Refine
Has Fulltext
- yes (18)
Is part of the Bibliography
- yes (18)
Document Type
- Journal article (18)
Language
- English (18)
Keywords
- melanoma (5)
- BRAF (2)
- PD-1 (2)
- angiogenesis (2)
- immunohistochemistry (2)
- machine learning (2)
- B7-H1 Antigen (1)
- BARF-mutated melanoma (1)
- BRAF mutation (1)
- COVID-19 (1)
- COX2 expression (1)
- CTLA-4 Antigen (1)
- Cancer Cell (1)
- Cx43 (1)
- Drug Therapy, Combination (1)
- Immune-related adverse event (1)
- Ipilimumab (1)
- Kaposi sarcoma (1)
- Merkel cell carcinoma (1)
- Minimal change disease (1)
- NRF2 (1)
- Nivolumab (1)
- PD‐L1 (1)
- PRAME (1)
- Programmed Cell Death 1 Receptor (1)
- Raman (1)
- SARS-CoV-2 (1)
- SERS (1)
- Skin Neoplasms (1)
- Sunitinib (1)
- Tyrosine kinase inhibition (1)
- adjuvant treatment (1)
- at-home sampling (1)
- avelumab (1)
- biomarker (1)
- checkpoint blocker (1)
- combined targeted therapy (1)
- cutaneous angiosarcoma (1)
- dabrafenib (1)
- drug monitoring (1)
- eosinophils (1)
- gold nanoparticles (1)
- hemangioma (1)
- high-risk Prostate Cancer (1)
- hydroxy-dabrafenib (1)
- immune checkpoint blockade (1)
- immune infiltration (1)
- immunology (1)
- ipilimumab (1)
- kidney cancer (1)
- lactate dehydrogenase (1)
- mRNA (1)
- mTOR (1)
- melanocytic markers (1)
- melanoma malignancy (1)
- miRNA (1)
- microRNA-221 (1)
- mitochondrial DNA (1)
- mtDNA (1)
- nivolumab (1)
- pan-RCC (1)
- population pharmacokinetics (1)
- programmed cell death receptor-1 (1)
- resistance (1)
- rhabdoid differentiation (1)
- rhabdoid melanoma (1)
- targeted therapy (1)
- therapy (1)
- trametinib (1)
- transcriptome (1)
- tumor microenvironment (1)
- volumetric absorptive micro-sampling (VAMS) (1)
Institute
- Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie (18)
- Urologische Klinik und Poliklinik (4)
- Medizinische Klinik und Poliklinik II (3)
- Pathologisches Institut (3)
- Theodor-Boveri-Institut für Biowissenschaften (3)
- Center for Computational and Theoretical Biology (2)
- Medizinische Klinik und Poliklinik I (2)
- Comprehensive Cancer Center Mainfranken (1)
- Institut für Pharmazie und Lebensmittelchemie (1)
- Institut für diagnostische und interventionelle Neuroradiologie (ehem. Abteilung für Neuroradiologie) (1)
Sonstige beteiligte Institutionen
Background
Gap junctions consisting of connexins (Cx) are fundamental in controlling cell proliferation, differentiation, and cell death. Cx43 is the most broadly expressed Cx in humans and is attributed an important role in skin tumor development. Its role in cutaneous vascular neoplasms is yet unknown.
Methods
Fifteen cases each of cutaneous angiosarcoma (cAS), Kaposi sarcoma (KS), and cherry hemangioma (CH) were assessed by immunohistochemistry for expression of Cx43. Expression pattern, intensity, and percentage of positively stained cells were analyzed. Solid basal cell carcinomas served as positive and healthy skin as negative controls.
Results
Most cases of cAS presented with a strong Cx43 staining of almost all tumor cells, whereas endothelia of KS showed medium expression and CH showed mostly weak expression. In comparison with KS or cAS, the staining intensity of CH was significantly lower (P ≤ 0.001). All tissue sections of both cAS and KS were characterized by a mostly diffuse, cytoplasmic staining pattern of the vascular endothelia. None of those showed nuclear staining.
Conclusion
The high-to-intermediate expression of Cx43 observed in all cases of cAS and KS suggests that this Cx may play a role in the development of malignant vascular neoplasms and serve as a helpful diagnostic marker.