Institut für Organische Chemie
Refine
Has Fulltext
- yes (313)
Is part of the Bibliography
- yes (313)
Year of publication
Document Type
- Journal article (313) (remove)
Keywords
- Organische Chemie (122)
- Chemie (9)
- 1 (8)
- fluorescence (8)
- self-assembly (8)
- water oxidation (8)
- 3 (7)
- RNA (7)
- polycyclic aromatic hydrocarbons (7)
- organic chemistry (6)
Institute
- Institut für Organische Chemie (313)
- Institut für Anorganische Chemie (16)
- Institut für Virologie und Immunbiologie (8)
- Theodor-Boveri-Institut für Biowissenschaften (8)
- Institut für Pharmazie und Lebensmittelchemie (6)
- Institut für Physikalische und Theoretische Chemie (5)
- Lehrstuhl für Tissue Engineering und Regenerative Medizin (5)
- Institut für Hygiene und Mikrobiologie (3)
- Physikalisches Institut (3)
- Institut für Funktionsmaterialien und Biofabrikation (2)
- Abteilung für Funktionswerkstoffe der Medizin und der Zahnheilkunde (1)
- Comprehensive Cancer Center Mainfranken (1)
- Deutsches Zentrum für Herzinsuffizienz (DZHI) (1)
- Fakultät für Chemie und Pharmazie (1)
- Institut für Molekulare Infektionsbiologie (1)
- Institut für Pharmakologie und Toxikologie (1)
- Julius-von-Sachs-Institut für Biowissenschaften (1)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (1)
- Lehrstuhl für Orthopädie (1)
- Neurologische Klinik und Poliklinik (1)
- Rudolf-Virchow-Zentrum (1)
Sonstige beteiligte Institutionen
- Agricultural Center, BASF SE, 67117 Limburgerhof, Germany (1)
- Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells, Göttingen (1)
- Department of Cellular Biochemistry, University Medical Center Göttingen (1)
- Department of Cellular Biochemistry, University Medical Centre Göttingen (1)
- Department of Molecular Biology, University Medical Centre Göttingen (1)
- Georg August University School of Science (1)
- Göttingen Center for Molecular Biosciences, University of Göttingen (1)
- Helmholtz Institute for RNA-based Infection Biology (HIRI), Josef-Schneider-Straße 2/D15, DE-97080 Wuerzburg, Germany (1)
- Institut für Molekulare Infektionsbiologie (MIB) der Universität Würzburg (1)
- Institute of Cancer Research (ICR) London (1)
EU-Project number / Contract (GA) number
- 682586 (15)
- 787937 (12)
- 693023 (2)
- 242175-VascuBone (1)
- 242175‐VascuBone (1)
- 643238 (1)
- 654000 (1)
- 715923 (1)
- LaserLab Europe (LLC001917) (1)
The precise interplay between the mRNA codon and the tRNA anticodon is crucial for ensuring efficient and accurate translation by the ribosome. The insertion of RNA nucleobase derivatives in the mRNA allowed us to modulate the stability of the codon-anticodon interaction in the decoding site of bacterial and eukaryotic ribosomes, allowing an in-depth analysis of codon recognition. We found the hydrogen bond between the N1 of purines and the N3 of pyrimidines to be sufficient for decoding of the first two codon nucleotides, whereas adequate stacking between the RNA bases is critical at the wobble position. Inosine, found in eukaryotic mRNAs, is an important example of destabilization of the codon-anticodon interaction. Whereas single inosines are efficiently translated, multiple inosines, e.g., in the serotonin receptor 5-HT2C mRNA, inhibit translation. Thus, our results indicate that despite the robustness of the decoding process, its tolerance toward the weakening of codon-anticodon interactions is limited.