Refine
Has Fulltext
- yes (14)
Is part of the Bibliography
- yes (14)
Document Type
- Journal article (14)
Language
- English (14)
Keywords
- echocardiography (5)
- prognosis (3)
- amyloidosis (2)
- cardiomyopathy (2)
- deformation (2)
- ejection fraction (2)
- Anderson-Fabry Disease (1)
- Cardiovascular magnetic-resonance (1)
- Chronic heart-failure (1)
- Coronary artery disease (1)
- D313Y genotype (1)
- Enzyme replacement therapy (1)
- Fabry cardiomyopathy (1)
- Fabry nephropathy (1)
- Fabry-associated pain (1)
- Guidelines (1)
- Hypertrophic cardiomyopathy (1)
- Impella (1)
- Management (1)
- Manifestation (1)
- Myocardial fibrosis (1)
- Non‐ischaemic cardiogenic shock (1)
- Prevalence (1)
- Prognostic impact (1)
- Risk-factors (1)
- Septal bulge (1)
- Task force (1)
- Valvular heart-desease (1)
- Ventricular-arrhythmias (1)
- alcohol (1)
- aneurysm (1)
- aortic valve stenosis (AS) (1)
- avascular necrosis (1)
- biomarker (1)
- blood pressure monitoring (1)
- bone (1)
- bull’s eye plot (1)
- calcium imaging (1)
- cardiac amyloidosis (1)
- cardiac transplantation (1)
- cardiovascular magnetic resonance (1)
- case report (1)
- chronic thromboembolic pulmonary hypertension (1)
- cigarette smoking (1)
- death rates (1)
- diagnostic medicine (1)
- diastolic dysfunction (1)
- dobutamine stress echocardiography (1)
- early-stage osteonecrosis (1)
- fabry disease (1)
- follow-up (1)
- heart disease (1)
- heart failure with mid-range ejection fraction (1)
- heart failure with reduced ejection fraction (1)
- hypertension (1)
- idiopathic osteonecrosis (1)
- implantation (1)
- inherited metabolic disorders (1)
- intake (1)
- left ventricular hypertrophy (1)
- left ventricular thrombusv (1)
- low-gradient AS (1)
- marrow (1)
- mild (1)
- mortality (1)
- myocardial infarction (1)
- myocardial fibrosis (1)
- nontraumatic osteonecrosis of the femoral head (1)
- occupational-status (1)
- prevalence (1)
- pseudo-severe AS (1)
- regression analysis (1)
- right ventricular dysfunction (1)
- risk factors (1)
- speckle tracking imaging (1)
- statins (1)
- stem cell transplantation (1)
- therapy (1)
- tricuspid pressure gradient (1)
- troponin T (1)
Institute
- Medizinische Klinik und Poliklinik I (13)
- Deutsches Zentrum für Herzinsuffizienz (DZHI) (6)
- Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik) (2)
- Medizinische Klinik und Poliklinik II (2)
- Institut für Pharmakologie und Toxikologie (1)
- Neurologische Klinik und Poliklinik (1)
- Pathologisches Institut (1)
Patients in the early stage of hypertensive heart disease tend to have normal echocardiographic findings. The aim of this study was to investigate whether pathology-specific echocardiographic morphologic and functional parameters can help to detect subclinical hypertensive heart disease. One hundred ten consecutive patients without a history and medication for arterial hypertension (AH) or other cardiac diseases were enrolled. Standard echocardiography and two-dimensional speckle tracking -imaging analysis were performed. Resting blood pressure (BP) measurement, cycle ergometer test (CET), and 24-hour ambulatory BP monitoring (ABPM) were conducted. Patients were referred to "septal bulge (SB)" group (basal-septal wall thickness >= 2 mm thicker than mid-septal wall thickness) or "no-SB" group. Echocardiographic SB was found in 48 (43.6%) of 110 patients. In this SB group, 38 (79.2%) patients showed AH either by CET or ABPM. In contrast, in the no-SB group (n = 62), 59 (95.2%) patients had no positive test for AH by CET or ABPM. When AH was solely defined by resting BP, SB was a reasonable predictive sign for AH (sensitivity 73%, specificity 76%). However, when AH was confirmed by CET or ABPM the echocardiographic SB strongly predicted clinical AH (sensitivity 93%, specificity 86%). In addition, regional myocardial deformation of the basal-septum in SB group was significantly lower than in no-SB group (14 +/- 4% vs. 17 +/- 4%; P < .001). In conclusion, SB is a morphologic echocardiographic sign for early hypertensive heart disease. Sophisticated BP evaluation including resting BP, ABPM, and CET should be performed in all patients with an accidental finding of a SB in echocardiography.