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Sex hormone-specific neuroanatomy of Takotsubo syndrome: is the insular cortex a moderator?
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-254776
- Takotsubo syndrome (TTS), a transient form of dysfunction in the heart's left ventricle, occurs predominantly in postmenopausal women who have emotional stress. Earlier studies support the concept that the human circulatory system is modulated by a cortical network (consisting of the anterior cingulate gyrus, amygdala, and insular cortex (Ic)) that plays a pivotal role in the central autonomic nervous system in relation to emotional stressors. The Ic plays a crucial role in the sympathovagal balance, and decreased levels of female sex hormonesTakotsubo syndrome (TTS), a transient form of dysfunction in the heart's left ventricle, occurs predominantly in postmenopausal women who have emotional stress. Earlier studies support the concept that the human circulatory system is modulated by a cortical network (consisting of the anterior cingulate gyrus, amygdala, and insular cortex (Ic)) that plays a pivotal role in the central autonomic nervous system in relation to emotional stressors. The Ic plays a crucial role in the sympathovagal balance, and decreased levels of female sex hormones have been speculated to change functional cerebral asymmetry, with a possible link to autonomic instability. In this review, we focus on the Ic as an important moderator of the human brain–heart axis in association with sex hormones. We also summarize the current knowledge regarding the sex-specific neuroanatomy in TTS.…
Autor(en): | Michiaki Nagai, Carola Yvette Förster, Keigo Dote |
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URN: | urn:nbn:de:bvb:20-opus-254776 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Klinik und Poliklinik für Anästhesiologie (ab 2004) |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Biomolecules |
ISSN: | 2218-273X |
Erscheinungsjahr: | 2022 |
Band / Jahrgang: | 12 |
Heft / Ausgabe: | 1 |
Aufsatznummer: | 110 |
Originalveröffentlichung / Quelle: | Biomolecules (2022) 12:1, 110. https://doi.org/10.3390/biom12010110 |
DOI: | https://doi.org/10.3390/biom12010110 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | Takotsubo cardiomyopathy; autonomic nervous system; central autonomic network; insular cortex; laterality; sex hormone |
Datum der Freischaltung: | 17.11.2022 |
Datum der Erstveröffentlichung: | 10.01.2022 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |