Refine
Has Fulltext
- yes (68)
Is part of the Bibliography
- yes (68)
Year of publication
Document Type
- Journal article (68) (remove)
Language
- English (68)
Keywords
- PET (16)
- Positronen-Emissions-Tomografie (15)
- theranostics (12)
- positron emission tomography (11)
- prostate cancer (10)
- PRRT (7)
- neuroendocrine tumor (7)
- radioligand therapy (7)
- CXCR4 (6)
- PET/CT (6)
- PSMA (5)
- SPECT (4)
- SSTR (4)
- inflammation (4)
- sympathetic nervous system (4)
- 18F-FDG (3)
- NET (3)
- RADS (3)
- machine learning (3)
- norepinephrine transporter (3)
- peptide receptor radionuclide therapy (3)
- prostate-specific membrane antigen (3)
- somatostatin receptor (3)
- 123I-mIBG (2)
- 123I-metaiodobenzylguanidine (2)
- 18F-FDS (2)
- 18F-LMI1195 (2)
- C-X-C motif chemokine receptor 4 (2)
- DOTATOC (2)
- MAG3 (2)
- MRI (2)
- PSMA I&T (2)
- PSMA-RADS (2)
- Prostate Cancer (2)
- SUV (2)
- [68Ga]PentixaFor (2)
- cardiac innervation imaging (2)
- cardiac nerve (2)
- chemokine receptor (2)
- diabetes (2)
- endoradiotherapy (2)
- heart failure (2)
- kidney (2)
- medullary thyroid carcinoma (2)
- molecular imaging (2)
- molecular medicine (2)
- multiple myeloma (2)
- myocardial sympathetic innervation imaging (2)
- personalized medicine (2)
- personalized treatment (2)
- precision medicine (2)
- prostate-specific membrane antigen (PSMA) (2)
- reporting and data system (2)
- somatostatin receptor (SSTR) (2)
- tyrosine kinase inhibitor (2)
- vandetanib (2)
- 11C-HED (1)
- 11C-Hydroxyephedrine (1)
- 11C-hydroxyephedrine (1)
- 123I-Ioflupane (1)
- 177Lu (1)
- 18F-DCFPL (1)
- 18F-DCFPyL (1)
- 18F-flurpiridaz (1)
- 18FFBnTP (1)
- 2- deoxy-2-(18F)fluoro-D-glucose (1)
- 2-deoxy-2-(18F)fluoro-D-glucose (1)
- 2-deoxy-2-18F-fluoro-D-sorbitol (1)
- 68Ga-DOTATATE/-TOC (1)
- 99mTc-DTPA (1)
- <sup>18</sup>F-FDG (1)
- <sup>68</sup>Ga-Pentixafor (1)
- AI (1)
- Antidepressants (1)
- Arginine (1)
- COVID-19 (1)
- CTCAE (1)
- CXCR4-targeting (1)
- Cardiovascular diseases (1)
- DCGAN (1)
- DaTscan (1)
- ECG (1)
- FV45 (1)
- GAN (1)
- GCA (1)
- GI (1)
- Ganglia (1)
- Gastrointestinal (1)
- Gleason score (1)
- Glomerular filtration (1)
- HFmrEF (1)
- Heart failure (1)
- Hyperkalaemia (1)
- ICD (1)
- Imaging pitfalls (1)
- Journal of Nuclear Cardiology (1)
- Lysine (1)
- MDD (1)
- MIBG (1)
- MPI (1)
- Magnetresonanztomografie (1)
- Medullärer Schilddrüsenkrebs (1)
- Myocardial-perfusion SPECT (1)
- Myokarditis (1)
- NEC (1)
- Neuroendocrine (1)
- Neuroendocrine Tumor (1)
- Nierenfunktionsstörung (1)
- Oncology (1)
- PMR (1)
- PSA (1)
- PSA response (1)
- PSMA-617 (1)
- PSMA-PET (1)
- PSMA-TV (1)
- PSMA‐617 (1)
- Parkinsonism (1)
- Parkinson’s disease (1)
- Pitfall (1)
- Positron Emission Tomography (1)
- Positron-Emission Tomography (1)
- Positronenemissionstomografie (1)
- Prostata (1)
- RLT (1)
- Radiofluorine (1)
- Radionuclide Therapy (1)
- Radiotracer (1)
- SARS-CoV-2 (1)
- SPECT Scanner (1)
- SPECT/CT (1)
- SSTR-PET (1)
- SSTR-RADS (1)
- Single-Photon-Emissions-Computertomographie (1)
- Sodium-Glucose Cotransporters (SGLTs) (1)
- Stammzelle (1)
- Standardisierung (1)
- T-shaped π-π stacking (1)
- T-shaped π–π stacking (1)
- TIMP-1 (1)
- TKI (1)
- Tracer (1)
- Virchow Node (1)
- ZDF rats (1)
- [11C]-Choline PET/CT (1)
- [11C]-Methionine (1)
- [177Lu]-DOTATATE/-DOTATOC (1)
- [177Lu]/[90Y]PentixaTher (1)
- [177Lu]Lu-PSMA I&T (1)
- [177Lu]PentixaTher (1)
- [18F]FDG PET/CT (1)
- [68Ga] (1)
- [68Ga]DOTATOC (1)
- [68Ga]Pentixafor (1)
- [90Y]PentixaTher (1)
- [99mTc]-Sestamibi scan (1)
