004 Datenverarbeitung; Informatik
Refine
Has Fulltext
- yes (285)
Year of publication
Document Type
- Journal article (127)
- Doctoral Thesis (80)
- Working Paper (37)
- Preprint (19)
- Conference Proceeding (9)
- Jahresbericht (5)
- Master Thesis (4)
- Report (3)
- Other (1)
Language
- English (257)
- German (27)
- Multiple languages (1)
Keywords
- virtual reality (16)
- Datennetz (14)
- Leistungsbewertung (13)
- Quran (8)
- Robotik (8)
- Koran (7)
- Mobiler Roboter (7)
- Text Mining (7)
- Autonomer Roboter (6)
- Simulation (6)
Institute
- Institut für Informatik (203)
- Theodor-Boveri-Institut für Biowissenschaften (29)
- Institut Mensch - Computer - Medien (17)
- Institut für deutsche Philologie (17)
- Institut für Klinische Epidemiologie und Biometrie (7)
- Rechenzentrum (7)
- Center for Computational and Theoretical Biology (4)
- Graduate School of Science and Technology (3)
- Medizinische Klinik und Poliklinik II (3)
- Institut für Funktionsmaterialien und Biofabrikation (2)
Schriftenreihe
Sonstige beteiligte Institutionen
- Cologne Game Lab (2)
- Birmingham City University (1)
- DATE Lab, KITE Research Insititute, University Health Network, Toronto, Canada (1)
- EMBL Heidelberg (1)
- INAF Padova, Italy (1)
- Jacobs University Bremen, Germany (1)
- Open University of the Netherlands (1)
- Servicezentrum Medizin-Informatik (Universitätsklinikum) (1)
- Social and Technological Systems (SaTS) lab, School of Art, Media, Performance and Design, York University, Toronto, Canada (1)
- TH Köln (1)
Tardigrades have fascinated researchers for more than 300 years because of their extraordinary capability to undergo cryptobiosis and survive extreme environmental conditions. However, the survival mechanisms of tardigrades are still poorly understood mainly due to the absence of detailed knowledge about the proteome and genome of these organisms. Our study was intended to provide a basis for the functional characterization of expressed proteins in different states of tardigrades. High-throughput, high-accuracy proteomics in combination with a newly developed tardigrade specific protein database resulted in the identification of more than 3000 proteins in three different states: early embryonic state and adult animals in active and anhydrobiotic state. This comprehensive proteome resource includes protein families such as chaperones, antioxidants, ribosomal proteins, cytoskeletal proteins, transporters, protein channels, nutrient reservoirs, and developmental proteins. A comparative analysis of protein families in the different states was performed by calculating the exponentially modified protein abundance index which classifies proteins in major and minor components. This is the first step to analyzing the proteins involved in early embryonic development, and furthermore proteins which might play an important role in the transition into the anhydrobiotic state.