William Shamburger

• Our research group focusses on the isolation, structural elucidation, and synthesis of bioactive natural products, among others, the naphthylisoquinoline alkaloids from tropical lianas. This intriguing class of compounds comprises representatives with activities against, e.g. P. falciparum, the cause of Malaria tropica, against the neglected disease leishmaniasis, and, as discovered more recently, against different types of cancer cells. Based on the high potency of theses extraordinary secondary metabolites, this thesis was devoted to theOur research group focusses on the isolation, structural elucidation, and synthesis of bioactive natural products, among others, the naphthylisoquinoline alkaloids from tropical lianas. This intriguing class of compounds comprises representatives with activities against, e.g. P. falciparum, the cause of Malaria tropica, against the neglected disease leishmaniasis, and, as discovered more recently, against different types of cancer cells. Based on the high potency of theses extraordinary secondary metabolites, this thesis was devoted to the total synthesis of bioactive natural products and closely related analogs.…
• Die bemerkenswerte Substanzklasse der Naphthylisochinolin-Alkaloide enthält Wirkstoffe mit Aktivitäten gegen P. falciparum, den Erreger der Malaria tropica, gegen Leishmaniose und, wie erst kürzlich entdeckt, Wirkstoffe mit Aktivität gegenüber Zelllinien verschiedener Krebsarten. Aufgrund der hohen Wirksamkeit dieser außergewöhnlichen Sekundärmetabolite wurde die vorliegende Doktorarbeit auf die Totalsynthese bioaktiver Naphthylisochinoline und davon abgeleiteter Derivate ausgerichtet.