Refine
Has Fulltext
- yes (24)
Is part of the Bibliography
- yes (24)
Year of publication
Document Type
- Journal article (24)
Language
- English (24)
Keywords
- cancer (3)
- CML (2)
- association (2)
- management (2)
- 316L stainless-steel (1)
- BCR‐ABL (1)
- BRAF(V600E) mutation (1)
- Biochemie (1)
- Bullous pemphigoid (1)
- CD74 (1)
- CXCR4 (1)
- Cancer (1)
- Chirurgie (1)
- EZH1 (1)
- EZH2 (1)
- Erbendorf (1)
- H3K27me3 (1)
- HLA class II (1)
- HLA peptidome (1)
- HUWE1 (1)
- Hautkrebs (1)
- Immunoadsorption (1)
- Immunoapheresis (1)
- Japanese population (1)
- Krebs <Medizin> (1)
- LASP1 (1)
- MIZ1 (1)
- MYC (1)
- PTCL (1)
- QCM (1)
- T-cell non-Hodgkin's lymphomas (1)
- Vohenstrauß (1)
- adsorption (1)
- allogeneic hematopoietic stem cell transplantation (1)
- animal experimentation (1)
- animal model (1)
- arteriovenous extracorporeal hemadsorption technique (1)
- beetle (1)
- biosensor (1)
- biosensors (1)
- bird communities (1)
- blood purification (1)
- blood-plasma (1)
- bone regeneration (1)
- borates (1)
- brain (1)
- brain metastasis (1)
- brucei genome (1)
- candidate gene (1)
- cell coagulation (1)
- cell self-assembled monolayers (1)
- chronic myeloid leukemia (1)
- cochlear implantation (1)
- colorectal cancer (1)
- conservation (1)
- coordination polymers (1)
- correlate (1)
- cytokines (1)
- developmental dyscalculia (1)
- digestive system (1)
- disability (1)
- disorders (1)
- dissection (1)
- distance-dependent decay (1)
- distant metastases (1)
- diversity (1)
- drug design/partial agonists (1)
- drug discovery (1)
- drug treatment (1)
- dyscalculia (1)
- dyslexia (1)
- electromyographic (1)
- endotoxin (1)
- epigenetics (1)
- evaluation (1)
- extracorporeal hemadsorption (1)
- extracorporeal techniques in hemadsorption therapy (1)
- facial nerve (1)
- fire (1)
- forest (1)
- genome architecture (1)
- genome-wide association (1)
- genomic imaging (1)
- guided bone regeneration (1)
- guidelines (1)
- helimagnets (1)
- hemocompatibility (1)
- histone variants (1)
- identification (1)
- immunohistochemistry (1)
- immunosorbents (1)
- impact (1)
- inelastic neutron scattering (1)
- ionic liquids (1)
- lanthanides (1)
- luminescence (1)
- mass casualties (1)
- mathematics (1)
- melt electrospinning writing (1)
- multiparametric magnetic resonance imaging (1)
- natural disturbance (1)
- neovascularization, physiologic (1)
- next generation sequencing (1)
- nilotinib (1)
- papillary (1)
- pharmacology (1)
- physics (1)
- platelet-adhesion (1)
- poly(ethylene glycol) (1)
- polycaprolactone (1)
- precursor cells (1)
- prelevance (1)
- protein adsorption (1)
- quality indicators (1)
- quantitative trait (1)
- radioiodine therapy (1)
- receptor signalling (1)
- rescue mission (1)
- scaffold (1)
- self-assembled monolayers (1)
- septic shock (1)
- single molecule real time (SMRT) (1)
- spin waves (1)
- stem cell transplantation (1)
- sulcal morphology (1)
- surface coating (1)
- surfaces (1)
- surgery (1)
- terror attack (1)
- tissue engineering (1)
- translational medical research (1)
- tumor infiltrating lymphocytes (1)
- tumor-suppressor gene (1)
- tyrosine kinase inhibitors (1)
- ubiquitination (1)
- windthrow (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (5)
- Abteilung für Funktionswerkstoffe der Medizin und der Zahnheilkunde (2)
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (2)
- Klinik und Poliklinik für Anästhesiologie (ab 2004) (2)
- Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie (2)
- Medizinische Klinik und Poliklinik I (2)
- Deutsches Zentrum für Herzinsuffizienz (DZHI) (1)
- Frauenklinik und Poliklinik (1)
- Institut für Anorganische Chemie (1)
- Institut für Experimentelle Biomedizin (1)
The ability to perform mathematical tasks is required in everyday life. Although heritability estimates suggest a genetic contribution, no previous study has conclusively identified a genetic risk variant for mathematical performance. Research has shown that the prevalence of mathematical disabilities is increased in children with dyslexia. We therefore correlated genome-wide data of 200 German children with spelling disability, with available quantitative data on mathematic ability. Replication of the top findings in additional dyslexia samples revealed that rs133885 was a genome-wide significant marker for mathematical abilities\((P_{comb}=7.71 x 10^{-10}, n=699)\), with an effect size of 4.87%. This association was also found in a sample from the general population (P=0.048, n=1080), albeit with a lower effect size. The identified variant encodes an amino-acid substitution in MYO18B, a protein with as yet unknown functions in the brain. As areas of the parietal cortex, in particular the intraparietal sulcus (IPS), are involved in numerical processing in humans, we investigated whether rs133885 was associated with IPS morphology using structural magnetic resonance imaging data from 79 neuropsychiatrically healthy adults. Carriers of the MYO18B risk-genotype displayed a significantly lower depth of the right IPS. This validates the identified association between rs133885 and mathematical disability at the level of a specific intermediate phenotype.