Metastatic Crohn's disease: an underestimated entity
Please always quote using this URN: urn:nbn:de:bvb:20-opus-258435
- Cutaneous metastatic Crohn’s disease (MCD) is a rare but challenging dermatologic manifestation of Crohn’s disease. It is histologically defined as the presence of non-caseating granulomas at skin sites separated from and non-contiguous to the gastrointestinal tract. Cutaneous metastatic Crohn’s disease should be distinguished from the much more frequent contiguous cutaneous manifestations of Crohn’s disease that present at perianal or, less common, peristomal sites with direct extension from the intestine to the adjacent skin. VersatileCutaneous metastatic Crohn’s disease (MCD) is a rare but challenging dermatologic manifestation of Crohn’s disease. It is histologically defined as the presence of non-caseating granulomas at skin sites separated from and non-contiguous to the gastrointestinal tract. Cutaneous metastatic Crohn’s disease should be distinguished from the much more frequent contiguous cutaneous manifestations of Crohn’s disease that present at perianal or, less common, peristomal sites with direct extension from the intestine to the adjacent skin. Versatile clinical presentation and the fact that occurrence can predate the initial diagnosis of Crohn’s disease may lead to misdiagnosis, delayed treatment and underreporting. As case numbers are small and randomized controlled studies on management are lacking, the therapeutic approach remains challenging and is often unsatisfactory. We here performed a systematic literature search identifying 264 published pediatric and adult cases of MCD and additionally report three of our own cases. Our review summarizes clinical characteristics, putative etiopathology, histologic findings, differential diagnoses and treatment options for MCD.…
Author: | Franziska IckrathORCiD, Johanna Stoevesandt, Lena Schulmeyer, Caroline Glatzel, Matthias Goebeler, Andreas Kerstan |
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URN: | urn:nbn:de:bvb:20-opus-258435 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie |
Language: | English |
Parent Title (English): | Journal of the German Society of Dermatology |
Year of Completion: | 2021 |
Volume: | 19 |
Issue: | 7 |
Pagenumber: | 973–982 |
Source: | Journal of the German Society of Dermatology 2021, 19(7):973–982. DOI: 10.1111/ddg.14447 |
DOI: | https://doi.org/10.1111/ddg.14447 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | Cutaneous metastatic Crohn’s disease; histologic findings; treatment options |
Release Date: | 2022/03/30 |
Licence (German): | CC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell 4.0 International |