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Has Fulltext

  • yes (4)

Is part of the Bibliography

  • yes (4)

Year of publication

  • 2010 (1)
  • 1989 (3)

Document Type

  • Journal article (3)
  • Review (1)

Language

  • German (2)
  • English (2)

Keywords

  • Bipyridinediylbisboranes / Redox systems / Cyclovoltammetry (1)
  • D-amino acid oxidase activator (1)
  • Psychisch Kranker (1)

Author

  • Wehner, Ingeborg (4)
  • Hünig, Siegfried (3)
  • Gawlik, Micha (1)
  • Jung, Sven (1)
  • Knapp, Michael (1)
  • Mende, Meinhard (1)
  • Pfuhlmann, Bruno (1)
  • Stoeber, Gerald (1)

Institute

  • Institut für Pharmazie und Lebensmittelchemie (3)
  • Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (1)

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The DAOA/G30 locus and affective disorders: haplotype based association study in a polydiagnostic approach (2010)
Gawlik, Micha ; Wehner, Ingeborg ; Mende, Meinhard ; Jung, Sven ; Pfuhlmann, Bruno ; Knapp, Michael ; Stoeber, Gerald
Background: The DAOA/G30 (D-amino acid oxidase activator) gene complex at chromosomal region 13q32-33 is one of the most intriguing susceptibility loci for the major psychiatric disorders, although there is no consensus about the specific risk alleles or haplotypes across studies. Methods: In a case-control sample of German descent (affective psychosis: n = 248; controls: n = 188) we examined seven single nucleotide polymorphisms (SNPs) around DAOA/G30 (rs3916966, rs1935058, rs2391191, rs1935062, rs947267, rs3918342, and rs9558575) for genetic association in a polydiagnostic approach (ICD 10; Leonhard’s classification). Results: No single marker showed evidence of overall association with affective disorder neither in ICD10 nor Leonhard’s classification. Haplotype analysis revealed no association with recurrent unipolar depression or bipolar disorder according to ICD10, within Leonhard’s classification manic-depression was associated with a 3-locus haplotype (rs2391191, rs1935062, and rs3916966; P = 0.022) and monopolar depression with a 5-locus combination at the DAOA/G30 core region (P = 0.036). Conclusion: Our data revealed potential evidence for partially overlapping risk haplotypes at the DAOA/G30 locus in Leonhard’s affective psychoses, but do not support a common genetic contribution of the DAOA/G30 gene complex to the pathogenesis of affective disorders.
Two Step Redox Systems LII: 2,2'-Bipyridylboronium Salts (1989)
Hünig, Siegfried ; Wehner, Ingeborg
Dications 1 derived from 2,2-bipyridine are found to exist as fully reversible two step redox systems with persistent radical ions (SEM) of high thermodynamic stability, if the bridge X forces the two pyridine rings into co planar positions. The well known derivative 1a (Diquat R) is now complemented by the boronium ions 1c and 1e -1g., as shown by voltammetry and the uv spectra of the corresponding radicals.
Mehrstufige reversible Redoxsysteme, LIII: 4,4'-Bipyridin-1-1'-diylbisborane (1989)
Hünig, Siegfried ; Wehner, Ingeborg
No abstract available
A convenient synthesis of 2,2',6,6'-Tetramethyl-4,4'-bipyridine and its oxidation to 2,2',6,6'-Tetracarboxy-4,4'-bipyridine (1989)
Hünig, Siegfried ; Wehner, Ingeborg
No abstract available
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