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Acetogenic Isoquinoline Alkaloids. XXIII. Structure of the Naphthyl Isoquinoline Alkaloid Dioncophylline A (1991)
Bringmann, Gerhard ; Zagst, Rainer ; Schöner, Bernd ; Busse, Holger ; Hemmerling, Martin ; Burschka, Christian
No abstract available
Structure and dynamics of free and metallated benzonaphthopyranones and -pyrans (1992)
Burschka, Christian ; Bringmann, Gerhard ; Busse, Holger ; Guessregen, Stefan ; Schoener, Bernd ; Zagst, Rainer
First calculations of the structures of metal-free and complexed biaryl lactones and their confrrmation by X-ray crystaIlography, the search for the transition states of their heIimerization processes, and the spectroscopic determination of the heIimerization barriers of related cyclic ethers by DNMR are reported.
Novel concepts in directed biaryl synthesis, IX: Synthesis and structure of benzonaphthopyranones, useful bridged model precursors for stereoselective biaryl syntheses (1992)
Bringmann, Gerhard ; Hartung, Thomas ; Goebel, Lothar ; Schupp, Olaf ; Ewers, Christian L. J. ; Schoener, Bernd ; Zagst, Rainer ; Peters, Karl ; Von Schnering, Hans Georg ; Burschka, Christian
A practicable two-step procedure for the preparation of a series of lactone-type bridged biaryls 7 as favorable substrates for subsequent atropisomer-selective ring-opening reactions is described. Due to the efficiency of the coupling step, which tolerates even a telt·butyl group next to the biaryl axis and avoids problems of regioselectivity, a variety of differently substituted representatives is prepared. These cover a broad range of steric hindrance and thus molecular distortion. The structures are investigated mainly by NMR spectroscopy and X-ray diffraction, showing the lactones 7 to be helically distorted, depending on the size of the residues R.
Nature's Lab for Derivatization: New and Revised Structures of a Variety of Streptophenazines Produced by a Sponge-Derived Streptomyces Strain (2014)
Kunz, Anna Lena ; Labes, Antje ; Wiese, Jutta ; Bruhn, Torsten ; Bringmann, Gerhard ; Imhoff, Johannes F.
Eight streptophenazines (A-H) have been identified so far as products of Streptomyces strain HB202, which was isolated from the sponge Halichondria panicea from the Baltic Sea. The variation of bioactivities based on small structural changes initiated further studies on new derivatives. Three new streptophenazines (I-K) were identified after fermentation in the present study. In addition, revised molecular structures of streptophenazines C, D, F and H are proposed. Streptophenazines G and K exhibited moderate antibacterial activity against the facultative pathogenic bacterium Staphylococcus epidermidis and against Bacillus subtilis. All tested compounds (streptophenazines G, I-K) also showed moderate activities against PDE 4B.
New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities (2011)
Pimentel-Elardo, Sheila M. ; Buback, Verena ; Gulder, Tobias A. M. ; Bugni, Tim S. ; Reppart, Jason ; Bringmann, Gerhard ; Ireland, Chris M. ; Schirmeister, Tanja ; Hentschel, Ute
Four new tetromycin derivatives, tetromycins 1–4 and a previously known one, tetromycin B (5) were isolated from Streptomyces axinellae Pol001T cultivated from the Mediterranean sponge Axinella polypoides. Structures were assigned using extensive 1D and 2D NMR spectroscopy as well as HRESIMS analysis. The compounds were tested for antiparasitic activities against Leishmania major and Trypanosoma brucei, and for protease inhibition against several cysteine proteases such as falcipain, rhodesain, cathepsin L, cathepsin B, and viral proteases SARS-CoV Mpro, and PLpro. The compounds showed antiparasitic activities against T. brucei and time-dependent inhibition of cathepsin L-like proteases with Ki values in the low micromolar range.
Coherent two-dimensional electronic spectroscopy in the Soret band of a chiral porphyrin dimer (2013)
Brixner, Tobias ; Koch, Federico ; Kullmann, Martin ; Selig, Ulrike ; Nuernberger, Patrick ; Götz, Daniel C. G. ; Bringmann, Gerhard
Using coherent two-dimensional (2D) electronic spectroscopy in fully noncollinear geometry, we observe the excitonic coupling of β,β'-linked bis[tetraphenylporphyrinato-zinc(II)] on an ultrafast timescale in the excited state. The results for two states in the Soret band originating from an excitonic splitting are explained by population transfer with approximately 100 fs from the energetically higher to the lower excitonic state. This interpretation is consistent with exemplary calculations of 2D spectra for a model four-level system with coupling.
Preussianone, a New Flavanone-Chromone Biflavonoid from Garcinia preussii Engl. (2012)
Messi, Bernadette Biloa ; Ndjoko-Ioset, Karine ; Hertlein-Amslinger, Barbara ; Lannang, Alain Meli ; Nkengfack, Augustin E. ; Wolfender, Jean-Luc ; Hostettmann, Kurt ; Bringmann, Gerhard
A new flavanone-chromone biflavonoid, preussianone (1), has been isolated from the leaves of Garcinia preussii, along with four known biflavonoids. The absolute stereostructures were elucidated by chemical, spectroscopic, and chiroptical methods. The biological properties of the new biflavonoid against several bacterial strains were evaluated.
Decandrinin, an unprecedented \(C_9\)-spiro-fused 7,8-\( seco-ent\)-abietane from the Godavari mangrove \(Ceriops\ decandra\) (2014)
Wang, Hui ; Li, Min-Yi ; Katele, Félix Zongwe ; Satyanandamurty, Tirumani ; Wu, Jun ; Bringmann, Gerhard
Decandrinin (1), an unprecedented \(C_9\)-spiro-fused 7,8-\(seco-ent\)-abietane, was obtained from the bark of an Indian mangrove, \(Ceriops\ decandra\), collected in the estuary of Godavari, Andhra Pradesh. The constitution and the relative configuration of 1 were determined by HRMS (ESI) and extensive NMR investigations, and the absolute configuration by circular dichroism (CD) and optical-rotatory dispersion (ORD) spectroscopy in combination with quantum-chemical calculations. Decandrinin is the first 7,8-\(seco-ent\)-abietane.
Helicusin E, Isochromophilone X and Isochromophilone XI: New Chloroazaphilones Produced by the Fungus Bartalinia robillardoides Strain LF550 (2013)
Jansen, Nils ; Ohlendorf, Birgit ; Erhard, Arlette ; Bruhn, Torsten ; Bringmann, Gerhard ; Imhoff, Johannes F.
Microbial studies of the Mediterranean sponge Tethya aurantium led to the isolation of the fungus Bartalinia robillardoides strain LF550. The strain produced a number of secondary metabolites belonging to the chloroazaphilones. This is the first report on the isolation of chloroazaphilones of a fungal strain belonging to the genus Bartalinia. Besides some known compounds (helicusin A (1) and deacetylsclerotiorin (2)), three new chloroazaphilones (helicusin E (3); isochromophilone X (4) and isochromophilone XI (5)) and one new pentaketide (bartanolide (6)) were isolated. The structure elucidations were based on spectroscopic analyses. All isolated compounds revealed different biological activity spectra against a test panel of four bacteria: three fungi; two tumor cell lines and two enzymes.
+/- Dioncophyllacine A, a naphthylisoquinoline alkaloid with a 4-methoxy substituent from the leaves of Triphyophyllum peltatum (1992)
Bringmann, Gerhard ; Ortmann, Thomas ; Zagst, Rainer ; Schoener, Bernd ; Assi, Laurent Ake ; Burschka, Christian
The isolation and structure elucidation of rac-dioncophyllacine A from the leaves of Triphyophyllun peltatum, is described. Unlike all other naphthylisoquinoline alkaloids, this fully dehydrogenated representative has an additional methoxy group at C-4, the position of which is deduced from NOE results. Dioncophyllacine A has a 7,1' site of the biaryl axis, as in dioncophylline A. Its constitution is confirmed by an X-ray structure analysis, which shows that the crystalline form of this new alkaloid is racemic.
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