Refine
Has Fulltext
- yes (82)
Is part of the Bibliography
- yes (82)
Year of publication
Document Type
- Journal article (82) (remove)
Language
- English (82)
Keywords
- Neurobiologie (38)
- Medizin (10)
- Durchblutung (5)
- Gehirn (5)
- rats (5)
- active zone (4)
- traumatic brain injury (4)
- Hypothalamus (3)
- Prostaglandine (3)
- TRH (3)
Institute
- Neurochirurgische Klinik und Poliklinik (77)
- Neurologische Klinik und Poliklinik (9)
- Physiologisches Institut (9)
- Klinik und Poliklinik für Unfall-, Hand-, Plastische und Wiederherstellungschirurgie (Chirurgische Klinik II) (4)
- Center for Computational and Theoretical Biology (3)
- Theodor-Boveri-Institut für Biowissenschaften (3)
- Institut für Medizinische Strahlenkunde und Zellforschung (2)
- Kinderklinik und Poliklinik (2)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (2)
- Rudolf-Virchow-Zentrum (2)
The amounts of tissue factor (TF) expressed by brain microvascular endothelial cells (BMECs) from normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were compared after stimulating the cells with different doses of lipopolysaccharide (LPS), thrombin, phorbol myristic acid (PMA), Ca\(^{2+}\)·ionophore (A23187), or tumor necrosis factor (TNF) and interleukin·l (IL.l). Treatment ofcultured BMECs fron. WKY and SHR with all of these factors dose·dependently increased their total amount of TF; no substantive differences in the Ieveis of enhanced TF expression were observed between WKY and SHR BMECs. We conclude that stimulated endothelium from rats with hypertension, a major stroke risk factor, is not hyperresponsive with respect to TF expression when compared to normotensive controls.