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  • yes (3)

Is part of the Bibliography

  • yes (3)

Year of publication

  • 1986 (1)
  • 1983 (1)
  • 1982 (1)

Document Type

  • Journal article (3)

Language

  • German (3)

Keywords

  • silicon compounds (2)
  • X-ray (1)
  • conformational anaylses (1)
  • curare-lik activity (1)
  • enantioselective reduction (1)
  • ethamoxytriphetol (1)
  • hypolipidemic activity (1)
  • microbiological transformation (1)
  • sila-subsitution (1)
  • structure-activity relationships (1)
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Author

  • Linoh, Haryanto (3)
  • Tacke, Reinhold (3)
  • Ernst, Ludger (2)
  • Abraham, Wolf-Rainer (1)
  • Attar-Bashi, Moayad T. (1)
  • Bentlage-Felten, Anke (1)
  • Frohnecke, Joachim (1)
  • Kieslich, Klaus (1)
  • Magda, Stephen (1)
  • Niedner, Roland (1)
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Institute

  • Institut für Anorganische Chemie (3)

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Sila-Analoga des Triparanols und Ethamoxytriphetols: Synthese sowie pharmakologische und toxikologische Eigenschaften (1986)
Tacke, Reinhold ; Bentlage-Felten, Anke ; Linoh, Haryanto ; Magda, Stephen
No abstract available.
Sila-Pharmaka, 26. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, III (1982)
Tacke, Reinhold ; Linoh, Haryanto ; Attar-Bashi, Moayad T. ; Sheldrick, William S. ; Ernst, Ludger ; Niedner, Roland ; Frohnecke, Joachim
The potentially curare-like silicon compounds 8a- 8f were synthesized and investigated with respect to their structure-activity relationships. The conformations of the compounds in the solid state and in solution were studied by X-ray diffraction analysis (8a- 8e) and IR NMR spectroscopy (8a- 8f), respectively. The muscle relaxing properties of 8a- 8f were investigated on the mouse. The observed structure-activity relationships are not in accordance with the classical "14 Å model" for neuromuscular blocking agents.
Mikrobiologische Umwandlung von Silicium-Verbindungen: Enantioselektive Reduktion von Acetessigsäure-(trimethylsilylalkyl)estern und deren Carba-Analoga (1983)
Tacke, Reinhold ; Linoh, Haryanto ; Stumpf, Burghard ; Abraham, Wolf-Rainer ; Kieslich, Klaus ; Ernst, Ludger
The trimethylsilylalkyl acetoacetates 1 b and 2 b as well as their carba analogues 1 a and 2 a have been reduced microbiologically by Kloeckera corticis (ATCC 20109), leading to the corresponding ( + )-3(S)-hydroxybutanoates 3b, 4b, 3a, and 4a. The enantiomeric purity was found to be 80% (3a, 3b, 4b) and 65% (4a), respectively. The reduction of lb and 2b is - to our knowledge - the first example for a controlled microbiological transformation of organosilicon substrates.
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