Refine
Has Fulltext
- yes (19)
Is part of the Bibliography
- yes (19)
Year of publication
Document Type
- Journal article (19)
Language
- English (19)
Keywords
- virtual reality (5)
- immersion (3)
- presence (3)
- EMG (2)
- Emotional processing (2)
- Psychologie (2)
- anxiety (2)
- emotional regulation (2)
- fMRI (2)
- fNIRS (2)
- facial expression (2)
- fear (2)
- fear conditioning (2)
- fear-potentiated startle (2)
- mimicry (2)
- perception (2)
- 5HTTLPR (1)
- Agoraphobia (1)
- Animal models (1)
- Anxiety sensitivity (1)
- Aviophobia (1)
- Avoidance behavior (1)
- BDNF (1)
- COMT VAL(158)MET polymorphism (1)
- Diaphragmatic breathing (1)
- Experimental study (1)
- Exposure therapy (1)
- NPSR1 (1)
- Openfield test (1)
- Thigmotaxis (1)
- Virtual reality (1)
- acoustic startle (1)
- acrophobia (1)
- addiction (1)
- amygdala (1)
- anxiety disorders (1)
- arousal (1)
- attention deficit/hyperactivity disorder (ADHD) (1)
- backward conditioning (1)
- behavior (1)
- brain derived neurotrophic factor (1)
- caffeine-induced anxiety (1)
- caudate (1)
- caudate nucleus (1)
- community sample (1)
- competition (1)
- context (1)
- contextual fear (1)
- contextual fear conditioning (1)
- cooperation (1)
- cue availability (1)
- cue exposure therapy (1)
- cue reactivity (1)
- cultural differences (1)
- delay conditioning (1)
- dopamine transporter (DAT) (1)
- dorsolateral prefrontal cortex (1)
- emotion (1)
- emotional empathy (1)
- emotional pictures (1)
- environments (1)
- event-related FMRI (1)
- exposure therapy (1)
- expressive displays (1)
- extinction (1)
- fear behavior (1)
- fear memory consolidation (1)
- flight phobics (1)
- forward conditioning (1)
- gender differences (1)
- gene × gene interaction (1)
- genetics memory (1)
- implicit and explicit responses (1)
- life events (1)
- medial prefrontal cortex (1)
- methylphenidate (1)
- mirrorneuronsystem (1)
- mood (1)
- nonconscious mimicry (1)
- orbifrontal cortex (1)
- pain relief (1)
- panic disorder (1)
- political leaders (1)
- posttraumatic-stress-disorder (1)
- prefrontal cortex (1)
- prepulse inhibition (1)
- presence questionnaire (1)
- public speaking (1)
- reconsolidation (1)
- responses (1)
- responsivity (1)
- self-focused attention (1)
- self-reference (1)
- serotonin transporter gene (1)
- single photon emission computed tomography (SPECT) (1)
- smoking (1)
- social anxiety (1)
- social context (1)
- social phobia (1)
- specific phobia (1)
- speech anxiety (1)
- spider phobia (1)
- striatum (1)
- substance use disorders (1)
- threat unpredictability (1)
- trace conditioning (1)
- transcranial direct current stimulation (1)
- valence (1)
Background:
Memory reconsolidation is the direct effect of memory reactivation followed by stabilization of newly synthesized proteins. It has been well proven that neural encoding of both newly and reactivated memories requires synaptic plasticity. Brain derived neurotrophic factor (BDNF) has been extensively investigated regarding its role in the formation of synaptic plasticity and in the alteration of fear memories. However, its role in fear reconsolidation is still unclear; hence, the current study has been designed to investigate the role of the BDNF val66met polymorphism (rs6265) in fear memory reconsolidation in humans.
Methods:
An auditory fear-conditioning paradigm was conducted, which comprised of three stages (acquisition, reactivation, and spontaneous recovery). One day after fear acquisition, the experimental group underwent reactivation of fear memory followed by the extinction training (reminder group), whereas the control group (non-reminder group) underwent only extinction training. On day 3, both groups were subjected to spontaneous recovery of earlier learned fearful memories. The treat-elicited defensive response due to conditioned threat was measured by assessing the skin conductance response to the conditioned stimulus. All participants were genotyped for rs6265.
Results:
The results indicate a diminishing effect of reminder on the persistence of fear memory only in the Met-allele carriers, suggesting a moderating effect of the BDNF polymorphism in fear memory reconsolidation.
Conclusions:
Our findings suggest a new role for BDNF gene variation in fear memory reconsolidation in humans.