Refine
Has Fulltext
- yes (42) (remove)
Is part of the Bibliography
- yes (42)
Year of publication
Document Type
- Journal article (42)
Language
- English (42)
Keywords
- gene expression (5)
- melanoma (4)
- Biologie (3)
- Medizin (3)
- prostate cancer (3)
- NRF2 (2)
- RCC (2)
- T cells (2)
- biomarker (2)
- gene regulation (2)
- meiosis (2)
- microRNA (2)
- oncogenes (2)
- retinoic acid (2)
- AP-1 (1)
- ATF4 (1)
- Acute tryptophan depletion (1)
- Anxiety-like behavior (1)
- Apoptosis (1)
- Axonal degeneration (1)
- B cell receptors (1)
- B-MYB (1)
- Biomarker (1)
- Bipolar disorder (1)
- Bone morphogenetic protein-2 (1)
- COX2 expression (1)
- CYR61 (1)
- Cancer (1)
- Cancer Cell (1)
- Central nervous system (1)
- Co-option (1)
- DNA methylation (1)
- DNA transcription (1)
- Dendritische Zelle (1)
- Diabetic polyneuropathy (1)
- Dopamine (1)
- Drosophila melanogaster (1)
- Fgf-signalling (1)
- Genome (1)
- Genomics (1)
- Hypothalamus (1)
- Insulin Degrading Enzyme (1)
- Interferon-alpha (1)
- Jmjd6 (1)
- Kidney cancer (1)
- Knock-out mice (1)
- Krebs (1)
- LASP1 (1)
- Long-term depression (1)
- MTCH2 (1)
- Major depression (1)
- Mechanisms (1)
- MircoRNA (1)
- Motor nerve biopsy (1)
- Myb-MuvB (1)
- Myofibroblast differentiation (1)
- Neuropathy (1)
- Neurotrophic factors (1)
- PSMA (1)
- Physiological functions (1)
- Profiling (1)
- Prognosis (1)
- Proliferation (1)
- RNA extraction (1)
- RNA-Seq (1)
- RNA-seq transcriptome (1)
- Receptor (1)
- Renal cell carcinoma (1)
- Restraint stress (1)
- Serotonin (1)
- Serotonin transporter polymorphism (1)
- Smooth-muscle-cells (1)
- Sunitinib (1)
- T cell receptors (1)
- TCR signaling cascade (1)
- TGF-beta (1)
- Tumour markers (1)
- Tyrosine kinase inhibition (1)
- Wilms tumor (1)
- Xiphophorus (1)
- YAP (1)
- YAP5SA (1)
- achiasmatic (1)
- adjuvant hormonal treatment (1)
- agrobacterium tumefaciens (1)
- alternative splicing (1)
- angiogenesis (1)
- apoptosis (1)
- arabidopsis thaliana (1)
- aspergillus fumigatus (1)
- beetle horns (1)
- biomarkers (1)
- breast cancer (1)
- c-Fos (1)
- cancer genomics (1)
- cancer models (1)
- cardiac aging (1)
- cardiac fibrosis (1)
- cell cycle (1)
- cell cycle and cell division (1)
- cell differentiation (1)
- cell migration (1)
- cell proliferation (1)
- cholera (1)
- chromatin (1)
- comparative genomics (1)
- crossing-over (1)
- cytokines (1)
- denritic cells (1)
- energy homeostasis (1)
- enhancer (1)
- evolutionary genetics (1)
- expression analysis (1)
- extracellular matrix (1)
- fish model (1)
- fishes Xiphophorus (1)
- forecasting (1)
- gametogenesis (1)
- gene prediction (1)
- gene targeting (1)
- genetic markers (1)
- genome (1)
- genome annotation (1)
- genomics (1)
- genus Xiphophorus (1)
- gonopodium (1)
- high-risk Prostate Cancer (1)
- high-risk prostate cancer (1)
- human genomics (1)
- hybrid origin (1)
- immune evasion (1)
- immune receptors (1)
- immune response (1)
- key innovation (1)
- kidney cancer (1)
- kidneys (1)
- long-term outcome (1)
- luciferase (1)
- male-specific traits (1)
- malignant tumors (1)
- matrix metalloproteinases (1)
- measles virus (1)
- medaka (1)
- melanoma malignancy (1)
- metastasis (1)
- metastasis-directed therapy (1)
- miR (1)
- miR-126 (1)
- miR-146a (1)
- miR-193a (1)
- miR-205 (1)
- miR-21 (1)
- miR-22 (1)
- miRNA (1)
- microRNA-221 (1)
- microRNAs (1)
- microarrays (1)
- mimecan (1)
- mitotic genes (1)
- mouse testis differentiation (1)
- myasthenia gravis (1)
- nephroblastoma (1)
- oligorecurrence (1)
- oncogenic YAP (1)
- oogenesis (1)
- osteoglycin (1)
- parthenogenesis (1)
- piRNA (1)
- plant genomics (1)
- preexisting bias (1)
- primary tumor cell culture (1)
- prognosis (1)
- ras (1)
- recombination (1)
- regression analysis (1)
- regulatory T cells (1)
- renal cancer (1)
- renal cell carcinoma (1)
- retrotransposons (1)
- reverse transcriptase-polymerase chain reaction (1)
- risk stratification (1)
- salvage radiotherapy (1)
- sequence motif analysis (1)
- sex combs (1)
- sex determination (1)
