Structural and Functional Analysis of Chordin-like 2/BMP-2 Interaction
Please always quote using this URN: urn:nbn:de:bvb:20-opus-29120
- We have established the novel interaction between mCHL2, Tsg and BMP-2 for the first time. Tsg binds to VWC1 and VWC3 of mCHL2 in a cooperative waz and plazs a role in strengthening the binding affinity. Furthermore, Tsg/mCHL2/BMP-2 termary complex and Tsg/mCHL2 binary complex have been isolated by gel-filtration chromatography. Therefore mCHL2 can form a ternary complex with Tsg and BMP-2 and this complex makes mCHL2 a better BMP-2 antagnonist.
Author: | Yi Huang |
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URN: | urn:nbn:de:bvb:20-opus-29120 |
Document Type: | Doctoral Thesis |
Granting Institution: | Universität Würzburg, Medizinische Fakultät |
Faculties: | Medizinische Fakultät / Institut für Klinische Biochemie und Pathobiochemie |
Date of final exam: | 2008/09/10 |
Language: | English |
Year of Completion: | 2008 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | BMP-2 |
Release Date: | 2008/10/08 |
Advisor: | Prof. Walter Sebald |