Refine
Has Fulltext
- yes (65)
Is part of the Bibliography
- yes (65)
Year of publication
Document Type
- Journal article (61)
- Doctoral Thesis (3)
- Book (1)
Keywords
- super-resolution microscopy (8)
- active zone (5)
- dSTORM (4)
- ceramides (3)
- fluorescence microscopy (3)
- immunotherapy (3)
- superresolution (3)
- BDNF (2)
- Bruchpilot (2)
- Expansion microscopy (2)
- RNS (2)
- SARS-CoV-2 (2)
- T cells (2)
- biology (2)
- fluorescence imaging (2)
- fluorescent probes (2)
- gene expression (2)
- imaging (2)
- imaging the immune system (2)
- induced pluripotent stem cells (2)
- infectious diseases (2)
- localization microscopy (2)
- membrane proteins (2)
- microscopy (2)
- neurotransmitter release (2)
- sphingolipids (2)
- tumour immunology (2)
- 3D tissue model (1)
- AI (1)
- ATG7 (1)
- Alzheimers disease (1)
- Amyotrophic-lateral-sclerosis (1)
- Apoptosis (1)
- Aspergillus fumigatus (1)
- Automated analysis (1)
- Autonomer Roboter (1)
- Axon degeneration (1)
- Axonal transport (1)
- BDNF stimulation (1)
- Benutzerschnittstelle (1)
- C.376A>G (p.S126G) (1)
- CA2+ channels (1)
- CA3 pyrimidal cells (1)
- CCL3 (1)
- CCL4 (1)
- CCL5 (1)
- CD28 (1)
- CENP-A (1)
- CSE4, CENP-A (1)
- Ca\(^{2+}\) channels (1)
- Cadherin-13 (CDH13) (1)
- Campylobacter jejuni (1)
- Carboxy-Terminus (1)
- DNA (1)
- DNA double-strand breaks (1)
- DNA nanotechnology (1)
- DNA-binding (1)
- DNS-Bindung (1)
- DRD1 (1)
- Epidemiologie (1)
- FLIMbee (1)
- FRAP (1)
- Fabry disease (1)
- G-protein-coupled receptors (1)
- G-quadruplex (1)
- GABA-A receptor (1)
- GPCR (1)
- Genexpression (1)
- Gleiten (1)
- H1 helix (1)
- H1-Helix (1)
- HDBSCAN (1)
- HIV (1)
- Helicasen (1)
- Human-Robot-Interaction (1)
- ImageJ plugin (1)
- Intermediate filaments (1)
- Ionizing radiation (1)
- Lacking neurofilaments (1)
- Latrophilin (1)
- Lehrbuch (1)
- Mensch-Maschine-Schnittstelle (1)
- Mensch-Maschine-System (1)
- Mensch-Roboter-Interaktion (1)
- MiMIC (1)
- Microtubules (1)
- Missense mutation (1)
- Mixed Reality (1)
- Mobiler Roboter (1)
- Moleküle (1)
- Motoneuron disease (1)
- Mouse model (1)
- NF-KAPPA-B (1)
- Neisseria (1)
- Neisseria meningitidis (1)
- Neurofilament (1)
- Open-source tool (1)
- PKCζ, (1)
- Pathogenese (1)
- Polyadenylierung (1)
- Progressive motor neuronopathy (1)
- Protein p53 (1)
- Protein p73 (1)
- RIM-binding protein (1)
- RNA metabolism (1)
- RNA protein interactions (1)
- RNA secondary structures (1)
- RNA-Export (1)
- RNA-binding protein (1)
- Radiation biology (1)
- Retroviren (1)
- Reverse Transkription (1)
- Robotik (1)
- SMLM (1)
- STORM (1)
- Si-rhodamine (1)
- Stat3 (1)
- Stathmin (1)
- Superagonistic antibody (1)
- T-cadherin (1)
- Teleoperation (1)
- Th1 cells (1)
- Therapie (1)
- Transgenic mice (1)
- Transkription (1)
- Transkriptionsfaktor (1)
- Translation (1)
- TrkB (1)
- Unc-13 (1)
- User Interface (1)
- Viren (1)
- Virologie (1)
- Visualisierung (1)
- Zellen (1)
- acid sphingomyelinase (1)
- actin (1)
- acute myeloid leukaemia (1)
- adhesion GPCR (1)
- alpha (1)
- antimicrobials (1)
- anxiety (1)
- assay systems (1)
- autophagy (1)
- autotoxicity (1)
- azido-ceramides (1)
- bacillus subtilis (1)
- bacterial genetics (1)
- bacterial infection (1)
- bacterial meningitis (1)
- basal ganglia (1)
- biological fluorescence (1)
- biological techniques (1)
- brain endothelial cells (1)
- cadherin-13 (CDH13) (1)
- caenorhabditis elegans (1)
- cancer microenvironment (1)
- carboxy terminus (1)
- cell fusion (1)
- cell membranes (1)
- cell migration (1)
- cell signalling (1)
- centomeres (1)
- centromere (1)
- ceramidase (1)
- ceramide (1)
- ceramide analogs (1)
- chemotherapy (1)
- chlamydia (1)
- chromatin (1)
- click-chemistry (1)
- compaction (1)
- complexes (1)
- compressed sensing (1)
- conformational restriction (1)
- correlative light and electron microscopy (1)
- cortico-striatal synapse (1)
- corticosteroids (1)
- cristae (1)
- cyanine dyes (1)
- cytokine release (1)
- dCIRL (1)
- dSPN (1)
- deep learning–artificial neural network (DL-ANN) (1)
- dendritic cell (1)
- developmental forms (1)
- diffraction limit (1)
- direct pathway (1)
- direct stochasticoptical reconstruction microscopy (1)
- disease model (1)
- diseases (1)
- dorsal raphe (1)
- dynamics (1)
- dynamics of ribosomal assembly (1)
- electrolytes (1)
- excitation-secretion coupling (1)
- expansion microscopy (1)
- fission yeast (1)
- fluorescent dyes (1)
- fluorescent protein (1)
- fluorescent-probes (1)
- fluorophore (1)
- fluoxetine (1)
- fungal infection (1)
- fungi (1)
- gamma H2AX-foci (1)
- gangliosides and lipid rafts (1)
- gap junction (1)
- gene regulation (1)
- genetic code expansion (1)
- glioblastoma multiforme (1)