- small RNA-sequencing (1)
- small interfering RNAs (1)
- surgical and invasive medical procedures (1)
- surgical oncology (1)
- swordtails (1)
- synaptonemal complex (1)
- targeted (1)
- thiol starvation (1)
- thymic carcinoma (1)
- thymoma (1)
- thymus (1)
- toxins (1)
- transcription (1)
- transcriptome (1)
- transposable elements (1)
- tumor model (1)
- venous infiltration (1)
- whole-genome sequencing (1)
- zebrafish (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (34)
- Urologische Klinik und Poliklinik (8)
- Pathologisches Institut (6)
- Comprehensive Cancer Center Mainfranken (4)
- Institut für Virologie und Immunbiologie (3)
- Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie (3)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (3)
- Medizinische Klinik und Poliklinik II (3)
- Rudolf-Virchow-Zentrum (3)
- Julius-von-Sachs-Institut für Biowissenschaften (2)
- Abteilung für Molekulare Innere Medizin (in der Medizinischen Klinik und Poliklinik II) (1)
- Augenklinik und Poliklinik (1)
- Deutsches Zentrum für Herzinsuffizienz (DZHI) (1)
- Frauenklinik und Poliklinik (1)
- Institut für Experimentelle Biomedizin (1)
- Institut für Klinische Biochemie und Pathobiochemie (1)
- Institut für Physikalische und Theoretische Chemie (1)
- Klinik und Poliklinik für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie (1)
- Klinik und Poliklinik für Nuklearmedizin (1)
- Klinik und Poliklinik für Strahlentherapie (1)
- Lehrstuhl für Biochemie (1)
- Lehrstuhl für Molekulare Psychiatrie (1)
- Lehrstuhl für Tissue Engineering und Regenerative Medizin (1)
- Neurologische Klinik und Poliklinik (1)
- Physiologisches Institut (1)
Sonstige beteiligte Institutionen
- IZKF (Interdisziplinäres Zentrum für Klinische Forschung), Universität Würzburg (1)
- IZKF Laboratory for Microarray Applications, University Hospital of Wuerzburg, Wuerzburg, Germany (1)
- Microarray Core Unit, Interdisciplinary Center for Clinical Science, University of Würzburg, Versbacher Straße, Würzburg 97080, Germany (1)
Prenatal stress (PS) has been shown to influence the development of the fetal brain and to increase the risk for the development of psychiatric disorders in later life. Furthermore, the variation of human serotonin transporter (5-HTT, SLC6A4) gene was suggested to exert a modulating effect on the association between early life stress and the risk for depression. In the present study, we used a 5-Htt6PS paradigm to investigate whether the effects of PS are dependent on the 5-Htt genotype. For this purpose, the effects of PS on cognition, anxiety- and depression-related behavior were examined using a maternal restraint stress paradigm of PS in C57BL6 wild-type (WT) and heterozygous 5-Htt deficient (5-Htt +/2) mice. Additionally, in female offspring, a genome-wide hippocampal gene expression profiling was performed using the Affymetrix GeneChipH Mouse Genome 430 2.0 Array. 5-Htt +/2 offspring showed enhanced memory performance and signs of reduced anxiety as compared to WT offspring. In contrast, exposure of 5-Htt +/2 mice to PS was associated with increased depressive-like behavior, an effect that tended to be more pronounced in female offspring. Further, 5-Htt genotype, PS and their interaction differentially affected the expression of numerous genes and related pathways within the female hippocampus. Specifically, MAPK and neurotrophin signaling were regulated by both the 5-Htt +/2 genotype and PS exposure, whereas cytokine and Wnt signaling were affected in a 5-Htt genotype6PS manner, indicating a gene6environment interaction at the molecular level. In conclusion, our data suggest that although the 5-Htt +/2 genotype shows clear adaptive capacity, 5-Htt +/2 mice –particularly females– at the same time appear to be more vulnerable to developmental stress exposure when compared to WT offspring. Moreover, hippocampal gene expression profiles suggest that distinct molecular mechanisms mediate the behavioral effects of the 5-Htt genotype, PS exposure, and their interaction.