)
- comparative genomics (1)
- crossing-over (1)
- cytokines (1)
- denritic cells (1)
- energy homeostasis (1)
- enhancer (1)
- experimental evolution (1)
- expression analysis (1)
- extracellular matrix (1)
- fish model (1)
- fishes Xiphophorus (1)
- forecasting (1)
- gametogenesis (1)
- gene prediction (1)
- gene targeting (1)
- genetic markers (1)
- genome (1)
- genome annotation (1)
- genome evolution (1)
- genomics (1)
- genus Xiphophorus (1)
- gonopodium (1)
- high-risk Prostate Cancer (1)
- high-risk prostate cancer (1)
- human genomics (1)
- hybrid origin (1)
- immune evasion (1)
- immune receptors (1)
- immune response (1)
- key innovation (1)
- kidney cancer (1)
- kidneys (1)
- long-term outcome (1)
- luciferase (1)
- male-specific traits (1)
- malignant tumors (1)
- matrix metalloproteinases (1)
- measles virus (1)
- medaka (1)
- melanoma malignancy (1)
- metastasis (1)
- metastasis-directed therapy (1)
- miR (1)
- miR-126 (1)
- miR-146a (1)
- miR-193a (1)
- miR-205 (1)
- miR-21 (1)
- miR-22 (1)
- miRNA (1)
- microRNA-221 (1)
- microRNAs (1)
- microarrays (1)
- mimecan (1)
- mitotic genes (1)
- mouse testis differentiation (1)
- nephroblastoma (1)
- oligorecurrence (1)
- oogenesis (1)
- osteoglycin (1)
- parthenogenesis (1)
- phenotypic screening (1)
- piRNA (1)
- plant genomics (1)
- preexisting bias (1)
- primary tumor cell culture (1)
- prognosis (1)
- ras (1)
- recombination (1)
- regression analysis (1)
- regulatory T cells (1)
- renal cancer (1)
- renal cell carcinoma (1)
- retrotransposons (1)
- reverse transcriptase-polymerase chain reaction (1)
- rheumatic diseases (1)
- rheumatology (1)
- risk stratification (1)
- salvage radiotherapy (1)
- sequence motif analysis (1)
- sex combs (1)
- sex determination (1)
- small RNA-sequencing (1)
- small interfering RNAs (1)
- surgical and invasive medical procedures (1)
- surgical oncology (1)
- swordtails (1)
- synaptonemal complex (1)
- thiol starvation (1)
- toxins (1)
- transcription (1)
- transcriptome (1)
- transposable elements (1)
- tumor model (1)
- venous infiltration (1)
- whole-genome sequencing (1)
- zebrafish (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (37) (remove)
Sonstige beteiligte Institutionen
- IZKF (Interdisziplinäres Zentrum für Klinische Forschung), Universität Würzburg (1)
- IZKF Laboratory for Microarray Applications, University Hospital of Wuerzburg, Wuerzburg, Germany (1)
- Microarray Core Unit, Interdisciplinary Center for Clinical Science, University of Würzburg, Versbacher Straße, Würzburg 97080, Germany (1)
Periodontal treatment prevents arthritis in mice and methotrexate ameliorates periodontal bone loss
(2019)
Recent studies indicate a causal relationship between the periodontal pathogen P. gingivalis and rheumatoid arthritis involving the production of autoantibodies against citrullinated peptides. We therefore postulated that therapeutic eradication P. gingivalis may ameliorate rheumatoid arthritis development and here turned to a mouse model in order to challenge our hypothesis. F1 (DBA/1 x B10.Q) mice were orally inoculated with P. gingivalis before collagen-induced arthritis was provoked. Chlorhexidine or metronidazole were orally administered either before or during the induction phase of arthritis and their effects on arthritis progression and alveolar bone loss were compared to intraperitoneally injected methotrexate. Arthritis incidence and severity were macroscopically scored and alveolar bone loss was evaluated via microcomputed tomography. Serum antibody titres against P. gingivalis were quantified by ELISA and microbial dysbiosis following oral inoculation was monitored in stool samples via microbiome analyses. Both, oral chlorhexidine and metronidazole reduced the incidence and ameliorated the severity of collagen-induced arthritis comparable to methotrexate. Likewise, all three therapies attenuated alveolar bone loss. Relative abundance of Porphyromonadaceae was increased after oral inoculation with P. gingivalis and decreased after treatment. This is the first study to describe beneficial effects of non-surgical periodontal treatment on collagen-induced arthritis in mice and suggests that mouthwash with chlorhexidine or metronidazole may also be beneficial for patients with rheumatoid arthritis and a coexisting periodontitis. Methotrexate ameliorated periodontitis in mice, further raising the possibility that methotrexate may also positively impact on the tooth supporting tissues of patients with rheumatoid arthritis.