- [\(^{68}\)Ga]Ga-FAPI (1)
- [\(^{68}\)Ga]Pentixafor (1)
- \(^{177}\)Lu (1)
- \(^{18}\)F (1)
- \(^{18}\)F-DCFPyL PET/CT (1)
- \(^{18}\)F-FDG (1)
- \(^{18}\)F-PSMA-1007 (1)
- \(^{18}\)F-fluorodeoxyglucose (1)
- \(^{68}\)Ga (1)
- activation (1)
- adrenocortical carcinoma (1)
- ageing (1)
- amino acids (1)
- angiogenesis (1)
- angiotensin II type 1 receptor (1)
- antidepressant (1)
- arrhythmia (1)
- artificial intelligence (1)
- biomarkers (1)
- blood flow (1)
- cardiac neurohormonal system (1)
- cardiac sympathetic nerve system (1)
- cardiac sympathetic nervous system (1)
- cardiomyocytes (1)
- cardioprotective potential (1)
- combination (1)
- computational biology and bioinformatics (1)
- coronary artery disease (1)
- depression (1)
- diabetic cardiomyopathy (1)
- editorial (1)
- ejection fraction (1)
- endocrinology (1)
- epithelial-cells (1)
- fatty acid (1)
- fibroblast activation protein (1)
- flare phenomenon (1)
- focused surgical approach (1)
- giant cell arteritis (1)
- glial fate modulation (1)
- glomerular filtration rate (1)
- heart failure with mid-range ejection fraction (1)
- hematotoxicity (1)
- hiPSC-CM (1)
- hyperkalemia (1)
- immune infiltration (1)
- implants (1)
- induced pluripotent stem cells (1)
- kidney function (1)
- kinase (1)
- late response (1)
- left-ventricular function (1)
- lung-cancer (1)
- mRNA (1)
- magnetic resonance imaging (1)
- major depressive disorder (1)
- matched pair (1)
- medicine (1)
- medium-sized animals (1)
- meningioma (1)
- mesenchymal stem cells (1)
- miRNA (1)
- mouse models (1)
- myelin (1)
- myocardial nerve (1)
- myocardial perfusion imaging (1)
- myocarditis (1)
- nephrology (1)
- nephrotoxicity (1)
- neural stem cells (1)
- neuroblastoma (1)
- neuroendocrine neoplasms (NEN) (1)
- neuroendocrine tumors (NET) (1)
- neurology (1)
- nonhuman primates (1)
- nuclear cardiology (1)
- obstructive pulmonary-disease (1)
- oligodendroglia (1)
- overall survival (1)
- pancreas (1)
- papillary thyroid carcinoma (PTC) (1)
- parathyroid adenoma (1)
- pathway (1)
- performance (1)
- phaeochromocytoma (1)
- polymyalgia rheumatica (1)
- preclinical research (1)
- prediction (1)
- primary hyperparathyroidism (1)
- prostate-specific antigen (1)
- protein (1)
- quantification (1)
- radioiodine (1)
- radiotracer (1)
- radiotracer kinetics (1)
- rats (1)
- renal (1)
- renal failure (1)
- renal function (1)
- renal imaging (1)
- renal scintigraphy (1)
- renin-angiotensin system (1)
- reporting and data systems (1)
- sarcoidosis (1)
- secretome (1)
- selpercatinib (1)
- sigma-1 receptor-directed molecular imaging (1)
- single photon emission computed tomography: sympathetic nerve (1)
- solid tumors (1)
- somatic mutations (1)
- spinal cord (1)
- spinal cord injury (1)
- split renal function (1)
- staging (1)
- standardization (1)
- standardized reporting system (1)
- statin (1)
- stem cell therapy (1)
- stem cells (1)
- stem-cell research (1)
- storage vesicle turnover (1)
- stroke (1)
- structure–activity relationships (1)
- taxane (1)
- thyroid carcinoma (TC) (1)
- tracer (1)
- transcriptome (1)
- transplantation (1)
- tumor heterogeneity (1)
- tumor microenvironment (1)
- unilateral ureteral obstruction (1)
- urology (1)
- valsartan (1)
- vasculature (1)
- vasculitis (1)
Institute
- Klinik und Poliklinik für Nuklearmedizin (65)
- Medizinische Klinik und Poliklinik I (10)
- Medizinische Klinik und Poliklinik II (10)
- Deutsches Zentrum für Herzinsuffizienz (DZHI) (8)
- Urologische Klinik und Poliklinik (8)
