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Aromaten(phosphan)metall-Komplexe, V: zur Addition von Carbanionen an (Benzol)ruthenium(II)- und -osmium(II)-Komplexe. Kristall- und Molekülstruktur von (exo-6-n-C4H9-Pi5-C6H6)OsI(PMe3)2 (1984)
Werner, Helmut ; Werner, Reiner ; Burschka, Christian
No abstract available
Cardiac rehabilitation in German speaking countries of Europe — evidence-based guidelines from Germany, Austria and Switzerland LLKardReha-DACH — part 2 (2021)
Schwaab, Bernhard ; Bjarnason-Wehrens, Birna ; Meng, Karin ; Albus, Christian ; Salzwedel, Annett ; Schmid, Jean-Paul ; Benzer, Werner ; Metz, Matthes ; Jensen, Katrin ; Rauch, Bernhard ; Bönner, Gerd ; Brzoska, Patrick ; Buhr-Schinner, Heike ; Charrier, Albrecht ; Cordes, Carsten ; Dörr, Gesine ; Eichler, Sarah ; Exner, Anne-Kathrin ; Fromm, Bernd ; Gielen, Stephan ; Glatz, Johannes ; Gohlke, Helmut ; Grilli, Maurizio ; Gysan, Detlef ; Härtel, Ursula ; Hahmann, Harry ; Herrmann-Lingen, Christoph ; Karger, Gabriele ; Karoff, Marthin ; Kiwus, Ulrich ; Knoglinger, Ernst ; Krusch, Christian-Wolfgang ; Langheim, Eike ; Mann, Johannes ; Max, Regina ; Metzendorf, Maria-Inti ; Nebel, Roland ; Niebauer, Josef ; Predel, Hans-Georg ; Preßler, Axel ; Razum, Oliver ; Reiss, Nils ; Saure, Daniel ; von Schacky, Clemens ; Schütt, Morten ; Schultz, Konrad ; Skoda, Eva-Maria ; Steube, Diethard ; Streibelt, Marco ; Stüttgen, Martin ; Stüttgen, Michaela ; Teufel, Martin ; Tschanz, Hansueli ; Völler, Heinz ; Vogel, Heiner ; Westphal, Ronja
Background: Scientific guidelines have been developed to update and harmonize exercise based cardiac rehabilitation (ebCR) in German speaking countries. Key recommendations for ebCR indications have recently been published in part 1 of this journal. The present part 2 updates the evidence with respect to contents and delivery of ebCR in clinical practice, focusing on exercise training (ET), psychological interventions (PI), patient education (PE). In addition, special patients' groups and new developments, such as telemedical (Tele) or home-based ebCR, are discussed as well. Methods: Generation of evidence and search of literature have been described in part 1. Results: Well documented evidence confirms the prognostic significance of ET in patients with coronary artery disease. Positive clinical effects of ET are described in patients with congestive heart failure, heart valve surgery or intervention, adults with congenital heart disease, and peripheral arterial disease. Specific recommendations for risk stratification and adequate exercise prescription for continuous-, interval-, and strength training are given in detail. PI when added to ebCR did not show significant positive effects in general. There was a positive trend towards reduction in depressive symptoms for “distress management” and “lifestyle changes”. PE is able to increase patients’ knowledge and motivation, as well as behavior changes, regarding physical activity, dietary habits, and smoking cessation. The evidence for distinct ebCR programs in special patients’ groups is less clear. Studies on Tele-CR predominantly included low-risk patients. Hence, it is questionable, whether clinical results derived from studies in conventional ebCR may be transferred to Tele-CR. Conclusions: ET is the cornerstone of ebCR. Additional PI should be included, adjusted to the needs of the individual patient. PE is able to promote patients self-management, empowerment, and motivation. Diversity-sensitive structures should be established to interact with the needs of special patient groups and gender issues. Tele-CR should be further investigated as a valuable tool to implement ebCR more widely and effectively.
Genetics of Escherichia coli uropathogenicity: Analysis of the O6:K15:H31 isolate 536 (1992)
Hacker, Jörg ; Ott, Manfred ; Blum, Gabriele ; Marre, Reinhard ; Heesemann, Jürgen ; Tschäpe, Helmut ; Goebel, Werner
E. coli strain 536 (06: K15: H31) isolated from a case of acute pyelonephritis, expresses S-fimbrial adhesins, P-related fimbriae, common type I fimbriae, and hemolysins. The respective chromosomally encoded determinants were cloned by constructing a genomic library of this strain. Furthermore, the strain produces the iron uptake substance, enterocheline, damages HeLa cells, and behaves in a serum-resistant mode. Genetic analysis of spontaneously arising non-hemolytic variants revealed that some of the virulence genes were physically linked to large unstable DNA regions, termed "pathogenicity islands", which were mapped in the respective positions on the E. coli K-12linkage map. By comparing the wild type strain and mutants in in vitro and in vivo assays, virulence features have been evaluated. In addition, a regulatory cross talk between adhesin determinants was found for the wild-type isolate. This particular mode of virulence regulation is missing in the mutant strain.
Cycloadditionsreaktionen von Organometallkomplexen, I: die Synthese viergliedriger Metalla-Heterocyclen durch [2 + 2]-Cycloaddition aus (Isonitril)cobalt-Komplexen und Isocyanaten sowie Isothiocyanaten (1982)
Werner, Helmut ; Heiser, Bernd ; Burschka, Christian
No abstract available
Strukturdynamische Organometall-Komplexe II: Synthese, Struktur und Dynamik der Komplexe C\(_5\)H\(_5\)M(2-R'C\(_3\)H\(_4\))PR\(_3\) (M = Pd, Pt) (1980)
Werner, Helmut ; Kuehn, Alfred ; Burschka, Christian
No abstract available
Treatment of invasive fungal infections in cancer patients—updated recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) (2014)
Mousset, Sabine ; Buchheidt, Dieter ; Heinz, Werner ; Ruhnke, Markus ; Cornely, Oliver A. ; Egerer, Gerlinde ; Krüger, William ; Link, Hartmut ; Neumann, Silke ; Ostermann, Helmut ; Panse, Jens ; Penack, Olaf ; Rieger, Christina ; Schmidt-Hieber, Martin ; Silling, Gerda ; Südhoff, Thomas ; Ullmann, Andrew J. ; Wolf, Hans-Heinrich ; Maschmeyer, Georg ; Böhme, Angelika
Invasive fungal infections are a main cause of morbidity and mortality in cancer patients undergoing intensive chemotherapy regimens. Early antifungal treatment is mandatory to improve survival. Today, a number of effective and better-tolerated but more expensive antifungal agents compared to the former gold standard amphotericin B deoxycholate are available. Clinical decision-making must consider results from numerous studies and published guidelines, as well as licensing status and cost pressure. New developments in antifungal prophylaxis improving survival rates result in a continuous need for actualization. The treatment options for invasive Candida infections include fluconazole, voriconazole, and amphotericin B and its lipid formulations, as well as echinocandins. Voriconazole, amphotericin B, amphotericin B lipid formulations, caspofungin, itraconazole, and posaconazole are available for the treatment of invasive aspergillosis. Additional procedures, such as surgical interventions, immunoregulatory therapy, and granulocyte transfusions, have to be considered. The Infectious Diseases Working Party of the German Society of Hematology and Oncology here presents its 2008 recommendations discussing the dos and do-nots, as well as the problems and possible solutions, of evidence criteria selection.
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