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The role of host factors in measles virus persistence (1994)
Schneider-Schaulies, Sibylle ; Schnorr, J.-J. ; Dunster, L. M. ; Schneider-Schaulies, Jürgen ; ter Meulen, Volker
As critical steps in the life cycle oJ measles virus (Mfl), the e.fficiency of uptake into and replication in susceptible host cells are governed by cellular determinants. Measles virus infections of cells of the human CNS are characterized by particular constraints imposed on v1:ral transcription and translation attenuating viral gene Junctions and thus contributing to the pathogenesis oJ MV persistence in these cells.
Spontaneous and differentiation dependent regulation of measles virus gene expression in human glial cells (1993)
Schneider-Schaulies, Sibylle ; Schneider-Schaulies, Jürgen ; Bayer, M. ; Löffler, S. ; ter Meulen, V.
The expression of measles virus (MV) in six different permanent human glioma cell lines (D-54, U-251, U-138, U-105, U-373, and D-32) was analyzed. Although all celllines were permissive for productive replication of all MV strains tested, U-251, D-54, and D-32 cells spontaneously revealed restrictions of MV transcription similar to those observed for primary rat astroglial cells and brain tissue. In vitro differentiation of D-54 and U-251 cells by substances affecting tbe intracellular cyclic AMP Ievel caused a significant reduction of tbe expression of tbe viral proteins after 18, 72, and 144 b of infection. This pronounced restriction was not paralleled to a comparable Ievel by an inhibition of tbe syntbesis and biological activity in vitro of virus·specific mRNAs as sbown by quantitative Northem (RNA) blot analyses and in vitro translation. The block in viral protein syntbesis could not be attributed to tbe induction of type I interferon by any of tbe substances tested. Our findings indicate tbat down-regulation of MV gene expression in human brain cells can occur by a cell type-rlependent regulation of tbe viral mRNA transcription and a differentiation-dependent regulation of translation, botb of wbicb may be crucial for the establisbment of persistent MV infections in tbe centrat nervous system.
HIV-1 gp120 receptor on CD4-negative brain cells activates a tyrosine kinase (1992)
Schneider-Schaulies, Jürgen ; Schneider-Schaulies, Sibylle ; Brinkmann, R. ; Tas, P. ; Halbrügge, M. ; Walter, U. ; Holmes, H.C. ; ter Meulen, Volker
Human immunodeficiency virus (HIV-1) infection in the human brain Ieads to characteristic neuropathological changes, which may result indirectly from interactions of the envelope glycoprotein gp 120 with neurons and/or glial cells. We therefore investigated the binding of recombinant gp120 (rgp120) to human neural cells and its effect on int~acellular.s.ignallin~. Herewe pre~ent evidence that rgp120, besides binding to galactocerebroside or galactosyl-sulfatlde, spec1f1cally bmds to a protem receptor of a relative molecular mass of approximately 180,000 Da (180 kDa) pre~ent. on the CD4-negative glioma cells D-54, but not on Molt4 T lymphocytes. Binding of rgp120 to this receptor rap1dly 1nduced a tyrosine-specific protein kinase activity leading to tyrosine phosphorylation of 130- and 115-kDa p~oteins. The c~ncentration of intracellular calciumwas not affected by rgp120 in these cells. Our data suggest a novel Signal transduc1ng HIV-1 gp120 receptor on CD4-negative glial cells, which may contribute to the neuropathological changes observed in HIV-1-infected brains.
Cell type specific MxA-mediated inhibition of measles virus transcription in human brain cells (1994)
Schneider-Schaulies, Sibylle ; Schneider-Schaulies, Jürgen ; Schuster, A. ; Bayer, M. ; Pavlovic, J. ; ter Meulen, V.
No abstract available
Neutral Sphingomyelinase-2 (NSM 2) Controls T Cell Metabolic Homeostasis and Reprogramming During Activation (2020)
De Lira, Maria Nathalia ; Raman, Sudha Janaki ; Schulze, Almut ; Schneider-Schaulies, Sibylle ; Avota, Elita
Neutral sphingomyelinase-2 (NSM2) is a member of a superfamily of enzymes responsible for conversion of sphingomyelin into phosphocholine and ceramide at the cytosolic leaflet of the plasma membrane. Upon specific ablation of NSM2, T cells proved to be hyper-responsive to CD3/CD28 co-stimulation, indicating that the enzyme acts to dampen early overshooting activation of these cells. It remained unclear whether hyper-reactivity of NSM2-deficient T cells is supported by a deregulated metabolic activity in these cells. Here, we demonstrate that ablation of NSM2 activity affects metabolism of the quiescent CD4\(^+\) T cells which accumulate ATP in mitochondria and increase basal glycolytic activity. This supports enhanced production of total ATP and metabolic switch early after TCR/CD28 stimulation. Most interestingly, increased metabolic activity in resting NSM2-deficient T cells does not support sustained response upon stimulation. While elevated under steady-state conditions in NSM2-deficient CD4\(^+\) T cells, the mTORC1 pathway regulating mitochondria size, oxidative phosphorylation, and ATP production is impaired after 24 h of stimulation. Taken together, the absence of NSM2 promotes a hyperactive metabolic state in unstimulated CD4\(^+\) T cells yet fails to support sustained T cell responses upon antigenic stimulation.
Restriction of measles virus gene expression in acute and subacute encephalitis in Lewis rats (1989)
Schneider-Schaulies, Sibylle ; Liebert, U. G. ; Baczko, K. ; Cattaneo, R. ; Billeter, M. ; ter Meulen, V.
No abstract available
Antibody-induced restriction of viral gene expression in measles encephalitis in rats (1990)
Liebert, U. G. ; Schneider-Schaulies, Sibylle ; Baczko, K. ; ter Meulen, V.
No abstract available
Restricted expression of measles virus in primary rat astroglial cells (1990)
Schneider-Schaulies, Sibylle ; Liebert, U. G. ; Baczko, K. ; ter Meulen, V.
No abstract available
Expression of measles virus RNA in peripheral blood mononuclear cells of patients with measles, SSPE, and autoimmune diseases (1991)
Schneider-Schaulies, Sibylle ; Kreth, H. W. ; Hofmann, G. ; Billeter, M. A. ; ter Meulen, V.
No abstract available
Augmentation of major histocompatibility complex class I and ICAM-1 expression on glial cells following measles virus infection: evidence for the role of type-1 interferon (1991)
Kraus, E. ; Schneider-Schaulies, Sibylle ; Miyasaka, M. ; Tamatani, T. ; Sedgwick, J.
No abstract available
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