004 Datenverarbeitung; Informatik
Refine
Has Fulltext
- yes (17)
Is part of the Bibliography
- yes (17)
Year of publication
Document Type
- Journal article (15)
- Preprint (2)
Language
- English (17)
Keywords
- cosmology (2)
- engineering (2)
- evolution (2)
- ACKR4 (1)
- AKT (1)
- Biology (1)
- Boolean function (1)
- Boolean tree (1)
- CD95 (1)
- CETCH cycle (1)
- CO2-sequestration (1)
- COVID-19 (1)
- Caenorhabditis elegans (1)
- Computer software (1)
- DNA storage (1)
- E8 symmetry (1)
- HGPS (1)
- Hurwitz theorem (1)
- ICEP (1)
- IGFBP2 (1)
- IronChip Evaluation Package (1)
- Lee Smolin (1)
- Microarray (1)
- Mycoplasma (1)
- Neuromuscular junctions (1)
- RNA sequencing (1)
- SARS-CoV-2 (1)
- Septins (1)
- Synapses (1)
- Synaptic vesicles (1)
- Vesicles (1)
- WNT (1)
- Yolk protein (1)
- Zebrafish (1)
- adaptation (1)
- aging (1)
- alignment (1)
- arabidopsis thaliana (1)
- arabidpsis thaliana (1)
- binary decision diagram (1)
- biofuel (1)
- bioinformatics (1)
- biomanufacturing (1)
- bit (1)
- brain (1)
- caenorhabditis elegans (1)
- carboxylation (1)
- caspase-3 (1)
- cerebral ischemia (1)
- cisplatin (1)
- colony-stimulating factor (1)
- comparative sequence analysis (1)
- computational (1)
- connector (1)
- corticotropin-releasing hormone (1)
- crosstalk (1)
- crystal growth (1)
- crystallization (1)
- database (1)
- design (1)
- differentiation (1)
- disease (1)
- drug-minded protein (1)
- elementary modes (1)
- emergent time (1)
- enzyme (1)
- expression (1)
- gamma (1)
- genes (1)
- genetic regulatory network (1)
- genetics (1)
- hepatotoxicity (1)
- heuristics (1)
- histidine kinase (1)
- homology modeling (1)
- immunity (1)
- inflation (1)
- inhibitor (1)
- intermediate host (1)
- internal transcribed spacer 2 (1)
- interpolation (1)
- life-span regulation (1)
- light-gated proteins (1)
- lymphotoxicity (1)
- metabolic modeling (1)
- metabolism (1)
- microbes (1)
- molecular systematics (1)
- mouse (1)
- mutation (1)
- nanocellulose (1)
- omics (1)
- organogenesis (1)
- origin (1)
- oxidative stress (1)
- pangolin (1)
- phase space (1)
- phase transition (1)
- photorespiration (1)
- phylogenetic tree (1)
- phylogeny (1)
- progeria (1)
- promoter (1)
- protein (1)
- protein chip (1)
- pseudomas-syringae (1)
- qubit (1)
- receptor (1)
- recombination (1)
- resistance (1)
- response regulator (1)
- ribosomal RNA (1)
- richtersius coronifer (1)
- secondary structure (1)
- sensor (1)
- sequence alignment (1)
- single-electron transistors (1)
- stable state (1)
- sun exposure (1)
- superoxide-dismutase (1)
- synthetic biology (1)
- synthetic pathways (1)
- tolerance (1)
- transcription (1)
- transmission (1)
- vitellogenin (1)
- water stress (1)
Though several previous studies reported the in vitro and in vivo antioxidant effect of kinetin (Kn), details on its action in cisplatin-induced toxicity are still scarce. In this study we evaluated, for the first time, the effects of kinetin in cisplatin (cp)- induced liver and lymphocyte toxicity in rats. Wistar male albino rats were divided into nine groups: (i) the control (C), (ii) groups 2,3 and 4, which received 0.25, 0.5 and 1 mg/kg kinetin for 10 days; (iii) the cisplatin (cp) group, which received a single intraperitoneal injection of CP (7.0 mg/kg); and (iv) groups 6, 7, 8 and 9, which received, for 10 days, 0.25, 0.5 and 1 mg/kg kinetin or 200 mg/kg vitamin C, respectively, and Cp on the fourth day. CP-injected rats showed a significant impairment in biochemical, oxidative stress and inflammatory parameters in hepatic tissue and lymphocytes. PCR showed a profound increase in caspase-3, and a significant decline in AKT gene expression. Intriguingly, Kn treatment restored the biochemical, redox status and inflammatory parameters. Hepatic AKT and caspase-3 expression as well as CD95 levels in lymphocytes were also restored. In conclusion, Kn mitigated oxidative imbalance, inflammation and apoptosis in CP-induced liver and lymphocyte toxicity; therefore, it can be considered as a promising therapy.