- Institut für Pharmazie und Lebensmittelchemie (4)
- Comprehensive Cancer Center Mainfranken (3)
- Pathologisches Institut (3)
- Institut für Anatomie und Zellbiologie (2)
- Institut für Klinische Biochemie und Pathobiochemie (2)
- Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik) (2)
- Neurologische Klinik und Poliklinik (2)
- Center for Computational and Theoretical Biology (1)
- Institut für Medizinische Strahlenkunde und Zellforschung (1)
- Institut für Pharmakologie und Toxikologie (1)
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (1)
- Klinik und Poliklinik für Anästhesiologie (ab 2004) (1)
- Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie (1)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (1)
Sonstige beteiligte Institutionen
- Johns Hopkins School of Medicine (11)
- Johns Hopkins University School of Medicine (4)
- Department of Biomedical Imaging, National Cerebral and Cardiovascular Research Center, Suita, Japan (1)
- Department of Nuclear Medicine, Kanazawa University (1)
- Division of Medical Technology and Science, Department of Medical Physics and Engineering, Course of Health Science, Osaka University Graduate School of Medicine, Suita Japan (1)
- Institut for Molecular Biology and CMBI, Department of Genomics, Stem Cell Biology and Regenerative Medicine, Leopold-Franzens-University Innsbruck, Innsbruck, Austria (1)
- Johns Hopkins Medicine (1)
- Johns Hopkins School of Medicine, Baltimore, MD, USA (1)
- Johns Hopkins School of Medicine, The Russell H Morgan Department of Radiology and Radiological Science, Baltimore, MD, USA (1)
- Johns Hopkins University, Baltimore, MD, U.S. (1)
EU-Project number / Contract (GA) number
- 701983 (24)
Diagnosis of cardiac sarcoidosis is often challenging. Whereas cardiac magnetic resonance imaging (CMR) and positron emission tomography/computed tomography (PET/CT) with \(^{18}\)F-fluorodeoxyglucose (FDG) are most commonly used to evaluate patients, PET/CT using radiolabeled somatostatin receptor (SSTR) ligands for visualization of inflammation might represent a more specific alternative. This study aimed to investigate the feasibility of SSTR–PET/CT for detecting cardiac sarcoidosis in comparison to CMR.
15 patients (6 males, 9 females) with sarcoidosis and suspicion on cardiac involvement underwent SSTR-PET/CT imaging and CMR. Images were visually scored. The AHA 17-segment model of the left myocardium was used for localization and comparison of inflamed myocardium for both imaging modalities. In semi-quantitative analysis, mean (SUV\(_{mean}\)) and maximum standardized uptake values (SUV\(_{max}\)) of affected myocardium were calculated and compared with both remote myocardium and left ventricular (LV) cavity.
SSTR-PET was positive in 7/15, CMR in 10/15 patients. Of the 3 CMR+/PET- subjects, one patient with minor involvement (<25% of wall thickness in CMR) was missed by PET. The remaining two CMR+/PET- patients displayed no adverse cardiac events during follow-up.
In the 17-segment model, PET/CT yielded 27 and CMR 29 positive segments. Overall concordance of the 2 modalities was 96.1% (245/255 segments analyzed). SUV\(_{mean}\) and SUV\(_{max}\) in inflamed areas were 2.0±1.2 and 2.6±1.2, respectively. The lesion-to-remote myocardium and lesion-to-LV cavity ratios were 1.8±0.2 and 1.9±0.2 for SUV\(_{mean}\) and 2.0±0.3 and 1.7±0.3 for SUV\(_{max}\), respectively.
Detection of cardiac sarcoidosis by SSTR-PET/CT is feasible. Our data warrant further analysis in larger prospective series.