Refine
Has Fulltext
- yes (27)
Is part of the Bibliography
- yes (27)
Year of publication
Document Type
- Journal article (27)
Language
- English (27)
Keywords
- T cells (4)
- GvHD (2)
- Multiple myeloma (2)
- alloreactive T cells (2)
- cancer (2)
- immune cells (2)
- mouse models (2)
- regulatory T cells (2)
- Activation (1)
- Allogeneic stem cell transplantation (1)
Institute
- Medizinische Klinik und Poliklinik II (25)
- Pathologisches Institut (7)
- Institut für Virologie und Immunbiologie (6)
- Abteilung für Molekulare Innere Medizin (in der Medizinischen Klinik und Poliklinik II) (5)
- Kinderklinik und Poliklinik (5)
- Graduate School of Life Sciences (4)
- Theodor-Boveri-Institut für Biowissenschaften (4)
- Rudolf-Virchow-Zentrum (3)
- Neurochirurgische Klinik und Poliklinik (2)
- Abteilung für Funktionswerkstoffe der Medizin und der Zahnheilkunde (1)
Sonstige beteiligte Institutionen
EU-Project number / Contract (GA) number
- 825575 (1)
Background
Medulloblastoma is the most common malignant brain tumor in children and can be divided in different molecular subgroups. Patients whose tumor is classified as a Group 3 tumor have a dismal prognosis. However only very few tumor models are available for this subgroup.
Methods
We established a robust orthotopic xenograft model with a cell line derived from the malignant pleural effusions of a child suffering from a Group 3 medulloblastoma.
Results
Besides classical characteristics of this tumor subgroup, the cells display cancer stem cell characteristics including neurosphere formation, multilineage differentiation, CD133/CD15 expression, high ALDH-activity and high tumorigenicity in immunocompromised mice with xenografts exactly recapitulating the original tumor architecture.
Conclusions
This model using unmanipulated, human medulloblastoma cells will enable translational research, specifically focused on Group 3 medulloblastoma.