- globotriaosylceramide (1)
- heat shock response (1)
- hippocampal (1)
- hippocampal neurons (1)
- homeostasis (1)
- homodimers (1)
- hospitalization (1)
- human induced pluripotent stem cell (hiPSC) (1)
- hyphae (1)
- hypotonic (1)
- hypotonic solutions (1)
- identification (1)
- illumination microscopy (1)
- image data (1)
- imaging and sensing (1)
- in vitro (1)
- in vivo (1)
- inflammation (1)
- ingle-molecule microscopy (1)
- innexins (1)
- interferon γ (1)
- isothiocyanates (1)
- isotonic (1)
- junction proteins (1)
- laboratory techniques and procedures (1)
- leptomeningeal cells (1)
- lipids (1)
- localization micoscopy (1)
- measles virus (1)
- mechanotransduction (1)
- median and dorsal raphe (1)
- medical and biological imaging (1)
- meningeal blood-csf barrier (1)
- metabotropic signalling (1)
- metastasis (1)
- microbiology (1)
- microbiology techniques (1)
- microtubule cytoskeleton (1)
- migration (1)
- mitochondria (1)
- molecular mobility (1)
- mossy fiber synapses (1)
- motor learning (1)
- mustard oil bomb (1)
- nanoarchitecture (1)
- nanoscale imaging (1)
- natural killer cell (1)
- natural killer cells (1)
- neisseria meningitidis (1)
- nervous-system (1)
- neural circuits (1)
- neurodevelopment (1)
- neuromuscular junction (1)
- neuropsychiatric disorders (1)
- neutral sphingomyelinase 2 (1)
- nuclear proe (1)
- nucleosome (1)
- optical reconstruction microscopy (1)
- p53 (1)
- pancreatic cancer (1)
- pattern recognition receptors (1)
- permeability (1)
- phlorizin (1)
- photoactivation (1)
- photodynamic therapy (1)
- plasticity (1)
- platform (1)
- prefrontal cortex (1)
- prenatal paternal depression (1)
- presynapse (1)
- presynaptic ER dynamics (1)
- presynaptic calcium (1)
- presynaptic differentiation (1)
- presynaptic homeostasis (1)
- presynaptic plasticity (1)
- propagation (1)
- proteins (1)
- psychiatric disorders (1)
- radial glia (1)
- reactive electrophilic species (1)
- reconstruction (1)
- redox homeostasis (1)
- release (1)
- resolution limit (1)
- reveals (1)
- risk pregnancy (1)
- schizosaccaromyces-pombe (1)
- secreted effectors (1)
- sensory neurons (1)
- sensory physiology (1)
- serotonin (1)
- serotonin-specific neurons (1)
- signal transduction (1)
- single molecule localization microscopy (1)
- single-molecule fluorescence spectroscopy (1)
- single-molecule tracking (1)
- sliding (1)
- somatic symptom burden (1)
- sphingolipid expansion microscopy (1)
- sphingosine-1-phosphate (1)
- spinal muscular atrophy (1)
- sporidia (1)
- stem cell transplantation (1)
- structure-function relationships (1)
- structured illumination (1)
- structured illumination microscope (1)
- structured illumination microscopy (1)
- sulforaphane (1)
- super-resolution (1)
- super-resolution imaging (1)
- super-resolution microscopy (SRM) (1)
- synapse formation (1)
- synapse structure (1)
- synaptic delay (1)
- synaptic localization (1)
- synaptic plasticity (1)
- synaptic transmission (1)
- synaptotagmin (1)
- tag fusion proteins (1)
- temporal range (1)
- the microtubule-organizing center (1)
- three-dimensional microscopy (1)
- tonicity (1)
- translation (1)
- translational research (1)
- transportome (1)
- treatment (1)
- ultrastructure (1)
- variants of unknown significance (1)
- volume regulation (1)
- α-Galactosidase A (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (56)
- Medizinische Klinik und Poliklinik II (8)
- Physiologisches Institut (8)
- Institut für Virologie und Immunbiologie (7)
- Institut für Hygiene und Mikrobiologie (6)
- Institut für Klinische Neurobiologie (6)
- Center for Computational and Theoretical Biology (5)
- Institut für Organische Chemie (5)
- Rudolf-Virchow-Zentrum (5)
- Institut für Anatomie und Zellbiologie (3)
Translation efficiency can be affected by mRNA stability and secondary structures, including G-quadruplex structures (G4s). The highly conserved DEAH-box helicase DHX36/RHAU resolves G4s on DNA and RNA in vitro, however a systems-wide analysis of DHX36 targets and function is lacking. We map globally DHX36 binding to RNA in human cell lines and find it preferentially interacting with G-rich and G4-forming sequences on more than 4500 mRNAs. While DHX36 knockout (KO) results in a significant increase in target mRNA abundance, ribosome occupancy and protein output from these targets decrease, suggesting that they were rendered translationally incompetent. Considering that DHX36 targets, harboring G4s, preferentially localize in stress granules, and that DHX36 KO results in increased SG formation and protein kinase R (PKR/EIF2AK2) phosphorylation, we speculate that DHX36 is involved in resolution of rG4 induced cellular stress.