Refine
Has Fulltext
- yes (26)
Is part of the Bibliography
- yes (26)
Year of publication
Document Type
- Journal article (26)
Language
- English (26)
Keywords
- ADHD (6)
- mice (3)
- neurodevelopment (3)
- prefrontal cortex (3)
- psychiatric disorders (3)
- serotonin (3)
- SLC2A3 (2)
- T-cadherin (2)
- attention-deficit/hyperactivity disorder (ADHD) (2)
- chronic stress (2)
- depression (2)
- hippocampus (2)
- mouse (2)
- pro-inflammatory cytokines (2)
- 3-dimensional MRI (1)
- 5-HT receptors (1)
- 5-HTT (1)
- 5-HTTLPR polymorphism (1)
- Adult (1)
- Aggression (1)
- Antisocial behavior (1)
- Association (1)
- C57BL/6 mice (1)
- CB1 receptor antagonists (1)
- COMT (1)
- Cadherin-13 (CDH13) (1)
- Central nervous system (1)
- Conduct disorder (1)
- DRD4 (1)
- Deficit/hyperactivity disorder (1)
- Diagnostic approach (1)
- Dopamine (1)
- Fgf-signalling (1)
- GLUT3 (1)
- GWAS (1)
- Gene (1)
- Hypothalamus (1)
- Large multicenter ADHD (1)
- NMDA receptor subunits NR2A and NR2B (1)
- OXTR (1)
- RNA sequencing (1)
- Rating scale (1)
- SARS-CoV-2 (1)
- SSRI (1)
- Serotonin (1)
- Susceptibility loci (1)
- Xenopus laevis oocytes (1)
- adhesion (1)
- adult-onset ADHD (1)
- adulthood (1)
- aging (1)
- allostatic load (1)
- amino acid analysis (1)
- anhedonia (1)
- animal behavior (1)
- animal behaviour (1)
- antioxidant nutrients (1)
- anxiety (1)
- anxiety-like behavior (1)
- association (1)
- attention (1)
- autism (1)
- blood flow (1)
- cadherin-13 (CDH13) (1)
- celecoxib (1)
- cell membranes (1)
- childhood maltreatment (1)
- chronic social stress (1)
- citalopram (1)
- cognitive impairment (1)
- collagens (1)
- comorbidity (1)
- comparative genomics (1)
- copy number variation (1)
- crystal structure (1)
- dangerous world (1)
- developmental plasticity (1)
- developmental trajectory (1)
- dicholine succinate (1)
- dorsal raphe (1)
- early-life stress (1)
- electroencephalogram (EEG) (1)
- elevated plus-maze (1)
- endoplasmic reticulum stress (1)
- energy metabolism (1)
- environment interaction (1)
- environmental enrichment (1)
- events (1)
- false belief (1)
- fear conditioning (1)
- female aggression (1)
- forced swimming (1)
- genetic variants (1)
- genetics (1)
- genetics of the nervous system (1)
- glucose (1)
- glucose transporter (1)
- glycogen synthase kinase-3 β (GSK-3β) (1)
- hippocampal neurogenesis (1)
- hippocampal plasticity (1)
- hyperactivity (1)
- impulsivity (1)
- induced pluripotent stem cells (1)
- inducible cyclooxygenase-2 (COX-2) (1)
- inflammation (1)
- insulin receptor (1)
- insulin receptor (IR) (1)
- integrins (1)
- ischemic stroke (1)
- knockout mice (1)
- lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5) (1)
- lerned helplessness (1)
- life history (1)
- life stress (1)
- linked polymorphic region (1)
- major depression (1)
- match-mismatch (1)
- maternal care (1)
- membrane potential (1)
- membrane proteins (1)
- metaanalysis (1)
- moderation (1)
- molecular neuroscience (1)
- motor performance (1)
- mouse model (1)
- mouse-brain (1)
- myelination (1)
- neurodegeneration (1)
- neuropsychiatric diseases (1)
- neurotransmitter biosynthesis (1)
- oxidative stress (1)
- phosphorylated glycogen synthase kinase-3beta (pGSK-3beta) (1)
- platelet activation (1)
- platelet aggregation (1)
- platelets (1)
- polygenic risk score (1)
- polymorphism (1)
- post-traumatic stress disorder (1)
- predation stress (1)
- predictive adaptive response hypothesis (1)
- pyridoxal phosphatase (1)
- radial glia (1)
- rare mendelian disorders (1)
- rhesus macaques (1)
- s allele (1)
- serotonin transporter gene (1)
- sex differences (1)
- sialic acid (1)
- sialyltransferase (1)
- sleep EEG (1)
- social behaviour (1)
- stress resilience (1)
- substance abuse disorder (1)
- theory of mind (1)
- toll-like receptors (1)
- treatment (1)
- tryptophan hydroxylase-2 (Tph2) (1)
- venturesomeness (1)
- vitamin B6 (1)
- white-matter integrity (1)
- γ-Aminobutyric acid (GABA) (1)
Institute
- Lehrstuhl für Molekulare Psychiatrie (26) (remove)
The interaction between brain serotonin (5-HT) deficiency and environmental adversity may predispose females to excessive aggression. Specifically, complete inactivation of the gene encoding tryptophan hydroxylase-2 (Tph2) results in the absence of neuronal 5-HT synthesis and excessive aggressiveness in both male and female null mutant (Tph2\(^{−/−}\)) mice. In heterozygous male mice (Tph2\(^{+/−}\)), there is a moderate reduction in brain 5-HT levels, and when they are exposed to stress, they exhibit increased aggression. Here, we exposed female Tph2\(^{+/−}\) mice to a five-day rat predation stress paradigm and assessed their emotionality and social interaction/aggression-like behaviors. Tph2\(^{+/−}\) females exhibited excessive aggression and increased dominant behavior. Stressed mutants displayed altered gene expression of the 5-HT receptors Htr1a and Htr2a, glycogen synthase kinase-3 β (GSK-3β), and c-fos as well as myelination-related transcripts in the prefrontal cortex: myelin basic protein (Mbp), proteolipid protein 1 (Plp1), myelin-associated glycoprotein (Mag), and myelin oligodendrocyte glycoprotein (Mog). The expression of the plasticity markers synaptophysin (Syp) and cAMP response element binding protein (Creb), but not AMPA receptor subunit A2 (GluA2), were affected by genotype. Moreover, in a separate experiment, naïve female Tph2\(^{+/−}\) mice showed signs of enhanced stress resilience in the modified swim test with repeated swimming sessions. Taken together, the combination of a moderate reduction in brain 5-HT with environmental challenges results in behavioral changes in female mice that resemble the aggression-related behavior and resilience seen in stressed male mutants; additionally, the combination is comparable to the phenotype of null mutants lacking neuronal 5-HT. Changes in myelination-associated processes are suspected to underpin the molecular mechanisms leading to aggressive behavior.