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Waider, Jonas ; Popp, Sandy ; Mlinar, Boris ; Montalbano, Alberto ; Bonfiglio, Francesco ; Aboagye, Benjamin ; Thuy, Elisabeth ; Kern, Raphael ; Thiel, Christopher ; Araragi, Naozumi ; Svirin, Evgeniy ; Schmitt-Böhrer, Angelika G. ; Corradetti, Renato ; Lowry, Christopher A. ; Lesch, Klaus-Peter
Brain serotonin (5-hydroxytryptamine, 5-HT) system dysfunction is implicated in exaggerated fear responses triggering various anxiety-, stress-, and trauma-related disorders. However, the underlying mechanisms are not well understood. Here, we investigated the impact of constitutively inactivated 5-HT synthesis on context-dependent fear learning and extinction using tryptophan hydroxylase 2 (Tph2) knockout mice. Fear conditioning and context-dependent fear memory extinction paradigms were combined with c-Fos imaging and electrophysiological recordings in the dorsal hippocampus (dHip). Tph2 mutant mice, completely devoid of 5-HT synthesis in brain, displayed accelerated fear memory formation and increased locomotor responses to foot shock. Furthermore, recall of context-dependent fear memory was increased. The behavioral responses were associated with increased c-Fos expression in the dHip and resistance to foot shock-induced impairment of hippocampal long-term potentiation (LTP). In conclusion, increased context-dependent fear memory resulting from brain 5-HT deficiency involves dysfunction of the hippocampal circuitry controlling contextual representation of fear-related behavioral responses.