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Overdose of dolutegravir in combination with tenofovir disaproxil fumarate/emtricitabine in suicide attempt in a 21-year old patient
Please always quote using this URN: urn:nbn:de:bvb:20-opus-151994
- A 21 year old MSM patient with newly diagnosed HIV infection was hospitalized in our department after ingestion of an overdose of his antiretroviral therapy (ART) comprising dolutegravir (DTG - Tivicay\(^{®}\)) and tenofovir disaproxil fumarate/emtricitabine (Truvada\(^{®}\)) in suicidal intention. On admission, the patient did not show any clinical signs of intoxication and laboratory findings were unremarkable. After 6 hours of intensive care monitoring, the patient was referred to a psychiatric clinic. 5 days after the day of intoxication,A 21 year old MSM patient with newly diagnosed HIV infection was hospitalized in our department after ingestion of an overdose of his antiretroviral therapy (ART) comprising dolutegravir (DTG - Tivicay\(^{®}\)) and tenofovir disaproxil fumarate/emtricitabine (Truvada\(^{®}\)) in suicidal intention. On admission, the patient did not show any clinical signs of intoxication and laboratory findings were unremarkable. After 6 hours of intensive care monitoring, the patient was referred to a psychiatric clinic. 5 days after the day of intoxication, serum creatinine levels increased to high normal values (1.2 mg/dl). However, levels never exceeded the upper threshold. 8 and 12 weeks later, serum creatinine normalized to levels measured prior to the intoxication. No other adverse events occurred, and the patient does not suffer from permanent impairments.…
Author: | Marcel Lee, Florian Eyer, Norbert Felgenhauer, Hartwig H. F. Klinker, Christoph D. Spinner |
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URN: | urn:nbn:de:bvb:20-opus-151994 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Medizinische Klinik und Poliklinik II |
Language: | English |
Parent Title (English): | AIDS Research and Therapy |
Year of Completion: | 2015 |
Volume: | 12 |
Issue: | 18 |
Source: | AIDS Research and Therapy (2015) 12:18. DOI: 10.1186/s12981-015-0054-y |
DOI: | https://doi.org/10.1186/s12981-015-0054-y |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten |
Tag: | AIDS; HIV; dolutegravir; emtricitabine; integrase inhibitor; overdose; suicide attempt; tenofovir disaproxil fumarate |
Release Date: | 2017/10/30 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |