004 Datenverarbeitung; Informatik
Refine
Has Fulltext
- yes (17)
Is part of the Bibliography
- yes (17) (remove)
Year of publication
Document Type
- Journal article (15)
- Preprint (2)
Language
- English (17)
Keywords
- cosmology (2)
- engineering (2)
- evolution (2)
- ACKR4 (1)
- AKT (1)
- Biology (1)
- Boolean function (1)
- Boolean tree (1)
- CD95 (1)
- CETCH cycle (1)
- CO2-sequestration (1)
- COVID-19 (1)
- Caenorhabditis elegans (1)
- Computer software (1)
- DNA storage (1)
- E8 symmetry (1)
- HGPS (1)
- Hurwitz theorem (1)
- ICEP (1)
- IGFBP2 (1)
- IronChip Evaluation Package (1)
- Lee Smolin (1)
- Microarray (1)
- Mycoplasma (1)
- Neuromuscular junctions (1)
- RNA sequencing (1)
- SARS-CoV-2 (1)
- Septins (1)
- Synapses (1)
- Synaptic vesicles (1)
- Vesicles (1)
- WNT (1)
- Yolk protein (1)
- Zebrafish (1)
- adaptation (1)
- aging (1)
- alignment (1)
- arabidopsis thaliana (1)
- arabidpsis thaliana (1)
- binary decision diagram (1)
- biofuel (1)
- bioinformatics (1)
- biomanufacturing (1)
- bit (1)
- brain (1)
- caenorhabditis elegans (1)
- carboxylation (1)
- caspase-3 (1)
- cerebral ischemia (1)
- cisplatin (1)
- colony-stimulating factor (1)
- comparative sequence analysis (1)
- computational (1)
- connector (1)
- corticotropin-releasing hormone (1)
- crosstalk (1)
- crystal growth (1)
- crystallization (1)
- database (1)
- design (1)
- differentiation (1)
- disease (1)
- drug-minded protein (1)
- elementary modes (1)
- emergent time (1)
- enzyme (1)
- expression (1)
- gamma (1)
- genes (1)
- genetic regulatory network (1)
- genetics (1)
- hepatotoxicity (1)
- heuristics (1)
- histidine kinase (1)
- homology modeling (1)
- immunity (1)
- inflation (1)
- inhibitor (1)
- intermediate host (1)
- internal transcribed spacer 2 (1)
- interpolation (1)
- life-span regulation (1)
- light-gated proteins (1)
- lymphotoxicity (1)
- metabolic modeling (1)
- metabolism (1)
- microbes (1)
- molecular systematics (1)
- mouse (1)
- mutation (1)
- nanocellulose (1)
- omics (1)
- organogenesis (1)
- origin (1)
- oxidative stress (1)
- pangolin (1)
- phase space (1)
- phase transition (1)
- photorespiration (1)
- phylogenetic tree (1)
- phylogeny (1)
- progeria (1)
- promoter (1)
- protein (1)
- protein chip (1)
- pseudomas-syringae (1)
- qubit (1)
- receptor (1)
- recombination (1)
- resistance (1)
- response regulator (1)
- ribosomal RNA (1)
- richtersius coronifer (1)
- secondary structure (1)
- sensor (1)
- sequence alignment (1)
- single-electron transistors (1)
- stable state (1)
- sun exposure (1)
- superoxide-dismutase (1)
- synthetic biology (1)
- synthetic pathways (1)
- tolerance (1)
- transcription (1)
- transmission (1)
- vitellogenin (1)
- water stress (1)
Two-component systems (TCS) are short signalling pathways generally occurring in prokaryotes. They frequently regulate prokaryotic stimulus responses and thus are also of interest for engineering in biotechnology and synthetic biology. The aim of this study is to better understand and describe rewiring of TCS while investigating different evolutionary scenarios. Based on large-scale screens of TCS in different organisms, this study gives detailed data, concrete alignments, and structure analysis on three general modification scenarios, where TCS were rewired for new responses and functions: (i) exchanges in the sequence within single TCS domains, (ii) exchange of whole TCS domains; (iii) addition of new components modulating TCS function. As a result, the replacement of stimulus and promotor cassettes to rewire TCS is well defined exploiting the alignments given here. The diverged TCS examples are non-trivial and the design is challenging. Designed connector proteins may also be useful to modify TCS in selected cases.