Sila-Pharmaka, 24. Mitt. [1]. Sila-Analoga von Nifedipin-ähnlichen 4-Aryl-2.6-dimethyl-1.4-dihydropyridin- 3.5-dicarbonsäure-dialkylestern, II.
Sila-Drugs, 24th Communication [1]. Sila-Analogues of Nifedipine-Like Dialkyl 4-Aryl-2,6-dimethyl-1,4-dihydropyridine- 3,5-dicarboxylates, II.
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-128381
- In the course of systematic studies on sila-substituted drugs the nifedipine-like 1.4-dihydropyridine derivatives 4a, 4b and 4c were prepared and investigated with respect to sila-substitution effects. By X-ray diffraction analyses 4a, 4b and 4c were found to be isostructural. The C/Si-analogues exhibit similar spasmolytic activities (in vitro, guinea pig ileum), comparable with that of nifedipine. However, the compounds differ substantially in their in vivo activity, as measured by the antihypertensive effect on the renal-hypertensive rat. TheIn the course of systematic studies on sila-substituted drugs the nifedipine-like 1.4-dihydropyridine derivatives 4a, 4b and 4c were prepared and investigated with respect to sila-substitution effects. By X-ray diffraction analyses 4a, 4b and 4c were found to be isostructural. The C/Si-analogues exhibit similar spasmolytic activities (in vitro, guinea pig ileum), comparable with that of nifedipine. However, the compounds differ substantially in their in vivo activity, as measured by the antihypertensive effect on the renal-hypertensive rat. The experimental results are discussed with respect to the carbon/silicon exchange.…
Autor(en): | R. Tacke, A. Bentlage, W. S. Sheldrick, L. Ernst, R. Towart, K. Stoepel |
---|---|
URN: | urn:nbn:de:bvb:20-opus-128381 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Fakultät für Chemie und Pharmazie / Institut für Anorganische Chemie |
Sprache der Veröffentlichung: | Deutsch |
Titel des übergeordneten Werkes / der Zeitschrift (Deutsch): | Zeitschrift für Naturforschung B |
Erscheinungsjahr: | 1982 |
Band / Jahrgang: | 37 |
Heft / Ausgabe: | 4 |
Seitenangabe: | 443-450 |
Originalveröffentlichung / Quelle: | Zeitschrift für Naturforschung B. Band 37, Heft 4, Seiten 443–450 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 5 Naturwissenschaften und Mathematik / 54 Chemie / 546 Anorganische Chemie |
Freie Schlagwort(e): | X-ray; pharmacological activity; sila-analogues of Nifedipine derivatives; structure-activity relationships |
Datum der Freischaltung: | 01.03.2016 |
Lizenz (Deutsch): | Deutsches Urheberrecht |